M Gonzalez Vicent, A Peretó, J Zubicaray, B Molina, S Vinagre, E Sebastián, J Iriondo, A Castillo, L Abad, A Sanz, G Lopez de Hontanar, M Ramirez, J Sevilla, M A Diaz
{"title":"Outcomes in allogeneic hematopoietic stem cell transplantation for Fanconi anemia.","authors":"M Gonzalez Vicent, A Peretó, J Zubicaray, B Molina, S Vinagre, E Sebastián, J Iriondo, A Castillo, L Abad, A Sanz, G Lopez de Hontanar, M Ramirez, J Sevilla, M A Diaz","doi":"10.1038/s41409-025-02591-5","DOIUrl":"https://doi.org/10.1038/s41409-025-02591-5","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew A Bergens, Yen P Lowder, Yan Li, Ernaya J Johnson, Hilary M Winthrop, Amy T Bush, Angela Xiong, Lauren Hill, Isabella Gorski, Bethany Weaver, S Yousuf Zafar, Edwin P Alyea, Nelson J Chao, Taewoong Choi, Cristina Gasparetto, Sanghee Hong, Mitchel E Horwitz, Chenyu Lin, Gwynn D Long, Richard D Lopez, Sendhilnathan Ramalingam, Stefanie Sarantopoulos, Keith M Sullivan, Anthony D Sung
{"title":"Food insecurity prior to hematopoietic stem cell transplant is associated with malnutrition and worse outcomes.","authors":"Matthew A Bergens, Yen P Lowder, Yan Li, Ernaya J Johnson, Hilary M Winthrop, Amy T Bush, Angela Xiong, Lauren Hill, Isabella Gorski, Bethany Weaver, S Yousuf Zafar, Edwin P Alyea, Nelson J Chao, Taewoong Choi, Cristina Gasparetto, Sanghee Hong, Mitchel E Horwitz, Chenyu Lin, Gwynn D Long, Richard D Lopez, Sendhilnathan Ramalingam, Stefanie Sarantopoulos, Keith M Sullivan, Anthony D Sung","doi":"10.1038/s41409-025-02587-1","DOIUrl":"https://doi.org/10.1038/s41409-025-02587-1","url":null,"abstract":"<p><p>Food insecurity (FI), defined as the lack of continuous access to adequate food, affects 17-55% of cancer patients. Effects may be exacerbated in hematopoietic stem cell transplant (HSCT) patients, who face nutritional challenges due to treatment side effects, leading to weight loss and malnutrition. We hypothesize that pre-HSCT FI increases the risk of malnutrition, requiring nutrition support, and adverse psychosocial outcomes. Between February 2018 and August 2022, 284 patients were screened before HSCT for FI. 71 (25%) were excluded due to missing data. Of the remaining 213, 20 (9.4%) reported pre-HSCT FI. Patients with FI were more likely to develop malnutrition during HSCT (70% vs. 45.1%, p = 0.034) and need total parenteral nutrition compared to those without FI (65% vs. 34.2%, p = 0.013). Patients with FI also were more likely to screen positive for depression (40% vs. 10.4%, p = 0.002) and financial toxicity (75% vs. 25%, p < 0.001). There were no significant differences in survival or other secondary outcomes. Our study demonstrates that pre-HSCT FI significantly increases likelihood of malnutrition, the need for total parenteral nutrition, and adverse psychosocial outcomes in HSCT patients. These findings highlight the critical importance of early identification and interventions to address FI as part of comprehensive cancer care.</p>","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jayastu Senapati, Guillermo Garcia-Manero, Courtney D DiNardo, Indraneel Deshmukh, Gautam Borthakur, Tapan M Kadia, Elias Jabbour, Nicholas J Short, Hussein A Abbas, Naveen Pemmaraju, Nitin Jain, Fadi G Haddad, Ghayas C Issa, Abhishek Maiti, Elizabeth Shpall, Uday Popat, Sanam Loghavi, Guilin Tang, Musa Yilmaz, Yesid Alvarado, Guillermo Montalban-Bravo, Farhad Ravandi, Hagop M Kantarjian, Naval G Daver
{"title":"Barriers to allogeneic stem cell transplantation in responding patients with TP53-mutated acute myeloid leukemia.","authors":"Jayastu Senapati, Guillermo Garcia-Manero, Courtney D DiNardo, Indraneel Deshmukh, Gautam Borthakur, Tapan M Kadia, Elias Jabbour, Nicholas J Short, Hussein A Abbas, Naveen Pemmaraju, Nitin Jain, Fadi G Haddad, Ghayas C Issa, Abhishek Maiti, Elizabeth Shpall, Uday Popat, Sanam Loghavi, Guilin Tang, Musa Yilmaz, Yesid Alvarado, Guillermo Montalban-Bravo, Farhad Ravandi, Hagop M Kantarjian, Naval G Daver","doi":"10.1038/s41409-025-02590-6","DOIUrl":"https://doi.org/10.1038/s41409-025-02590-6","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of