Bone Marrow Transplantation最新文献

{"title":"Real-world approaches to preventing acute myeloid leukemia relapse after allogeneic transplantation: a national survey by GITMO (Gruppo Italiano Trapianto Midollo Osseo).","authors":"Francesco Saraceni, Emanuele Angelucci, Mario Arpinati, Andrea Bacigalupo, Giorgia Battipaglia, Fabio Benedetti, Alessandra Biffi, Carlo Borghero, Gladis Bortoletto, Stefania Bramanti, Fabiana Cacace, Mariangela Pedata, Irene M Cavattoni, Martina Chiarucci, Patrizia Chiusolo, Fabio Ciceri, Angela Cuoghi, Carmen Di Grazia, Nicola Di Renzo, Franca Fagioli, Marta Lisa Battista, Francesca Patriarca, Ilaria Foggetti, Andrea Gilioli, Valentina Giudice, Anna Grassi, Annalisa Imovilli, Anna Paola Iori, Giorgio La Nasa, Lucia Brunello, Salvatore Leotta, Jacopo Mariotti, Stefano Pozzi, Fabrizio Pane, Matteo Parma, Domenico Pastore, Alessandra Picardi, Simona Piemontese, Eugenia Piras, Arcangelo Prete, Alessandro Rambaldi, Daniele Avenoso, Francesco Saglio, Martina Salvatori, Giorgia Saporiti, Bianca Serio, Simona Sica, Cristina Skert, Francesco Paolo Tambaro, Elisabetta Terruzzi, Manuela Tumino, Vincenzo Federico, Alessandro Isidori, Francesco Zallio, Eliana Degrandi, Michele Malagola, Luca Castagna, Francesca Bonifazi, Massimo Martino","doi":"10.1038/s41409-026-02989-9","DOIUrl":"https://doi.org/10.1038/s41409-026-02989-9","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From salvage therapy to survivorship: mapping the late effects of autologous stem cell transplantation in autoimmune disease","authors":"Santhosh Thyagu, Piyanuch Kongtim","doi":"10.1038/s41409-026-02927-9","DOIUrl":"10.1038/s41409-026-02927-9","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":"61 10","pages":"1306-1307"},"PeriodicalIF":5.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41409-026-02927-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal timing of letermovir prophylaxis after allogeneic hematopoietic stem cell transplantation: insights from a real-world time-varying exposure analysis","authors":"Xueyao Li, Wenhao Wang, Ruixin Li, Jieya Luo, Xin Chen, Weihua Zhai, Rongli Zhang, Jialin Wei, Donglin Yang, Yi He, Aiming Pang, Sizhou Feng, Mingzhe Han, Yigeng Cao, Erlie Jiang","doi":"10.1038/s41409-026-02993-z","DOIUrl":"10.1038/s41409-026-02993-z","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":"61 10","pages":"1467-1471"},"PeriodicalIF":5.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41409-026-02993-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the conditioning armamentarium in adult acute lymphoblastic leukaemia: is treosulfan ready to challenge total body irradiation?","authors":"M. Joseph John, Dinesh Bhurani","doi":"10.1038/s41409-026-03006-9","DOIUrl":"10.1038/s41409-026-03006-9","url":null,"abstract":"Expanding the Conditioning Armamentarium in Acute Lymphoblastic Leukaemia: Is Treosulfan Ready to Challenge Total Body Irradiation?","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":"61 10","pages":"1303-1305"},"PeriodicalIF":5.1,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41409-026-03006-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world effectiveness and safety of belumosudil in pediatric refractory chronic graft-versus-host disease","authors":"Min Zhou, Peifang Xiao, Bohan Li, Li Gao, Yixin Hu, Shengqin Cheng, Yongping Zhang, Jie Li, Liyan Fan, Qingwei Wang, Yuanyuan Tian, Jun Lu, Yanhua Yao, Shaoyan Hu","doi":"10.1038/s41409-026-02997-9","DOIUrl":"10.1038/s41409-026-02997-9","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":"61 10","pages":"1464-1466"},"PeriodicalIF":5.