BMC MedicinePub Date : 2026-04-28DOI: 10.1186/s12916-026-04815-x
Monica Aas, Thole H Hoppen, Nexhmedin Morina, Shiyu Zhang, Bin Li, Vid Mlakar, Julian Mutz
{"title":"Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing.","authors":"Monica Aas, Thole H Hoppen, Nexhmedin Morina, Shiyu Zhang, Bin Li, Vid Mlakar, Julian Mutz","doi":"10.1186/s12916-026-04815-x","DOIUrl":"https://doi.org/10.1186/s12916-026-04815-x","url":null,"abstract":"<p><strong>Background: </strong>Adverse events across the lifespan have been linked to poorer health outcomes, but the biological mechanisms remain unclear. The aim of this study was to quantify the independent and joint associations of adversity experienced in childhood and/or adulthood with molecular, clinical and functional markers of biological ageing.</p><p><strong>Methods: </strong>We analysed data from up to 153,557 middle-aged and older adults in the UK Biobank. Adversity was assessed through questionnaires capturing five types of childhood and adulthood adverse events. Biological ageing markers included metabolomic age (MileAge) delta, a metabolomic mortality profile, the frailty index, telomere length and grip strength. Regression models were adjusted for age, sex, education, income, ethnicity and neighbourhood deprivation.</p><p><strong>Results: </strong>Across childhood and adulthood exposures, adversity and its severity were most consistently associated with higher frailty index values. The strongest associations were observed in individuals exposed to multiple types of adverse events. Individuals who experienced adversity in both childhood and adulthood also had a metabolite-predicted age exceeding their chronological age and lower grip strength. Abuse was more consistently associated with biological ageing markers than neglect.</p><p><strong>Conclusions: </strong>Cumulative exposure to adversity across childhood and adulthood is associated with older biological ageing profiles across multiple domains. These findings highlight biological ageing as a potential pathway linking adversity to poor health outcomes and premature mortality.</p>","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"24 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC MedicinePub Date : 2026-04-28DOI: 10.1186/s12916-026-04884-y
Naomi C S Auwerda, Muhau M Mungamba, Eva Van der Linden, Erik Beune, Karlijn A C Meeks, Peter Henneman, Charles Agyemang, Mary Nicolaou, Ina Danquah, Georges E Janssens, Gajja S Salomons, Felix P Chilunga
{"title":"Dietary intake and epigenetic aging in an African population: food groups, dietary patterns, and plant-based diets in the RODAM study.","authors":"Naomi C S Auwerda, Muhau M Mungamba, Eva Van der Linden, Erik Beune, Karlijn A C Meeks, Peter Henneman, Charles Agyemang, Mary Nicolaou, Ina Danquah, Georges E Janssens, Gajja S Salomons, Felix P Chilunga","doi":"10.1186/s12916-026-04884-y","DOIUrl":"https://doi.org/10.1186/s12916-026-04884-y","url":null,"abstract":"","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC MedicinePub Date : 2026-04-28DOI: 10.1186/s12916-026-04891-z
Yue Chen, Srimanti Dutta, Rashmita Bajracharya, Francisco Cortès-Ibañez, Renée Turzanski Fortner, Verena Katzke, Rudolf Kaaks
{"title":"Smoking history, eligibility for lung cancer screening and risk of death by lung cancer or other causes -- a longitudinal, time-variable analysis of the EPIC-Heidelberg cohort.","authors":"Yue Chen, Srimanti Dutta, Rashmita Bajracharya, Francisco Cortès-Ibañez, Renée Turzanski Fortner, Verena Katzke, Rudolf Kaaks","doi":"10.1186/s12916-026-04891-z","DOIUrl":"10.1186/s12916-026-04891-z","url":null,"abstract":"","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"24 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC MedicinePub Date : 2026-04-27DOI: 10.1186/s12916-026-04882-0
Aurora Román-Domínguez, Cristina Mas-Bargues, Virgilio Pérez, Miguel Medina, Jesús Ávila, Consuelo Borrás, José Viña
{"title":"Peripheral blood biomarkers RCAN1, Clusterin, RAGE, and malondialdehyde for early diagnosis and progression of Alzheimer's disease.","authors":"Aurora Román-Domínguez, Cristina Mas-Bargues, Virgilio Pérez, Miguel Medina, Jesús Ávila, Consuelo Borrás, José Viña","doi":"10.1186/s12916-026-04882-0","DOIUrl":"https://doi.org/10.1186/s12916-026-04882-0","url":null,"abstract":"","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC MedicinePub Date : 2026-04-25DOI: 10.1186/s12916-026-04883-z
Fabian Stögbauer, Tobias Weiser, Ali Bashiri Dezfouli, Johannes Wirth, Luca Engelmann, Jan Budczies, Iordanis Ourailidis, Melanie Boxberg, Katharina Pigorsch, Benedikt Schmidl, Nicole Strittmatter, Katja Steiger, Carolin Mogler, Barbara Wollenberg
