Journal of thyroid disorders & therapy最新文献_第3页

Elephantiasis in a Patient with EMO Syndrome EMO综合征患者的象皮病

Journal of thyroid disorders & therapy Pub Date : 2018-01-01 DOI: 10.4172/2167-7948.1000226

Xianghui Meng, Shu-hang Xu, Guofang Chen, Xiangfei Meng, Zhoujun Liu, Hong-jie Di, Chao Liu

引用次数: 0

Acute Myelopathy Associated with Hashimoto's Disease 与桥本氏病相关的急性脊髓病

Journal of thyroid disorders & therapy Pub Date : 2018-01-01 DOI: 10.4172/2167-7948.1000229

Mnaili Mohamed Amine, E. Ilyas, Bourazza Ahmed

引用次数: 0

Spectrum of Thyroid Disorders in Sero Positive Rheumatoid Arthritis 血清阳性类风湿性关节炎的甲状腺疾病谱

Journal of thyroid disorders & therapy Pub Date : 2017-11-15 DOI: 10.4172/2167-7948.1000225

M. Nadeem, A. Khaliq, M. H. Bhat, F. Mustafa, Muzaffar Mushtaqe

{"title":"Spectrum of Thyroid Disorders in Sero Positive Rheumatoid Arthritis","authors":"M. Nadeem, A. Khaliq, M. H. Bhat, F. Mustafa, Muzaffar Mushtaqe","doi":"10.4172/2167-7948.1000225","DOIUrl":"https://doi.org/10.4172/2167-7948.1000225","url":null,"abstract":"Introduction: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by a symmetrical inflammation of the synovium, resulting in tenderness and destruction of bone and cartilage in various joints, particularly the smaller joints of the hands and feet. Although the cause of RA is unknown, autoimmunity plays a pivotal role in its chronicity and progression. Autoimmune thyroid disease (ATD) in the form of Hashimoto's thyroiditis and Graves' disease are all organ-specific. The relationship between RA and the thyroid gland has been studied extensively, with several studies demonstrating the autoimmune nature of thyroid dysfunction in RA.Aims and Objectives: To study prevalence of thyroid dysfunction in rheumatoid arthritis patients.Material and Methods: The present study was conducted in Postgraduate Department of Medicine, Government Medical College Srinagar over a period of 18 months in patients attending OPD clinic. The study was of prospective nature, and analytical cross sectional study.Results: The mean age of patients was 48.2 ± 12.1.ESR was elevated in 89 (23.1%) patients while as it was normal in 296 (76.9%) patients. CRP was positive in 199 (51.7%) patients while as it was negative in 186 (48.3%) patients. RF was more than 3 times elevated in 238 (61.8%) patients, <3 times raised in 131 (34%) patients and negative in only 16 (4.2%) patients. Anti CCP was more than 3 times elevated in 300 (77.9%) patients, <3 times raised in 25 (6.5%) patients and negative in 60 (15.6%) patients.Anti-TPO antibodies were negative in 302 (78.4%) patients with rheumatoid arthritis and was positive in 83 (21.5%) patients.Conclusion: Thyroid dysfunction is prevalent in patients with rheumatoid arthritis with percentage of 41.8%, subclinical hypothyroidism is the most common thyroid dysfunction encountered (37.9%) followed by overt hypothyroidism (3.6%), hyperthyroidism is very rare seen only 0.3% patients. Regular screening of patients is recommended.","PeriodicalId":91565,"journal":{"name":"Journal of thyroid disorders & therapy","volume":"6 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7948.1000225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42578396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

New Immunoassays of Bioactive TSH Improve Detection of Thyroid Disorders 生物活性TSH的新免疫测定法改进甲状腺疾病的检测

Journal of thyroid disorders & therapy Pub Date : 2017-10-30 DOI: 10.4172/2167-7948.1000223

