Biomedica最新文献_第3页

Fusariosis in cancer patients: 13 case series report and literature review 癌症患者镰刀菌病13例系列报告及文献回顾

IF 0.9 4区医学

Biomedica Pub Date : 2023-08-31 DOI: 10.7705/biomedica.6925

Sonia Isabel Cuervo-Maldonado, José Camilo Álvarez-Rodríguez, Cristian Leonardo Cubides, Juan Camilo Barrera, Juan Diego Montañez-Abril, Erika Paola Vergara-Vela, Carlos Humberto Saavedra-Trujillo, María José López-Mora, Gloria Elena Mora-Figueroa, Adriana Celis-Ramírez, Rose Mary Jaramillo-Calle, Rafael Parra-Medina

{"title":"Fusariosis in cancer patients: 13 case series report and literature review","authors":"Sonia Isabel Cuervo-Maldonado, José Camilo Álvarez-Rodríguez, Cristian Leonardo Cubides, Juan Camilo Barrera, Juan Diego Montañez-Abril, Erika Paola Vergara-Vela, Carlos Humberto Saavedra-Trujillo, María José López-Mora, Gloria Elena Mora-Figueroa, Adriana Celis-Ramírez, Rose Mary Jaramillo-Calle, Rafael Parra-Medina","doi":"10.7705/biomedica.6925","DOIUrl":"10.7705/biomedica.6925","url":null,"abstract":"The fusariosis is an opportunistic mycosis caused by Fusarium spp. Its clinical presentation depends on the immunological status of the host, especially in patients with hematooncological diseases, whose manifestations vary from localized to invasive fungal infections. Skin or blood culture helps to guide combined antifungal treatment with amphotericin B and voriconazole.\u0000Here, we present 13 cases in a period of eleven years of patients with cancer who developed disseminated fusariosis and their outcomes, together with a review of the related literature.\u0000In this series of cases, mortality was 61.5 % (8/13), despite the use of the antifungal. Out of the 13 cases, 11 had hematological neoplasia and 2 solid neoplasia. The most determinant risk factor was profound neutropenia. Skin involvement and positive blood cultures in most cases allowed combined treatment prescription. Persistent febrile neutropenia associated with skin lesions, onychomycosis, nodules, or lung masses lead to suspicion of Fusarium spp. fungal invasive infection.\u0000The aim of this series of cases is to remind healthcare professionals that oncological patients with deep and persistent febrile neutropenia can develop fusariosis.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10300490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Make the diagnosis - Second part 进行诊断-第二部分

IF 0.9 4区医学

Biomedica Pub Date : 2023-08-31 DOI: 10.7705/biomedica.7219

Yenny Ariza, Cristian Leonardo Cubides, Daniel Alejandro Cubillos, Carmen Lucía Roa, José Camilo Álvarez, Sonia Isabel Cuervo-Maldonado

引用次数: 5

Description of the colonizing mycobiota of endotracheal tubes from patients admitted to two intensive care units in Bogotá, Colombia 哥伦比亚波哥大两个重症监护室患者气管导管的定殖分枝杆菌群描述

IF 0.9 4区医学

Biomedica Pub Date : 2023-08-31 DOI: 10.7705/biomedica.6884

Mónica Gabriela Huertas, Miguel Rodríguez, Patricia Castro, Sergio Danilo Cruz, Erika Alejandra Cifuentes, Andrés Felipe Yepes, María Mercedes Zambrano, Ana Margarita Baldión

{"title":"Description of the colonizing mycobiota of endotracheal tubes from patients admitted to two intensive care units in Bogotá, Colombia","authors":"Mónica Gabriela Huertas, Miguel Rodríguez, Patricia Castro, Sergio Danilo Cruz, Erika Alejandra Cifuentes, Andrés Felipe Yepes, María Mercedes Zambrano, Ana Margarita Baldión","doi":"10.7705/biomedica.6884","DOIUrl":"10.7705/biomedica.6884","url":null,"abstract":"Introduction. Medical device colonization by pathogenic microorganisms is a risk factor for increasing infections associated with health care and, consequently, the morbidity and mortality of intubated patients. In Colombia, fungal colonization of endotracheal tubes has not been described, and this information could lead to new therapeutic options for the benefit of patients.\u0000Objective. To describe the colonizing fungi of the endotracheal tubes from patients in the intensive care unit, along with its antifungal sensitivity profile.\u0000Materials and methods. We conducted a descriptive, observational study in two health centers for 12 months. Endotracheal tubes were collected from patients in intensive care units. Samples were processed for culture, fungi identification, and antifungal sensitivity profile assessment.\u0000Results. A total of 121 endotracheal tubes, obtained from 113 patients, were analyzed: 41.32 % of the tubes were colonized by Candida albicans (64.62%), C. non‑albicans\u0000(30.77%), Cryptococcus spp. (3.08%) or molds (1.54%). All fungi evaluated showed a high sensitivity to antifungals, with a mean of 91%.\u0000Conclusion. Fungal colonization was found in the endotracheal tubes of patients under invasive mechanical ventilation. The antifungal sensitivity profile in these patients was favorable. A clinical study is required to find possible correlations between the colonizing microorganisms and infectivity.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10300495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meningeal cryptococcosis and SARS-CoV-2 infection in people living with HIV/AIDS. 艾滋病毒/艾滋病患者的脑膜隐球菌病和严重急性呼吸系统综合征冠状病毒2型感染。

