Biorheology最新文献_第2页

Investigation and prediction of the extensional viscosity of okra mucilage using the Giesekus model. 用Giesekus模型研究和预测秋葵黏液的拉伸粘度。

IF 1.1 4区医学

Biorheology Pub Date : 2023-01-01 DOI: 10.3233/BIR-220006

Nguyen Ngoc Minh

{"title":"Investigation and prediction of the extensional viscosity of okra mucilage using the Giesekus model.","authors":"Nguyen Ngoc Minh","doi":"10.3233/BIR-220006","DOIUrl":"https://doi.org/10.3233/BIR-220006","url":null,"abstract":"Background: Okra is a vegetable that is widely grown around the world. Okra mucilage contains a high mucus concentration that can be useful for supporting the swallowing process. Although the extensional rheology of okra mucilage is essential to its flow, its extensional viscosity has not received much attention.Objective: Using a filament stretching rheometer, the extensional viscosity of the mucilage in okra was examined. The Giesekus model was used to predict this parameter.Methods: The okra mucilage with different concentrations was extracted from fresh okra. The extensional viscosity was measured using a filament breakup apparatus. The diameter of the liquid bridge was measured by a laser micrometer and it was also observed by a high-speed camera. A rotational rheometer was used to measure the shear viscosity. In addition, the master curves for the shear viscosity were plotted to eliminate the influence of solvent and shear rate and evaluate the influence of concentration on the elasticity of okra mucilage. The okra mucilage shear and extensional viscosity were predicted using the Giesekus model.Results: Every sample of okra mucilage exhibited shear thinning behavior. In addition to having a high extensional viscosity that is hundreds of times higher than its shear viscosity, okra mucilage also exhibited stretching phenomena. The master curves demonstrated that the pseudoplasticity of the okra mucilage increased along with the concentration. The rheological behavior of the mucilage in okra can be explained by the Giesekus model.Conclusions: Okra mucilage's shear viscosity exhibited shear thinning behavior and a strong extensional viscosity that was significantly higher than its shear viscosity. The shear and extensional viscosity of okra mucilage can be described and predicted using the Giesekus model.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"59 1-2","pages":"29-42"},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9594607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rheology of saliva in health and disease. 唾液流变学在健康和疾病中的应用。

IF 1.1 4区医学

Biorheology Pub Date : 2023-01-01 DOI: 10.3233/BIR-210014

S K Rereddy, A C Cao, B Blackwell, R Poling-Skutvik, P E Arratia, N Mirza

{"title":"Rheology of saliva in health and disease.","authors":"S K Rereddy, A C Cao, B Blackwell, R Poling-Skutvik, P E Arratia, N Mirza","doi":"10.3233/BIR-210014","DOIUrl":"https://doi.org/10.3233/BIR-210014","url":null,"abstract":"Background: Saliva is a complex fluid that lubricates the oropharynx and facilitates chewing, swallowing, and vocalization. Viscoelasticity is critical for the ability of saliva to fulfill these functions. Xerostomia, or a sensation of dry mouth, occurs in 17-26% of the population. Although many equate xerostomia with hyposalivation, high-risk patients frequently report oral dryness in the absence of decreased salivary flow.Objective: This study aims to determine if xerostomia is associated with alterations in the rheological properties of saliva in addition to decreased salivary production.Methods: The study population included patients with post-radiation xerostomia, patients with anticholinergic-induced xerostomia and healthy controls. Salivary volumetric flow rate was measured, shear viscosity was measured using oscillatory rheometry, and extensional viscosity was measured using capillary thinning methods. Groups were compared using descriptive statistics and univariate analysis.Results: A total of 36 subjects were included: 15 with post-radiation xerostomia, 9 with anticholinergic-induced xerostomia and 12 controls. Salivary volumetric flow was significantly decreased in post-radiation and anticholinergic-induced patients compared to controls. On capillary thinning testing, saliva from xerostomia patients had significantly greater extensional viscosity compared to controls. However, saliva from the three groups showed no significant difference in the complex viscosity or the storage or loss modulus of saliva with oscillatory rheology.Conclusions: Xerostomia is associated with decreased salivary volumetric flow and quantitative changes in the rheologic properties of saliva.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"59 1-2","pages":"19-27"},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Shear stimulated red blood cell microparticles: Effect on clot structure, flow and fibrinolysis. 剪切刺激红细胞微粒：对血凝块结构、流动和纤维蛋白溶解的影响

