BMC Cardiovascular Disorders最新文献

{"title":"The relationships between anthropometric measurements, organ weights and intracranial, carotid and coronary atherosclerosis.","authors":"Hatice Kubra Ata Ozturk, Volkan Zeybek, Ayse Kurtulus Dereli, Kemalettin Acar, Ismail Dogu Kılıc, Ozgur Tekin, Alper Akca","doi":"10.1186/s12872-025-04607-w","DOIUrl":"10.1186/s12872-025-04607-w","url":null,"abstract":"<p><strong>Background: </strong>Atherosclerosis is the most common cause of cardiovascular-cerebrovascular diseases. Obesity and atherosclerosis are related, and obesity can lead to systemic diseases and an increase in organ weight. Anthropometric measurements such as body mass index, waist circumference and hip circumference are used to determine the risk of obesity. We conducted this study to evaluate the relationship between obesity and atherosclerosis in postmortem cases. We aimed to determine the relationships among anthropometric measurements; subcutaneous adipose tissue thickness; atherosclerosis in the intracranial, carotid, and coronary arteries and organ weights.</p><p><strong>Methods: </strong>Prospective data analysis was performed from 230 forensic autopsies of 18-75-year-olds from 22/01/2020 to 22/01/2021. Age, sex, history of disease, cause of death, height, weight, body mass index, waist circumference, hip circumference, waist/hip ratio, subcutaneous adipose tissue thickness, and organ weights of the patients were recorded. Atheroma plaques and stenosis in the intracranial, carotid, and coronary arteries were examined. Statistical analysis was performed using IBM SPSS Statistics version 29. The Mann-Whitney U or Kruskal Wallis tests were employed to compare continuous variables. Categorical variables were compared using the Chi-square test.</p><p><strong>Results: </strong>This study included 187 (81.3%) males and 43 (18.7%) females, and the mean age of the patients was 49.3 ± 17.5 years. Body mass index was significantly and positively correlated with waist circumference, hip circumference, subcutaneous adipose tissue thickness, and the waist/hip ratio. Body mass index, waist/hip ratio, and subcutaneous adipose tissue thickness were significantly positively correlated with heart, liver, kidney, and spleen weights. While body mass index, waist/hip ratio, and subcutaneous adipose tissue thickness were negatively correlated with brain weight in females, this correlation was not detected in males. There were significant associations between the waist/hip ratio and atheroma plaque in the intracranial arteries and ≥ 50% stenosis in the LAD-RCA arteries.</p><p><strong>Conclusions: </strong>The methods used in the assessment of obesity are important. In study, obesity was approached from a broad perspective by evaluating anthropometric measurements used for obesity diagnosis and atherosclerosis together with organ weights in postmortem cases. We believe that our study will contribute to the assessment of cardiovascular disease risk factors.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"155"},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A-kinase anchoring protein 1: an independent predictor of coronary artery disease.","authors":"Wei Yan, Yun-Lang Dai, Jun-Xia Han","doi":"10.1186/s12872-025-04613-y","DOIUrl":"10.1186/s12872-025-04613-y","url":null,"abstract":"<p><strong>Introduction: </strong>Coronary artery disease (CAD) is the leading cause of death worldwide. A-kinase anchoring protein 1 (AKAP1), thought to regulate the function and structure of mitochondria, is enriched in the heart, where it plays a protective role. However, data on the serum AKAP1 concentration levels in patients with CAD are currently lacking. To address this, the serum levels of AKAP1 in patients with CAD were quantified and their predictive ability for CAD was evaluated in this study.</p><p><strong>Methods: </strong>A total of 255 patients referred for coronary angiography were included in this study and classified into two groups (CAD and non-CAD group). A comparative analysis of clinical data and serum AKAP1 concentration levels was performed between the two groups. The patients were then divided into quartiles according to AKAP1 levels. A multivariate logistic regression model was used to assess the independent association of AKAP1 with CAD.