S. Donadio-Andréi, C. Ronin

{"title":"New Immunoassays of Bioactive TSH Improve Detection of Thyroid Disorders","authors":"S. Donadio-Andréi, C. Ronin","doi":"10.4172/2167-7948.1000223","DOIUrl":"https://doi.org/10.4172/2167-7948.1000223","url":null,"abstract":"Background: TSH assays have long been showing discordances, especially in the upper limit of the reference range. There is thus a need to improve TSH measurement and detection of thyroid dysfunction. This study aimed at evaluating the ability of new TSH assays to detect early thyroid deficiency in a healthy population with no suspicion of thyroid disorders. \u0000Methods: We selected 797 subjects without declared hyperthyroidism, hypothyroidism, goiter, personal or familial thyroid dysfunction, thyroid autoimmunity or medication among 1,623 individuals recruited in a multicenter prospective study (2012-2014). Hypothyroidism-related clinical signs (hCS) were collected, TSH and thyroid hormones levels measured by routine tests and 4 new assays based on calibration with a biologically active recombinant TSH. Analysis was performed as a function of gender and age (<60 y and ≥ 60 y). \u0000Results: Expression of hCS appeared to vary as a function of gender and age in healthy individuals. The cohort displayed a higher percentage of males with no hCS in both 97.5th centile), FT4 levels were found to be slightly reduced and the expression of hCS increased (median, 2.0 vs. 1.0) when TSH was measured by the new assays compared to the routine assay. Detection of subclinical TSH was particularly improved in elderly women. \u0000Conclusion: New assays measuring bioactive TSH exhibited a good correlation with expression of hCS and FT4 levels, especially in ≥ 60 y women. Such assays may improve the monitoring of elderly people as well as the whole healthy population, especially in the context of environmental hazards.","PeriodicalId":91565,"journal":{"name":"Journal of thyroid disorders & therapy","volume":"6 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7948.1000223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49371661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical Ocular Features in Children and Young Adults with Thyroid Diseases 儿童和青年甲状腺疾病的临床眼部特征

Journal of thyroid disorders & therapy Pub Date : 2017-09-09 DOI: 10.4172/2167-7948.1000221

J. Jankauskiene, D. Jarusaitiene

{"title":"Clinical Ocular Features in Children and Young Adults with Thyroid Diseases","authors":"J. Jankauskiene, D. Jarusaitiene","doi":"10.4172/2167-7948.1000221","DOIUrl":"https://doi.org/10.4172/2167-7948.1000221","url":null,"abstract":"The study of clinical ocular manifestations recruited 105 patients who presented to the Endocrine and Eye clinics of Lithuanian University of Medical Sciences with a history of thyroid diseases. The study comprised two groups of patients: the group I included 36 patients (under 18 years) and the group II-69 (from 18 to 34 years). As the control group, 25 children and 30 young adults of similar age without thyroid, eye and systemic diseases were selected. \u0000A comprehensive ophthalmic assessment including patient’s complaints, best-corrected Snellen visual acuity, ocular motility, proptosis measurements, intraocular pressure (IOP), eyelid signs (lid aperture, lid retraction), slit lamp and fundus investigation was performed. \u0000Our investigation confirms that in children with thyroid diseases ocular symptoms and signs such as upper eyelid retraction, stare and mild proptosis were predominant. Young adults with thyroid diseases complained of foreign body sensation, photosensitivity and pain. There was manifestation of eyelid retraction, eyelid oedema and redness, conjunctival redness and chemosis, eyelid retraction, proptosis and widened palpebral fissure. A small number of young adults with thyroid diseases suffered from severe ocular complications as keratopathy, diplopia. \u0000This examination may be useful in early diagnosis of ocular changes in children and young adults with thyroid diseases.","PeriodicalId":91565,"journal":{"name":"Journal of thyroid disorders & therapy","volume":"6 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7948.1000221","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45594356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Asphyxia Following Complete Thyrodiectomy in a Patient with Relapsed GraveÃ¢Â€Â™s Disease 复发性GraveÃ¢Â€Â™s疾病患者完全甲状腺切除术后的窒息

Journal of thyroid disorders & therapy Pub Date : 2017-08-21 DOI: 10.4172/2167-7948.1000220

Han-Yun Wu, Ming-Ho Wu

引用次数: 0

Ultrasonographic United Stiffness Score System: Resolving the Discrepancy between Acoustic Radiation Force Impulse and Real-time Elastography in Evaluating the Thyroid Nodules Stiffness 超声联合硬度评分系统：解决声辐射力脉冲与实时弹性成像评估甲状腺结节硬度的差异

Journal of thyroid disorders & therapy Pub Date : 2017-08-09 DOI: 10.4172/2167-7948.1000219