IF 0.9 4区医学

Biomedica Pub Date : 2023-08-31 DOI: 10.7705/biomedica.6872

Fernando Antonio Messina, Andrés Benchetrit, Andrea Bocassi, María de Las Mercedes Romero, Sofía Bauer, Emmanuel Marín, Facundo Bertera, Guillermo Onis, Matías Enzenhofer, Milagro Sánchez, Lilia Mammana, Dana Mijalovsky, Gabriela Santiso

{"title":"Meningeal cryptococcosis and SARS-CoV-2 infection in people living with HIV/AIDS.","authors":"Fernando Antonio Messina, Andrés Benchetrit, Andrea Bocassi, María de Las Mercedes Romero, Sofía Bauer, Emmanuel Marín, Facundo Bertera, Guillermo Onis, Matías Enzenhofer, Milagro Sánchez, Lilia Mammana, Dana Mijalovsky, Gabriela Santiso","doi":"10.7705/biomedica.6872","DOIUrl":"10.7705/biomedica.6872","url":null,"abstract":"Introduction: Fungal infections in patients with COVID-19 was one of the most debated topics during the pandemic.Objectives: To analyze the clinical characteristics and evolution of people living with HIV/AIDS and coinfection with cryptococcus and COVID-19 (group A) or without it (group B).Materials and methods: This is an analytical and retrospective study. We reviewed medical records of patients with meningeal cryptococcosis between April 2020 and May 2021.Results: We studied 65 people living with HIV/AIDS and with cryptococcosis infection diagnosed from April 2020 to May 2021. Fifteen patients with HIV/AIDS suffered from cryptococcosis and COVID-19, and out of these, 14 presented meningitis (group A), while 28 suffered from meningeal cryptococcosis, but did not have COVID-19 (group B).Conclusions: No statistically significant differences were observed between the two groups (A and B) considering: intracranial hypertension, presence of Cryptococcus antigens in cerebrospinal fluid, sensorium deterioration or mortality. The detection of Cryptococcus antigens in serum by lateral flow assay was highly effective to rapidly diagnose cryptococcosis in patients with HIV/AIDS who also developed COVID-19. Patients of both groups consulted for cryptoccocosis sometime after, in comparison with the pre-pandemic cases related to this infection.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10308910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Candida auris: a global pathogen that has taken root in Colombia [奥里斯假丝酵母：一种扎根于哥伦比亚的全球病原体]。

IF 0.9 4区医学

Biomedica Pub Date : 2023-08-31 DOI: 10.7705/biomedica.7082

Patricia Escandón, Shawn R Lockhart, Nancy A Chow, Tom M Chiller

{"title":"Candida auris: a global pathogen that has taken root in Colombia","authors":"Patricia Escandón, Shawn R Lockhart, Nancy A Chow, Tom M Chiller","doi":"10.7705/biomedica.7082","DOIUrl":"10.7705/biomedica.7082","url":null,"abstract":"Candida auris has been recognized as an emerging multidrug-resistant pathogen with a significant public health burden, causing cases of invasive infection and colonization due to its persistence on inanimate surfaces, ability to colonize skin of some patients, and high transmissibility in healthcare settings.\u0000The first sporadic report of the isolation of this species from the ear canal of a patient in Asia was in 2009 and reports from other regions of the world soon followed. However, it was not until 2015 that global epidemiological alerts were communicated as a result of an increasing number of reports of invasive infections caused by C. auris in several countries.\u0000Colombia was soon added to this list in 2016 after an unusual increase in the number of C. haemulonii isolates was reported, later confirmed as C. auris. Since the issuing of a national alert by the Colombian National Institute of Health together with the Ministry of Health in 2016, the number of cases reported reached over 2,000 by 2022. Colombian isolates have not shown pan resistance to available antifungals, unlike C. auris strains reported in other regions of the world, which leaves patients in Colombia with therapeutic options for these infections. However, increasing fluconazole resistance is being observed. Whole-genome sequencing of Colombian C. auris isolates has enhanced molecular epidemiological data, grouping Colombian isolates in clade IV together with other South American isolates.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disaster mycology 灾难真菌学

