Journal of lung, pulmonary & respiratory research最新文献_第6页

Prevalence of mycobacterium tuberculosis and their possible risk factors in suspected tuberculosis patients of district mardan khyber pakhtunkhwa, Pakistan 巴基斯坦开伯尔-普赫图赫瓦马丹区疑似结核病患者结核分枝杆菌的流行及其可能的危险因素

Journal of lung, pulmonary & respiratory research Pub Date : 2019-11-25 DOI: 10.15406/JLPRR.2019.06.00215

M. Naveed, M. Shahid, Adil Hassan, Mujeeb- ur-Rehman, A. Hayat

{"title":"Prevalence of mycobacterium tuberculosis and their possible risk factors in suspected tuberculosis patients of district mardan khyber pakhtunkhwa, Pakistan","authors":"M. Naveed, M. Shahid, Adil Hassan, Mujeeb- ur-Rehman, A. Hayat","doi":"10.15406/JLPRR.2019.06.00215","DOIUrl":"https://doi.org/10.15406/JLPRR.2019.06.00215","url":null,"abstract":"Tuberculosis (TB) is one of the chronic contagious diseases caused by M.tuberculosis that affects humans and animals and one of the leading causes of morbidity and mortality throughout the globe.1,2 It primarily causes pulmonary tuberculosis by affecting lungs of the patients but can also infects bones, meninges, joints, intestines, skin, lymph glands, kidneys, and body’s further organs during its second phase of infection and cause extra pulmonary tuberculosis.3 At the initial phase of infection, most of the individuals show symptomless tuberculosis while most of the patients developed imprecise symptoms like mild cough, wheeze, weight loss, evening pyrexia, night sweats, increased weight loss, lethargy, and general ill-health. However specific symptoms may be determined by the site of infection.4 M. tuberculosis is frequently spread from infected tuberculosis patients to other persons by aerosolized droplet nuclei which are generated during coughing, speaking, laughing sneezing and shouting. The droplets nuclei may persist in the air for some time and dry quickly, and when these nuclei breathe in by the individual it can achieve direct entrance to the terminal air passages. The infected person may be producing more than three thousand contagious particles per cough.5 It concerns a major health issue and cause serious illness among millions of people annually and considered the second leading cause of death after HIV infection.2","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"8 1","pages":"91-95"},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75353310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-dose computerized tomography in lung cancer screening 肺癌筛查中的低剂量计算机断层扫描

Journal of lung, pulmonary & respiratory research Pub Date : 2019-11-19 DOI: 10.15406/jlprr.2019.06.00214

R. Cheepsattayakorn

{"title":"Low-dose computerized tomography in lung cancer screening","authors":"R. Cheepsattayakorn","doi":"10.15406/jlprr.2019.06.00214","DOIUrl":"https://doi.org/10.15406/jlprr.2019.06.00214","url":null,"abstract":"Lung cancer screening has been a passionately debated topic since the late 1990s. Five-year survival is 53.5 %, 26.1 %, and 3.9 % when cancer is confined to the lung at the time of diagnosis, when there is regional nodal involvement, and when there is distant metastasis, respectively. The goal of lung cancer screening (LCS) is to shift the timing of the diagnosis to an earlier point, thus, the disease is localized to the lung, and then appropriate treatment can reduce the mortality of lung cancer. Study results from several lung cancer screening trials worldwide, including the United States, Japan, the Netherlands, Denmark, and Italy demonstrated that low-dose computerized tomography (LDCT) scanner used in LCS can increase the detection rate of lung cancer at an earlier stage. At the time of screening, the information about smoking cessation should be provided to all current smokers, while the multidisciplinary clinic affords a second opportunity to counsel patients about the benefits of quitting smoking. After two rounds of screening, there are fewer false positives as a result of comparison with the baseline screening CT that may reveal two years of pulmonary nodule stability. Decreasing the number of false -positive lung cancer screens is an area for future research. Genetic profiles and the results of the baseline screening examination can potentiate further refining the risk modeling. Risk modeling could define the frequency of follow-up in addition to who should be screened. In conclusion, LCS with LDCT has shown that there are indolent lung cancers that may not be fatal. Further studies are urgently needed if the maximization of the risk-benefit ratio in LCS has to be achieved.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90562584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alternative Approach to Removal of a Retained Chest Tube 取出胸管的另一种方法