Jia Zhan, Xuehong Diao, Jia-Mei Jin, Lin Chen, Yue Chen

{"title":"Ultrasonographic United Stiffness Score System: Resolving the Discrepancy between Acoustic Radiation Force Impulse and Real-time Elastography in Evaluating the Thyroid Nodules Stiffness","authors":"Jia Zhan, Xuehong Diao, Jia-Mei Jin, Lin Chen, Yue Chen","doi":"10.4172/2167-7948.1000219","DOIUrl":"https://doi.org/10.4172/2167-7948.1000219","url":null,"abstract":"Objective: The aim of this study was to assess the ultrasonographic united stiffness score system (UUSSS) in diagnosing thyroid nodules, and retrospectively analyze the discrepancy between acoustic radiation force impulse (ARFI) and real-time elastography (RTE). \u0000Methods: 170 conventional ultrasound (US) proven thyroid nodules in 70 patients were included and all were examined by RTE and ARFI. RTE and ARFI were first analyzed respectively, comparing with pathological findings. Then nodules have discrepancy between ARFI and RTE were retrospectively analyzed by UUSSS. \u0000Results: The AUC (area under curve) of ARFI combined RTE in 170 nodules was 0.87 (sensitivity=79.4% (54/68), specificity=84.3% (86/102), PPV=77.1% (54/70), NPV=86.0% (86/100), accuracy for ARFI were 82.4% (140/170), relatively to RTE was 0.83, 80.9%, 65.7%, 61.1%, 83.8%, 71.8%.The AUC of UUSSS was 0.876 (sensitivity=83.8% (57/68), specificity=87.3% (89/102), PPV=81.4% (57/70), NPV=89.0% (89/100), accuracy for UUSSS was 85.9% (146/170). The difference between area under UUSSS and RTE ROC curves was statistically significant (p<0.05), but was insignificant between UUSSS and ARFI (p=0.2245). There were 47 thyroid nodules had discrepancy in assessing the stiffness between ARFI and RTE. In these nodules, the accuracy of UUSSS was 83.0% (39/47), there were significant difference compare to RTE (20/47) (p=0.000), and ARFI (27/47) (p=0.012). \u0000Conclusions: UUSSS is useful to increase the diagnostic accuracy compare to independent RTE and ARFI, especially for those had discrepancy between ARFI and RTE. UUSSS is easy and convenient to re-evaluate stiffness on RTE and ARFI basis, and it place no additional cost burden.","PeriodicalId":91565,"journal":{"name":"Journal of thyroid disorders & therapy","volume":"2017 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7948.1000219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47509505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Report of a Track Seeding of Thyroid Papillary Carcinoma During Robot- Assisted Transaxillary Thyroidectomy 机器人辅助下经腋窝甲状腺切除术中甲状腺乳头状癌轨迹播种的报道

Journal of thyroid disorders & therapy Pub Date : 2017-07-21 DOI: 10.4172/2167-7948.1000218

E. Chabrillac, S. Zerdoud, P. Graff-Cailleaud, S. Fontaine, J. Sarini

{"title":"Report of a Track Seeding of Thyroid Papillary Carcinoma During Robot- Assisted Transaxillary Thyroidectomy","authors":"E. Chabrillac, S. Zerdoud, P. Graff-Cailleaud, S. Fontaine, J. Sarini","doi":"10.4172/2167-7948.1000218","DOIUrl":"https://doi.org/10.4172/2167-7948.1000218","url":null,"abstract":"Background: The Robotic Thyroidectomy (RT) is a minimally invasive surgical technique initially developed in Asia, for cultural reasons. The principles of its use are still undergoing development. Showing to all appearances satisfying outcomes, the long-time safety and medico-economic benefit of the procedure have not been established yet. The use of this technique in thyroid carcinology remains rare, and provides specific risks, not encountered with the Open Thyroidectomy (OT). \u0000Patient Findings: We report the case of a patient who underwent a two-stages RT for a pT3 follicular carcinoma causing dissemination along the surgical track, in spite of the radioactive iodine treatment. \u0000Summary: This case reminds us the limits of the RT in the oncologic field and the lack of perspective, with the recent discovery of the risk of dissemination along the surgical track. Our synthetic review of the literature comparing RT to OT shows the advantages and limitations of the RT. \u0000Conclusions: The development of the RT should pursue its way, but the use of this procedure in thyroid carcinology must remain reasonable. Further data is necessary to assess the long-term oncologic safety, regarding even the uncommon risks, as the track seeding. To this day, OT remains the gold standard for the complex thyroid pathologies.","PeriodicalId":91565,"journal":{"name":"Journal of thyroid disorders & therapy","volume":"6 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7948.1000218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42220132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of Laparoscopic Sleeve Gastrectomy on Clinical Hypothyroidism inMorbidly Obese Patients 腹腔镜袖胃切除术治疗病态肥胖患者甲状腺功能减退的疗效观察

Journal of thyroid disorders & therapy Pub Date : 2017-06-30 DOI: 10.4172/2167-7948.1000217