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination in haematopoietic stem cell transplantation and cellular therapies: consensus, divergence, and uncertainties in global practice","authors":"Nalian H. Ibrahim, Sapna Dhunlall, Rachel Woolstencroft, Alice J. Liu, Violet Z. Zhu, Michelle K. Yong, Monica A. Slavin, Benjamin W. Teh","doi":"10.1038/s41409-026-02995-x","DOIUrl":"10.1038/s41409-026-02995-x","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":"61 10","pages":"1461-1463"},"PeriodicalIF":5.1,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late complications after autologous HSCT for autoimmune diseases: a retrospective survey from the autoimmune diseases working party (ADWP), transplant complications working party (TCWP) and paediatric diseases working party (PDWP) of the european society for blood and marrow transplantation (EBMT)","authors":"Kirill Kirgizov, Raffaella Greco, Manuela Badoglio, Myriam Labopin, Riccardo Saccardi, Montserrat Rovira, Dominique Farge, Mieke W. H. Roeven, John Moore, Varun Mehra, Francesco Onida, Alexey Polushin, Jürgen Finke, Tobias Alexander, Joachim Burman, Nicoletta Del Papa, Diana M. Greenfield, Majid Kazmi, Alicia Rovo, Nina Salooja, Helene Schoemans, Basil Sharrack, Chiara Nozzoli, André Tichelli, Peter Bader, Selim Corbacioglu, Zinaida Peric, Elisa Roldan, Grzegorz W. Basak, John A. Snowden","doi":"10.1038/s41409-026-02983-1","DOIUrl":"10.1038/s41409-026-02983-1","url":null,"abstract":"Autologous hematopoietic stem cell transplantation (aHSCT) has evolved as a treatment for severe autoimmune diseases (ADs). Advances in transplant procedures and supportive care have led to improvements in long-term survival but there is limited data on ‘late effects’. The aim of this retrospective EBMT registry study is to assess the incidence of ‘late effects’ after aHSCT for ADs. All EBMT centres were invited and data were received for 579 patients (median age 37 years, range 2.7–73.8), who received aHSCT between 1997 and 2016. Median follow-up was 89 months (IQR 82.4–95.5). Indications included multiple sclerosis (MS, 46.8%), systemic sclerosis (SSc, 28.7%), Crohn’s disease (CD, 12.6%), systemic lupus erythematosus (SLE, 2.4%) and other ADs (9.5%). Conditioning was mainly based on Cy/ATG (51.9%) or BEAM/ATG (25.3%). At 10-years, the cumulative incidence of secondary ADs was 10.3% (95% CI: 7.7–13.3), new post-transplant cancers 4.1% (95% CI: 2.2–6.8), endocrine complications 16.2% (95% CI: 12.6–20.1), and cardiovascular complications 14.7% (95% CI: 11.2–18.6). Median time to endocrine events (15.4 months) was generally sooner than median times to secondary ADs (24.5 months) and cardiovascular (25.3 months), with new cancers occurring relatively late (median time 81.7 months). Overall, at 10-years, progression-free survival (PFS) was 40.1% (95% CI: 34.7–45.4), overall survival (OS) 83.5% (95% CI: 79.3–86.9) and non-relapse mortality (NRM) 5.0% (95% CI: 3.2–7.4). By multivariate analysis, secondary ADs were relatively higher in CD vs SSc (HR = 4.93, p = 0.01) and MS (HR = 2.05, p = 0.055), while cardiovascular complications were significantly increased in SSc compared to MS (HR = 8.85, p < 10−3) or CD (HR = 3.45, p = 0.016). The incidence of post-aHSCT cancers was related to increasing age (HR per 10 y = 2.26, p < 10−3), without significant association with disease type. Incidence of endocrine complications were significantly lower in SSc compared to MS (HR = 0.35, p = 0.027) and CD (HR = 0.33, p = 0.041) and significantly more frequent in females (HR = 4.27, p < 10-3). Autologous HSCT for ADs is associated with a cumulative burden of non-infectious late complications, including thyroid dysfunction, osteoporosis, cardiovascular complications, gonadal dysfunction, secondary ADs and subsequent cancers. These impact all ages of patient and vary depending on AD indication, reflecting disease characteristics and other treatments. This study highlights the importance of screening, monitoring, and treatment of late effects in this setting.","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":"61 10","pages":"1416-1422"},"PeriodicalIF":5.1,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of