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Post stroke fall and associated factors among stroke survivors at hospitals in Jimma town, oromia regional state, Southwest Ethiopia, 2025: a cross sectional study. 2025年埃塞俄比亚西南部奥罗米亚州Jimma镇医院中风幸存者中风后跌倒及相关因素:一项横断面研究
IF 2.2 3区 医学
BMC Neurology Pub Date : 2025-08-09 DOI: 10.1186/s12883-025-04320-3
Yohannes Girma Legese, Foad Akmel, Keiru Abajebal, Dechasa Imiru Wayessa, Sisay Deme, Yazachew Mekonnen, Tesfalem Yitbarek
{"title":"Post stroke fall and associated factors among stroke survivors at hospitals in Jimma town, oromia regional state, Southwest Ethiopia, 2025: a cross sectional study.","authors":"Yohannes Girma Legese, Foad Akmel, Keiru Abajebal, Dechasa Imiru Wayessa, Sisay Deme, Yazachew Mekonnen, Tesfalem Yitbarek","doi":"10.1186/s12883-025-04320-3","DOIUrl":"10.1186/s12883-025-04320-3","url":null,"abstract":"<p><strong>Background: </strong>Post-stroke fall is a common incidence among stroke survivors, and it has several detrimental effects on this group of people. It significantly influences their well-being, increasing morbidity and reducing functional independence. It also leads to limiting activity and participation, increasing dependence and developing a fear of movements. In addition, it delay the progress of motor and cognitive recovery, as the patients may avoid activities that increase their risk of falling. Therefore, assessing post-stroke falls and their associated factors is necessary to address their consequences.</p><p><strong>Subjects: </strong>Stroke survivors who attended stroke units and physiotherapy outpatient clinics at hospitals in Jimma town, Oromia Regional State, South west Ethiopia.</p><p><strong>Method: </strong>A hospital-based cross-sectional study with a systematic random sampling technique was employed, and the data collection occurred through chart review, physical examination, and face-to-face interviews. The collected data was analyzed on SPSS Version 25. Bi-variable analysis was used to determine potential candidate variables. Finally, an adjusted odds ratio with a P value < 0.05 and a 95% confidence interval was considered statistically significant.</p><p><strong>Result: </strong>Among the study participants, 59.5% (235) of stroke survivors experienced post-stroke falls. Key factors includes an older age group (AOR = 3.2; 95% CI = 1.159-9.020), hemorrhagic type of stroke (AOR = 1.8; 95% CI = 1.036-3.088), spastic muscle tone (AOR = 2.7; 95% CI = 1.343-5.394), altered mental status (AOR = 1.7; 95% CI = 1.019-2.819), less number one caregiver (AOR = 1.8; 95% CI = 1.119-3.026), and late admission to hospital (AOR = 2.1; 95% CI = 1.115-3.952).</p><p><strong>Conclusion: </strong>More than half of stroke survivors had a history Post-stroke falls in the Jimma town with key factors including older age, type of stroke, spastic muscle tone, ≤one caregiver, late admission to hospital, and altered mental status.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"329"},"PeriodicalIF":2.2,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of remote electrical neuromodulation in migraine: a comprehensive systematic review and meta-analysis. 远程神经电调节治疗偏头痛的疗效和安全性:一项全面的系统综述和荟萃分析。
IF 2.2 3区 医学
BMC Neurology Pub Date : 2025-08-09 DOI: 10.1186/s12883-025-04291-5
Asmaa Zakria Alnajjar, Mohamed M M Mustafa, Omar Khaled Abdelsalam, Israa Sharabati, Amr K Hassan, Meran Allam, Moaz Elsayed Abouelmagd
{"title":"Efficacy and safety of remote electrical neuromodulation in migraine: a comprehensive systematic review and meta-analysis.","authors":"Asmaa Zakria Alnajjar, Mohamed M M Mustafa, Omar Khaled Abdelsalam, Israa Sharabati, Amr K Hassan, Meran Allam, Moaz Elsayed Abouelmagd","doi":"10.1186/s12883-025-04291-5","DOIUrl":"10.1186/s12883-025-04291-5","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"327"},"PeriodicalIF":2.2,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"The efficacy and safety of Atogepant for migraine prophylaxis: a systematic review and meta-analysis of randomized controlled trials". 阿托格坦预防偏头痛的有效性和安全性:随机对照试验的系统回顾和荟萃分析。