</p><p><strong>Results: </strong>The CAD group showed a lower AKAP1 concentration than the non-CAD group (P < 0.01). The AKAP1 level was correlated with a history of CAD (P < 0.001). The receiver operator characteristic (ROC) curve analysis showed a low ability of AKAP1 in predicting CAD (area under the ROC curve = 0.649). Finally, in the multivariate logistic regression model with the highest quartile as the reference, the lowest quartile of AKAP1 remained significantly associated with an increased risk for CAD (odds ratio (OR) = 5.677, 95% confidence interval [CI] 1.704 to 18.912, P = 0.005).</p><p><strong>Conclusions: </strong>Our results confirmed that serum AKAP1 levels are inversely associated with CAD and may therefore be used as a marker for CAD prediction. But additional studies are needed to confirm and further elucidate our results.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"156"},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Predictive factors for multivessel disease in patients with acute coronary syndrome: analysis from the CCC-ACS project in China.","authors":"Houlin He, Jun Wang, Yasong Wang, Ruoxi Gu, Dongyuan Sun, Lingfei Zheng, Xiaoxiang Tian, Yaling Han, Xiaozeng Wang","doi":"10.1186/s12872-025-04592-0","DOIUrl":"10.1186/s12872-025-04592-0","url":null,"abstract":"","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"154"},"PeriodicalIF":2.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between venous thromboembolism and inflammatory bowel disease in Taiwan: a nationwide retrospective cohort study.","authors":"Yi-Jen Fang, Hui-Hsia Hsieh, Heng-Jun Lin, Cheng-Li Lin, Wan-Yi Lee, Chi-Hua Chen, Fuu-Jen Tsai, Bang-Jau You, Ni Tien, Yun-Ping Lim","doi":"10.1186/s12872-025-04600-3","DOIUrl":"10.1186/s12872-025-04600-3","url":null,"abstract":"<p><strong>Background: </strong>Inflammation significantly influences thrombosis development, with venous thromboembolism (VTE) risk linked to various systemic inflammatory diseases, but not fully established in inflammatory bowel disease (IBD). Using a population-based cohort study conducted in Taiwan, we investigated the impact of IBD on the risk of VTE, deep vein thrombosis (DVT), and pulmonary embolism (PE), as well as the impact of anti-IBD treatments.</p><p><strong>Methods: </strong>A study was conducted on a cohort of patients with IBD diagnosed between 2010 and 2019 using the National Health Insurance database. The risks of VTE, DVT, and PE, as well as anti-IBD treatment use, were examined using Cox proportional hazard regression analysis.</p><p><strong>Results: </strong>The overall number of person-years recorded for 12,126 patients with IBD (mean age: 49.18 years; 55.31% male) and 12,126 controls (mean age: 49.19 years; 55.31% male) was 64,057 and 72,056, with a follow-up duration for the two cohorts was 5.28 and 5.94 years, respectively. After adjusting for age, gender, and comorbidities, the adjusted hazard ratios (aHRs) of VTE, DVT, and PE in patients with IBD were 5.58 [95% confidence interval (CI) = 3.97-7.87], 5.48 (95% CI = 3.83-7.86), and 4.96 (95% CI = 2.00-12.35) times higher, respectively, than those in the control cohort. Male patients with IBD and those under the age of 50 were more likely to develop VTE (aHR = 8.54, 95% CI = 2.00-12.35; aHR = 15.75, 95% CI = 5.73-43.26, respectively). Compared to the cohort of patients with IBD receiving no treatment, patients receiving anti-IBD treatments did not show a significant change in the risk of developing VTE. Additionally, compared to the IV steroid cohort, patients with IBD who only used oral steroids had a substantially lower incidence of VTE, particularly with average doses of ≤ 80 mg (aHR = 0.24, 95% CI = 0.10-0.59).