Laura Prin-Felix, Maxime Jullien, Pierre Peterlin, Amandine Le Bourgeois, Alice Garnier, Sophie Vantyghem, Aude-Marie Fourmont, Thierry Guillaume, Patrice Chevallier
{"title":"Treosulfan or busulfan plus clofarabine as reduced intensity conditioning regimen before allotransplant for adults with myeloid malignancies.","authors":"Laura Prin-Felix, Maxime Jullien, Pierre Peterlin, Amandine Le Bourgeois, Alice Garnier, Sophie Vantyghem, Aude-Marie Fourmont, Thierry Guillaume, Patrice Chevallier","doi":"10.1038/s41409-026-03017-6","DOIUrl":"https://doi.org/10.1038/s41409-026-03017-6","url":null,"abstract":"<p><p>This single-center retrospective study included 142 adults with myeloid malignancies undergoing allogeneic hematopoietic stem cell transplantation with peripheral blood stem cells from matched related or unrelated donors between 2010 and 2023. The aim was to compare outcomes between patients receiving a clofarabine-based reduced-intensity conditioning regimen combined either with busulfan (CloB2, n = 108) or treosulfan (CloT3, n = 34). CloB2 consisted of busulfan 3.2 mg/kg/day 2 days (d) with 1 or 2 d of anti-thymocyte globulin (ATG). CloT3 consisted of treosulfan 10 g/m²/d 3 d and 2 d of ATG. The CloT3 group included more patients with adverse-risk acute myeloid leukemia (AML). Neutrophil recovery was significantly faster after CloT3, resulting in a shorter hospital stay. No significant differences were observed between groups regarding overall survival (OS), disease-free survival (DFS) and graft-versus-host disease (GVHD)-free/relapse-free survival, non-relapse mortality (NRM), relapse incidence (RI), or acute and chronic GVHD. Among AML patients, univariable analysis showed similar outcomes, except for slower neutrophil recovery and higher RI with CloB2. In multivariable analysis, adverse ELN-2017 risk score, was associated with lower OS and DFS. CloT3 was independently associated with improved OS (p = 0.038), DFS (p = 0.026) and lower RI (p = 0.024). These exploratory results support further prospective studies, particularly in AML patients.</p>","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gloria Iacoboni, Pere Barba, Irma Khvedelidze, Maud Ngoya, Paolo Corradini, Pierre Sesques, Marion Subklewe, Maria Gomes da Silva, Gilles Crochet, Jaroslaw Dybko, Izaskun Zeberio, Alejandro Martin Garcia-Sancho, Tom van Meerten, Robin Sanderson, Bertram Glass, Anna Sureda, Peter Dreger, Olivier Hermine, Ali Bazarbachi
{"title":"Real-world CAR-T practice patterns in patients with mantle cell lymphoma: an international survey on behalf of the EBMT lymphoma working party.","authors":"Gloria Iacoboni, Pere Barba, Irma Khvedelidze, Maud Ngoya, Paolo Corradini, Pierre Sesques, Marion Subklewe, Maria Gomes da Silva, Gilles Crochet, Jaroslaw Dybko, Izaskun Zeberio, Alejandro Martin Garcia-Sancho, Tom van Meerten, Robin Sanderson, Bertram Glass, Anna Sureda, Peter Dreger, Olivier Hermine, Ali Bazarbachi","doi":"10.1038/s41409-026-03013-w","DOIUrl":"https://doi.org/10.1038/s41409-026-03013-w","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jarosław Biliński, Marcin Jasiński, Julia Krasnodębska, Grzegorz W Basak, Emmanuelle Polge, William Boreland, Alexander Kulagin, Oleg Goloshchapov, Hildegard Greinix, Depei Wu, Kazimierz Halaburda, Sebastien Maury, Christine Robin, Alina Tanase, Lavinia Lipan, Gwendolyn van Gorkom, Tessa Kerre, Alberto Mussetti, Charlotte E Graham, Hélène Schoemans, Ivan Moiseev, Katharina Kleinschmidt, Krzysztof Kałwak, Olaf Penack, Zinaida Perić
