BMC Medicine最新文献

{"title":"'It's the perfect storm': why are people with eating disorders at risk of suicide? A qualitative study.","authors":"Una Foye, Saakshi Kakar, Niamh McNamara, Agnieszka Musial, Tom Jewell, Jessica R Griffiths, Carol Kan, Gerome Breen, Rachel Rowan Olive, T Suratwala, Aman Sidhu, Lizzie Mitchell, George Mycock, Katie Graden, Saskia Evans Perks, Elia Chitwa, Holly Whitehead, Ulrike Schmidt, Rina Dutta, Moritz Herle","doi":"10.1186/s12916-025-04326-1","DOIUrl":"10.1186/s12916-025-04326-1","url":null,"abstract":"<p><strong>Background: </strong>Eating disorders (EDs) are associated with elevated all-cause mortality, with suicide cited as the second leading cause of death among individuals with EDs. Evidence suggests that individuals with anorexia nervosa are 18 times, and those with bulimia nervosa seven times more likely to die by suicide, relative to gender- and age-matched comparison groups. Limited research has focused on why people with EDs experience such high rates of suicidality. The study aims to gather perspectives from people with lived experience of an ED and clinicians working with EDs to understand suicidality among people with EDs.</p><p><strong>Methods: </strong>Using a qualitative design, we conducted semi-structured interviews with people with lived experience of an ED (n = 30), and clinicians who work with people with EDs (n = 19). Participants with lived experience presented with a range of EDs. Clinicians worked across a range of service settings as well as adolescent and adult services. We used a multi-perspective reflexive thematic analysis to code the data and generate the themes.</p><p><strong>Results: </strong>Key themes identified include 'no way out': the unique role of eating disorders in suicidality across illness and recovery, the outsider experience: feeling unseen, misunderstood, and burdensome, sparks of hope: protective Factors against suicidality, and 'they only see weight': how gaps in ED care reinforce isolation and risk. These findings underscore the complex and multifaceted reasons why people with EDs are at risk of suicide, acknowledging the unique risk factors associated with the illness itself as well as the various risk periods that affect those with EDs.</p><p><strong>Conclusions: </strong>The results are novel and illuminate psychological processes that are not currently incorporated within existing theoretical models of suicide, indicating that prevailing frameworks may lack the specificity or sensitivity required to account for the distinctive experiences of individuals with EDs. Consequently, these findings provide preliminary evidence to inform the development of a more nuanced theoretical model of suicidality specific to this population. Moreover, they suggest potential targets for intervention and highlight the need to critically evaluate treatment approaches that prioritise rapid symptom remission, which may, at times, exceed individuals' psychological capacity to cope.</p>","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"23 1","pages":"481"},"PeriodicalIF":8.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a multimodal automatic interictal epileptiform discharge detection model: a prospective multi-center study.","authors":"Nan Lin, Lian Li, Weifang Gao, Peng Hu, Gonglin Yuan, Heyang Sun, Fang Qi, Lin Wang, Shengsong Wang, Zi Liang, Haibo He, Yisu Dong, Zaifen Gao, Xiaoqiu Shao, Liying Cui, Qiang Lu","doi":"10.1186/s12916-025-04316-3","DOIUrl":"10.1186/s12916-025-04316-3","url":null,"abstract":"<p><strong>Background: </strong>Visual identification of interictal epileptiform discharge (IED) is expert-biased and time-consuming. Accurate automated IED detection models can facilitate epilepsy diagnosis. This study aims to develop a multimodal IED detection model (vEpiNetV2) and conduct a multi-center validation.</p><p><strong>Methods: </strong>We constructed a large training dataset to train vEpiNetV2, which comprises 26,706 IEDs and 194,797 non-IED 4-s video-EEG epochs from 530 patients at Peking Union Medical College Hospital (PUMCH). The automated IED detection model was constructed using deep learning based on video and electroencephalogram (EEG) features. We proposed a bad channel removal model and patient detection method to improve the robustness of vEpiNetV2 for multi-center validation. Performance is verified in a prospective multi-center test dataset, with area under the precision-recall curve (AUPRC) and area under the curve (AUC) as metrics.