center volume on outcomes in allogeneic hematopoietic cell transplantation for children.","authors":"Motohiro Kato, Hideki Nakashone, Keitaro Matsuo, Yuri Ito, Atsumi Yanagisawa, Marie Ohbiki, Ken Tabuchi, Tatsuo Ichinohe, Yoshiko Hashii, Junya Kanda, Hideki Goto, Koji Kato, Makoto Yoshimitsu, Atsushi Sato, Moeko Hino, Kimikazu Matsumoto, Kimikazu Yakushijin, Yoshiko Atsuta, Takahiro Fukuda","doi":"10.1038/s41409-025-02569-3","DOIUrl":"https://doi.org/10.1038/s41409-025-02569-3","url":null,"abstract":"<p><p>The impact of center volume on outcomes in pediatric hematopoietic cell transplantation (HCT) is not well established. We retrospectively analyzed data from a nationwide registry, including 6966 pediatric patients who underwent their first allogeneic HCT at 123 centers in Japan between 2001 and 2020. Centers were categorized by transplant volume as low volume centers (C1, the smallest number of transplantation), medium-low volume centers (C2), medium-high volume centers (C3), and high volume centers (C4, the greatest number of transplantation), and outcomes were compared across these categories. The analysis revealed no statistically significant differences in HCT outcomes among center categories. The 5-year OS by center category was 66.8% (95% CI 64.4-69.0%) for C1, 66.8% (95% CI 64.5-69.0%) for C2, 67.9% (95% CI 65.6-70.2%) for C3, and 68.3% (95% CI 65.9-70.6%) for C4. These results were consistent even when analysis was restricted to malignant and nonmalignant diseases. Our findings suggest that, unlike in adult HCT, outcomes for pediatric HCT are not significantly affected by center volume. These results indicate the consistent quality of care across centers, supporting the accessibility of HCT at various institutions for pediatric patients.</p>","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guillermo Ortí, Guillaume Dachy, Charlotte E Graham, Zinaida Peric, Ana Alarcon, Francesca Del Bufalo, Matteo Doglio, Jan-Inge Henter, Claire Roddie, Orla Stewart, W C J Van de Donk, Roser Velasco, Mahmoud Aljurf, Annalisa Ruggeri, Francesco Onida, Isabel Sánchez-Ortega, Ibrahim Yakoub-Agha, Olaf Penack
{"title":"Less frequent complications following CAR T-cell therapies: hemophagocytic lymphohistiocytosis, graft-versus-host disease, thrombotic microangiopathy, coagulation disorders and secondary malignancies: best practice recommendations from the EBMT Practice Harmonization and Guidelines Committee.","authors":"Guillermo Ortí, Guillaume Dachy, Charlotte E Graham, Zinaida Peric, Ana Alarcon, Francesca Del Bufalo, Matteo Doglio, Jan-Inge Henter, Claire Roddie, Orla Stewart, W C J Van de Donk, Roser Velasco, Mahmoud Aljurf, Annalisa Ruggeri, Francesco Onida, Isabel Sánchez-Ortega, Ibrahim Yakoub-Agha, Olaf Penack","doi":"10.1038/s41409-025-02567-5","DOIUrl":"https://doi.org/10.1038/s41409-025-02567-5","url":null,"abstract":"<p><p>CAR T-cell therapies have revolutionized the treatment of hematologic malignancies; however, alongside the well-known complications of cytokine release syndrome (CRS), neurotoxicity, immune effector cell-associated hematotoxicity (ICAHT), and infections, other non-classical toxicities are emerging. This review, developed by the EBMT Practice Harmonization and Guidelines Committee, addresses the management of other critical post-CAR T-cell complications including hemophagocytic lymphohistiocytosis (HLH), graft-versus-host disease (GvHD), thrombotic microangiopathy (TMA), coagulation disorders and secondary malignancies. These complications, though less frequent, present a significant challenge, often contributing to morbidity and mortality with no standardized management protocols. This review provides best practice recommendations for early identification, risk mitigation, and therapeutic interventions, supported by limited but emerging clinical evidence. Comprehensive expert guidance is essential for optimal management of these under-explored toxicities following CAR T-cell therapies.</p>","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L Lopez-Corral, C Blázquez-Goñi, E Pérez-López, F M Martín-Domínguez, A Cabero Martínez, N Rodríguez-Torres, M Cabrero, I Espigado-Tocino, A A Martín López, R Parody-Porras, M Baile González, T Caballero-Velázquez, M Cortés-Rodríguez, E Soria-Saldise, A Avendaño Pita, P Alcalde-Mellado, A García Bacelar, E Rodríguez-Arbolí, M López Parra, J F Falantes-González, A Navarro-Bailón, L Vázquez López, V Escamilla-Gómez, F Sánchez-Guijo, J A Pérez-Simón