</p><p><strong>Conclusion: </strong>Patients with IBD are at an increased risk of developing VTE, particularly DVT and PE. While our study found that anti-IBD treatments did not significantly alter this risk, proactive management of associated factors and close monitoring remains essential for preventing VTE in this population. Identifying and addressing specific associated factors should be prioritized in clinical practice to mitigate the heightened risk of VTE in IBD patients.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"153"},"PeriodicalIF":2.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of the Geriatric Nutritional Risk Index in mortality prediction among critically ill acute myocardial infarction patients.","authors":"Shanshan Tang, Chengcheng Wu, Yanbin Su, Yongle Li","doi":"10.1186/s12872-025-04546-6","DOIUrl":"10.1186/s12872-025-04546-6","url":null,"abstract":"<p><strong>Background: </strong>Nutritional status is a key factor influencing outcomes in critically ill patients with acute myocardial infarction (AMI). This study investigated the association between the Geriatric Nutritional Risk Index (GNRI) and mortality among ICU-admitted AMI patients, as well as GNRI's potential to improve the predictive accuracy of current scoring systems.</p><p><strong>Methods: </strong>In this retrospective cohort study, data from 5,506 ICU-admitted AMI patients were sourced from three open-access critical care databases. Based on GNRI scores, patients were grouped into two categories: GNRI ≤ 98 and GNRI > 98. Statistical tools such as logistic regression and Cox proportional hazards models assessed in-hospital and 30-day mortality. Kaplan-Meier survival curves and restricted cubic splines analyzed survival trends and dose-response relationships. Sensitivity analyses, including propensity score matching (PSM), inverse probability weighting (IPW), and dropping missing data analysis validated the robustness of findings. The receiver operating characteristic (ROC) curve compared GNRI's predictive ability with SOFA and APSIII scores. A sensitivity analysis was performed using a four-tier GNRI classification: no risk (> 98), low risk (92-98), moderate risk (82-<92), and major risk (< 82) to further explore its gradient relationship with mortality.</p><p><strong>Results: </strong>Patients with GNRI ≤ 98 showed higher mortality rates for in-hospital (21.8% vs. 10.4%) and 30-day (22.5% vs. 10.7%) outcomes. GNRI displayed an inverse correlation with in-hospital mortality (OR 0.51, 95% CI 0.43-0.60) and 30-day mortality (HR 0.57, 95% CI 0.50-0.66), even after adjusting for confounders. Subgroup analysis emphasized GNRI's reliability as a predictive marker, particularly in patients with eGFR ≥ 90. ROC analysis confirmed GNRI's predictive performance (AUC = 0.64) and its enhancement of SOFA (AUC = 0.72) and APSIII (AUC = 0.66) scores (all p < 0.001). Sensitivity analyses reinforced GNRI's link to mortality.</p><p><strong>Conclusion: </strong>GNRI serves as a robust predictor of in-hospital and 30-day mortality among critically ill AMI patients. Its integration with existing scoring systems improves risk stratification in this high-risk population.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"152"},"PeriodicalIF":2.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of patient knowledge with drug-modifiable cardiovascular risk factor control in coronary artery disease patients with and without diabetes mellitus: results from the cross-sectional KNOW-ABC study.","authors":"Maximilian Brockmeyer, Michaela Fell, Claudio Parco, Alexander Hoss, Kris G Vargas, Emilia Wies, Yingfeng Lin, Yvonne Heinen, Nadja Chernyak, Andrea Icks, Christian Jung, Malte Kelm, Georg Wolff","doi":"10.1186/s12872-025-04599-7","DOIUrl":"10.1186/s12872-025-04599-7","url":null,"abstract":"<p><strong>Background: </strong>Control of major drug-modifiable risk factors for glycated hemoglobin (HbA1c), blood pressure (BP), and low-density lipoprotein cholesterol (LDL-C) remains unsatisfactory in the secondary prevention of coronary artery disease (CAD). We aimed to analyze patient knowledge and attainment of LDL-C, BP, and HbA1c treatment goals and associated factors in German CAD patients with and without diabetes mellitus (DM).