BMC Neurology最新文献

{"title":"The potential role of serum and urine galectin-3 values in the diagnosis and staging of Parkinson's disease.","authors":"Miray Erdem, Derya Ozdogru, Elif Banu Soker, Burak Ademoglu, Nevzat Unal, Onur Serdar Gencler","doi":"10.1186/s12883-025-04390-3","DOIUrl":"https://doi.org/10.1186/s12883-025-04390-3","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"365"},"PeriodicalIF":2.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of MRI-double inversion recovery sequence for early diagnosis of multiple sclerosis: case series.","authors":"Dan Zhu, Yongjia Shao, Nana Zhang, Zhourui Wu, Liming Cheng, Hongyu Zhou, ShuGuang Chu","doi":"10.1186/s12883-025-04386-z","DOIUrl":"https://doi.org/10.1186/s12883-025-04386-z","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"364"},"PeriodicalIF":2.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life, depression, daytime sleepiness and fatigue in Omani people with epilepsy: a cross-sectional study.","authors":"Jansirani Natarajan, Mickael Antoine Joseph, Abdullah Al-Asmi, Vidya Seshan, Laila Darwish Al Balushi, Suad Moosa Al Junaibi, Jaber Al Khabouri","doi":"10.1186/s12883-025-04402-2","DOIUrl":"https://doi.org/10.1186/s12883-025-04402-2","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy is a prevalent neurological disorder that can adversely affect multiple life domains, including mental health, sleep quality, and overall well-being. In Oman, where modern healthcare services have expanded substantially, limited data exist on how these factors influence the health-related quality of life (HRQoL) of adults with epilepsy. Accordingly, this study aimed to evaluate HRQoL and its relationships with depression, daytime sleepiness, and fatigue in Omani adults with epilepsy.</p><p><strong>Methods: </strong>A cross-sectional descriptive study was conducted among 238 Omani adults with epilepsy at two tertiary hospitals in Muscat. HRQoL was assessed using the Quality of Life in Epilepsy-31 (QOLIE-31), while depression, daytime sleepiness, and fatigue were measured via the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E), the Epworth Daytime Sleepiness Scale (EDSS), and the Fatigue Severity Scale (FSS), respectively. Independent t-tests and one-way ANOVAs examined differences in QOLIE-31 scores, and Pearson correlations assessed relationships among the four scales. Continuous variables are reported as mean ± standard deviation (SD) and categorical variables as frequencies and percentages. Statistical analyses were two-tailed; results with p < .05 were considered significant.</p><p><strong>Results: </strong>Participants had a mean age of 32.74 years (SD = 11.77), and 55.5% were male. About 52.5% experienced generalized-onset tonic-clonic seizures, while 47.5% reported focal-onset seizures. Idiopathic epilepsy was common (50.8%), and half of the participants (50.4%) were on monotherapy. Regarding QOLIE-31 categories, 10.5% of participants had low HRQoL, 71.4% had moderate HRQoL, and 18.1% had high HRQoL. On the NDDIE, 34.9% screened positive for depression. Excessive daytime sleepiness (ESS ≥ 11) was observed in 11.3% of participants, and 54.6% reported clinically significant fatigue (FSS ≥ 36). Higher QOLIE-31 scores were associated with living in Muscat (p < .01), having a higher income (p < .01), being employed (p < .01), having idiopathic epilepsy (p < .05), and receiving monotherapy (p < .001). Depression, daytime sleepiness, and fatigue each showed a significant negative correlation with QOLIE-31 (p < .01).</p><p><strong>Conclusions: </strong>This study highlights the multidimensional impact of epilepsy on Omani adults, demonstrating that clinical and socioeconomic factors-along with depression, sleepiness, and fatigue-significantly shape HRQoL. Targeted interventions aimed at seizure control, mental‑health support, and social empowerment are critical for optimizing well‑being in this population.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"366"},"PeriodicalIF":2.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory \"status dyskineticus\" in a child with post-herpes simplex virus 1 N-methyl-D-aspartate receptor encephalitis: a case report.","authors":"Alessandro Santagostino Barbone, Elisa De Grandis, Thea Giacomini, Silvia Buratti, Camilla Micalizzi, Giacomo Brisca, Alessia Aiello, Concetta Micalizzi, Maria Margherita Mancardi","doi":"10.1186/s12883-025-04346-7","DOIUrl":"https://doi.org/10.1186/s12883-025-04346-7","url":null,"abstract":"<p><strong>Background: </strong>Herpes simplex virus 1 (HSV-1) encephalitis may result in relapsing neurological symptoms secondary to immune-mediated processes, including anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Refractory status dyskineticus (RSD), a severe subset of status dystonicus, is characterized by a hyperkinetic movement disorder phenotype alongside dystonic features. This critical condition presents substantial challenges in neurocritical care. The present case highlights the importance of prompt intervention and immunotherapy escalation in managing severe movement disorders due to pediatric autoimmune encephalitis.