Journal of lung, pulmonary & respiratory research Pub Date : 2019-09-10 DOI: 10.17554/j.issn.2410-0579.2019.05.44

Modupeola Diyaolu, B. Malone, M. Firstenberg

引用次数: 0

Superior vena cava syndrome and lung cancer: survival and prognostic factors 上腔静脉综合征与肺癌:生存和预后因素

Journal of lung, pulmonary & respiratory research Pub Date : 2019-09-02 DOI: 10.15406/jlprr.2019.06.00213

N. Fahem, A. Migaou, A. Ben Saad, S. Jobeur, Saoussen cheikh Mhammed, N. Rouatbi

{"title":"Superior vena cava syndrome and lung cancer: survival and prognostic factors","authors":"N. Fahem, A. Migaou, A. Ben Saad, S. Jobeur, Saoussen cheikh Mhammed, N. Rouatbi","doi":"10.15406/jlprr.2019.06.00213","DOIUrl":"https://doi.org/10.15406/jlprr.2019.06.00213","url":null,"abstract":"Introduction: The superior vena cava syndrome (SVCS) is a set of signs related to the obstruction of the upper cava current caused by a compression, an invasion or a thrombosis of the superior vena cava. Its etiologies are numerous but dominated by neoplastic causes mainly of bronchopulmonary origin. Aim of the work: The aim of this study is to evaluate survival and to identify the prognostic factors of superior vena cava syndrome in patients with lung cancer. We also propose to draw up the clinical profile as well as the therapeutic management in SVCS of malignant origin. Materials and methods: A total of 108 patients with SVCS complicating primary bronchial cancer were hospitalized in the Pneumology Department at Fattouma Bourguiba University Hospital during a period of 25 years. Results: The results showed the existence of a clear male predominance (98.1%) and an average age of 60.2 years. Smoking was found in 68.5% of cases .The superior vena cava syndrome revealed a neoplasm in 55% of cases and it was metachronous in 30.5% of cases. Median survival was 7months. In univariate study, survival was reduced in patients having general health impairment with Performans Status (PS) score≥2, signs of severity of SVCS, altered respiratory function, chronic respiratory failure, histological type of non small cell lung carcinoma and exclusive symptomatic treatment for bronchopulmonary cancer. Multivariate analysis revealed that gender, smoking, PS score and signs of severity were independent prognostic factors. Conclusion: The management of the SVCS is multidisciplinary. It requires medical treatment whose effectiveness is still uncertain and radiotherapy which is considered the gold standard of treatment for SVCS.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82359617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Influence of PM2.5 on spermatogenesis dysfunction via the reactive-oxygen-species-mediated Mitogen-activated-protein-kinase signaling pathway PM2.5通过活性氧介导的丝裂原活化蛋白激酶信号通路对精子发生功能障碍的影响

Journal of lung, pulmonary & respiratory research Pub Date : 2019-08-30 DOI: 10.15406/jlprr.2019.06.00212

