{"title":"Diagnostic Challenges of Binax Urinary EIA for Detection of Legionella pneumophila","authors":"L. Christian, Yerdon Heather N, Akinbola Bolaji","doi":"10.23937/2378-3516/1410162","DOIUrl":"https://doi.org/10.23937/2378-3516/1410162","url":null,"abstract":"A middle-aged African American male with a history of stage 2 chronic kidney disease status post double kidney transplant was admitted after developing symptoms of respiratory infection during the peak of COVID-19. The patient rapidly developed acute hypoxemic respiratory failure. Differentials for the patient included COVID-19, opportunistic infection such as mycoplasma, and legionella. During the admission, the patient had numerous infectious disease screening tests run including a COVID-19 test and Binax urine antigen test for legionella that all came back negative. The patient was started on Doxycycline, due to a recent Mycoplasma infection, Ceftriaxone, Lasix, and Methylprednisolone. Treatment was ineffective and the decision was made to step up investigations to a more invasive procedure. The patient then had bronchoalveolar lavage samples cultured returning a positive legionella sample. The patient was then successfully treated with Azithromycin with resolution of symptoms.","PeriodicalId":91516,"journal":{"name":"International journal of respiratory and pulmonary medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41421705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. PradoVictor, X. ChenShasha, Basu Anupam, J. WakefieldConnor, Sukhal Shashvat, A. PatelSanjay, B. SmithSean
{"title":"Hemithorax Opacification & Large Volume Thoracentesis: A Novel Predictor of Re-Expansion Pulmonary Edema","authors":"E. PradoVictor, X. ChenShasha, Basu Anupam, J. WakefieldConnor, Sukhal Shashvat, A. PatelSanjay, B. SmithSean","doi":"10.23937/2378-3516/1410159","DOIUrl":"https://doi.org/10.23937/2378-3516/1410159","url":null,"abstract":"Introduction: Symptomatic pleural effusions are a common reason for hospital visits. Guidelines recommend draining < 1.5 L with large-volume thoracentesis (LVT) to avoid re-expansion pulmonary edema (REPE). Hemithorax opacification by pleural fluid on chest X-ray (CXR) has not been studied as predictor of REPE. We evaluated the incidence of REPE using hemithorax opacification on CXR. Methods: We reviewed LVTs with preand post-procedural chest CXR from 2008 to 2019 at a tertiary urban hospital. Image J software was used to calculate the percentage of hemithorax opacification before and after drainage. CXRs were independently reviewed by a radiologist and interventional pulmonologist-both blinded to clinical data. Clinical REPE was separately according to clinical signs and symptoms. Results: 198 LVTs with CXRs were reviewed. Median volume drained was 1.8 L (IQR 1.6 L-2.0 L) and median percent opacification drained was 26% (IQR 13-40%): 11.1% of cases drained > 50% opacification, and 17.7% had complete drainage. 177 post-procedural CXRs were amenable for evaluation and 20.3% had evidence of radiographic REPE. In those with radiographic REPE, 2.5% had clinical REPE. Multivariate regression analysis demonstrated that draining > 50% of the opacified hemithorax was associated with radiographic REPE (OR 3.51, 95% CI 1.09-11.26, p = 0.035) and clinical REPE (OR 11.22, 95% CI 1.67-75.16, p = 0.013). Conclusion: Radiographic REPE was relatively common, but often without symptoms. The reduction of > 50% of hemithorax opacification is a novel predictor of REPE. We suggest individualizing limitations of fluid removal according to hemithorax opacification and clinical scenario rather than an arbitrary cutoff of 1.5 L.","PeriodicalId":91516,"journal":{"name":"International journal of respiratory and pulmonary medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48208441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Burden of Hypersensitivity Pneumonitis at a Single Respiratory Centre of Sri Lanka","authors":"Rathnayake Chanaka","doi":"10.23937/2378-3516/1410157","DOIUrl":"https://doi.org/10.23937/2378-3516/1410157","url":null,"abstract":"Background and objective: Hypersensitivity pneumonitis (HP) or extrinsic allergic alveolitis (EAA) is a diffuse parenchymal lung disease due to an inflammation of air spaces and airways secondary to an exposure to organic dust, bioaerosols, microorganisms (fungi, bacteria, protozoa) or certain reactive chemical species. Previous studies done in Sri Lanka recognized that it accounts for about one forth of ILD cases in total. Though the previous studied done in Sri Lanka looked into ILD patients in overall, no single study has