</p><p><strong>Results: </strong>To fairly evaluate the model performance, we constructed a large test dataset containing 149 patients, 377 h video-EEG data, and 9232 IEDs from PUMCH, Children's Hospital Affiliated to Shandong University (SDQLCH) and Beijing Tiantan Hospital (BJTTH). Amplitude discrepancies are observed across centers and could be classified by a classifier. vEpiNetV2 demonstrated favorable accuracy for the IED detection, achieving AUPRC/AUC values of 0.76/0.98 (PUMCH), 0.78/0.96 (SDQLCH), and 0.76/0.98 (BJTTH), with false positive rates of 0.16-0.31 per minute at 80% sensitivity. Incorporating video features improves precision by 9%, 7%, and 5% at three centers, respectively. At 95% sensitivity, video features eliminated 24% false positives in the whole test dataset. While bad channels decreased model precision, video features compensate for this deficiency. Accurate patient detection is essential; otherwise, incorrect patient detection can negatively impact overall performance.</p><p><strong>Conclusions: </strong>The multimodal IED detection model, which integrates video and EEG features, demonstrated high precision and robustness. The large multi-center validation confirmed its potential for real-world clinical application and the value of video features in IED analysis.</p>","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"23 1","pages":"479"},"PeriodicalIF":8.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic work-up of anemia and associated health outcomes in people with heart failure.","authors":"Guobin Su, Ruowei Xiao, Dongze Ji, Kaiyu He, Anna Hallert, Gianluigi Savarese, Lars H Lund, Yang Xu, Juan Jesus Carrero","doi":"10.1186/s12916-025-04303-8","DOIUrl":"10.1186/s12916-025-04303-8","url":null,"abstract":"<p><strong>Background: </strong>Anemia is common in patients with heart failure (HF). Although iron testing is recommended, it is uncertain that solely emphasizing iron testing could result in lesser attention to other causes, like bleeding or cancer. This study aimed to evaluate the diagnostic work-up of incident anemia in patients with HF in routine care and associated health outcomes.</p><p><strong>Methods: </strong>Observational study of 8932 non-anemic adults with HF in Stockholm, Sweden, was quantified for incidence of anemia, diagnostic work-up (recognition, laboratory/invasive testing) and treatment across severity of anemia and setting of care. Time-varying Cox regression explored associations between developing anemia and rate of major adverse cardiovascular events (MACE), HF hospitalization, cancer, and death.</p><p><strong>Results: </strong>During median 2.7 years, 34% of patients developed incident anemia, and 13% developed severe anemia. Within 6 months from incident anemia, ferritin and transferrin saturation were tested in 44% overall and 65% of severe cases. Testing of liver enzymes, creatinine, and C-reactive protein was, however, done in > 90% of cases. Colonoscopy, esophagogastroduodenoscopy, urinalysis, and cystoscopy were performed in 2-10% of cases. Few patients were recognized with an ICD code diagnosis of anemia (16%). Treatments were infrequent: oral iron (10%), intravenous iron (16%), blood transfusions (6%), and erythropoietin-stimulating agents (< 1%). More anemia cases received treatment in cardiology care (43%) versus primary care (29%). New-onset anemia was associated with risk of MACE (adjusted HR 2.13, 95% CI 1.85-2.44), HF hospitalization (4.85, 4.30-5.48), cancer (3.41, 3.09-3.77), and death (2.04, 1.82-2.29).</p><p><strong>Conclusions: </strong>One in three patients with HF experienced anemia, which was associated with adverse health outcomes. Testing for iron stores and invasive work-up was suboptimal. A large proportion of anemia events remained under-recognized and untreated, a pattern of care that warrants correction.</p>","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"23 1","pages":"471"},"PeriodicalIF":8.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota links to cognitive impairment in bipolar disorder via modulating synaptic plasticity.","authors":"Anying Tang, Hangyuan Jiang, Jie Li, Yi Chen, Jinyu Zhang, Dandan Wang, Shaohua Hu, Jianbo Lai","doi":"10.1186/s12916-025-04313-6","DOIUrl":"10.1186/s12916-025-04313-6","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment is an intractable clinical manifestation of bipolar disorder (BD), but its underlying mechanisms remain largely unexplored. Preliminary evidence suggests that gut microbiota can potentially influence cognitive function by modulating synaptic plasticity. Herein, we characterized the gut microbial structure in BD patients with and without cognitive impairment and explored its influence on neuroplasticity in mice.</p><p><strong>Methods: </strong>The gut structure of microbiota in BD without cognitive impairment (BD-nCI) patients, BD with cognitive impairment (BD-CI) patients, and healthy controls (HCs) were characterized, and the correlation between specific bacterial genera and clinical parameters was determined. ABX-treated C57 BL/J male mice were transplanted with fecal microbiota from BD-nCI, BD-CI patients or HCs and subjected to behavioral testing. The change of gut microbiota in recipient mice and its influence on the dendritic complexity and synaptic plasticity of prefrontal neurons were examined. Finally, microbiota supplementation from healthy individuals in the BD-CI mice was performed to further determine the role of gut microbiota.