</p><p><strong>Case presentation: </strong>A previously healthy 2-year-old boy was admitted with HSV-1 encephalitis, confirmed by brain MRI and cerebrospinal fluid (CSF) analysis. When initially treated with acyclovir, the patient achieved partial recovery but later developed encephalopathy, vomiting, behavioral regression, and severe dyskinetic movements. Upon transfer to our center, NMDAR antibodies were detected in the CSF, with no evidence of HSV reactivation. Despite first-line immunotherapy with intravenous steroids and immunoglobulins, his condition deteriorated, progressing to status dyskineticus (SD), with dystonia, hyperthermia, and hypercapnia, requiring intensive care management and mechanical ventilation. A treatment escalation regimen including both immunotherapy with rituximab, rapamycin, bortezomib, and multiple symptomatic therapies resulted in gradual improvement and resolution of the movement disorder.</p><p><strong>Conclusions: </strong>This case underscores the crucial role of neurocritical care in managing refractory movement disorders associated with autoimmune encephalitis. Early recognition and immunotherapy escalation are essential to improve outcomes in children with complex, life-threatening neurological conditions. A comprehensive, multidisciplinary approach in the neurocritical care setting is key to achieving recovery and minimizing long-term neurological damage.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"368"},"PeriodicalIF":2.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum transferrin as a potential marker for prediction of prognosis for sudden sensorineural hearing loss: a prospective study.","authors":"Silin Zhang, Weiping Wang, Xiaowu Huang, Sa Chen, Danyi Du, Yu Chen, Xiangmin Zhang","doi":"10.1186/s12883-025-04387-y","DOIUrl":"https://doi.org/10.1186/s12883-025-04387-y","url":null,"abstract":"<p><strong>Objective: </strong>Clinically significant prognostic indicators have not been identified for sudden sensorineural hearing loss (SSNHL). Consequently, this research aimed to evaluate the effectiveness of iron parameters in predicting prognostic outcomes for patients with SSNHL.</p><p><strong>Methods: </strong>Ninety-one individuals with SSNHL were prospectively enrolled and received steroid treatment at a dosage of 1 mg/kg/day for two weeks. Baseline characteristics and iron parameters were collected from participants. Afterward, the pre-and post-treatment hearing of the enrolled patients was compared. The effective group, defined as those with a pure tone audiometry (PTA) improvement of impaired frequencies of ≥ 15 dB or restoration to normal/ unaffected ear levels。.</p><p><strong>Results: </strong>In the entire cohort, the effective group exhibited a significantly younger age (p = 0.005) and baseline hearing level as well as transferrin saturation (p = 0.036) and higher transferrin levels (p = 0.002) in comparison to the ineffective group. Multivariate analysis identified age (OR, 0.931; 95% CI, 0.889-0.976; p = 0.003), the baseline hearing level (OR, 0.928; 95% CI, 0.894-0.964; p<0.001) and transferrin level (OR, 9.15; 95% CI, 1.838-45.555; p = 0.007) as independent predictors of treatment outcome.</p><p><strong>Conclusions: </strong>Higher transferrin levels were associated with an optimal outcome for SSNHL, however further research is needed to understand the mechanisms underlying this effect.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"367"},"PeriodicalIF":2.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"APOE ε2 is associated with reduced risk of early post-stroke cognitive impairment but not with long-term functional outcome.","authors":"Yangbo Hou, Shuyun Hua, Zhi Guo, Jiwei Cheng, Guoyi Li, Liangqi Wang, Qian Xiao","doi":"10.1186/s12883-025-04371-6","DOIUrl":"https://doi.org/10.1186/s12883-025-04371-6","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"363"},"PeriodicalIF":2.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting spinal neurological prognosis in patients with surgical treatment for thoracic spinal stenosis based on neurological and neurophysiological evaluation.","authors":"Tun Liu, Jia Li, Huaguang Qi, Wentao Wang, Bin Guo, Yongjie Zhang, Kuo Jiang, Songchuan Zhao, Jin Wang, Gang Wu, Gang Wang","doi":"10.1186/s12883-025-04369-0","DOIUrl":"https://doi.org/10.1186/s12883-025-04369-0","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"359"},"PeriodicalIF":2.2,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of thoracolumbar fascia injury for patients with Parkinson's disease and construction of a nomogram model.","authors":"Yitong Xiong, Chengfang Chen, Luyao Shi, Yiyao Yang, Chenjun Zhai, Tao Jiang, Zhanyun Ren, Lei Shen","doi":"10.1186/s12883-025-04382-3","DOIUrl":"https://doi.org/10.1186/s12883-025-04382-3","url":null,"abstract":"<p><strong>Background: </strong>Thoracolumbar fascia injury (TLFI) is common in Parkinson's disease (PD) patients; however, the related risk factors are still controversial, and few studies have focused on clinical prediction models for TLFI. The aim of this study was to investigate the risk factors for TLFI in patients with PD and construct a clinical nomogram prediction model.