IF 2.2 3区 医学
BMC Neurology Pub Date : 2025-08-09 DOI: 10.1186/s12883-025-04350-x
Ayesha Shaukat, Laiba Shakeel, Rumaisa Riaz, Saad Ashraf, Aymar Akilimali
{"title":"\"The efficacy and safety of Atogepant for migraine prophylaxis: a systematic review and meta-analysis of randomized controlled trials\".","authors":"Ayesha Shaukat, Laiba Shakeel, Rumaisa Riaz, Saad Ashraf, Aymar Akilimali","doi":"10.1186/s12883-025-04350-x","DOIUrl":"10.1186/s12883-025-04350-x","url":null,"abstract":"<p><strong>Background: </strong>Migraine is a complex neurological disorder characterized by recurrent, disabling headaches and various sensory symptoms, affecting about 15% of the global population annually. It is the second most common neurological condition worldwide, causing significant disability. While current prophylactic treatments include beta-blockers, tricyclic antidepressants, anticonvulsants, and monoclonal antibodies targeting the CGRP pathway, not all patients respond adequately. Atogepant, an oral CGRP receptor antagonist, has emerged as a promising option for migraine prevention with improved tolerability.</p><p><strong>Methods: </strong>This meta-analysis follows PRISMA guidelines, involving a comprehensive search of Cochrane CENTRAL, PubMed/MEDLINE, and Google Scholar databases up to July 2024. Efficacy outcomes included mean monthly migraine days (MMDs), mean monthly headache days (MHDs), monthly acute medication use days and the percentage of patients with a ≥ 50% reduction in MMDs. Safety outcomes were measured by adverse events (AEs). Statistical analysis employed the Inverse Variance and Mantel-Haenszel random-effects models, with heterogeneity assessed using the I² index.</p><p><strong>Results: </strong>Six RCTs with 4325 patients (3054 on Atogepant, 1271 on placebo) met the inclusion criteria. The combined analysis indicated a significant reduction in MMDs favoring Atogepant over placebo (SMD - 0.39, 95% CI: -0.45 to -0.33; p < 0.00001; I²=0%). Similarly, significant reductions were observed in MHDs, monthly acute medication use days, and the proportion of patients achieving a ≥ 50% reduction in MMDs.</p><p><strong>Conclusion: </strong>Atogepant is an effective and safe option for migraine prophylaxis, showing significant reductions in MMDs. Further extensive trials are recommended to assess the long-term efficacy, safety, and cost efficiency of Atogepant compared to other preventive medications.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"326"},"PeriodicalIF":2.2,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between the triglyceride-glucose index and symptomatic intracranial atherosclerotic stenosis in nondiabetic patients: a retrospective study. 非糖尿病患者甘油三酯-葡萄糖指数与症状性颅内动脉粥样硬化性狭窄之间的关系:一项回顾性研究
IF 2.2 3区 医学
BMC Neurology Pub Date : 2025-08-08 DOI: 10.1186/s12883-025-04324-z
Yang Yang, Chunhao Mei, Xiaoning Guo, Bojun Han, Qingguang Wang
{"title":"Association between the triglyceride-glucose index and symptomatic intracranial atherosclerotic stenosis in nondiabetic patients: a retrospective study.","authors":"Yang Yang, Chunhao Mei, Xiaoning Guo, Bojun Han, Qingguang Wang","doi":"10.1186/s12883-025-04324-z","DOIUrl":"10.1186/s12883-025-04324-z","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"325"},"PeriodicalIF":2.2,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhombencephalitis associated with varicella-zoster virus masquerading as Guillain-Barré syndrome. 菱形脑炎与伪装成格林-巴-罗综合征的水痘-带状疱疹病毒有关。
IF 2.2 3区 医学
BMC Neurology Pub Date : 2025-08-05 DOI: 10.1186/s12883-025-04245-x
Khaloud Al Shaaibi, Vorakamol Phoophiboon, Karen E A Burns