</p><p><strong>Results: </strong>16S-ribosomal RNA gene sequencing reveals that gut microbial diversity and composition are significantly different among BD-nCI patients, BD-CI patients, and HCs. The Spearman correlation analysis suggested that glucose metabolism-related bacteria, such as Prevotella, Faecalibacterium, and Roseburia, were correlated with cognitive impairment test scores, and inflammation-related bacteria, such as Lachnoclostridium and Bacteroides, were correlated with depressive severity. Fecal microbiota transplantation resulted in depression-like behavior, impaired working memory and object recognition memory in BD-CI recipient mice. Compared with BD-nCI mice, BD-CI mice exhibited more severely impaired object recognition memory, along with greater reductions in dendritic complexity and synaptic plasticity. Supplementation of gut microbiota from healthy individuals partially reversed emotional and cognitive phenotypes and neuronal plasticity in BD-CI mice.</p><p><strong>Conclusions: </strong>This study first characterized the gut microbiota in BD-CI patients and highlighted the potential role of gut microbiota in BD-related cognitive deficits by modulating neuronal plasticity in mice model.</p>","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"23 1","pages":"470"},"PeriodicalIF":8.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effectiveness of international travel controls to identify MPXV-infected travelers: a simulation study.","authors":"Keisuke Ejima, Yuqian Wang, Akira Endo, Hiroaki Murayama, Yun Shan Goh, Alex R Cook, Yong Dam Jeong, Shingo Iwami, Hyeongki Park, Borame Sue Lee Dickens, Shihui Jin, Jue Tao Lim, Conrad En Zuo Chan, Po Ying Chia, Barnaby E Young, Yang Yang, Martin Chio, David Chien Lye, Marco Ajelli","doi":"10.1186/s12916-025-04286-6","DOIUrl":"10.1186/s12916-025-04286-6","url":null,"abstract":"<p><strong>Background: </strong>In August 2024, the World Health Organization (WHO) declared a public health emergency due to the rapid spread of mpox in Africa and beyond. International travel controls (ITCs), such as health screening and viral testing, could help avoid/delay the global spread of MPXV, fostering preparedness and response efforts. However, it is not clear whether the viral tests at immigration are sufficient to avoid introduction of MPXV and which samples should be used on the viral tests.</p><p><strong>Methods: </strong>We conducted a simulation study using epidemiological and viral load data to assess the effectiveness of health screening and polymerase chain reaction (PCR) testing at immigration. The primary outcome was the proportion of MPXV-infected travelers identified under various international travel control policies. To estimate time-varying false-negative rates of PCR tests with different detection limits, we employed viral dynamics models calibrated to data from three anatomical sites: oropharynx, saliva, and rectum. Additionally, we simulated the effects of these control measures on the recommended duration of a post-entry monitoring period. Travelers were assumed to depart from mpox-affected countries, defined as those with ongoing MPXV transmission, potentially representing both historically endemic regions and countries with recent outbreaks.</p><p><strong>Results: </strong>Our results show that under an endemic scenario, the combination of health screening and PCR testing using saliva swabs identifies approximately 74% of MPXV-infected travelers. Using rectal swabs slightly improves detection, identifying up to 79% of infected individuals. A comparable improvement can also be achieved by increasing test sensitivity (i.e., reducing the detection limit from 250 to 10 copies/mL). Based on the distribution of post-entry incubation periods, we estimated that travelers from mpox-affected regions should self-monitor and adopt precautionary behavior for at least 16 days to mitigate the risk of onward transmission.</p><p><strong>Conclusions: </strong>Health screening and PCR testing at immigration are likely to miss a significant proportion of MPXV-infected travelers, thus a lengthy quarantine period would be required to prevent onward local transmission. Careful consideration on other factors such as economic costs and likelihood of widespread local outbreak will need to be weighed against the adoption of these measures to prevent local mpox transmission given MPXV transmissibility and severity.</p>","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"23 1","pages":"473"},"PeriodicalIF":8.