{"title":"GvHD prophylaxis with tacrolimus, sirolimus, and mycophenolate mofetil after reduced intensity conditioning hematopoietic stem cell allogeneic transplantation.","authors":"L Lopez-Corral, C Blázquez-Goñi, E Pérez-López, F M Martín-Domínguez, A Cabero Martínez, N Rodríguez-Torres, M Cabrero, I Espigado-Tocino, A A Martín López, R Parody-Porras, M Baile González, T Caballero-Velázquez, M Cortés-Rodríguez, E Soria-Saldise, A Avendaño Pita, P Alcalde-Mellado, A García Bacelar, E Rodríguez-Arbolí, M López Parra, J F Falantes-González, A Navarro-Bailón, L Vázquez López, V Escamilla-Gómez, F Sánchez-Guijo, J A Pérez-Simón","doi":"10.1038/s41409-025-02562-w","DOIUrl":"https://doi.org/10.1038/s41409-025-02562-w","url":null,"abstract":"<p><p>We present the largest prospective real-world experience in 159 patients who received the triple combination of tacrolimus/sirolimus/mycophenolate mofetil after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-alloHSCT) from matched-related (MRD), matched-unrelated (MUD) or mismatched-unrelated donors (MMURD). Despite the high-risk and elderly population, non-relapse mortality (NRM) at day +100 and 1 year was 5.1% and 8.6%. Grades 2-4 and 3-4 acute Graft-versus-host disease (GvHD) at day +180 was 30.3% and 13%, respectively. Chronic GvHD at 1 and 3 years was 23.2% and 41% and for moderate/severe was 13.2% and 26.6%, respectively. With a median follow-up of 20 months, the 1- and 3-year progression-free survival was 60% and 49%, the GvHD-free relapse-free survival was 44% and 32%, and the overall survival was 70.3% and 61%, respectively, for the entire cohort. Patients receiving allo-HSCT from MMURD showed a higher incidence of aGvHD with impact on survival endpoints. GvHD prophylaxis with the triple-drug combination tacrolimus/sirolimus/mycophenolate mofetil showed excellent results in terms of NRM, GvHD and survival in a high-risk, frail and elderly population in the context of RIC-HSCT from MRD and MUD. The subgroup of patients receiving RIC-HSCT from MMURD might probably benefit from other prophylaxis strategies.</p>","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Sureda, Astrid Pavlovsky, Dalah Haidar, Fjoralba Kristo, Vanessa Stache, Athanasios Zomas
{"title":"Real-world outcomes of brentuximab vedotin as consolidation therapy after autologous stem cell transplantation in relapsed/refractory Hodgkin lymphoma: A systematic review and meta-analysis.","authors":"Anna Sureda, Astrid Pavlovsky, Dalah Haidar, Fjoralba Kristo, Vanessa Stache, Athanasios Zomas","doi":"10.1038/s41409-025-02557-7","DOIUrl":"https://doi.org/10.1038/s41409-025-02557-7","url":null,"abstract":"<p><p>Brentuximab vedotin (BV) as post-autologous stem cell transplantation (ASCT) consolidation was shown to reduce the relapse risk among high-risk patients with relapsed/refractory Hodgkin lymphoma (RRHL) in the clinical trial setting. This systematic review and meta-analysis characterizes real-world evidence (RWE) on the effectiveness and safety of BV as post-ASCT consolidation in 1504 adult and pediatric patients with RRHL from 23 studies across 17 countries. A random-effects model yielded pooled progression-free survival (PFS) and overall survival rates (OS); PFS: 2-year, 74.2%; 5-year, 65.8%; OS: 2-year, 95.8%; 5-year, 91.9%. The most common any-grade adverse events were neuropathy (34.2%) and neutropenia (20.2%). Despite heterogeneity in populations and outcomes, this analysis utilizing real-world data corroborates the efficacy and safety of BV as post-ASCT consolidation in RRHL reported in the experimental arm of the Phase III AETHERA trial. The favorable PFS results in cases exposed to BV prior to ASCT indicate the value of BV in controlling Hodgkin lymphoma (HL) in the salvage setting. Continued research is essential to refine BV treatment strategies amid the evolving treatment landscape.