Visualizing and exploring nonlinear behavior, timescales, and mechanical signatures of human blood.

IF 1 4区医学 Q4 BIOPHYSICS

Biorheology Pub Date : 2021-01-01 DOI:10.3233/BIR-201007

Matthew Armstrong, Erin Milner, Chi Nguyen, Trevor Corrigan, Yu-Fan Lee

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引用次数: 4

Abstract

Background: Human blood is a thixo-elasto-visco-plastic (TEVP) material that exhibits unique fluctuations in mechanical properties based on physiology, and shear rate. We demonstrate new visual tools to help visualize and characterize these varied mechanical properties.

Objective: Our objective is to demonstrate contemporary visual and numerical tools to help visualize and characterize the varied mechanical properties of human blood.

Methods: Using the ARESG2 strain-controlled rheometer with double wall couette geometry and eight human blood donors, with lab test results, elastic and viscous properties are investigated using Series of Physical Processes (SPP) and MITLaos to both analyze and visualize the mechanical signatures of the blood.

Results: Variations of mechanical properties are shown via SPP generated Cole-Cole plots and MITLaos analysis. These variations are a function of physiological properties of blood on the day of the blood draw based on hematocrit, fibrinogen, cholesterol, triglycerides, and a host of other proteins and constituents. Each rheological experiment with blood is replicated with an analogous experiments with 0.04 wt% xanthan in glycerol, and water to demonstrate that the mechanical properties of the human blood, and its rheological signatures are unique to human blood.

Conclusions: Human blood is proven to be a TEVP material, as shown on a series of Cole-Cole plots for eight different donors, at two different frequency and strain amplitude combinations. Variations in Cole-Cole plots for each donor are shown. MITLaos average mechanical properties are calculated and shown. Aggregated elastic and viscous projections and a Cole-Cole plot is shown for Donors 1-8, along with 95% confidence interval.

查看原文本刊更多论文

可视化和探索非线性行为，时间尺度，和人类血液的机械特征。

背景:人体血液是一种触敏-弹性-粘塑性(TEVP)材料，在生理和剪切速率的基础上表现出独特的机械性能波动。我们展示了新的可视化工具，以帮助可视化和表征这些不同的机械性能。目的:我们的目标是展示当代视觉和数字工具，以帮助可视化和表征人类血液的各种机械特性。方法:采用ARESG2双壁库特几何应变控制流变仪和8名献血者，结合实验室测试结果，利用SPP系列物理过程(Series of Physical Processes)和MITLaos分析和可视化血液的力学特征，研究血液的弹性和粘性特性。结果:通过SPP生成的Cole-Cole图和MITLaos分析显示了力学性能的变化。这些变化是抽血当天血液生理特性的功能，基于血细胞比容、纤维蛋白原、胆固醇、甘油三酯和许多其他蛋白质和成分。每个血液流变学实验都与0.04 wt%的黄原胶甘油和水的类似实验重复，以证明人类血液的机械特性及其流变学特征是人类血液所独有的。结论:人类血液被证明是一种TEVP材料，如8个不同献血者在两种不同频率和应变幅度组合下的一系列Cole-Cole图所示。显示了每个供体的Cole-Cole图的变化。计算并显示了MITLaos的平均力学性能。捐助者1-8显示了聚合弹性和粘性预测以及Cole-Cole图，以及95%置信区间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biorheology 医学-工程：生物医学

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials. The scope of papers solicited by Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.