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of early-onset cardiovascular disease attributable to fine particulate matter pollution from 1990 to 2021: a systematic analysis for the global burden of disease study 2021.","authors":"Yixuan Jiang, Huihuan Luo, Guangguo Fu, Jinmiao Chen, Haidong Kan, Renjie Chen","doi":"10.1186/s12916-025-04309-2","DOIUrl":"10.1186/s12916-025-04309-2","url":null,"abstract":"<p><strong>Background: </strong>Fine particulate matter (PM_2.5) is linked to early-onset cardiovascular disease (CVD); however, the corresponding disease burden has not been assessed. This study aims to evaluate the global, regional, and national early-onset CVD burden attributable to PM_2.5 from 1990 to 2021.</p><p><strong>Methods: </strong>We calculated the number, age-standardized rate, and percentage of CVD deaths and disability-adjusted life-years (DALYs) attributable to PM_2.5 among individuals aged 25-49 years from 1990 to 2021 based on the Global Burden of Disease Study 2021. Stratified analyses were performed by sex, age, disease subtype, sociodemographic index (SDI), and country. We further calculated estimated annual percentage change to assess the temporal trends.</p><p><strong>Results: </strong>In 2021, the age-standardized death and DALY rates (per 100,000) of early-onset CVD attributable to total PM_2.5 were 10.93 (95% confidence interval, 10.89-10.97) and 562.12 (561.84-562.39), respectively. The burden was generally higher in males, with age-standardized death and DALY rates approximately double those in females. Individuals living in regions with lower SDI faced substantially greater burden compared to those in higher-SDI regions. Those with ischemic heart disease experienced higher burden than individuals with stroke. From 1990 to 2021, the burden attributable to total and household PM_2.5 declined consistently, with estimated annual percentage change in age-standardized death rates of - 1.56% (- 1.68% to - 1.45%) and - 3.22% (- 3.48% to - 2.96%), respectively. The burden from ambient PM_2.5 continued to rise, and only began to decline since the last decade, with an estimated annual percentage change in age-standardized death rates of 0.37% (0.23%-0.52%). In contrast, the late-onset CVD burden decreased for both ambient and household exposures.</p><p><strong>Conclusions: </strong>Despite significant reduction in early-onset CVD burden attributable to total and household PM_2.5 from 1990 to 2021, the burden from ambient PM_2.5 remains a persistent challenge. Males, individuals living in regions with lower SDI, and those with ischemic heart disease face a higher burden. Geographically tailored and population-specific interventions are needed to mitigate early-onset CVD burden.</p>","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"23 1","pages":"472"},"PeriodicalIF":8.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testing the effect of a dynamic descriptive social norm message on meat-free food selection in worksite cafeterias: a randomized controlled trial.","authors":"Elif Naz Çoker, Rachel Pechey, Susan A Jebb","doi":"10.1186/s12916-025-04302-9","DOIUrl":"10.1186/s12916-025-04302-9","url":null,"abstract":"<p><strong>Background: </strong>Overconsumption of meat is a threat to planetary health. Meat consumption is socially and culturally patterned, and interventions using social norms could be a promising strategy to encourage meat reduction.</p><p><strong>Methods: </strong>We developed and tested the effectiveness of a dynamic descriptive social norm message displayed in worksite cafeterias (N = 25, intervention = 12, control = 13) to increase meat-free meal selection. The message was developed based on existing evidence and in collaboration with the catering company operating the cafeterias. The message communicated a specific change in target behavior, using a relevant and relatable referent group, grounding the desired behavior change in time and place, and included a clear call to action. The social norm messages were displayed in each intervention cafeteria for 8 weeks on free-standing banners, posters, and floor stickers. We compared the change in weekly percentage of meat-free meal sales (measured as number of meals sold) between intervention and control cafeterias through linear mixed-effects models. We conducted fidelity checks in intervention cafeterias and interviewed customers to assess perceptions of the intervention.</p><p><strong>Results: </strong>There was no evidence that the intervention led to an increase in sales of meat-free meals (- 2.22 percentage point change, 95% CIs [- 7.33, 2.90], p = 0.378). Pre-intervention baseline sales of meat-free meals varied by site, but there was no evidence the intervention was differentially effective for sites with higher vs. lower baselines. There was also no evidence that the intervention changed overall meal sales. The intervention was implemented with high fidelity, though out of 155 customers interviewed, 57% reported that they did not notice the messages, and only 2% correctly recalled the message.