IF 1.1 4区医学

Biorheology Pub Date : 2023-01-01 DOI: 10.3233/BIR-220012

James P Buerck, Kylie M Foster, Preston R Larson, Edgar A O'Rear

{"title":"Shear stimulated red blood cell microparticles: Effect on clot structure, flow and fibrinolysis.","authors":"James P Buerck, Kylie M Foster, Preston R Larson, Edgar A O'Rear","doi":"10.3233/BIR-220012","DOIUrl":"10.3233/BIR-220012","url":null,"abstract":"Background: Microparticles (MPs) have activity in thrombus promotion and generation. Erythrocyte microparticles (ErMPs) have been reported to accelerate fibrinolysis in the absence of permeation. We hypothesized that shear induced ErMPs would affect fibrin structure of clots and change flow with implications for fibrinolysis.Objective: To determine the effect of ErMPs on clot structure and fibrinolysis.Methods: Plasma with elevated ErMPs was isolated from whole blood or from washed red blood cells (RBCs) resuspended in platelet free plasma (PFP) after high shear. Dynamic light scattering (DLS) provided size distribution of ErMPs from sheared samples and unsheared PFP controls. Clots were formed by recalcification for flow/lysis experiments and examined by confocal microscopy and SEM. Flow rates through clots and time-to-lysis were recorded. A cellular automata model showed the effect of ErMPs on fibrin polymerization and clot structure.Results: Coverage of fibrin increased by 41% in clots formed from plasma of sheared RBCs in PFP over controls. Flow rate decreased by 46.7% under a pressure gradient of 10 mmHg/cm with reduction in time to lysis from 5.7 ± 0.7 min to 12.2 ± 1.1 min (p < 0.01). Particle size of ErMPs from sheared samples (200 nm) was comparable to endogenous microparticles.Conclusions: ErMPs alter the fibrin network in a thrombus and affect hydraulic permeability resulting in decelerated delivery of fibrinolytic drugs.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"59 1-2","pages":"43-59"},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9596205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of non-Newtonian blood modeling and pulsatility on hemodynamics in the food and drug administration's benchmark nozzle model. 非牛顿血液模型和脉动对食品和药物管理局基准喷嘴模型中血液动力学的影响。

IF 1.1 4区医学

Biorheology Pub Date : 2023-01-01 DOI: 10.3233/BIR-201019

Bryan C Good

{"title":"The effects of non-Newtonian blood modeling and pulsatility on hemodynamics in the food and drug administration's benchmark nozzle model.","authors":"Bryan C Good","doi":"10.3233/BIR-201019","DOIUrl":"https://doi.org/10.3233/BIR-201019","url":null,"abstract":"Background: Computational fluid dynamics (CFD) is an important tool for predicting cardiovascular device performance. The FDA developed a benchmark nozzle model in which experimental and CFD data were compared, however, the studies were limited by steady flows and Newtonian models.Objective: Newtonian and non-Newtonian blood models will be compared under steady and pulsatile flows to evaluate their influence on hemodynamics in the FDA nozzle.Methods: CFD simulations were validated against the FDA data for steady flow with a Newtonian model. Further simulations were performed using Newtonian and non-Newtonian models under both steady and pulsatile flows.Results: CFD results were within the experimental standard deviations at nearly all locations and Reynolds numbers. The model differences were most evident at Re = 500, in the recirculation regions, and during diastole. The non-Newtonian model predicted blunter upstream velocity profiles, higher velocities in the throat, and differences in the recirculation flow patterns. The non-Newtonian model also predicted a greater pressure drop at Re = 500 with minimal differences observed at higher Reynolds numbers.Conclusions: An improved modeling framework and validation procedure were used to further investigate hemodynamics in geometries relevant to cardiovascular devices and found that accounting for blood's non-Newtonian and pulsatile behavior can lead to large differences in predictions in hemodynamic parameters.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"59 1-2","pages":"1-18"},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9655879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A broad and variable lumbosacral myotome map uncovered by foraminal nerve root stimulation. 韧带神经根刺激法揭示了一个广泛而多变的腰骶部肌图。

IF 2.8 4区医学

Biorheology Pub Date : 2022-05-13 Print Date: 2022-11-01 DOI: 10.3171/2022.3.SPINE2212

Dennis London, Ben Birkenfeld, Joel Thomas, Marat Avshalumov, Alon Y Mogilner, Steven Falowski, Antonios Mammis

