Meningeal cryptococcosis and SARS-CoV-2 infection in people living with HIV/AIDS.

IF 0.8 4区医学 Q4 TROPICAL MEDICINE

Biomedica Pub Date : 2023-08-31 DOI:10.7705/biomedica.6872

Fernando Antonio Messina, Andrés Benchetrit, Andrea Bocassi, María de Las Mercedes Romero, Sofía Bauer, Emmanuel Marín, Facundo Bertera, Guillermo Onis, Matías Enzenhofer, Milagro Sánchez, Lilia Mammana, Dana Mijalovsky, Gabriela Santiso

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Abstract

Introduction: Fungal infections in patients with COVID-19 was one of the most debated topics during the pandemic.

Objectives: To analyze the clinical characteristics and evolution of people living with HIV/AIDS and coinfection with cryptococcus and COVID-19 (group A) or without it (group B).

Materials and methods: This is an analytical and retrospective study. We reviewed medical records of patients with meningeal cryptococcosis between April 2020 and May 2021.

Results: We studied 65 people living with HIV/AIDS and with cryptococcosis infection diagnosed from April 2020 to May 2021. Fifteen patients with HIV/AIDS suffered from cryptococcosis and COVID-19, and out of these, 14 presented meningitis (group A), while 28 suffered from meningeal cryptococcosis, but did not have COVID-19 (group B).

Conclusions: No statistically significant differences were observed between the two groups (A and B) considering: intracranial hypertension, presence of Cryptococcus antigens in cerebrospinal fluid, sensorium deterioration or mortality. The detection of Cryptococcus antigens in serum by lateral flow assay was highly effective to rapidly diagnose cryptococcosis in patients with HIV/AIDS who also developed COVID-19. Patients of both groups consulted for cryptoccocosis sometime after, in comparison with the pre-pandemic cases related to this infection.

Abstract Image

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艾滋病毒/艾滋病患者的脑膜隐球菌病和严重急性呼吸系统综合征冠状病毒2型感染。

简介：新冠肺炎患者的真菌感染是大流行期间最具争议的话题之一。目的：分析艾滋病合并隐球菌和新冠肺炎感染者（A组）和非隐球菌和新冠肺炎合并感染者（B组）的临床特征和演变。材料和方法：这是一项分析性和回顾性研究。我们回顾了2020年4月至2021年5月期间脑膜隐球菌病患者的医疗记录。结果：我们研究了2020年四月至2021年五月诊断的65名艾滋病毒/艾滋病患者和隐球菌病感染者。15名艾滋病毒/艾滋病患者患有隐球菌病和新冠肺炎，其中14人出现脑膜炎（A组），28人患有脑膜炎隐球菌病，但没有新冠肺炎（B组）。结论：考虑到颅内高压、脑脊液中存在隐球菌抗原、感觉功能恶化或死亡率，两组（A组和B组）之间没有观察到统计学上的显著差异。侧流法检测血清中隐球菌抗原对于快速诊断同样患有新冠肺炎的艾滋病毒/艾滋病患者的隐球菌病是非常有效的。与疫情前与这种感染相关的病例相比，这两组患者在之后的某个时候都咨询了隐茧病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedica 医学-热带医学

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biomédica is the quarterly journal of the Instituto Nacional de Salud of Colombia [Colombias National Health Institute]. Its purpose is to publish the results of original research that contributes meaningfully to knowledge in health and biomedical sciences.