</p><p><strong>Conclusions: </strong>There was no evidence that empirically informed and co-created dynamic descriptive social norm messages increased selection of meat-free meals in worksite cafeterias. This could be due to low salience of the intervention in a busy, fast-paced environment, or the strength of existing eating habits in a workplace cafeteria. The findings suggest that norm messaging interventions, when delivered as an isolated intervention, may not be effective to change a complex and socially grounded dietary behavior such as meat consumption.</p><p><strong>Trial registration: </strong>OSF Registries, Registered September 23, 2022, https://osf.io/h7zkf.</p>","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"23 1","pages":"474"},"PeriodicalIF":8.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional and internalizing disorders co-aggregate with cardiometabolic and immune-related diseases within families: a population-based cohort study.","authors":"Olivier D Steen, Martje Bos, Sonja L van Ockenburg, Yiling Zhou, Ilja M Nolte, Harold Snieder, Kenneth Kendler, Judith G M Rosmalen, Hanna M van Loo","doi":"10.1186/s12916-025-04293-7","DOIUrl":"10.1186/s12916-025-04293-7","url":null,"abstract":"<p><strong>Background: </strong>Functional disorders share familial risk with internalizing disorders such as generalized anxiety disorder and depression, and are comorbid with cardiometabolic and immune-related diseases. We investigated whether functional and internalizing disorders co-aggregate with these diseases in families to gain insight into the aetiology of functional and internalizing disorders.  METHODS: We included 166,774 subjects (aged 3-94), from the population-based Lifelines Cohort Study, a Dutch general population cohort. We defined cases for three functional disorders (myalgic encephalomyelitis/chronic fatigue syndrome; ME/CFS, fibromyalgia, and irritable bowel syndrome; IBS), two internalizing disorders (major depressive disorder; MDD and generalized anxiety disorder; GAD), cardiometabolic diseases (obesity, metabolic associated steatotic liver disease, type 2 diabetes, hypertension and cardiovascular disease) and immune-related diseases (composite measures of auto-immune disease and atopy). We used logistic regression to model the prevalence of these disorders in the general population and in participants with affected relatives. Using these prevalence estimates, we assessed familial co-aggregation with (1) recurrence risk ratios (λ_R), and (2) familial correlations (r_f).</p><p><strong>Results: </strong>All functional and internalizing disorders co-aggregated with immune-related diseases (λ_R range 1.06-1.24). ME/CFS, FM, and MDD co-aggregated with most cardiometabolic diseases (λ_R range 1.00-1.23). MDD, fibromyalgia, and ME/CFS showed similar familial correlation patterns with both disease groups (r_f range 0.12-0.44), while patterns of IBS and GAD were more variable.</p><p><strong>Conclusions: </strong>Internalizing and functional disorders share familial risk with immune-related and cardiometabolic diseases. This suggests that risk factors relevant to immune-related and cardiometabolic diseases may also be relevant for FDs. Future studies should investigate such risk factors to identify novel treatment targets.</p>","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"23 1","pages":"469"},"PeriodicalIF":8.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Exploring the link between dietary patterns and gastric adenocarcinoma in Brazil: a mediation analysis.","authors":"Alex Richard Costa Silva, Gianfranco Alicandro, Valdete Regina Guandalini, Patrícia Paula da Fonseca Grili, Paulo Pimentel Assumpção, Mônica Santiago Barbosa, Rosane Oliveira de Sant'Ana, Felipe José Fernández Coimbra, Maria Paula Curado","doi":"10.1186/s12916-025-04330-5","DOIUrl":"10.1186/s12916-025-04330-5","url":null,"abstract":"","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"23 1","pages":"464"},"PeriodicalIF":8.3,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer.","authors":"Mingzhou Li, Jianbiao Xiao, Shasha Song, Fangyi Han, Hongling Liu, Yang Lin, Yunfei Ni, Sisi Zeng, Xin Zou, Jieqiong Wu, Feifei Wang, Shaowan Xu, You Liang, Peishuang Xu, Huirong Hong, Junfeng Qiu, Jianing Cao, Qin Zhu, Li Liang","doi":"10.1186/s12916-025-04331-4","DOIUrl":"10.1186/s12916-025-04331-4","url":null,"abstract":"","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"23 1","pages":"465"},"PeriodicalIF":8.3,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}