</p><p><strong>Methods: </strong>The clinical data of 351 patients with PD from October 2019 to September 2022 were retrospectively analyzed. MRI images were used to evaluate the presence or absence of TLFI. Binary logistic regression analysis was used to determine the independent risk factors for TLFI in patients with PD. The independent predictors were used as predictors to construct a nomogram model, and the predictive efficacy of the model was evaluated by receiver operating characteristic (ROC) curves and calibration curves (CCs). Decision curve analysis (DCA) was used to evaluate the clinical application value of the model.</p><p><strong>Results: </strong>A higher UPDRS-III score, a lack of regular exercise, sagittal imbalance, sarcopenia and a low level of albumin were independent risk factors for TLFI in patients with PD. The area under the ROC curve was 0.974, and the CC and the ideal curve fit were good; the DCA. results showed that the model had high net benefits within all thresholds and had high clinical application value.</p><p><strong>Conclusion: </strong>TLFI is closely related to higher a UPDRS-III score, a lack of daily exercise, sagittal imbalance, sarcopenia, and lower albumin levels in patients with PD. Patients with these factors should pay more attention to TLFI prevention and treatment.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"352"},"PeriodicalIF":2.2,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of \"pons chocolate chip sign\" in heterozygous HTRA1-related cerebral small vessel disease.","authors":"Yu Guo, Qing Peng, Yishuang Yang, Zhe Wang, Yong Shan, HaoTian Yan, Haiqiang Jin, Li Bai, Wei Sun, Zhaoxia Wang, Zihao Zhang, Yun Yuan, Chen Ling","doi":"10.1186/s12883-025-04374-3","DOIUrl":"https://doi.org/10.1186/s12883-025-04374-3","url":null,"abstract":"<p><strong>Background and purpose: </strong>Heterozygous HTRA1-related cerebral small vessel disease (hHTRA1-CSVD) presents diagnostic challenges due to its clinical and imaging similarities with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and sporadic cerebral small vessel disease (CSVD). Recently, the \"chocolate chip sign\" around the midbrain has been proposed as a potential imaging marker for hHTRA1-CSVD. However, the diagnostic value of similar findings around the pons remains unclear. This study aims to assess the diagnostic performance of the \"pons chocolate chip sign\" in distinguishing hHTRA1-CSVD from CADASIL and sporadic CSVD.</p><p><strong>Materials and methods: </strong>This cross-sectional study included seven patients with hHTRA1-CSVD, twenty-seven patients with CADASIL and twelve patients with sporadic CSVD. All participants underwent 7.0T magnetic resonance imaging (MRI). The \"pons chocolate chip sign\" was defined as round or ovoid hypointense dots (≥ 2 mm in diameter) surrounding the pons on T2*-weighted gradient echo images. The number of chocolate chips was independently assessed by two blinded neurologists. Diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis, with genetic diagnosis as the gold standard.</p><p><strong>Results: </strong>The \"pons chocolate chip sign\" was found in 5/7 patients with hHTRA1-CSVD, compared to 2/27 in CADASIL and 0/12 in sporadic CSVD. ROC analysis revealed that it exhibited good discriminatory capability for hHTRA1-CSVD (area under the curve [AUC] = 0.84, 95% confidence interval [CI]: 0.63-1.00, P = 0.004). At an optimal cutoff of chocolate chips ≥ 1, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and Youden index were 71.42%, 94.87%, 71.42%, 94.87%, and 0.66, respectively. When the cutoff was increased to ≥ 3 chocolate chips, the specificity improved further, reaching 100%.</p><p><strong>Conclusions: </strong>The \"pons chocolate chip sign\" demonstrates high specificity for hHTRA1-CSVD and good discriminatory performance in differentiating hHTRA1-CSVD from CADASIL and sporadic CSVD.</p>","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"360"},"PeriodicalIF":2.2,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tirofiban-induced acute profound thrombocytopenia in endovascular therapy for acute ischemic stroke: a rare case report.","authors":"Jiuling Liu, Melysze Deanne Oorloff, Adithya Nadella, Yun Yan, Ning Zhou","doi":"10.1186/s12883-025-04368-1","DOIUrl":"https://doi.org/10.1186/s12883-025-04368-1","url":null,"abstract":"","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"25 1","pages":"355"},"PeriodicalIF":2.2,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}