looked into the hypersensitivity pneumonitis in details to identify its characteristics and impact on the community. This study was aimed at filling that gap. Methods: This was an observational descriptive study. To avoid selection bias consecutive patients presenting with clinical radiological and pathological, characteristics consistent with the diagnosis of hypersensitivity pneumonitis were recruited to the study after their diagnosis being reviewed by the ILD MDT, over a period of 12 months from 2019 to 2020. Forty patients had been enrolled to the study by end of this period. Demographic, clinical, radiological and aetiological data were collected with a random identification code for each patient in view of maintaining the confidentiality during data collection. Data was analysed by a separate person who didn’t involve with the data collection using SPSS (26 version). Population characteristics studied were described using descriptive statistics such as mean, median and standard deviation and frequency. Results: Out of Forty patients (N = 40) there were 27 (67.5%) females and 13 (32.5%) males. Mean age of the population was 62.975 years (SD = 11.346 years). Twenty three (57.5%) patients were less than 65 years of which twenty one were aged between 45 to 65 years while two (5%) were aged 35-45 years. Rest of the patients were above 65 years. Shortness of breath (72.5%) and Cough (67.5%) were the most common symptoms on presentation. Mean duration of symptoms was 6 months (SD = 2.4 months). 18 (45%) patients had severe restrictive (FVC less than 50% of predicted) lung disease by presentation, while another 18 (45%) had moderate restriction (FVC of 50% to 80% of predicted). Moderate to severe fibrosis were evident in almost 36 (90%) patients while only 4 (10%) having mild or no fibrosis. Exposure to poultry was identified in 12 cases (30%), while six (15%) had been exposed to paddy. There were 4 (10%) carpentry workers, 4 (10%) textile workers and two (5%) welders in the studied population. In 10 (25%) cases the aetiology was unknown. Discussion: The majority of patients were in the working age range and were females. There had been a substantial patient delay in seeking medical help for their condition. Most of the affected were having moderate to severe disease clinically and radiologically by presentation. Majority had moderate to severe fibrosis established on presentation. Poultry and paddy were the most common offend","PeriodicalId":91516,"journal":{"name":"International journal of respiratory and pulmonary medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68748394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eldaboosy Safwat Am, F. Mahmoud, Farouk Abdullah, A. Ahmad, A. Amgad, O. NourMohamed, Ahmed Gasmesleed, Mutair Abbas Al
{"title":"Indications and Prognostic Outcome of Inferior Vena Cava Filter: Almoosa Hospital's Experience","authors":"Eldaboosy Safwat Am, F. Mahmoud, Farouk Abdullah, A. Ahmad, A. Amgad, O. NourMohamed, Ahmed Gasmesleed, Mutair Abbas Al","doi":"10.23937/2378-3516/1410156","DOIUrl":"https://doi.org/10.23937/2378-3516/1410156","url":null,"abstract":"","PeriodicalId":91516,"journal":{"name":"International journal of respiratory and pulmonary medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46236037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mycophenolate Adverse Effect Masquerading as Extensive Pneumatosis Intestinalis (PI) after Lung Transplantation","authors":"Al Fahid, D. Janaki, Iacono Aldo, T. Irina","doi":"10.23937/2378-3516/1410155","DOIUrl":"https://doi.org/10.23937/2378-3516/1410155","url":null,"abstract":"Pneumatosis Intestinalis (PI) is a rare post lung transplant complication which is characterized by the presence of gas within the wall of the small and large intestine. PI in lung transplant recipients has been previously described and is associated with disease of varying clinical trajectories. Here we describe a case of PI in a lung transplant recipient that was attributed to immunosuppression with Mycophenolate Mofetil (MMF) as evidenced by the presence of increased crypt epithelial apoptosis on biopsy of the duodenum and clinical improvement with withdrawal of the offending agent. This case demonstrates that medication adverse effects are an important differential to consider in lung transplant recipients with PI.","PeriodicalId":91516,"journal":{"name":"International journal of respiratory and pulmonary medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48517106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Etiology of Pleural Effusion among Adults in Three