R. Cheepsattayakorn

{"title":"Influence of PM2.5 on spermatogenesis dysfunction via the reactive-oxygen-species-mediated Mitogen-activated-protein-kinase signaling pathway","authors":"R. Cheepsattayakorn","doi":"10.15406/jlprr.2019.06.00212","DOIUrl":"https://doi.org/10.15406/jlprr.2019.06.00212","url":null,"abstract":"Approximately 15 % of the world‘s couples confront childless, and about 50 % of them are due to male reproductive disorders. Several previous studies demonstrated that PM2.5 particles has been consistently associated with critical human sperm reduction and impairment of human sperm chromatin and DNA from traffic exhaust pollution. Blood-testis barrier (BTB), a critically physical barrier between the seminiferous tubules and the blood vessels prevents sperm antigens from entering the blood circulation and facilitating and initiating an autoimmune response that contributing to spermatogenesis interference. Reactive oxygen species (ROS) are involved in the redox-sensitive signal transduction factors activation, such as Jun NH2-terminal kinase (JNK), p 38, extracellular signal-regulated kinase (ERK), and mitogen-activated protein kinases (MAPK) that critically influence BTB disruption. After PM2.5 exposure, there are decreased superoxide dismutase (SOD) expression, increased malondialdehyde (MDA) expression, increased nuclear factor erythroid 2-related factor 2 (Nrf-2) expression, increased expression of the four junctional proteins (β-catenin, Cx43, occludin, zonula occludens-1 (ZO-1)), thus improve sperm quality and quantity. PM2.5 particles markedly induce increasing phosphorylation of MAPKs via the ROS-mediated MAPK signaling pathway that causes BTB disruption, but this effect is lesser in the vitamins C and E intervention as well as increasing cleaved caspase-3 expression and the Bcl-2/Bax ratio. In conclusion, combined therapeutic administration of vitamins C and E can maintain the BTB integrity, reduce oxidative stress and cell apoptosis, and prevent toxic effects.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83313320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variability of lung function and respiratory muscles power in healthy and asthmatic subjects 健康和哮喘受试者肺功能和呼吸肌力量的变异性

Journal of lung, pulmonary & respiratory research Pub Date : 2019-08-12 DOI: 10.15406/jlprr.2019.06.00209

O. Abdalla, O. Musa

{"title":"Variability of lung function and respiratory muscles power in healthy and asthmatic subjects","authors":"O. Abdalla, O. Musa","doi":"10.15406/jlprr.2019.06.00209","DOIUrl":"https://doi.org/10.15406/jlprr.2019.06.00209","url":null,"abstract":"Airway function is one of the many biologic functions that exhibit circadian variability over 24-h periods. Studies of circadian variability of lung function in normal subjects as well as asthmatics are particularly scarce, and those of MEP and MIP are unknown. The aim of this study to determine circadian variation in lung function (FVC, FEV1 and PEFR) and respiratory muscle pressures(MEP and MIP) for measurement of respiratory muscle power at 6:00am (early morning),12:00midday, 6:00pm( evening) and 12:00 midnight in healthy subjects and in patients with mild asthma at 6:00am and 6:00pm , to elaborate on the possibility of using MEP and MIP variability as a new diagnostic test for asthma. This is a cross sectional study performed in Khartoum, the capital of Sudan during December 2010. Thirty healthy, symptoms free non smokers normal subjects aged 20-64 years selected randomly and 15 mild asthmatics, clinically free during the time of study aged 19-49 years were included in the study. There is significant drop in healthy subjects early in the morning compared to 6:00pm, the drop in FVC was 9.75%, in FEV1 was 8.79%, in PEFR was 8.44%, in MEP was 10.04%, and in MIP was 17.57%. There is also significant drop in asthmatics early in the morning in MEP and MIP (21.76%, 27.57% respectively), is comparable to FEV1 (22.56%) and PEFR (23.86%). The sensitivity and specificity of variability for MEP (53%, 77%) and MIP (60%, 63%) comparable to sensitivity and specificity of FEV1 variability (40%, 86%) and PEFR variability (46%, 73%). The obtained comparable results of MEP, MIP variability to FEV1, PEFR variability in normal and asthmatic subjects could imply that MEP & MIP can be used in assessing airway calibre as in asthma. The study concluded that MEP & MIP variability could be sensitive tests to confirm asthma diagnosis.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75321964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory muscles power reversibility test as a new test in asthma diagnosis 呼吸肌力可逆性试验作为哮喘诊断的新方法

Journal of lung, pulmonary & respiratory research Pub Date : 2019-08-01 DOI: 10.15406/jlprr.2019.03.00211