</p><p><strong>Methods/results: </strong>A total of 204 CAD patients (68 ± 8 years; 75.0% male; 84 with DM (41.2%)) completed a questionnaire assessing their knowledge of LDL-C (< 55 mg/dL), BP (age-adapted), and HbA1c (< 7.0%) treatment goals and levels of information on predefined CAD topics as well as associated factors, including CAD duration, adherence to pharmacotherapy, and physician monitoring of secondary prevention. LDL-C, BP, and HbA1c were measured. The mean duration of CAD was 9.8 ± 8 years. A total of 98.5% reported good adherence to pharmacotherapy. Measurements of LDL-C (81.4%) and HbA1c (71.4%) were predominantly performed by general practitioners. LDL-C goals were attained significantly better in patients with DM (39.3% with vs. 16.7% without DM, p < 0.01). The attainment of BP goals did not differ between patients with and without DM (71.4% vs. 72.5%, p = 0.87). HbA1c goals were attained by 48.8% of DM patients. LDL-C goals were known by 6.0% of patients with vs. 9.2% without DM (p = 0.44), and BP goals were known by 36.9% with vs. 30.0% without DM (p = 0.36). Knowledge of HbA1c goals was prevalent in 53.6% of DM patients. Subjective levels of information on CAD topics did not differ between patients with and without DM. Logistic regression revealed that DM (odds ratio (OR) 3.73, 95% confidence interval (CI) 1.82-7.63) and knowledge of treatment goals were associated with LDL-C goal attainment (OR 3.84, CI 1.19-12.41); no such associations were identified for BP or HbA1c.</p><p><strong>Conclusions: </strong>In German CAD patients with and without DM, a remarkable lack of knowledge and attainment of LDL-C treatment goals exists compared with BP and HbA1c. DM and knowledge of treatment goals were significantly associated with LDL-C treatment goal attainment. General practitioners rather than cardiologists or other specialties currently manage risk factor control.</p><p><strong>Trial registration: </strong>German Clinical Trials Register studyID DRKS00030703.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"148"},"PeriodicalIF":2.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical differences based on sex and clusters of biomarkers in patients with COVID-19: analysis from the CARDIO COVID 19-20 registry.","authors":"Frank Cañón-Estrada, Juan Andrés Muñoz-Ordoñez, Manuela Escalante-Forero, Yorlany Rodas, Andrea Alejandra Arteaga-Tobar, Valeria Azcarate-Rodriguez, Eduardo Perna, Iván Mendoza, Fernando Wyss, José Luis Barisani, Mario Speranza, Walter Alarco, Juan Carlos Ortega, Andrés Ulate, Jessica Mercedes, Daniel Quesada Chaves, Paola Oliver, Andrea Valencia-Orozco, Mario Miguel Barbosa, Hoover León-Giraldo, Noel Alberto Flórez, Juan Esteban Gómez-Mesa","doi":"10.1186/s12872-025-04565-3","DOIUrl":"10.1186/s12872-025-04565-3","url":null,"abstract":"<p><strong>Background: </strong>The inflammatory response associated with COVID-19 varies with sex, potentially affecting disease outcomes. Males have a higher risk of complications compared to females, requiring an evaluation of differences in inflammatory response severity based on sex.</p><p><strong>Objective: </strong>To compare clinical data, biochemical biomarkers, and outcomes among hospitalized COVID-19 patients in Latin America and the Caribbean (LA&C) based on sex and to perform a cluster analysis of biomarker profiles for both sexes.</p><p><strong>Methods: </strong>This prospective, multicenter observational registry made by the Inter-American Council of Heart Failure and Pulmonary Hypertension of the Inter-American Society of Cardiology included hospitalized COVID-19 patients from 44 hospitals in 14 countries in LA&C between May 1, 2020, and June 30, 2021.</p><p><strong>Results: </strong>Of 3,260 patients (1,201 females and 2,059 males), males had higher C-reactive protein and ferritin levels, while females had higher natriuretic peptides and d-dimer levels. Males had more cardiovascular complications (acute coronary syndrome [3.3% vs. 2.2%], decompensated heart failure [8.9% vs. 7.8%], pulmonary embolism [4.4% vs. 2.9%]), intensive care unit (ICU) admissions (56.9% vs. 47.7%), and overall mortality (27.5% vs. 22.1%). Cluster analysis identified three groups: one with normal-range biomarkers but elevated ferritin, one with coagulation abnormalities, and one with an inflammatory profile linked to renal injury and increased non-cardiovascular mortality.