{"title":"A broad and variable lumbosacral myotome map uncovered by foraminal nerve root stimulation.","authors":"Dennis London, Ben Birkenfeld, Joel Thomas, Marat Avshalumov, Alon Y Mogilner, Steven Falowski, Antonios Mammis","doi":"10.3171/2022.3.SPINE2212","DOIUrl":"10.3171/2022.3.SPINE2212","url":null,"abstract":"Objective: The human myotome is fundamental to the diagnosis and treatment of neurological disorders. However, this map was largely constructed decades ago, and its breadth, variability, and reliability remain poorly described, limiting its practical use.Methods: The authors used a novel method to reconstruct the myotome map in patients (n = 42) undergoing placement of dorsal root ganglion electrodes for the treatment of chronic pain. They electrically stimulated nerve roots (n = 79) in the intervertebral foramina at T12-S1 and measured triggered electromyography responses.Results: L4 and L5 stimulation resulted in quadriceps muscle (62% and 33% of stimulations, respectively) and tibialis anterior (TA) muscle (25% and 67%, respectively) activation, while S1 stimulation resulted in gastrocnemius muscle activation (46%). However, L5 and S1 both resulted in abductor hallucis (AH) muscle activation (17% and 31%), L5 stimulation resulted in gastrocnemius muscle stimulation (42%), and S1 stimulation in TA muscle activation (38%). The authors also mapped the breadth of the myotome in individual patients, finding coactivation of adductor and quadriceps, quadriceps and TA, and TA and gastrocnemius muscles under L3, L4, and both L5 and S1 stimulation, respectively. While the AH muscle was commonly activated by S1 stimulation, this rarely occurred together with TA or gastrocnemius muscle activation. Other less common coactivations were also observed throughout T12-S1 stimulation.Conclusions: The muscular innervation of the lumbosacral nerve roots varies significantly from the classic myotome map and between patients. Furthermore, in individual patients, each nerve root may innervate a broader range of muscles than is commonly assumed. This finding is important to prevent misdiagnosis of radicular pathologies.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"32 1","pages":"680-686"},"PeriodicalIF":2.8,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74876560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rising Star Awards. 新星奖。

IF 1.1 4区医学

Biorheology Pub Date : 2021-01-01 DOI: 10.3233/BIR-219902

引用次数: 0

Hemodynamic effects of the human aorta arch with different inflow rate waveforms from the ascending aorta inlet: A numerical study. 升主动脉入口不同流速波形对人主动脉弓血流动力学影响的数值研究。

IF 1.1 4区医学

Biorheology Pub Date : 2021-01-01 DOI: 10.3233/BIR-201009

Ying Chen, Yunmei Yang, Wenchang Tan, Liqin Fu, Xiaoyan Deng, Yubin Xing

{"title":"Hemodynamic effects of the human aorta arch with different inflow rate waveforms from the ascending aorta inlet: A numerical study.","authors":"Ying Chen, Yunmei Yang, Wenchang Tan, Liqin Fu, Xiaoyan Deng, Yubin Xing","doi":"10.3233/BIR-201009","DOIUrl":"https://doi.org/10.3233/BIR-201009","url":null,"abstract":"Background: Heart failure (HF) is a common disease globally. Ventricular assist devices (VADs) are widely used to treat HF. In contrast to the natural heart, different VADs generate different blood flow waves in the aorta.Objective: To explore whether the different inflow rate waveforms from the ascending aorta generate far-reaching hemodynamic influences on the human aortic arch.Methods: An aortic geometric model was reconstructed based on computed tomography data of a patient with HF. A total of five numerical simulations were conducted, including a case with the inflow rate waveforms from the ascending aorta with normal physiological conditions, two HF, and two with typical VAD support. The hemodynamic parameters, wall shear stress (WSS), oscillatory shear index (OSI), relative residence time (RRT), and the strength of the helical flow, were calculated.Results: In contrast to the natural heart, numerical simulations showed that HF decreased WSS and induced higher OSI and RRT. Moreover, HF weakened helical flow strength. Pulsatile flow VADs that elevated the WSS, induced some helical flow, while continuous flow VADs could not.Conclusions: HF leads to an adverse hemodynamic environment by decreasing WSS and reducing the helical flow strength. Based upon hemodynamic effects, pulsatile flow VADs may be more advantageous than continuous flow VADs. Thus, pulsatile flow VADs may be a better option for patients with HF.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"58 1-2","pages":"27-38"},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/BIR-201009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25447090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Visualizing and exploring nonlinear behavior, timescales, and mechanical signatures of human blood. 可视化和探索非线性行为，时间尺度，和人类血液的机械特征。