{"title":"Personalizing the treatment of head and neck cancer in vitro: The 3D-OTC model.","authors":"Fabian Stögbauer, Tobias Weiser, Ali Bashiri Dezfouli, Johannes Wirth, Luca Engelmann, Jan Budczies, Iordanis Ourailidis, Melanie Boxberg, Katharina Pigorsch, Benedikt Schmidl, Nicole Strittmatter, Katja Steiger, Carolin Mogler, Barbara Wollenberg","doi":"10.1186/s12916-026-04883-z","DOIUrl":"https://doi.org/10.1186/s12916-026-04883-z","url":null,"abstract":"","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"24 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC MedicinePub Date : 2026-04-25DOI: 10.1186/s12916-026-04873-1
André Maurício Passos Liber, Mirella Barboni, Yoshitsugu Aoki, Jan Kremers, Cyrille Vaillend
{"title":"Dystrophin-gene mutation location influences severity of electroretinogram defects in mouse models of Duchenne muscular dystrophy.","authors":"André Maurício Passos Liber, Mirella Barboni, Yoshitsugu Aoki, Jan Kremers, Cyrille Vaillend","doi":"10.1186/s12916-026-04873-1","DOIUrl":"https://doi.org/10.1186/s12916-026-04873-1","url":null,"abstract":"<p><strong>Background: </strong>Duchenne muscular dystrophy (DMD) results from mutations in the DMD gene, which differentially affect dystrophin isoforms (Dp427, Dp260, Dp140, Dp71) expressed in distinct brain and retinal cell types. The selective loss of one or more isoforms contributes to heterogeneous cognitive and neuropsychiatric comorbidities. Here, we investigated whether specific mutations differentially affect retinal function by comparing genotype-dependent electroretinographic (ERG) responses in mouse models lacking different dystrophins.</p><p><strong>Methods: </strong>We analyzed in vivo dark-adapted (DA) and light-adapted (LA) flash electroretinograms (ERG) in four adult DMD mouse models: Mdx and mdx5cv mice lacking Dp427; mdx<sup>2Cv</sup> mice lacking Dp427 and Dp260; and dmd-null mouse lacking all dystrophins, compared to their respective WT littermate male mice and to ERGs previously recorded in mdx52 mice (lacking Dp427, Dp260 and Dp140).</p><p><strong>Results: </strong>Mutations affecting the expression of the Dp140 and Dp71 isoforms produced more severe ERG abnormalities, consistent with findings in patients and aligned with intellectual disability severity. ERG parameter analysis revealed unique roles for Dp427 and Dp260 in rod ribbon-synapse transmission, additional Dp260 function in inner retina, and involvement of Dp140/Dp71 in cone photoreceptor pathways.</p><p><strong>Conclusions: </strong>These findings highlight the relevance of ERG as a potential biomarker for central dysfunction in DMD, and support its translational application for patient stratification and targeted therapeutic approaches.</p>","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"24 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC MedicinePub Date : 2026-04-24DOI: 10.1186/s12916-026-04892-y
Valeriia Dotsenko, Hana Hien Le, Sonja Rajić, Robert Moulder, Jalmari Kettunen, M Karoliina Hirvonen, Alex M Dickens, Tuulia Hyötyläinen, Bernhard Tewes, Timo Zimmermann, Ralf Mohrbacher, Tomi Suomi, Terho Lehtimäki, Riitta Lahesmaa, Matej Orešič, Laura L Elo, Emma Raitoharju, Detlef Schuppan, Markku Mäki, Keijo Viiri
{"title":"Therapeutic TG2 inhibition reverses systemic multiomic dysregulation in celiac disease.","authors":"Valeriia Dotsenko, Hana Hien Le, Sonja Rajić, Robert Moulder, Jalmari Kettunen, M Karoliina Hirvonen, Alex M Dickens, Tuulia Hyötyläinen, Bernhard Tewes, Timo Zimmermann, Ralf Mohrbacher, Tomi Suomi, Terho Lehtimäki, Riitta Lahesmaa, Matej Orešič, Laura L Elo, Emma Raitoharju, Detlef Schuppan, Markku Mäki, Keijo Viiri","doi":"10.1186/s12916-026-04892-y","DOIUrl":"https://doi.org/10.1186/s12916-026-04892-y","url":null,"abstract":"","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC MedicinePub Date : 2026-04-24DOI: 10.1186/s12916-026-04890-0
Shuang Wu, Siqi Lyu, Yimeng Wang, Hanyang Liang, Wei Xu, Juan Wang, Xinghui Shao, Han Zhang, Hongyu Liu, Bi Huang, Yang Chen, Gregory Y H Lip
{"title":"Adulthood stressful life events as predictors of incident cardiovascular disease: insights from two prospective cohorts.","authors":"Shuang Wu, Siqi Lyu, Yimeng Wang, Hanyang Liang, Wei Xu, Juan Wang, Xinghui Shao, Han Zhang, Hongyu Liu, Bi Huang, Yang Chen, Gregory Y H Lip","doi":"10.1186/s12916-026-04890-0","DOIUrl":"https://doi.org/10.1186/s12916-026-04890-0","url":null,"abstract":"","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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