{"title":"Rhombencephalitis associated with varicella-zoster virus masquerading as Guillain-Barré syndrome.","authors":"Khaloud Al Shaaibi, Vorakamol Phoophiboon, Karen E A Burns","doi":"10.1186/s12883-025-04245-x","DOIUrl":"10.1186/s12883-025-04245-x","url":null,"abstract":"<p><strong>Background: </strong>Although rare, rhombencephalitis or inflammation of the brainstem and cerebellum has significantly associated morbidity and mortality.</p><p><strong>Clinical features: </strong>We describe the case of a 64-year-old previously healthy, immunocompetent man who presented with acute bulbar symptoms (difficulty swallowing, change in phonation, and drooling). His symptoms progressed in severity and he ultimately required intubation due to declining lung function and inability to manage his secretions. Clinical examination revealed bulbar dysfunction without involvement of other cranial nerves. A lumbar puncture revealed albuminocytological dissociation: elevated protein (9.8 g/L), nonerythroid cell count (13 cells/µL) with predominantly lymphocytic count. He received a five-day course of intravenous immunoglobulin for presumed Guillain-Barré syndrome. Initial magnetic resonance imaging (MRI) showed mild microangiopathic changes in the brain with no parenchymal, leptomeningeal, or cranial nerve enhancement. Cerebrospinal fluid (CSF) analysis was positive for varicella zoster virus (VZV). He was treated with intravenous Acyclovir 10 mg/kg three times daily for 14 days with no initial improvement and underwent a tracheostomy. Subsequent MRI was consistent with rhombencephalitis.</p><p><strong>Conclusions: </strong>VZV rhombencephalitis with cranial neuropathies represents a rare and potentially fatal condition. Early recognition and investigation with lumbar puncture and imaging are critical for establishing the diagnosis and initiating treatment.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"324"},"PeriodicalIF":2.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Random X chromosome inactivation in female Charcot-Marie-Tooth disease type X1: insights from sural nerve biopsy analysis. 女性沙科-玛丽-图斯病X1型随机X染色体失活:来自腓肠神经活检分析的见解。
IF 2.2 3区 医学
BMC Neurology Pub Date : 2025-08-04 DOI: 10.1186/s12883-025-04297-z
Can Ebru Bekircan-Kurt, Evrim Aksu-Menges, Eray Taha Kumtepe, Ceren Damla Durmaz, Yunus Kasim Terzi, Zeynep Ergul-Ulger, Çagri Mesut Temucin, Sevim Erdem-Ozdamar, Ersin Tan, Burcu Balci-Hayta
{"title":"Random X chromosome inactivation in female Charcot-Marie-Tooth disease type X1: insights from sural nerve biopsy analysis.","authors":"Can Ebru Bekircan-Kurt, Evrim Aksu-Menges, Eray Taha Kumtepe, Ceren Damla Durmaz, Yunus Kasim Terzi, Zeynep Ergul-Ulger, Çagri Mesut Temucin, Sevim Erdem-Ozdamar, Ersin Tan, Burcu Balci-Hayta","doi":"10.1186/s12883-025-04297-z","DOIUrl":"10.1186/s12883-025-04297-z","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"321"},"PeriodicalIF":2.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of early rituximab treatment in anti-mGluR1 encephalitis: a case report. 利妥昔单抗早期治疗抗mglur1脑炎疗效1例。
IF 2.2 3区 医学
BMC Neurology Pub Date : 2025-08-04 DOI: 10.1186/s12883-025-04345-8
Kazuki Yamada, Hiroaki Yaguchi, Shuntaro Nakamura, Kazuhiro Horiuchi, Shintaro Fujii, Taichi Nomura, Akihiko Kudo, Akira Takekoshi, Nobuaki Yoshikura, Akio Kimura, Takayoshi Shimohata, Ichiro Yabe
{"title":"Efficacy of early rituximab treatment in anti-mGluR1 encephalitis: a case report.","authors":"Kazuki Yamada, Hiroaki Yaguchi, Shuntaro Nakamura, Kazuhiro Horiuchi, Shintaro Fujii, Taichi Nomura, Akihiko Kudo, Akira Takekoshi, Nobuaki Yoshikura, Akio Kimura, Takayoshi Shimohata, Ichiro Yabe","doi":"10.1186/s12883-025-04345-8","DOIUrl":"10.1186/s12883-025-04345-8","url":null,"abstract":"<p><strong>Background: </strong>Anti-mGluR1 encephalitis is a form of autoimmune encephalitis, with limited reports globally and only two cases reported from Japan. There are uncertainties regarding the optimal immunosuppressive agents and individual drug responses. Herein, we report a case of anti-mGluR1 encephalitis from Japan, notable for a favorable outcome after an early rituximab initiation and an observed increase in cerebellar blood flow during the early disease stages.