Journal of thyroid disorders & therapy最新文献_第9页

Novel Findings in Familial Nonmedullary Thyroid Cancer Genetics 家族性非髓样甲状腺癌遗传学的新发现

Journal of thyroid disorders & therapy Pub Date : 2015-03-31 DOI: 10.4172/2167-7948.1000E119

E. Orenes-Piñero

引用次数: 4

Influence of the Subclinical Hypothyroidism on the Left Ventricular Systolic and Diastolic Function (pilot study) 亚临床甲状腺功能减退症对左心室收缩和舒张功能的影响(初步研究)

Journal of thyroid disorders & therapy Pub Date : 2015-03-13 DOI: 10.4172/2167-7948.1000177

V. V. Nakova

{"title":"Influence of the Subclinical Hypothyroidism on the Left Ventricular Systolic and Diastolic Function (pilot study)","authors":"V. V. Nakova","doi":"10.4172/2167-7948.1000177","DOIUrl":"https://doi.org/10.4172/2167-7948.1000177","url":null,"abstract":"Introduction: The clinically manifested hypothyroidism is associated with systolic and diastolic dysfunction. Studies investigating the left ventricular function in subclinical hypothyroidism (ScH) have shown controversial results. The aim of the study was to assess whether ScH is associated with the left ventricular systolic and diastolic dysfunction. \u0000Material and methods: Seventeen consecutive patients with newly diagnosed ScH and 20 healthy euthyroid patients as controls were analyzed. The two groups were appropriate by: age, sex, and body mass index. Laboratory analyses were performed in all patients - determination of TSH, free thyroxin (FT4), free triijodothyronine (FT3), antibodies directed to thyroid peroxidase (TPOAb) and antitiroglobulin antibodies (TgAb), and the assessment of left ventricular systolic and diastolic function by M-mode, two-dimensional echocardiography, pulse, continuous and color-Doppler, advanced echocardiographic modalities Tissue Doppler (TDI) and two-dimensional speckle tracking. \u0000Results: ScH patients had statistically significant lower ejection fraction, smaller ratio s/d (where s is the systolic velocity and d is the diastolic velocity through the pulmonary veins) and lower negative longitudinal global strain compared with the control group (62.1 ± 2.1 vs. 58.7 ± 6.2%, p<0.05, 1.27 ± 0.12 vs. 1.06 ± 0.20, p<0.001, -0.21 ± 0.01 versus -0.19 ± 0.01%, p<0.05, respectively). There was a statistically significant negative correlation of TSH with s/d and S/ TDI (r = 0.43 and r = 0.26, p<0.05, respectively). There was a statistically significant negative correlation of free thyroxine with myocardial performance index (r = -0.17, p<0.05), and a positive correlatin with s/d (r =0.48, p<0.05). \u0000Conclusion: ScH was associated","PeriodicalId":91565,"journal":{"name":"Journal of thyroid disorders & therapy","volume":"4 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2015-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7948.1000177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70840070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Severe Autoimmune Hyperthyroidism in Two Patients with Pulmonary Arterial Hypertension after Treatment with Epoprostenol 2例肺动脉高压患者应用Epoprostenol治疗后的严重自身免疫性甲状腺功能亢进

Journal of thyroid disorders & therapy Pub Date : 2015-03-03 DOI: 10.4172/2167-7948.1000176

Pavani Srimatk, Ada

引用次数: 6

Family History Correlates with More Aggressive Variants of Papillary ThyroidCancer 家族史与更具侵袭性甲状腺乳头状癌变异相关

Journal of thyroid disorders & therapy Pub Date : 2015-02-16 DOI: 10.4172/2167-7948.1000175

J. Lew

{"title":"Family History Correlates with More Aggressive Variants of Papillary ThyroidCancer","authors":"J. Lew","doi":"10.4172/2167-7948.1000175","DOIUrl":"https://doi.org/10.4172/2167-7948.1000175","url":null,"abstract":"Background: Papillary thyroid cancer (PTC) generally occurs sporadically but about 5% of cases are familial in origin. Furthermore, family history has been established as an influential risk factor for PTC. This study determines whether patients with a family history of thyroid cancer harbor more aggressive variants of PTC. \u0000Materials and Methods: A retrospective review of prospectively collected data of 1779 consecutive patients who underwent thyroidectomy was performed. Patients were divided into patients who had a history of PTC in first degree relatives (n=39) and those that did not (n=1740). Patients with PTC on final pathology were further subdivided into those with less aggressive (classic and follicular) and patients with more aggressive (diffuse sclerosing and tall cell) variants of PTC. A two tailed Z test at a significance level of p<0.05 was used to compare groups. \u0000Results: Of 1779 patients included, 39 (2.2%) had a family history of PTC. Of patients with a positive family history, 20 (51.2%) had PTC on final pathology. Furthermore, these patients had a significantly increased incidence of more aggressive variants of PTC at 15.4% (6/39) compared to patients with no family history of PTC at 2.7% (47/1740) (p<0.05). \u0000Conclusions: Patients with a positive family history of PTC have a significantly higher incidence of more \u0000aggressive PTC variants. A positive PTC family history, therefore, should be considered a risk factor for its more aggressive variants","PeriodicalId":91565,"journal":{"name":"Journal of thyroid disorders & therapy","volume":"4 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2015-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70840376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Differentiated Thyroid Cancer in Children: The Contribution of RadioiodineTherapy 儿童分化型甲状腺癌:放射性碘治疗的作用