{"title":"Fecal microbiota transplantation in the treatment of acute graft-versus-host disease: A retrospective study performed by the Complications Working Party and Pediatric Diseases Working Party of the EBMT.","authors":"Jarosław Biliński, Marcin Jasiński, Julia Krasnodębska, Grzegorz W Basak, Emmanuelle Polge, William Boreland, Alexander Kulagin, Oleg Goloshchapov, Hildegard Greinix, Depei Wu, Kazimierz Halaburda, Sebastien Maury, Christine Robin, Alina Tanase, Lavinia Lipan, Gwendolyn van Gorkom, Tessa Kerre, Alberto Mussetti, Charlotte E Graham, Hélène Schoemans, Ivan Moiseev, Katharina Kleinschmidt, Krzysztof Kałwak, Olaf Penack, Zinaida Perić","doi":"10.1038/s41409-026-03010-z","DOIUrl":"https://doi.org/10.1038/s41409-026-03010-z","url":null,"abstract":"<p><p>Acute graft-versus-host disease (aGvHD) is a major cause of non-relapse mortality following allogeneic hematopoietic stem cell transplantation (alloHSCT). While corticosteroids are the standard first-line therapy, approximately half of the patients become steroid-refractory or -dependent (SR/D). Fecal microbiota transplantation (FMT) has emerged as a therapeutic strategy targeting the underlying gut dysbiosis associated with aGvHD. This study presents retrospective data on FMT for SR/D-aGvHD. This retrospective, multicenter study was conducted by the Complications Working Party of the EBMT. Data were collected from 9 centers on patients who received FMT for the treatment of SR/D-aGvHD between 2014 and 2019. The primary endpoint was the overall response rate (ORR) at day 28 post-FMT. Forty-seven patients were analyzed. The primary indication for FMT was gastrointestinal aGvHD (GI-aGvHD). In this heavily pre-treated, ruxolitinib-naïve population, the ORR at day 28 was 60.5%, increasing to 69.2% by day 56. At last follow-up, 23 patients (64% of survivors) had no symptoms of aGvHD. Adverse events related to FMT were reported in 24 patients (51.1%). A clinically significant secondary benefit was the 54.5% decolonization rate of antibiotic-resistant bacteria. In this cohort FMT demonstrated efficacy for SR/D-aGvHD, with response rates comparable to those of modern targeted agents.</p>","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jule Ussmann, Clara Wall, Lara Bischof, Jacob Jendro, Sofia Voigt, Dominic Brauer, Donata Backhaus, Maximilian Merz, Vladan Vučinić, Marco Herling, Carmen Herling, Georg-Nikolaus Franke, Uwe Platzbecker, Timm Denecke, Klaus H Metzeler, Sebastian Schwind, Hans-Jonas Meyer, Madlen Jentzsch
{"title":"Low muscle quality, but not muscle mass, in abdominal CT-scans associates with adverse outcomes in AML patients undergoing an allogeneic stem cell transplantation.","authors":"Jule Ussmann, Clara Wall, Lara Bischof, Jacob Jendro, Sofia Voigt, Dominic Brauer, Donata Backhaus, Maximilian Merz, Vladan Vučinić, Marco Herling, Carmen Herling, Georg-Nikolaus Franke, Uwe Platzbecker, Timm Denecke, Klaus H Metzeler, Sebastian Schwind, Hans-Jonas Meyer, Madlen Jentzsch","doi":"10.1038/s41409-026-03005-w","DOIUrl":"https://doi.org/10.1038/s41409-026-03005-w","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expanding the donor pool in secondary AML: a step forward, with caveats.","authors":"Nihar Desai","doi":"10.1038/s41409-026-03009-6","DOIUrl":"https://doi.org/10.1038/s41409-026-03009-6","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joanna Drozd-Sokolowska, Patrick Gilbert, Joe Tuffnell, Linda Koster, Grzegorz Helbig, Uwe Platzbecker, Pavel Jindra, Carlo Borghero, Thomas Cluzeau, Matthias Eder, Francis Ayuk, Francesco Onida, Carmelo Gurnari, Christof Scheid, Kavita Raj, Régis Peffault de Latour, Antonio Risitano, Marie Robin, Donal P McLornan