</p><p><strong>Conclusions: </strong>In the LA&C population hospitalized with COVID-19, males had higher inflammatory biomarker levels, correlating with increased cardiovascular complications and mortality. The cluster with an inflammatory profile showed higher non-cardiovascular mortality, while clusters with elevated ferritin levels were associated with increased ICU admissions.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"147"},"PeriodicalIF":2.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The features of distinctive bipolar intracardiac electrograms for ventricular arrhythmias in the DGCV system origin.","authors":"Weiqian Lin, Jiasheng Yu, Cheng Zheng, Jiafeng Lin, Guojuan Xu","doi":"10.1186/s12872-025-04606-x","DOIUrl":"10.1186/s12872-025-04606-x","url":null,"abstract":"<p><strong>Aims: </strong>To investigate the characteristics of bipolar intracardiac electrograms (bi-EGMs) in target sites of ventricular arrhythmias (VAs) originating from the distal great vein system (DGCVs).</p><p><strong>Methods: </strong>169 patients undergoing first-time ablation for VAs originated from DGCVs were enrolled in present study. Successful ablation was achieved in 146 patients. Bi-EGMs on successful sites were recorded and analyzed.</p><p><strong>Results: </strong>In the 146 cases, the DGCVs was subdivided into DGCV (100 cases), AIV (28cases), and summit-CV (18 cases) subgroup based on anatomic location of final target site. An A and V wave were consistently recorded in Bi-EGM of target sites. A total of 59 cases showed A/V ≥ 1 while 87 patients were < 1. The incidence of A/V ≥ 1 recorded in target sites was higher in the DGCV subgroup (52%, 52/100) compared to the AIV (10.71%, 3/28) and summit-CV (22.22%, 4/18) subgroups (all p < 0.05). In A/V > 1 cases, pacing-induced ventricle capture, atrium capture or alternate atrium and ventricle capture, and no chamber capture were 83.05%(49/59), 6.78%(4/59),10.19%(6/59), respectively, and they were 90.80%(79/87), 1.15%(1/87), 8.05%(7/87) (p > 0.05) in 87 cases of A/V < 1. A presystolic multicomponent fractionated potential was frequently observed in target sites of DGCVs VAs(102/146, 69.86%), with the DGCV subgroup being more frequent than the AIV and summit-CV subgroups (74/100, 74% vs. 19/28, 67.86% vs. 9/18, 50%).</p><p><strong>Conclusion: </strong>Catheter ablation of VAs arising from DGCV system is challenging. Different from traditional concept of atrioventricular annulus VAs, whose AV ratio of target sites should be less than 1, A/V ≥ 1 could be observed in VAs arising from DGCVs. In this region, target site identification should not be restrained by AV ratio. In addition, the presence of specific potentials in Bi-EGMs, can serve as an indicator for identifying target sites.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"150"},"PeriodicalIF":2.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender disparities in hypertension prevalence, awareness and healthcare seeking behaviour among young adults in Nigeria.","authors":"Rabiu Ibrahim Jalo, Eniola Adetola Bamgboye, Mobolaji Modinat Salawu, Joshua Odunayo Akinyemi, Uzoamaka Uja, Okechukwu Samuel Ogah, Oyediran Emmanuel Oyewole, Oluwadolapo Salisu, Mahmoud Umar Sani, IkeOluwapo Oyeneye Ajayi","doi":"10.1186/s12872-025-04603-0","DOIUrl":"10.1186/s12872-025-04603-0","url":null,"abstract":"<p><strong>Background: </strong>The burden of hypertension and healthcare seeking behaviour can be driven by gender-related inequalities in access to care. Low hypertension awareness often originates in early adulthood, determining gender patterns in hypertension. The factors that contribute to these patterns in this life stage are critical for improving hypertension control and reducing cardiovascular disease risk. This study was conducted to assess the gender disparities in hypertension prevalence, awareness and healthcare seeking behaviour among young adults in three selected states in Nigeria.