</p><p><strong>Case presentation: </strong>The patient was a 65-year-old woman who experienced dizziness for 3 months, followed by worsening gait instability. She was referred to our department due to progressive difficulty standing and walking. Neurological examination revealed dysarthria, severe cerebellar ataxia, and impaired performance on the finger-to-nose and knee-to-heel tests. Blood tests were negative for rheumatologic autoantibodies, and cerebrospinal fluid (CSF) analysis showed a cell count of 4/µL and a protein level of 40.0 mg/dL. However, the IgG index was elevated at 1.35, and oligoclonal bands were positive. Brain magnetic resonance imaging showed no abnormalities, but ¹²³I-iodoamphetamine single-photon emission computed tomography revealed mild hyperperfusion in the bilateral cerebellar hemispheres. Based on the clinical presentation, immune-mediated cerebellar ataxia was suspected. The patient was treated with intravenous methylprednisolone, oral prednisolone, and intravenous immunoglobulin. Further diagnostic testing using tissue- and cell-based assays detected mGluR1 antibodies in pretreatment serum and CSF, confirming the diagnosis of anti-mGluR1 encephalitis. As the initial treatment was insufficient, rituximab was administered, leading to significant improvement, including the ability to walk unaided. At the most recent follow-up, >6 months postonset, she showed no symptom progression or cerebellar atrophy.</p><p><strong>Conclusions: </strong>We experienced a case of anti-mGluR1 encephalitis with increased cerebellar blood flow, where early RTX administration led to a favorable outcome. Its early use, as an acute treatment and for maintenance, may help prevent recurrence and contribute to a positive prognosis.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"319"},"PeriodicalIF":2.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between dietary vitamin B1 intake and stroke risk in older patients: a retrospective cross-sectional study. 老年患者膳食维生素B1摄入量与卒中风险之间的关系:一项回顾性横断面研究
IF 2.2 3区 医学
BMC Neurology Pub Date : 2025-08-04 DOI: 10.1186/s12883-025-04333-y
Shitu Zhuo, Zhenjie Chen, Lichao Ye, Jixing Chen, Zheng Yu, Meili Yang
{"title":"Association between dietary vitamin B1 intake and stroke risk in older patients: a retrospective cross-sectional study.","authors":"Shitu Zhuo, Zhenjie Chen, Lichao Ye, Jixing Chen, Zheng Yu, Meili Yang","doi":"10.1186/s12883-025-04333-y","DOIUrl":"10.1186/s12883-025-04333-y","url":null,"abstract":"<p><strong>Background: </strong>Stroke is associated with vitamin B12, folate, and vitamin B1 (VitB1); however, large-scale data supporting the association between VitB1 and stroke risk are lacking. In this study, we aimed to investigate the correlation between VitB1 intake and stroke risk in U.S. adults.</p><p><strong>Methods: </strong>This retrospective study examined American adults using data from the National Health and Nutrition Examination Survey (NHANES). We analyzed data collected from eight NHANES conducted between 2003 and 2018, focusing on 15,381 participants aged ≥ 60 years. After excluding participants with missing information, the study comprised 11,724 individuals. All data were analyzed using univariate and multivariate logistic regression methods, restricted cubic spline, and sensitivity analyses.</p><p><strong>Results: </strong>A total of 11,724 people were investigated in this survey. Dietary VitB1 levels were higher in the non-stroke group than in the stroke group (p < 0.001). Multivariate analysis revealed that VitB1 intake (as a continuous variable) and stroke risk exhibited an inverse association, with odds ratios (ORs) of 0.71 (95% confidence interval [CI]: 0.61, 0.82) and 0.72 (95% CI: 0.61, 0.84) in the crude model and Model 1, respectively. According to the fully adjusted model, each unit increase in VitB1 intake was linked to a 37% reduction in stroke risk (OR = 0.63, 95% CI: 0.48, 0.83); that is, the greater the VitB1 intake, the lower the stroke risk.