International journal of respiratory and pulmonary medicine最新文献

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Effects of Chest Physical Therapy in Patients with Non-Tuberculous Mycobacteria. 胸部物理治疗对非结核分枝杆菌患者的影响。

International journal of respiratory and pulmonary medicine Pub Date : 2017-01-01 Epub Date: 2017-01-21 DOI: 10.23937/2378-3516/1410065

Ashwin Basavaraj, Leopoldo Segal, Jonathan Samuels, Jeremy Feintuch, Joshua Feintuch, Kevin Alter, Daniella Moffson, Adrienne Scott, Doreen Addrizzo-Harris, Mengling Liu, David Kamelhar

{"title":"Effects of Chest Physical Therapy in Patients with Non-Tuberculous Mycobacteria.","authors":"Ashwin Basavaraj, Leopoldo Segal, Jonathan Samuels, Jeremy Feintuch, Joshua Feintuch, Kevin Alter, Daniella Moffson, Adrienne Scott, Doreen Addrizzo-Harris, Mengling Liu, David Kamelhar","doi":"10.23937/2378-3516/1410065","DOIUrl":"https://doi.org/10.23937/2378-3516/1410065","url":null,"abstract":"Antibiotic therapy against non-tuberculous mycobacteria (NTM) is prolonged and can be associated with toxicity. We sought to evaluate whether chest physical therapy (PT) was associated with clinical improvement in patients with NTM not receiving anti-mycobacterial pharmacotherapy. A retrospective review of 77 subjects that were followed from June 2006 to September 2014 was performed. Baseline time point was defined as the first positive sputum culture for NTM; symptoms, pulmonary function, and radiology reports were studied. Subjects were followed for up to 24 months and results analyzed at specified time points. Half of the subjects received chest PT at baseline. Cough improved at 12 (p = 0.001) and 24 months (p = 0.003) in the overall cohort when compared with baseline, despite lack of NTM antibiotic treatment. Cough decreased at 6 (p = 0.01), 9 (p = 0.02), 12 (p = 0.02) and 24 months (p = 0.002) in subjects that received chest PT. Sputum production also improved at 24 months in the overall cohort (p = 0.01). There was an increase in the percent change of total lung capacity in subjects that received chest PT (p = 0.005). Select patients with NTM may have clinical improvement with chest PT, without being subjected to prolonged antibiotic therapy. Future studies are warranted to prospectively evaluate outcomes in the setting of non-pharmacologic treatment and aid with the decision of antibiotic initiation.","PeriodicalId":91516,"journal":{"name":"International journal of respiratory and pulmonary medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.23937/2378-3516/1410065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35320047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Electron Microscopic Analysis of Silicate and Calcium Particles in Cigarette Smoke Tar. 卷烟焦油中硅酸盐和钙粒子的电子显微镜分析。

International journal of respiratory and pulmonary medicine Pub Date : 2016-01-01 Epub Date: 2016-02-11 DOI: 10.23937/2378-3516/1410039

R Steven Pappas, Mary M Halstead, Clifford H Watson

{"title":"Electron Microscopic Analysis of Silicate and Calcium Particles in Cigarette Smoke Tar.","authors":"R Steven Pappas, Mary M Halstead, Clifford H Watson","doi":"10.23937/2378-3516/1410039","DOIUrl":"10.23937/2378-3516/1410039","url":null,"abstract":"Scanning electron microscopy with energy dispersive x-ray spectroscopy (SEM-EDS) supplies information that is complementary to those data traditionally obtained using inductively coupled plasma-mass spectrometry for analysis of inorganic tobacco and tobacco smoke constituents. The SEM-EDS approach was used to identify select inorganic constituents of mainstream cigarette smoke \"tar.\" The nature of SEM-EDS instrumentation makes it an ideal choice for microstructural analyses as it provides information relevant to inorganic constituents that could result from exposure to combusted tobacco products. Our analyses show that aluminum silicates, silica, and calcium compounds were common constituents of cigarette mainstream smoke \"tar.\" Identifying inorganic tobacco smoke constituents is important because inhalation of fine inorganic particles could lead to inflammatory responses in the lung and systemic inflammatory responses. As cigarette smoking causes chronic inflammation in the respiratory tract, information on inorganic particulate in mainstream smoke informs efforts to determine causative agents associated with increased morbidity and mortality from tobacco use.","PeriodicalId":91516,"journal":{"name":"International journal of respiratory and pulmonary medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858188/pdf/nihms778651.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34465619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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