Pediatrics & therapeutics : current research最新文献

{"title":"Treatment Strategies & Prognosis for Alzheimers disease","authors":"Karin Zimermann","doi":"10.35248/2161-0665.21.11.386","DOIUrl":"https://doi.org/10.35248/2161-0665.21.11.386","url":null,"abstract":"","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"11 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69979470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothyroidism Prevention, Causes, & Natural Remedies","authors":"Jordyn Johnson","doi":"10.35248/2161-0665.21.11.387","DOIUrl":"https://doi.org/10.35248/2161-0665.21.11.387","url":null,"abstract":"","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"11 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69979483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leukemia, Causes & Risk factors","authors":"Anika Cohen","doi":"10.35248/2161-0665.21.11.385","DOIUrl":"https://doi.org/10.35248/2161-0665.21.11.385","url":null,"abstract":"","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"11 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69979408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin C2D: Co-operate to Dominate","authors":"Anika Cohen","doi":"10.35248/2161-0665.21.11.383","DOIUrl":"https://doi.org/10.35248/2161-0665.21.11.383","url":null,"abstract":"","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"11 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69979321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing nonoperative management of blunt pancreatic trauma in children: a study of 40 cases","authors":"E. S. Nkembi","doi":"10.35248/2161-0665.20.10.357","DOIUrl":"https://doi.org/10.35248/2161-0665.20.10.357","url":null,"abstract":"Introduction: Blunt pancreatic trauma (BPT) in children is uncommon but has a high morbidity. Nonoperative management (NOM) is still very controversial. This study aimed to assess the efficacy of NOM and describe the morbidity associated with it.  Methods: We analysed retrospectively the records of 40 consecutive children hospitalized in the University Hospital of Lille for BPT treated conservatively from 1997 to 2017. Use of surgery during treatment and discovery of pancreatic morphological abnormalities after the trauma were considered cases of NOM failure. Results: Pancreatic lesions were grade I (n=15), grade II (n=5), grade III (n=19), and grade IV (n=1). The median overall length of stay (LOS) was 28.0 days [4.0 to 106.0] and the median time to refeeding after trauma was 11.5 days [2.0 to 98.0]. Main short-term complications included introduction of parenteral nutrition for a median period of 21.5 days [5.0 to 102.0] (n=30) and onset of pancreatic pseudocysts (n=18). The pseudocysts were associated with increased morbidity concerning the LOS, the time to refeeding, the introduction of parenteral nutrition and its duration. However, they received conservative first-line treatment in 80% of cases, by watchful waiting (n=4), percutaneous drainage (n=1), or endoscopic drainage (n=10). Only 15% of cases of NOM resulted in failure, with use of surgery (n=4) and/or existence of pancreatic morphological abnormalities after the trauma (n=3). No patients had clinical signs of pancreatic insufficiency by the end of follow-up. Conclusion: NOM is safe and effective for of all forms of BPT, despite the initial high morbidity associated with it. Long-term follow-up could be necessary to assess the incidental impact in cases of morphological abnormalities existing more than 6 months after the trauma.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"10 1","pages":"101-112"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69978910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 3 Year Old with Hypoxia other Treatments Besides Oxygen","authors":"A. Porto, K. Levasseur","doi":"10.35248/2161-0665.2020.10.362","DOIUrl":"https://doi.org/10.35248/2161-0665.2020.10.362","url":null,"abstract":"Background: Glucose-6-phosphatase Dehydrogenase (G6PD) deficiency causes acute hemolysis when exposed to oxidative stress. Methemoglobinemia has been associated with G6PD deficiency, and recognition is important to avoid further complications. Case Presentation: A 3-year-old healthy boy presents to the pediatric emergency department with acute onset of difficulty in breathing, perioral cyanosis and hypoxia not responding to oxygen therapy. Transfusion of packed red blood cells was given with improvement of symptoms. Laboratory results were significant for anemia and methemoglobinemia. Further tests revealed deficiency in glucose-6-phosphatase dehydrogenase enzyme. Discussion: G6PD deficiency can cause acute hemolytic anemia. Cyanosis can be exacerbated by the presence of methemoglobinemia. Management must include transfusion of packed red blood cells and avoidance of methylene blue to prevent further hemolysis. Conclusion: G6PD deficiency can manifest after exposure to oxidative stressors with acute onset hemolytic anemia and hypoxia. Occasionally methemoglobinemia could be present contributing to worsening symptoms.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"10 1","pages":"146-152"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69979140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Concentration of Vancomycin in Children with Central Diabetes Insipidus: A Retrospective Case Series","authors":"Fumihiro Ochi, H. Tauchi, H. Kimura, Junpei Hamada, M. Ueda, Toshihiro Jogamoto, K. Nagai, M. Eguchi-Ishimae, M. Eguchi","doi":"10.35248/2161-0665.20.10.359","DOIUrl":"https://doi.org/10.35248/2161-0665.20.10.359","url":null,"abstract":"Although the high concentration of vancomycin (VCM) has the potential to cause acute kidney injury and ototoxicity, there were no studies focused on its pharmacokinetics in children with central diabetes insipidus (CDI). We, therefore, evaluated the pharmacokinetic indices of VCM in children with CDI diagnosed and treated at Ehime University Hospital between January 2008 and December 2019. Five patients with CDI administered VCM, were retrospectively reviewed. VCM median initial dose, trough value, clearance (CL) and half-life (t1/2) were 42.0 mg/kg/day (range, 18.8 mg/kg/day-60.0 mg/kg/day), 34.5 mg/L (range, 12.5 mg/L-182 mg/L), 6.54 mL/min (range, 1.57-47.1 mL/min), and 7.11 hr (range, 3.35 hr -38.5 hr), respectively. VCM trough values were high in cases of untreated or inadequately treated CDI. Our results suggest that the decrease in CL and the increase in the volume of distribution caused by CDI and sepsis could result in an extended VCM t1/2 and a higher VCM trough value in patients with CDI.