Internal medicine review (Washington, D.C. : Online)最新文献

Effects of technology-based mindfulness training on wellbeing and stress 基于技术的正念训练对健康和压力的影响

Internal medicine review (Washington, D.C. : Online) Pub Date : 2021-01-01 DOI: 10.18103/IMR.V7I1.901

Tatjana Schauer, S. Diefenbach

{"title":"Effects of technology-based mindfulness training on wellbeing and stress","authors":"Tatjana Schauer, S. Diefenbach","doi":"10.18103/IMR.V7I1.901","DOIUrl":"https://doi.org/10.18103/IMR.V7I1.901","url":null,"abstract":"More and more people practice mindfulness to reduce stress and improve their wellbeing. In this regards, technology-based interventions such as smartphone apps provide an interesting potential. Our study explores effects on users' perceived wellbeing and stress on the example of the mindfulness-based app My Blossom. Forty-four new users answered four online questionnaires in one-week intervals, containing established multi-item wellbeing and stress scales for as well as single-item direct explicit questions about perceived changes in wellbeing and stress. In combination, these two forms of assessment provided insights to what degree users are conscious of a possible change and whether these perceptions are in parallel to the more indirect measures. Paired t tests show significant improvements in positive and negative affect, mood and stress in both scales and overall ratings after three weeks of mindfulness-training with My Blossom compared to the pre-intervention baseline. These findings suggest mindfulness-training in form of an app as an interesting alternative to mindfulness-trainings under instructions of a physically present trainer and the power to increase wellbeing and decrease stress. Future research should concentrate on the specific mechanisms and possible design factors of app-based mindfulness-trainings (e.g., variety of training offers, degree of guidance, reminder functions) as well as long term effects.","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90554510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Episodic memory recognition of the hippocampus using a deep learning method 海马情景记忆识别的深度学习方法

Internal medicine review (Washington, D.C. : Online) Pub Date : 2021-01-01 DOI: 10.18103/IMR.V7I1.915

T. Kuremoto

引用次数: 0

Photoelectric dye-based retinal prosthesis (OUReP) as a novel type of artificial retina 光电染料视网膜假体(OUReP)是一种新型的人工视网膜

Internal medicine review (Washington, D.C. : Online) Pub Date : 2021-01-01 DOI: 10.18103/IMR.V7I1.916

T. Matsuo, Tetsuya Uchida

{"title":"Photoelectric dye-based retinal prosthesis (OUReP) as a novel type of artificial retina","authors":"T. Matsuo, Tetsuya Uchida","doi":"10.18103/IMR.V7I1.916","DOIUrl":"https://doi.org/10.18103/IMR.V7I1.916","url":null,"abstract":"We have developed the world's first novel type of artificial retina, OUReP (Okayama University Retinal Prosthesis), in which a photoelectric dye that converts light energy into electric potential is covalently bonded to the surface of a polyethylene thin film as an insulator. The receptor that absorbs light and the output device that generates displacement current to stimulate nearby neurons are integrated in a sheet of thin film. It has become possible to measure the surface potential of the artificial retina OUReP using a Kelvin probe that measures the surface potential of semiconductors. When light is turned on and off to the artificial retina OUReP, the surface potential changes rapidly. As the light intensity is increased, the potential change on the surface of the artificial retina becomes larger. As for safety, the artificial retina OUReP was not toxic in all tests for biological evaluation of medical devices. As for efficacy, the artificial retina OUReP was implanted under the retina by vitreous surgery in monkey eyes which had chemically-induced macular degeneration with photoreceptor cell loss. Over the next 6 months, retinal detachment did not occur during the course, and the artificial retina was in contact with the retinal tissue. The amplitude of the visual evoked potential attenuated by macular degeneration recovered 1 month after implantation of the artificial retina, and the recovery of amplitude was maintained until 6 months after the implantation. By using multielectrode array-mounted dish recording system, it has been proved that action potential spikes are induced when the artificial retina is placed on degenerative retinal tissue of retinal dystrophic rats or mice and exposed to light, which is used as an index of the effectiveness of the artificial retina. We have established manufacturing and quality control of the device in a clean room facility, proved the safety and efficacy, and are preparing for first-in-human investigator-initiated clinical trials.","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86883240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Etiologies of Proptosis: A review. 前列腺突出的病因:综述。

Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-03-01 DOI: 10.18103/imr.v6i3.852

Nicole J Topilow, Ann Q Tran, Eubee B Koo, Chrisfouad R Alabiad

引用次数: 22

What we could learn about Chagas´ disease from our experimental therapeutic trials 从我们的实验性治疗试验中，我们可以了解到什么是恰加斯病

Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i1.844

S. Isasi, J. Muiño

引用次数: 0

Phase III Vaccines for SARS-CoV-2: A Review of Development and Available Data SARS-CoV-2三期疫苗:发展和现有数据综述

Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i5.905

Hamid Ehsan, M. K. Sana, A. Sarwar, Nazma Hanif, Sana Khan

{"title":"Phase III Vaccines for SARS-CoV-2: A Review of Development and Available Data","authors":"Hamid Ehsan, M. K. Sana, A. Sarwar, Nazma Hanif, Sana Khan","doi":"10.18103/imr.v6i5.905","DOIUrl":"https://doi.org/10.18103/imr.v6i5.905","url":null,"abstract":"Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has caused more than 35 million confirmed cases and more than 1 million deaths so far. This has led to global efforts to find effective treatment and vaccination to control disease transmission and decrease severity. The current efforts are focused on developing a vaccine that is safe and effective after one or two doses, provides protection for a minimum of six months, provides protection for high-risk population and reduces the risk of onward viral transmission. In this review, we summarize available information related to the development and safety profile of these phase III vaccines against SARS-CoV-2. Methods Literature search was performed on PubMed, Cochrane and ClinicalTrial.gov using keywords like “SARS-CoV-2”, “COVID-19”, and “Phase III vaccines”. Two individuals performed screening of the resultant library. We assessed different articles for information focusing on vaccines in phase III trials. Results As of September 3, 2020 update by the World Health Organization (WHO), there are currently more than 137 candidate vaccines undergoing preclinical development and of these 34 candidate vaccines are in the clinical evaluation phase, 18 are in phase I and 5 are in phase II. Currently, there are 9 vaccines in the phase III development process. Conclusion Multiple phase III trials of COVID-19 vaccines are in progress across the globe, highlighting the collaborative international efforts to develop a safe and effective vaccine. The available efficacy and safety data of phase I/II trials of these vaccines have shown promising results. Pharmaceutical companies are using different strategies including inactivated vaccines, RNA vaccines, recombinant viral vector vaccines and live attenuated BCG vaccine.","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80795591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Emerging Use of Cannabis in cases of Hyperemesis Gravidarum; A Critical Review 大麻在妊娠剧吐中的新应用批评性评论

Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i1.846

G. Koren

引用次数: 0

Individual and Couple Side-Effects After Radical Prostatectomy: Personal Reflections from a Research Scientist 根治性前列腺切除术后的个体和夫妻副作用:一位研究科学家的个人反思

Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i3.851

W. Schumm

引用次数: 0

Amyloid Structure and Properties and Its Relation to Human Diseases 淀粉样蛋白的结构和性质及其与人类疾病的关系

Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i1.849

N. Lisitza

引用次数: 0

Alarm Distress Baby Scale (ADBB) in Assessing Social Withdrawal in Infants with an Underlying Organic Illness – Congenital Heart Disease, Prader Willi Syndrome, Cleft Lip and/or Palate – An Overview 警报窘迫婴儿量表(ADBB)评估潜在器质性疾病婴儿的社会退缩-先天性心脏病，Prader Willi综合征，唇裂和/或腭裂-综述

Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i4.883

C. Pérez-Martínez, S. Menahem, S. Viaux-Savelon, A. Guédeney

引用次数: 2