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What we could learn about Chagas´ disease from our experimental therapeutic trials 从我们的实验性治疗试验中，我们可以了解到什么是恰加斯病
Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i1.844
S. Isasi, J. Muiño
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引用次数: 0
Phase III Vaccines for SARS-CoV-2: A Review of Development and Available Data SARS-CoV-2三期疫苗:发展和现有数据综述
Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i5.905
Hamid Ehsan, M. K. Sana, A. Sarwar, Nazma Hanif, Sana Khan
{"title":"Phase III Vaccines for SARS-CoV-2: A Review of Development and Available Data","authors":"Hamid Ehsan, M. K. Sana, A. Sarwar, Nazma Hanif, Sana Khan","doi":"10.18103/imr.v6i5.905","DOIUrl":"https://doi.org/10.18103/imr.v6i5.905","url":null,"abstract":"Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has caused more than 35 million confirmed cases and more than 1 million deaths so far. This has led to global efforts to find effective treatment and vaccination to control disease transmission and decrease severity. The current efforts are focused on developing a vaccine that is safe and effective after one or two doses, provides protection for a minimum of six months, provides protection for high-risk population and reduces the risk of onward viral transmission. In this review, we summarize available information related to the development and safety profile of these phase III vaccines against SARS-CoV-2. Methods Literature search was performed on PubMed, Cochrane and ClinicalTrial.gov using keywords like “SARS-CoV-2”, “COVID-19”, and “Phase III vaccines”. Two individuals performed screening of the resultant library. We assessed different articles for information focusing on vaccines in phase III trials. Results As of September 3, 2020 update by the World Health Organization (WHO), there are currently more than 137 candidate vaccines undergoing preclinical development and of these 34 candidate vaccines are in the clinical evaluation phase, 18 are in phase I and 5 are in phase II. Currently, there are 9 vaccines in the phase III development process. Conclusion Multiple phase III trials of COVID-19 vaccines are in progress across the globe, highlighting the collaborative international efforts to develop a safe and effective vaccine. The available efficacy and safety data of phase I/II trials of these vaccines have shown promising results. Pharmaceutical companies are using different strategies including inactivated vaccines, RNA vaccines, recombinant viral vector vaccines and live attenuated BCG vaccine.","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80795591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Emerging Use of Cannabis in cases of Hyperemesis Gravidarum; A Critical Review 大麻在妊娠剧吐中的新应用批评性评论
Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i1.846
G. Koren
{"title":"The Emerging Use of Cannabis in cases of Hyperemesis Gravidarum; A Critical Review","authors":"G. Koren","doi":"10.18103/imr.v6i1.846","DOIUrl":"https://doi.org/10.18103/imr.v6i1.846","url":null,"abstract":"","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90545321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Pulse Rate on Judgments of Airway Compromise Events During Infant Modified Barium Swallow Studies 在婴儿改良钡吞咽研究中，脉搏率对气道损害事件判断的影响
Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i5.904
M. Gosa, A. Bolland
{"title":"Effect of Pulse Rate on Judgments of Airway Compromise Events During Infant Modified Barium Swallow Studies","authors":"M. Gosa, A. Bolland","doi":"10.18103/imr.v6i5.904","DOIUrl":"https://doi.org/10.18103/imr.v6i5.904","url":null,"abstract":"Purpose: This research project sought to determine the effect of pulse rate on judgments of moderate to severe airway compromise events during infant MBSS. Method: This retrospective analysis investigated potential differences in Penetration Aspiration Scale (PAS) scores for swallows viewed at three different simulated pulse rate conditions by providing video files for review that featured 30 images per second (ips), 15 ips, and 7.5 ips. Analysts who were trained to achieve high consensus scored 20 different infant swallows recorded during MBSS at each of the simulated pulse rate conditions using the PAS. Result: Significant differences in PAS scores were found between infant MBSS reviewed at 30 pps and simulated 7.5 pps, with scores lower at simulated 7.5 pps, indicating analysts perceived less severe airway compromise events during the infant MBSS reviewed at lower pulse rates. Conclusion: The results from this research study indicate that the accurate identification of airway compromise events is affected by the pulse rate applied during the infant MBSS.","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73597241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomics and Personalized Medicine 基因组学和个性化医疗
Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i2.845
H. Blum
{"title":"Genomics and Personalized Medicine","authors":"H. Blum","doi":"10.18103/imr.v6i2.845","DOIUrl":"https://doi.org/10.18103/imr.v6i2.845","url":null,"abstract":"","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75250271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Individual and Couple Side-Effects After Radical Prostatectomy: Personal Reflections from a Research Scientist 根治性前列腺切除术后的个体和夫妻副作用:一位研究科学家的个人反思
Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i3.851
W. Schumm
{"title":"Individual and Couple Side-Effects After Radical Prostatectomy: Personal Reflections from a Research Scientist","authors":"W. Schumm","doi":"10.18103/imr.v6i3.851","DOIUrl":"https://doi.org/10.18103/imr.v6i3.851","url":null,"abstract":"","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73503286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amyloid Structure and Properties and Its Relation to Human Diseases 淀粉样蛋白的结构和性质及其与人类疾病的关系
Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i1.849
N. Lisitza
{"title":"Amyloid Structure and Properties and Its Relation to Human Diseases","authors":"N. Lisitza","doi":"10.18103/imr.v6i1.849","DOIUrl":"https://doi.org/10.18103/imr.v6i1.849","url":null,"abstract":"","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76708981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alarm Distress Baby Scale (ADBB) in Assessing Social Withdrawal in Infants with an Underlying Organic Illness – Congenital Heart Disease, Prader Willi Syndrome, Cleft Lip and/or Palate – An Overview 警报窘迫婴儿量表(ADBB)评估潜在器质性疾病婴儿的社会退缩-先天性心脏病，Prader Willi综合征，唇裂和/或腭裂-综述
Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i4.883
C. Pérez-Martínez, S. Menahem, S. Viaux-Savelon, A. Guédeney
{"title":"Alarm Distress Baby Scale (ADBB) in Assessing Social Withdrawal in Infants with an Underlying Organic Illness – Congenital Heart Disease, Prader Willi Syndrome, Cleft Lip and/or Palate – An Overview","authors":"C. Pérez-Martínez, S. Menahem, S. Viaux-Savelon, A. Guédeney","doi":"10.18103/imr.v6i4.883","DOIUrl":"https://doi.org/10.18103/imr.v6i4.883","url":null,"abstract":"","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90324385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A comprehensive review of mold research literature from 2011 - 2018 2011 - 2018年霉菌研究文献综述
Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i1.836
M. Dooley
{"title":"A comprehensive review of mold research literature from 2011 - 2018","authors":"M. Dooley","doi":"10.18103/imr.v6i1.836","DOIUrl":"https://doi.org/10.18103/imr.v6i1.836","url":null,"abstract":"","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87522724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The Evolution of the Treatment of Anal Fissure in the United States 美国肛裂治疗的演变
Internal medicine review (Washington, D.C. : Online) Pub Date : 2020-01-01 DOI: 10.18103/imr.v6i1.848
Alexander Marcia, H. Abcarian, A. Abcarian
{"title":"The Evolution of the Treatment of Anal Fissure in the United States","authors":"Alexander Marcia, H. Abcarian, A. Abcarian","doi":"10.18103/imr.v6i1.848","DOIUrl":"https://doi.org/10.18103/imr.v6i1.848","url":null,"abstract":"","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"12384 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88058472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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