IF 1.1 4区医学

Biorheology Pub Date : 2021-01-01 DOI: 10.3233/BIR-201007

Matthew Armstrong, Erin Milner, Chi Nguyen, Trevor Corrigan, Yu-Fan Lee

{"title":"Visualizing and exploring nonlinear behavior, timescales, and mechanical signatures of human blood.","authors":"Matthew Armstrong, Erin Milner, Chi Nguyen, Trevor Corrigan, Yu-Fan Lee","doi":"10.3233/BIR-201007","DOIUrl":"https://doi.org/10.3233/BIR-201007","url":null,"abstract":"Background: Human blood is a thixo-elasto-visco-plastic (TEVP) material that exhibits unique fluctuations in mechanical properties based on physiology, and shear rate. We demonstrate new visual tools to help visualize and characterize these varied mechanical properties.Objective: Our objective is to demonstrate contemporary visual and numerical tools to help visualize and characterize the varied mechanical properties of human blood.Methods: Using the ARESG2 strain-controlled rheometer with double wall couette geometry and eight human blood donors, with lab test results, elastic and viscous properties are investigated using Series of Physical Processes (SPP) and MITLaos to both analyze and visualize the mechanical signatures of the blood.Results: Variations of mechanical properties are shown via SPP generated Cole-Cole plots and MITLaos analysis. These variations are a function of physiological properties of blood on the day of the blood draw based on hematocrit, fibrinogen, cholesterol, triglycerides, and a host of other proteins and constituents. Each rheological experiment with blood is replicated with an analogous experiments with 0.04 wt% xanthan in glycerol, and water to demonstrate that the mechanical properties of the human blood, and its rheological signatures are unique to human blood.Conclusions: Human blood is proven to be a TEVP material, as shown on a series of Cole-Cole plots for eight different donors, at two different frequency and strain amplitude combinations. Variations in Cole-Cole plots for each donor are shown. MITLaos average mechanical properties are calculated and shown. Aggregated elastic and viscous projections and a Cole-Cole plot is shown for Donors 1-8, along with 95% confidence interval.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"58 1-2","pages":"1-26"},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/BIR-201007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38817314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Spectral analysis of blood flow oscillations to assess the plantar skin blood flow regulation in response to preconditioning local vibrations. 血流振荡的频谱分析，以评估足底皮肤血流调节响应于预处理局部振动。

IF 1.1 4区医学

Biorheology Pub Date : 2021-01-01 DOI: 10.3233/BIR-201011

Xiaotong Zhu, Keying Zhang, Li He, Fuyuan Liao, Yuanchun Ren, Yih-Kuen Jan

{"title":"Spectral analysis of blood flow oscillations to assess the plantar skin blood flow regulation in response to preconditioning local vibrations.","authors":"Xiaotong Zhu, Keying Zhang, Li He, Fuyuan Liao, Yuanchun Ren, Yih-Kuen Jan","doi":"10.3233/BIR-201011","DOIUrl":"https://doi.org/10.3233/BIR-201011","url":null,"abstract":"Background: Local vibration has shown promise in improving skin blood flow and wound healing. However, the underlying mechanism of local vibration as a preconditioning intervention to alter plantar skin blood flow after walking is unclear.Objective: The objective was to use wavelet analysis of skin blood flow oscillations to investigate the effect of preconditioning local vibration on plantar tissues after walking.Methods: A double-blind, repeated measures design was tested in 10 healthy participants. The protocol included 10-min baseline, 10-min local vibrations (100 Hz or sham), 10-min walking, and 10-min recovery periods. Skin blood flow was measured over the first metatarsal head of the right foot during the baseline and recovery periods. Wavelet amplitudes after walking were expressed as the ratio of the wavelet amplitude before walking.Results: The results showed the significant difference in the metabolic (vibration 10.06 ± 1.97, sham 5.78 ± 1.53, p < 0.01) and neurogenic (vibration 7.45 ± 1.54, sham 4.78 ± 1.22, p < 0.01) controls. There were no significant differences in the myogenic, respiratory and cardiac controls between the preconditioning local vibration and sham conditions.Conclusions: Our results showed that preconditioning local vibration altered the normalization rates of plantar skin blood flow after walking by stimulating the metabolic and neurogenic controls.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"58 1-2","pages":"39-49"},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/BIR-201011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38906381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface. 前言。

IF 1.1 4区医学

Biorheology Pub Date : 2021-01-01 DOI: 10.3233/BIR-219900

引用次数: 0