</p><p><strong>Conclusions: </strong>These findings indicate that lower dietary VitB1 intake was associated with an increased risk of stroke in older individuals, highlighting the potential importance of adequate dietary thiamine intake in stroke prevention strategies for the aging population.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"322"},"PeriodicalIF":2.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ruptured intracranial aneurysm with spontaneous occlusion of internal carotid artery: clinical characteristics, prognostic risk factors, and survival analysis. 颅内动脉瘤破裂并发自发性颈内动脉闭塞:临床特征、预后危险因素及生存分析。
IF 2.2 3区 医学
BMC Neurology Pub Date : 2025-08-04 DOI: 10.1186/s12883-025-04347-6
Bo Liu, Pengran Liu, Yang Guo, Hao Yin, Xihai Zhu, Yaohua Li, Bangyue Wang, Yan Zhao, Linchun Huan, Xiaopeng Cui, Xuequan Feng, Xinyu Yang, Xiaojun Zhang
{"title":"Ruptured intracranial aneurysm with spontaneous occlusion of internal carotid artery: clinical characteristics, prognostic risk factors, and survival analysis.","authors":"Bo Liu, Pengran Liu, Yang Guo, Hao Yin, Xihai Zhu, Yaohua Li, Bangyue Wang, Yan Zhao, Linchun Huan, Xiaopeng Cui, Xuequan Feng, Xinyu Yang, Xiaojun Zhang","doi":"10.1186/s12883-025-04347-6","DOIUrl":"10.1186/s12883-025-04347-6","url":null,"abstract":"<p><strong>Background: </strong>Ruptured intracranial aneurysm (RIA) combined with internal carotid artery occlusion (ICAO) is a rare and serious vascular condition. We aimed to describe the clinical characteristics and outcomes of these patients.</p><p><strong>Methods: </strong>We retrospectively analyzed cases of RIA with concurrent spontaneous ICAO from the Chinese Multicenter Aneurysm Database (CMAD). Logistic regression analysis was used to identify independent risk factors associated with patient prognosis. Cox proportional hazards model was performed to determine predictors of cumulative mortality.</p><p><strong>Results: </strong>We analyzed 52 cases of RIA with ICAO, including 41 unilateral and 11 bilateral cases. Among unilateral ICAO cases, aneurysms were ipsilateral in 8, contralateral in 16, and midline in 17. Treatment included coiling (31 cases), clipping (6 cases), and conservative management (15 cases). Prognosis was favorable in 26 cases and unfavorable in 17, including 12 deaths. Logistic regression identified Hunt-Hess grade IV-V, conservative treatment, and symptomatic cerebral infarction as independent risk factors for unfavorable outcome. Cox proportional hazards model found Hunt-Hess grade IV-V to be a predictor of mortality during the 2-year follow-up.</p><p><strong>Conclusion: </strong>Hunt-Hess grade, treatment, and in-hospital cerebral infarction independently predict unfavorable outcome, with grades IV-V linked to early death. ICAO may increase the risk of aneurysm rupture, highlighting the importance of aneurysm location and its related hemodynamic mechanisms in clinical management.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"323"},"PeriodicalIF":2.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotection through adiponectin receptor agonist: an updated meta-analysis of preclinical Alzheimer's disease studies. 通过脂联素受体激动剂的神经保护:临床前阿尔茨海默病研究的最新荟萃分析。
IF 2.2 3区 医学
BMC Neurology Pub Date : 2025-08-04 DOI: 10.1186/s12883-025-04356-5
Tannaz Novinbahador, Amin Abbasi, Roghayeh Molani-Gol, Leili Aghebati-Maleki, Amirhesam Pouraghaei, Hassan Soleimanpour
{"title":"Neuroprotection through adiponectin receptor agonist: an updated meta-analysis of preclinical Alzheimer's disease studies.","authors":"Tannaz Novinbahador, Amin Abbasi, Roghayeh Molani-Gol, Leili Aghebati-Maleki, Amirhesam Pouraghaei, Hassan Soleimanpour","doi":"10.1186/s12883-025-04356-5","DOIUrl":"10.1186/s12883-025-04356-5","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"320"},"PeriodicalIF":2.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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