IF 0.9 4区医学

Biomedica Pub Date : 2023-08-31 DOI: 10.7705/biomedica.6943

Daniel F Q Smith, Arturo Casadevall

{"title":"Disaster mycology","authors":"Daniel F Q Smith, Arturo Casadevall","doi":"10.7705/biomedica.6943","DOIUrl":"10.7705/biomedica.6943","url":null,"abstract":"Natural and human-made disasters have long played a role in shaping the environment and microbial communities, also affecting non-microbial life on Earth. Disaster microbiology is a new concept based on the notion that a disaster changes the environment causing adaptation or alteration of microbial populations -growth, death, transportation to a new area, development traits, or resistance- that can have downstream effects on the affected ecosystem. Such downstream effects include blooms of microbial populations and the ability to colonize a new niche or host, cause disease, or survive in former extreme conditions. Throughout history, fungal populations have been affected by disasters. There are prehistoric archeological records of fungal blooms after asteroid impacts and fungi implicated in the fall of the dinosaurs. In recent times, drought and dust storms have caused disturbance of soil fungi, and hurricanes have induced the growth of molds on wet surfaces, resulting in an increased incidence of fungal disease. Probably, the anticipated increase in extreme heat would force fungi adaptation to survive at high temperatures, like those in the human body, and thus be able to infect mammals. This may lead to a drastic rise of new fungal diseases in humans.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Método rápido para determinar el eje cardíaco con D1 y D3 用D1和D3快速测定心轴的方法

IF 0.9 4区医学

Biomedica Pub Date : 2023-07-19 DOI: 10.5377/alerta.v6i2.15444

Hugo Daniel Parrales López

引用次数: 0

Impacto de la COVID-19 sobre la salud mental en Uruguay COVID-19对乌拉圭心理健康的影响

IF 0.9 4区医学

Biomedica Pub Date : 2023-07-19 DOI: 10.5377/alerta.v6i2.16213

G. Castellano, Guadalupe Herrera, Jimena Heinzen, D. Alfonso

{"title":"Impacto de la COVID-19 sobre la salud mental en Uruguay","authors":"G. Castellano, Guadalupe Herrera, Jimena Heinzen, D. Alfonso","doi":"10.5377/alerta.v6i2.16213","DOIUrl":"https://doi.org/10.5377/alerta.v6i2.16213","url":null,"abstract":"Introducción. Los antecedentes de cuarentenas han señalado impactos en el corto y largo plazo en la salud mental.Objetivo. Describir las repercusiones generadas en el área de la salud mental en la población uruguaya mayor de 18 años, de las variables ansiedad, tristeza y dificultades para conciliar el sueño, en el periodo comprendido entre el 13 de marzo de 2020 al 10 de junio de 2021. Metodología. Estudio transversal analítico. Se aplicó una encuesta web, auto-administrada. Se analizaron las frecuencias absolutas y relativas porcentuales y sus intervalos de confianza (95 %). Se estimaron modelos logísticos binarios para las variables dicotómicas y modelos logísticos multinomiales para «dificultad para conciliar el sueño». Resultados. En relación a los elementos de ansiedad, 27,1 % (IC 95 % 24,8-29,3) y 31,0 % (IC 95 % 28-33,3) respondieron sentirse ansiosos en el primer y segundo corte, respectivamente. El 19,9 % (IC 95 % 17,6 - 21,7) en el primer corte, mientras que el 31,4 % (IC 95 % 20,06-33,89) lo confirmaron en el segundo. El nivel educativo medio se asoció con la presencia de ansiedad (p < 0,001), mientras el bajo se asoció con tristeza (p = 0,005). Se observó un efecto protector en hogares con más de cinco miembros para la variable tristeza con un OR de 0,41 (IC 95 % 0,22 - 0,75). Se encontró relación entre el género femenino y la presencia de ansiedad y tristeza. Los niveles educativos medio y alto se vieron relacionados con la presencia de ansiedad y la tristeza se asoció con el desempleo. Los trastornos del sueño se asociaron al género femenino, desempleo y enfermedades no transmisibles.Conclusión. Los trastornos de ansiedad, la afectación del sueño y los sentimientos de tristeza fueron prevalentes, las familias de mayor número de miembros tuvieron un efecto protector sobre estas manifestaciones","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90384136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Excelencia científica para la consolidación del sistema nacional de salud 巩固国家卫生系统的科学卓越

IF 0.9 4区医学

Biomedica Pub Date : 2023-07-19 DOI: 10.5377/alerta.v6i2.15573

Xochitl Sandoval López

引用次数: 0

Pénfigo foliáceo, variedad seborreica, reporte de caso 叶性天疱疮，脂溢性品种，病例报告

IF 0.9 4区医学

Biomedica Pub Date : 2023-07-19 DOI: 10.5377/alerta.v6i2.16217

César Steven Linares Rosales, Óscar David Brizuela Alfaro, Ivania Cristina Arévalo Mojica

引用次数: 0