Journal of thyroid disorders & therapy Pub Date : 2015-01-30 DOI: 10.4172/2167-7948.1000171

A. Mhiri, I. Elbez, I. Slim, M. F. B. Slimène

引用次数: 3

Iodine Deficiency Disorders 缺碘症

Journal of thyroid disorders & therapy Pub Date : 2015-01-30 DOI: 10.4172/2167-7948.1000172

Vargas-Uricoechea Hernando, Bonelo-Perdomo Anilza, Sierra-Torres Carlos Hernán

{"title":"Iodine Deficiency Disorders","authors":"Vargas-Uricoechea Hernando, Bonelo-Perdomo Anilza, Sierra-Torres Carlos Hernán","doi":"10.4172/2167-7948.1000172","DOIUrl":"https://doi.org/10.4172/2167-7948.1000172","url":null,"abstract":"Iodine deficiency disorders are among the most significant public health problems in the world at the present time, especially among children and pregnant women, considered the highest risk population. These disorders hinder socio-economic development in the affected areas. IDD are a permanent natural occurrence that affects the entire planet, which means that the people living in iodine-deficient areas will always be exposed to the consequences of that deficiency, in particular increased perinatal mortality, mental retardation and brain developmental delay. Consequently, it is the major cause of preventable brain damage in childhood, and its elimination is one of the biggest challenges in public health. Iodine is present in small amounts in the body and its main role is to act as the substrate for thyroid hormone synthesis. When dietary requirements are not met, the frequency of IDD increases. In general, these disorders are underdiagnosed and, in many countries, there is no awareness of the associated problems or of the iodine status in the population. \u0000Methods: Accurate methodological review of the medical literature included in the MEDLINE database using the MeSH terms “iodine”, “disorders”, “iodide”, “deficiency”, combined with the logical operators “AND”, “OR” and “NOT” and the “also try” characteristic of data published in “any date”, limiting the search to results including the link with abstracts and full text, exclusively in humans and regardless of gender. For the preliminary evaluation, the following types of studies were selected: clinical trials, meta-analyses, randomized controlled trials, clinical practice guidelines, and review articles. The search was limited to papers published in English, and related to the population between 0 and 18, and adults 19 and over, from January 1974 to November 2014.","PeriodicalId":91565,"journal":{"name":"Journal of thyroid disorders & therapy","volume":"2015 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2015-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7948.1000172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70839714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 480

Ulcerated Nodal Metastasis from Thyroid Papillary Carcinoma 甲状腺乳头状癌溃疡性淋巴结转移

Journal of thyroid disorders & therapy Pub Date : 2015-01-22 DOI: 10.4172/2167-7948.1000170

I. Cruz, M. Penín

引用次数: 4

The Utility of Color-Flow Doppler Sonography in the Evaluation of Hyperthyroidism 彩色血流多普勒超声在甲状腺机能亢进诊断中的应用

Journal of thyroid disorders & therapy Pub Date : 2015-01-18 DOI: 10.4172/2167-7948.1000E117

A. Bhargava

引用次数: 4

Autoimmune Thyroid Diseases Concomitant with Crohn’s Disease and Ulcerative Colitis 伴随克罗恩病和溃疡性结肠炎的自身免疫性甲状腺疾病

Journal of thyroid disorders & therapy Pub Date : 2014-12-17 DOI: 10.4172/2167-7948.1000169

T. Shizuma

引用次数: 3

Radiofrequency Ablation for the Papillary Thyroid Micro-carcinoma in the Highrisk Surgical Patient 射频消融治疗高危手术患者甲状腺乳头状微癌

Journal of thyroid disorders & therapy Pub Date : 2014-12-15 DOI: 10.4172/2167-7948.1000167

E. Jeon, H. Shon, E. Jung

引用次数: 5