{"title":"Allogeneic hematopoietic cell transplantation for myelodysplastic syndromes harboring a paroxysmal nocturnal hemoglobinuria clone-a study on behalf of the Chronic Malignancies and Severe Aplastic Anemia Working Parties of the EBMT.","authors":"Joanna Drozd-Sokolowska, Patrick Gilbert, Joe Tuffnell, Linda Koster, Grzegorz Helbig, Uwe Platzbecker, Pavel Jindra, Carlo Borghero, Thomas Cluzeau, Matthias Eder, Francis Ayuk, Francesco Onida, Carmelo Gurnari, Christof Scheid, Kavita Raj, Régis Peffault de Latour, Antonio Risitano, Marie Robin, Donal P McLornan","doi":"10.1038/s41409-026-03007-8","DOIUrl":"https://doi.org/10.1038/s41409-026-03007-8","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arnon Nagler, Norbert Claude Gorin, Christian Chabannon, Guillermo Puigventós, Romée Heemskerk, Isabel Sánchez-Ortega, Tuula Rintala, Yann Mahé, Emanuele Angelucci, Silvia Montoto, Michelle Kenyon, Hilda Mekelenkamp, Donal P McLornan, Antonio M Risitano, Mette Hazenberg, Anna Sureda, Ibrahim Yakoub Agha, Annalisa Ruggeri, Fabio Ciceri, Raffaella Greco
{"title":"Defining global priorities in hematopoietic transplantation and cellular therapy: a statement paper from EBMT Global Committee.","authors":"Arnon Nagler, Norbert Claude Gorin, Christian Chabannon, Guillermo Puigventós, Romée Heemskerk, Isabel Sánchez-Ortega, Tuula Rintala, Yann Mahé, Emanuele Angelucci, Silvia Montoto, Michelle Kenyon, Hilda Mekelenkamp, Donal P McLornan, Antonio M Risitano, Mette Hazenberg, Anna Sureda, Ibrahim Yakoub Agha, Annalisa Ruggeri, Fabio Ciceri, Raffaella Greco","doi":"10.1038/s41409-026-03008-7","DOIUrl":"10.1038/s41409-026-03008-7","url":null,"abstract":"<p><p>Hematopoietic cell transplantation, cellular and gene therapies, and (CAR)-T cells have revolutionized outcomes in hematologic disorders. However, major disparities persist in their availability, accessibility, and affordability, particularly in low- and middle-income countries (LMICs). The EBMT Global Committee aims to address these inequalities. A structured survey was distributed to EBMT members to identify regional and thematic priorities, assess current infrastructure, and assess willingness to contribute to global initiatives. Responses were analyzed descriptively and served as the basis for the current statement paper. A total of 145 responses from 43 countries were collected. Most respondents (67.1%) reported working in JACIE- or FACT-accredited centers. The highest priority regions for EBMT outreach were Eastern Europe (non-EU) (43.9%), Latin America (38.2%), and Africa (33.5%), followed by the Middle East (29.5%). The leading thematic priorities were education and training (74.3%), scientific collaboration (56.0%), and registry development (43.4%). Most respondents expressed willingness to actively contribute, particularly in educational activities (59.7%). Qualitative responses emphasized the need for practical guidelines, mentorship programs, telemedicine, virtual discussion/clinical rounds on difficult cases, and support for LMIC capacity building. The EBMT community strongly supports an expanded global role focused on education, capacity building, and collaboration in underserved regions.</p>","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sencer Goklemez, Steven Z Pavletic, Hyoyoung Choo-Wosoba, Filip Pirsl, Edward W Cowen, Eduard Schulz, Seray Berfin Karagoz, Ashley Carpenter, Resat Cinar, Najla El Jurdi
{"title":"Elevated plasma anandamide levels in sclerotic chronic graft-versus-host disease highlight the endocannabinoid system as a potential therapeutic target.","authors":"Sencer Goklemez, Steven Z Pavletic, Hyoyoung Choo-Wosoba, Filip Pirsl, Edward W Cowen, Eduard Schulz, Seray Berfin Karagoz, Ashley Carpenter, Resat Cinar, Najla El Jurdi","doi":"10.1038/s41409-026-03004-x","DOIUrl":"https://doi.org/10.1038/s41409-026-03004-x","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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