IPSS-M and transplant conditioning intensity in allogeneic stem cell transplant for myelodysplastic neoplasms","authors":"Zilu Zhang, Xiaoqian Xu, Qi Wen, Ruoxuan Zhang, Hongru Chen, Minli Hu, Chupeng Zhang, Chuanhe Jiang, Luxiang Wang, Jiayu Huang, Zengkai Pan, Hua Jin, Yanmin Zhao, Wei Shi, Yang Cao, Xiaodong Mo, Xiaoxia Hu","doi":"10.1038/s41409-026-02939-5","DOIUrl":"10.1038/s41409-026-02939-5","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":"61 10","pages":"1456-1458"},"PeriodicalIF":5.1,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graft-versus-host disease prophylaxis with abatacept plus intermediate dose cyclophosphamide for GVHD prophylaxis after peripheral blood stem transplantation: a single institution study","authors":"Pallavi Surana, Mendel Goldfinger, Ioannis Mantzaris, Marina Konopleva, R. Alejandro Sica, Noah Kornblum, Aditi Shastri, Lauren C. Shapiro, Stephen Z. Peeke, Ritesh Aggarwal, Kira Gritsman, Eric J. Feldman, Alyssa de Castro, Jhannine Verceles, Royston Browne, Ridhi Gupta, David Levitz, Amanda Lombardo, Kith Pradhan, Plabani Sahu, Brittany Moavero, Angela Czavar, Amit Verma, Dennis L. Cooper","doi":"10.1038/s41409-026-03000-1","DOIUrl":"10.1038/s41409-026-03000-1","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":"61 10","pages":"1459-1460"},"PeriodicalIF":5.1,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary autoimmune and inflammatory diseases after allogeneic hematopoietic stem cell transplantation: a retrospective study from the EBMT Complications Working Party (CWP)","authors":"Arsene Mekinian, Artem Oganesyan, Zinaida Perić, Myriam Labopin, Urpu Salmenniemi, José Antonio Pérez Simón, Anke Verlinden, Ioanna Sakellari, Mohsen Alzahrani, Massimo Martino, Frédéric Baron, John A. Snowden, Hakan Ozdogu, Alexander Kulagin, Edgar Jost, Anna Torrent, Fabio Benedetti, Anna De Becker, Sylvie François, Montserrat Rovira, Hans Christian Reinhardt, Alessandra Biffi, Mark Ringhoffer, Pascal Ambron, Jose Luis López Lorenzo, Nabil Yafour, Alexandre Galvagni, Manuela Badoglio, Ivan Moiseev, Tobias Alexander, Mohamad Mohty, Olivier Fain, Raffaella Greco, Olaf Penack","doi":"10.1038/s41409-026-02981-3","DOIUrl":"10.1038/s41409-026-02981-3","url":null,"abstract":"Secondary autoimmune and inflammatory diseases (SAIDs) are underrecognized and poorly described after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The standardization of management is hindered by the scarcity of data on epidemiology, pathogenesis, and clinical outcomes. To improve the evidence base, we performed a retrospective multicenter EBMT database study of patients who underwent allo-HSCT between 2005 and 2019 for either hematological malignancy or severe aplastic anemia with available information on SAIDs. We included 129 cases of SAIDs and 14,617 controls. The 5-year incidence of SAIDs was 0.9% (95% confidence interval (CI): 0.7–1.1), and the 10-year incidence was 1.1% (95% CI: 0.9–1.3). The median time from allo-HSCT to the diagnosis of SAIDs was 442 days [interquartile range (IQR): 242–1082]. Overall survival after the onset of SAIDs was 83.4% (95% CI 74.6–89.3) at 2 years and 73.4% (95% CI: 62–82) at 5 years. In multivariate analysis, risk factors significantly associated with SAIDs were bone marrow failure (Hazard Ratio (HR): 3.41 [95% CI, 1.55–7.52], p = 0.002), female donor to male patient (HR 1.77 [95% CI, 1.15–2.73], p = 0.009), and the presence of chronic GvHD (HR 1.61 [95% CI, 1.04–2.51], p = 0.034). SAIDs after allo-HSCT are rare but clinically significant entities requiring further investigations, exploring treatment and prevention strategies, as well as improving diagnostic approaches.","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":"61 10","pages":"1405-1415"},"PeriodicalIF":5.1,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}