</p>","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bone marrow versus peripheral blood stem cells as the graft source for allogeneic transplantation from HLA-matched relative donors in adult T-cell leukemia/lymphoma: A nationwide retrospective study by the ATL working group of the Japanese Society for Transplantation and Cellular Therapy.","authors":"Hidehiro Itonaga, Takuya Fukushima, Koji Kato, Hiroyuki Muranushi, Masahito Tokunaga, Takahiro Fukuda, Toshiro Kawakita, Takeharu Kato, Yasuo Mori, Sawako Nakachi, Youko Suehiro, Takuro Kuriyama, Machiko Fujioka, Makoto Onizuka, Tatsuo Ichinohe, Marie Ohbiki, Yoshiko Atsuta, Shigeo Fuji, Makoto Yoshimitsu","doi":"10.1038/s41409-025-02563-9","DOIUrl":"https://doi.org/10.1038/s41409-025-02563-9","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Queralt Salas, Raquel Salinas-González, Laia Guardia, María Teresa Solano, Cristina Padilla, Cristina Moreno, Paola Charr, Noemi de Llobet, Carla Mestre, Enric Cascos, Joan Cid, Miquel Lozano, Cristina Gallego, Bernat Carreras, Vanessa Vilas, Montserrat Duch, Julia Martínez-Sanchez, Maribel Díaz-Ricart, Jordi Esteve, Enric Carreras, María Suárez-Lledó, Laura Rosiñol, Sara Laxe, Concepción Closa, Carmen Martínez, Francesc Fernández-Avilés, Montserrat Rovira
{"title":"Frailty assessment and outpatient pre-habilitation for adults undergoing allogeneic hematopoietic cell transplantation.","authors":"María Queralt Salas, Raquel Salinas-González, Laia Guardia, María Teresa Solano, Cristina Padilla, Cristina Moreno, Paola Charr, Noemi de Llobet, Carla Mestre, Enric Cascos, Joan Cid, Miquel Lozano, Cristina Gallego, Bernat Carreras, Vanessa Vilas, Montserrat Duch, Julia Martínez-Sanchez, Maribel Díaz-Ricart, Jordi Esteve, Enric Carreras, María Suárez-Lledó, Laura Rosiñol, Sara Laxe, Concepción Closa, Carmen Martínez, Francesc Fernández-Avilés, Montserrat Rovira","doi":"10.1038/s41409-025-02571-9","DOIUrl":"10.1038/s41409-025-02571-9","url":null,"abstract":"<p><p>This study reports the preliminary results of a Frailty program involving all allo-HCT candidates, initiated at our institution in April 2021. The program started with the assessment of patients' frailty at first consultation and at transplant admission using the HCT Frailty Scale. After observing the dynamics of the frailty syndrome, in June 2022 the program incorporated an individualized 4-8-weeks pre-habilitation program composed by personalized home-based exercise regimens to mitigate or prevent patients' frailty at transplantation. This study includes the 120 patients transplanted during the program, 58 of them participating in the pre-habilitation program. The results indicate that the distribution of frailty was the same in first consultation and at HCT admission in non-pre-habilitated patients, but it changed from the proportions of fit, pre-frail and frail patients of 22.8%, 66.7%, 10.5% at first consultation, to the proportions 45.6%, 50.9% and 3.5% (P = 0.041) at admission in the pre-habilitated ones. And that the likelihood of OS was lower in the frail than in the fit and the pre-frail groups (1-year OS: 45.7% vs. 77.2%, O = 0.021). Therefore, the study provides preliminary evidence that pre habilitation programs significantly reduces frailty among transplant candidates and, eventually, increase the likelihood of OS.</p>","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Candice Laverne Hendricks, Juanita Mellet, Voula Stivaktas, Melvin Ambele, Michael Sean Pepper
{"title":"HIV-exposed uninfected umbilical cord blood haematopoietic stem/progenitor cells differ immunophenotypically from those from HIV unexposed umbilical cord blood but have similar expansion and colony-forming properties in vitro.","authors":"Candice Laverne Hendricks, Juanita Mellet, Voula Stivaktas, Melvin Ambele, Michael Sean Pepper","doi":"10.1038/s41409-025-02574-6","DOIUrl":"10.1038/s41409-025-02574-6","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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