</p><p><strong>Methods: </strong>Using a cross-sectional design, we assessed gender differences in prevalence, awareness and healthcare seeking behaviour for hypertension among 924 young adults aged 18 - 40 years in three states of Nigeria (Abia, Oyo and Kano States). Pearson's Chi-square was used to test associations between variables. Predictors of gender disparities were assessed with binary logistic regression at 5% level of statistical significance.</p><p><strong>Results: </strong>Of these, 416 (45.0%) were less than 30 years old while 508 (55.0%) of the respondents were ≥ 30 years of age with a mean age ± SD of 29.6 ± 6.8 and 29.8 ± 6.8 for male and female respondents respectively. Overall, the prevalence of hypertension among young adults in the three states was 169 (18.2%); higher among females 107 (19.2%) compared to males 61 (16.7%). Awareness of high blood pressure (BP) was higher among female respondents 333 (59.7%) compared to their male counterparts 192 (52.5%) and the difference was statistically significant (p = 0.03). Visits to a health care provider was higher among females (16.0%) than males (8.7%). Age, marital status, ethnicity, education and occupation were significantly associated (p < 0.005) with elevated BP among female hypertensives while age, marital status and ethnicity were significantly associated with elevated BP among male hypertensives.</p><p><strong>Conclusions: </strong>The study showed gender specific differences with regards to the burden, awareness and health seeking behaviour for hypertension among young adults in Nigeria. There is need for gender specific interventions to control the increasing burden of hypertension in Nigeria.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"151"},"PeriodicalIF":2.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound assessment of the association between left atrial remodeling and fibrosis in patients with valvular atrial fibrillation: a clinical investigation.","authors":"Tao Xu, Haotian Hu, Runyu Zhu, Wenshu Hu, Xinyi Li, Dian Shen, Aoyi Zhang, Chang Zhou","doi":"10.1186/s12872-025-04580-4","DOIUrl":"10.1186/s12872-025-04580-4","url":null,"abstract":"<p><strong>Background: </strong>Advanced heart failure in patients with valvular atrial fibrillation (VAF) poses a significant threat to human health. Noninvasive assessment of left atrial remodeling in various pathological conditions is instrumental in guiding clinical treatment decisions, evaluating efficacy, and predicting prognosis.</p><p><strong>Methods: </strong>The study enrolled 63 patients diagnosed with mitral stenosis (MS), among whom 44 presented concomitant atrial fibrillation (AF) and 19 had sinus rhythm. Left atrial volume and functional parameters were evaluated using real-time three-dimensional echocardiography (RT-3DE) and two-dimensional speckle tracking imaging (2D-STI) techniques, while left atrial stiffness index (LASI) was calculated accordingly. During surgery, left atrial myocardial specimens were obtained to determine the CVF through histopathological evaluation, reflecting the extent of left atrial myocardial fibrosis. Comparative analysis was conducted between the AF group and the control group regarding left atrial volume, functional parameters, LASI, as well as their correlation with CVF.</p><p><strong>Results: </strong>(1) Patients with MS combined with AF exhibit larger left atrial volume, decreased strain at all stages, reduced function, and increased stiffness of the left atrium compared to patients in sinus rhythm. (2) LASI was positively correlated with CVF in both the control and AF groups, exhibiting the highest correlation coefficient (p < 0.05).</p><p><strong>Conclusion: </strong>The application of RT-3DE, 2D-STI, and LASI enables effective evaluation of left atrial structure and function changes in patients with VAF. LASI provides a more accurate indication of the extent of myocardial fibrosis.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"149"},"PeriodicalIF":2.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}