O. Abdalla, O. Musa

{"title":"Respiratory muscles power reversibility test as a new test in asthma diagnosis","authors":"O. Abdalla, O. Musa","doi":"10.15406/jlprr.2019.03.00211","DOIUrl":"https://doi.org/10.15406/jlprr.2019.03.00211","url":null,"abstract":"Making diagnosis of asthma requires a critical evaluation of the patient’s symptoms, medical history, physical examination and diagnostic tests. It is known that a reduction of respiratory muscle pressures (MIP and MEP) for assessment of respiratory muscles power has been associated with several neuromuscular diseases, but it is also possible to point out lower values in patients with chronic obstructive pulmonary diseases as in asthma. As asthma diagnosis by reversibility test is not very sensitive in intermittent and mild asthma and pulmonary function is related to respiratory muscle pressures (RMP), could we use the reversibility of RMP in the patients for asthma diagnosis is the main issue investigated in this research. The aim of the study to determine the validity of asthma diagnosis by reversibility testing of respiratory muscles power. A cross-sectional hospital based study carried out in Lung function tests clinic in Police and Alban Gadeed hospitals in Khartoum during the years 2010-2011 to determine the reversibility of the lung function (FEV1 and PEFR) and respiratory muscles power (MEP and MIP). Thirty five known asthmatic subjects attending the referred chest clinic for follow up, and 20 healthy non asthmatic controls were included in the study. FEV1, PEFR, MEP and MIP were measured for all subjects before and after bronchodilator. Reversibility test was considered positive assuming the cut-off point for FEV1, MEP and MIP is ≥12% and for PEFR≥20%.The results showed percent of change in asthmatic group before and after bronchodilator test for FEV1 , PEFR, MEP, MIP were: 10.45, 11.84, 12.15 and 16.73 respectively. The difference was statistically significant. Sensitivity and specificity of reversibility testing for FEV1 (40%, 75%), for PEFR (31%, 65%), for MEP (49%, 70%) and for MIP (71%, 65%). In conclusion, the respiratory muscles power reversibility test could be a potentially sensitive diagnostic test for asthma","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75564299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of CT-scan findings of lung lesions and pathologic diagnosis 肺部病变的ct表现与病理诊断的相关性

Journal of lung, pulmonary & respiratory research Pub Date : 2019-08-01 DOI: 10.15406/jlprr.2019.06.00210

Fereshteh Bagheri, S. Jafari, M. R. Sasani, M. Athari, Amin Dehdashtian

{"title":"Correlation of CT-scan findings of lung lesions and pathologic diagnosis","authors":"Fereshteh Bagheri, S. Jafari, M. R. Sasani, M. Athari, Amin Dehdashtian","doi":"10.15406/jlprr.2019.06.00210","DOIUrl":"https://doi.org/10.15406/jlprr.2019.06.00210","url":null,"abstract":"Background: we aimed to evaluate the features of lung nodules and masses in Ct scan that help to distinguish malignant lesions from benign ones. Method: The study was performed on 50 pulmonary lesions biopsied at the Shahid Faghih Hospital by an interventional radiologist. CT scan findings were evaluated by a radiologist and compared with pathologic outcomes. Data was entered into SPSS software and by Descriptive statistical methods of frequency and Roc curve analysis and Chi-squared test and T-test at the level of alpha 0.05 was analyzed. Results: The relationship between smoking and malignancy was determined in this study. There was no significance found in mean age and sex, lesion density and enhancement of benign and malignant nodules. Smooth border was mostly seen in benign lesions and lobulated and spiculated borders in malignant lesions. Popcorn calcification was in favor of benignity and calcification in periphery of lesion was in favor of malignancy. Cavity was mostly seen in benign lesions Conclusion: smoking and the spiculated or lobulated margins, calcification in the periphery of the lesion were associated with malignant lesions, and the smooth margin and popcorn calcification and cavity formation were mostly seen in benign lesions. Enhancement showed no significance.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89901401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compliance with CPAP in patients with obstructive sleep apnea 阻塞性睡眠呼吸暂停患者CPAP的依从性

Journal of lung, pulmonary & respiratory research Pub Date : 2019-06-27 DOI: 10.15406/jlprr.2019.06.00207

Codinardo Carlos

引用次数: 0

Giant pulmonary chondroid hamartoma in a 74-year-old female patient. A case report and brief review of literature 巨大肺软骨样错构瘤，74岁女性患者。病例报告及文献综述

Journal of lung, pulmonary & respiratory research Pub Date : 2019-06-10 DOI: 10.15406/jlprr.2019.06.00206

Jan Pojda, S. Hürlimann, A. Leiser

引用次数: 1