Ahmed Elnabil, O. Ahmed, B. Mostafa

{"title":"Effect of Laparoscopic Sleeve Gastrectomy on Clinical Hypothyroidism inMorbidly Obese Patients","authors":"Ahmed Elnabil, O. Ahmed, B. Mostafa","doi":"10.4172/2167-7948.1000217","DOIUrl":"https://doi.org/10.4172/2167-7948.1000217","url":null,"abstract":"Background: Laparoscopic sleeve gastrectomy (LSG) has an increase in popularity as a definitive bariatric \u0000 operation. The purpose of this study was to evaluate excess weight loss (EWL) and the change in thyroxin (T4) \u0000 requirement in morbidly obese patients with clinical hypothyroidism after LSG. \u0000Methods: Between June 2012 and June 2015, 33 morbidly obese patients candidate for laparoscopic sleeve \u0000 gastrectomy were enrolled in a prospective comparative study at Ain Shams University Hospitals, Egypt, and \u0000 Muhayl National Hospital, Saudi Arabia. The patients were assigned to either Group A (13 patients) with clinical \u0000 hypothyroidism on thyroxin treatment or Group B (20 patients) with euthyroid as control group. We compared \u0000 postoperative EWL between two groups and preoperative and postoperative thyroxin requirements in Group A at \u0000 one-year follow up. \u0000Results: There was no significant difference in excess weight loss at 3,6 and 12 months after surgery between \u0000 two groups, the dose of L-thyroxin was highly significantly decreased from 130.76 ± 49.11(mcg/d) to 69.23 ± \u0000 67.81(mcg/d) in 10/13 patients (77%), with complete resolution in 5/13(38.5%), and 5 patients (38.5%) had 40% \u0000 median reduction of their thyroxin requirements range (16.5%-62.5%), while 3/13 patients (23%) continued on the \u0000 same preoperative thyroxin dose. The mean change and percentage change in T4 requirement for all of Group A \u0000 were 61.53 ± 48.53 mcg (range: 0-150 mcg) and 54.34 ± 42.12% (range: 0-100%), respectively. \u0000Conclusion: .Improvement of clinical hypothyroidism after laparoscopic sleeve gastrectomy was evidenced by \u0000 a reduction in T4 requirement with comparable weight loss to euthyroid patients at short-term follow up.","PeriodicalId":91565,"journal":{"name":"Journal of thyroid disorders & therapy","volume":"6 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43013591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Surgical Treatment of Large Neglected Tall-Cell Thyroid Papillary Cancer with Neck Skin Infiltration and Exulceration: A Case Report and Literature 大面积被忽视的高细胞甲状腺乳头状癌伴颈部皮肤浸润溃烂的手术治疗:1例报告及文献

Journal of thyroid disorders & therapy Pub Date : 2017-06-19 DOI: 10.4172/2167-7948.1000216

G. Zorić, I. Paunović, Aleks, A. Diklić, N. Kalezić, Biljana Certic, Vesna S Rakić, K. Taušanović, B. Odalović, V. Živaljević

{"title":"Surgical Treatment of Large Neglected Tall-Cell Thyroid Papillary Cancer with Neck Skin Infiltration and Exulceration: A Case Report and Literature","authors":"G. Zorić, I. Paunović, Aleks, A. Diklić, N. Kalezić, Biljana Certic, Vesna S Rakić, K. Taušanović, B. Odalović, V. Živaljević","doi":"10.4172/2167-7948.1000216","DOIUrl":"https://doi.org/10.4172/2167-7948.1000216","url":null,"abstract":"Background: To present for the first time a clinical case of a patient with giant neglected and exulcerated tall-cell papillary thyroid cancer, who was surgically treated. \u0000Methods: We report a case of a 73-year-old woman with large firm infiltrated and exulcerated anterior neck tumefaction (12 cm in diameter) clinically suspected as anaplastic thyroid cancer. Patient had a goiter for more than 20 years with rapid growth in last months, after that presented with infiltration and exulceration of the skin. \u0000Results: Fine needle aspiration biopsy (FNAB) revealed papillary thyroid cancer (PTC). Total thyroidectomy with en-block dissection of the infrahyoid muscles and skin was performed. Lymph node metastasis were not present. Pathologically, goiter and tall-cell papillary carcinoma were present without anaplastic dedifferentiation. Postoperative radioiodine therapy was done, than L-thyroxin suppressive therapy, patient refused transcutaneous radiotherapy. Serum thyroglobulin was 0.15 ng/ml. Vocal cord paralysis and hypocalcaemia were not present. In following 3 years patient did not come to postoperative control, then she came with local recurrence of disease and tracheostomy. Tumor reduction was a second operation which was performed. Pathologically, it was tall-cell papillary carcinoma with regional lymph node metastases. The skin defect was reconstructed with a local transpositional flap. Patient refused radioiodine and transcutaneous radiotherapy and died 4 years after first operation, she was 77-years old. \u0000Conclusions: Skin infiltration and exulceration are rare in papillary thyroid cancer but they can be found in patients with neglected and poorly differentiated papillary carcinomas. Exulcerated tall cell papillary carcinoma can be unpredictable even in radically performed operation.","PeriodicalId":91565,"journal":{"name":"Journal of thyroid disorders & therapy","volume":" ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43162088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0