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"10 1","pages":"127-134"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69979033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Occurence of Papulonecrotic Tuberculid and Erythema Induratum in a Child: A Case Report","authors":"Ezomike Nkeiruka. Elsie, Machona Sharon Musonda, Hlela Carol.","doi":"10.35248/2161-0665.20.10.361","DOIUrl":"https://doi.org/10.35248/2161-0665.20.10.361","url":null,"abstract":"Hypersensitivity reactions to Mycobacterium tuberculosis (tuberculids) include papulonecrotic tuberculid (PNT), erythema induratum (EI), and lichen scrofulosorum. . These rarely coexist in a child. We, therefore, report coexistence of papulonecrotic tuberculid and erythema induratum in a four-year old male. He presented with two-week history of skin eruptions involving the arm, abdomen and ears. Reddish bumps later appeared on the legs. Examination revealed erythematous papules, with central necrosis, on the lateral aspect of the left upper arm, ear helices and trunk. There were also several symmetrically distributed non-tender erythematous nodules, some with necrosis, on the shins and calves. Histology of the biopsied papules (PNT) revealed intense wedge-shaped necrosis with perivascular inflammation.and of the leg nodule (EI), extensive dermal fat necrosis with granulomatous lymphocytic infiltration. These findings are compatible with TB. Chest-xray revealed hilar and paratracheal adenopathy. Sputum was positive for Mycobacterium tuberculosis DNA using polymerase chain reaction (PCR). He did well on anti-tuberculosis medications. erythema induratum (EI), and lichen scrofulosorum. . These rarely coexist in a child. We therefore report coexistence of papulonecrotic tuberculid and erythema induratum in a four-year old male. He presented with two-week history of skin eruptions involving the arm, abdomen and ears. Reddish bumps later appeared on the legs. Examination revealed erythematous papules, with central necrosis, on the lateral aspect of the left upper arm, ear helices and trunk. There were also several symmetrically distributed non-tender erythematous nodules, some with necrosis, on the shins and calves. Histology of the biopsied papules (PNT) revealed intense wedge-shaped necrosis with perivascular inflammation.and of leg nodule (EI) extensive dermal fat necrosis with granulomatous lymphocytic infiltration. These findings are compatible with TB. Chest-xray revealed hilar and paratracheal adenopathy. Sputum was positive for Mycobacterium tuberculosis DNA using polymerase chain reaction (PCR). He did well on anti-tuberculosis medications.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"10 1","pages":"136-145"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69979102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Online Sources and SocialNetworking Sites on Breastfeeding Rate andPractices in Jordan","authors":"E. Badran, Noor N. Aldamiri, Azhar Shamasneh, Lana M. Braik, Sabika S. Allehdan, R. Tayyem","doi":"10.35248/2161-0665.20.10.358","DOIUrl":"https://doi.org/10.35248/2161-0665.20.10.358","url":null,"abstract":"Objective: This study asses the influence of using mobile health in supporting breastfeeding through online sources and Social Network Sites (SNS) among pregnant and lactating mothers on EBF rates and practices at one and two months postpartum. Design: A cross-sectional study with initial face-to-face interviews using structured questionnaire followed up with telephone interviews at one and two months postpartum was conducted at University Hospital over two months period. A convenient sample of 181. Jordanian women in their third trimester of pregnancy was recruited. The included data were: personal characteristics, breastfeeding intention and rate at 1 and 2 months, and questions about the use of online researching or different SNS resources, in providing necessary information for breastfeeding, along with how much the information was trusted and if it had an impact on BF practices. Breastfeeding status and use of online resources were assessed at the initial and follow-up Interviews. Results: Online sources were used by 74% of participants. They most often used Google (44%), followed by Facebook (24.6%), as significant sources of obtaining and sharing information with others for breastfeeding support. Moreover, 82.5% of those users did so before giving birth, and were overwhelmingly confident (92.5%) in the accuracy of the obtained information. Users (n=134) were significantly more likely than non-users (n=47) to indicate that online sources enhanced breastfeeding practices and influenced their decision to continue EBF. Using these sites during pregnancy was associated with a significantly higher EBF rate among users at the first month and second month postpartum respectively. Conclusion: The study demonstrated high use of online and SNS resources that enhanced BF practices and rate at one and two months of age. In areas where breastfeeding programs are lacking, there is a need to design interactive mobile health platforms to motivate women to engage in breastfeeding during pregnancy.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"10 1","pages":"113-126"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69978966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect in the Acid-Base Status, Electrolyte Levels and Anion-Gap Following Fluid Resuscitation with Normal Saline, Lactated Ringers and Isotonic Electrolyte Solution Fluids Among Pediatric Patients","authors":"M. Torres, Rodelia G Cipriano","doi":"10.26226/morressier.5fa2cf404d4e91fe5c54b83c","DOIUrl":"https://doi.org/10.26226/morressier.5fa2cf404d4e91fe5c54b83c","url":null,"abstract":"Background: Currently, the increasing number of available fluids has generated controversy about the optimal choice of resuscitation fluid. Popular intravenous fluids in clinical use may have an impact on electrolyte concentration and metabolic balance and each resuscitation fluid should be considered as a powerful pharmacological agent. Based on the non-physiological composition of normal saline, the interest to find a fluid that will provide the optimal composition has moved from synthetic colloid solutions to more physiologic balanced solutions.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45546976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}