University Hospitals in Beirut: A One-Year Retrospective Cross Sectional Analytical Study","authors":"I. Ali, Rida Amrou, M. Ibrahim","doi":"10.23937/2378-3516/1410149","DOIUrl":"https://doi.org/10.23937/2378-3516/1410149","url":null,"abstract":"Background: Pleural effusion, the pathological accumulation of fluid in the pleural space, is very common. It has a wide differential diagnosis, and a delayed etiological diagnosis can be associated with markedly higher morbidity and mortality. It is divided into two main types: Transudative and Exudative, depending on the mechanism of fluid accumulation. The most common causes of pleural effusion are: Congestive heart failure, infections, malignancy, liver and kidney failure. Thoracentesis may be indicated as a therapeutic procedure to relieve symptoms or as a diagnostic procedure by analyzing the pleural fluid using Light’s criteria which differentiate Transudative from Exudative effusions. The main objective of this study is to determine the prevalence and etiologies of different types of pleural effusion, and to assess its relation with some potential risk factors. Methods: This is a one-year retrospective cross-sectional analytical study. We collected data from 131 patients who underwent thoracentesis at the Lebanese Hospital Geitawi, Rafic Hariri University Hospital, and Makassed General Hospital, between January 1st 2016 and January 1st 2017. Results: This study showed that 78% of our patients had exudative pleural effusion, while the rest 22% had transudative effusion. Cardiovascular diseases were the most common causes of transudates (76.6%) and infectious parapneumonic effusions were the most common causes of exudates (48.8%). Conclusion: In Lebanon, the results were similar to those of developing countries, where the parapneumonic pleural effusion is the main cause of pleural effusion.","PeriodicalId":91516,"journal":{"name":"International journal of respiratory and pulmonary medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46617617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Szewczyk Joanne, Nguyen Dao M, Warde Prem R, Shukla Bhavarth, Ferreira Tanira, Parekh Dipen J, Gershengorn Hayley B
{"title":"Incidence of Post-Procedural COVID-19 at an Urban Academic Medical Center during High Prevalence Months","authors":"Szewczyk Joanne, Nguyen Dao M, Warde Prem R, Shukla Bhavarth, Ferreira Tanira, Parekh Dipen J, Gershengorn Hayley B","doi":"10.23937/2378-3516/1410150","DOIUrl":"https://doi.org/10.23937/2378-3516/1410150","url":null,"abstract":"In the beginning of the pandemic, after elective procedures resumed in Florida, we tested all patients for COVID-19, nasal pharyngeal swab PCR 72 hrs prior to any procedure. We conducted a retrospective cohort to see the incidence of COVID-19 post-procedural. Methods: We conducted a retrospective cohort study of all adult cases of same day or hospital-based procedures at the University of Miami Hospital and Clinics from April 1-September 23, 2020 who were COVID-19-negative (by SARS-CoV-2 polymerase chain reaction testing) within 72 hours pre-procedure, had contact with our health system 5-14 days post-procedure, and were either screened for COVID-19 symptoms or tested for SARS-CoV-2 during this contact. This timeframe was selected as median time to symptom onset after exposure is 5 days and 99% are symptomatic by 14 days. Results: The cohort consisted of 8,881 cases of which 879 (9.9%) were both screened for symptoms and tested for SARS-CoV-2 within 5-14 days post-procedure; 5,748 (64.7%) were screened but not tested and 131 (1.5%) were tested but not screened (Figure 1 and Table 1). Overall, 82 post-procedure screens (1.2% of screens) revealed COVID-19-associated symptoms and 13 tests (1.3% of tests) were positive; 91 (1.0% of all cases) had either symptoms or a test consistent with COVID-19. A positive symptom screen was only 40.0% sensitive, but 94.9% specific for a positive COVID-19 test; negative predictive value was 99.3%. Conclusion: COVID-19 acquisition post procedure demonstrates a strikingly low rate of infection (< 1.5%). As Miami was one of the pandemic epicenters during the period of our study, this finding provides reassurance that proceeding with hospital-based procedures is quite safe even with high community COVID-19 prevalence. This is especially important right now as COVID-19 surges across the nation. RESEaRcH aRTIclE","PeriodicalId":91516,"journal":{"name":"International journal of respiratory and pulmonary medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41328082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}