Borneo Journal of Pharmacy最新文献_第5页

Chemical Screening and Antioxidant Activity of Ethyl Acetate Fraction and Residue from Lansium domesticum Ethanolic Extract 国内镧乙醇提取物乙酸乙酯组分和残渣的化学筛选及其抗氧化活性

Borneo Journal of Pharmacy Pub Date : 2023-02-28 DOI: 10.33084/bjop.v6i1.3867

P. Apridamayanti, R. Sari

{"title":"Chemical Screening and Antioxidant Activity of Ethyl Acetate Fraction and Residue from Lansium domesticum Ethanolic Extract","authors":"P. Apridamayanti, R. Sari","doi":"10.33084/bjop.v6i1.3867","DOIUrl":"https://doi.org/10.33084/bjop.v6i1.3867","url":null,"abstract":"Langsat (Lansium domesticum) is a plant that thrives in the tropics. The search for photoprotective compounds derived from natural ingredients has been intensively conducted to develop cosmetic formulations to obtain safe and protective products against UV rays. This study aims to identify chemical compounds in the ethyl acetate fraction and residues of ethanol extract from L. domesticum bark using tube and gas chromatography-mass spectrophotometry tests. At the same time, the antioxidant activity and SPF values were assessed with the DPPH and FRAP methods. The qualitative GC-MS test obtained the percentage peak value and molecular weight. Furthermore, the antioxidant activity was tested using the compound DPPH measured with an ELISA reader at a wavelength of 515.5 nm with UV/vis spectrophotometer and FRAP method using FeCl3 and TPTZ compounds at 615 nm. The SPF value was assessed using Mansur's formula with UV/Vis spectrophotometer at 290 to 320 nm. The results obtained in the ethyl acetate fraction showed terpenoids, while the residue contains phenolics, flavonoids, tannins, and saponins. The GC-MS tests found that the ethyl acetate fraction had 47 types of chemical compounds, including terpenoids and fatty acids group; in the residue, four classes were found, with terpenoid and fatty acid groups being more predominant. Based on the results, the ethyl acetate fraction has an IC50 value of 341.25±26.45 µg/ml and 436.3±10.8 µg/ml; the residue was 94.72±34.22 µg/ml and 2602.79±11.8 µg/ml. Additionally, the SPF values for both were 2.87 and 3.9.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81067323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover, Content, and Editorial Note from Borneo J Pharm Vol. 6 No. 1 February 2023 封面、内容和编辑注释来自Borneo J Pharm第6卷第1期2023年2月

Borneo Journal of Pharmacy Pub Date : 2023-02-28 DOI: 10.33084/bjop.v6i1.5077

C. E. O. Borneo J Pharm

{"title":"Cover, Content, and Editorial Note from Borneo J Pharm Vol. 6 No. 1 February 2023","authors":"C. E. O. Borneo J Pharm","doi":"10.33084/bjop.v6i1.5077","DOIUrl":"https://doi.org/10.33084/bjop.v6i1.5077","url":null,"abstract":"Assalamu’alaikum Wr. Wb. \u0000Alhamdulillahirabbil ‘alamin. The next edition of Borneo Journal of Pharmacy (Borneo J Pharm), has been published in February 2023. This edition contains ten articles: Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, Clinical-Community Pharmacy, and Management Pharmacy. This edition includes writings from six countries: Anguilla, Costa Rica, India, Indonesia, Nigeria, and Russian Federation. The authors come from several institutions, including Universitas Islam Indonesia, Sekolah Tinggi Ilmu Farmasi Riau, Universitas Andalas, Pyatigorsk Medical and Pharmaceutical Institute, Universitas Muhammadiyah Banjarmasin, Universitas Tanjungpura, Universidad de Costa Rica, Ahmadu Bello University, Akademi Farmasi Surabaya, Universitas Airlangga, Universitas Sumatera Utara, Sekolah Tinggi Ilmu Kesehatan Senior Medan, Prathima Institute of Medical Sciences, Saint James School of Medicine, Vaagdevi Degree and PG College, and Vydehi Institute of Medical Science and Research Center. \u0000Editorial boards are fully aware that there are still room for improvement in this edition, hence with all humility willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank all editors and reviewers, and contributors of the scientific articles who have provided the repetoire in this issue. We hope that all parties, especially the contributors, could re-participate for the publication in the next edition on May 2023. \u0000Wassalamu’alaikum Wr. Wb.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"56 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77396880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in Mean Arterial and Blood Pressure in Using Nicardipine in Hypertensive Crisis Patients at the Hajj General Hospital Surabaya from August to December 2021 2021年8月至12月泗水朝觐总医院高血压危重患者使用尼卡地平后平均动脉和血压的变化

Borneo Journal of Pharmacy Pub Date : 2023-02-28 DOI: 10.33084/bjop.v6i1.3493

Selly Septi Fandinata, Rizky Darmawan, N. M. Ulfa, Deddy Aryanda Putra

{"title":"Changes in Mean Arterial and Blood Pressure in Using Nicardipine in Hypertensive Crisis Patients at the Hajj General Hospital Surabaya from August to December 2021","authors":"Selly Septi Fandinata, Rizky Darmawan, N. M. Ulfa, Deddy Aryanda Putra","doi":"10.33084/bjop.v6i1.3493","DOIUrl":"https://doi.org/10.33084/bjop.v6i1.3493","url":null,"abstract":"Hypertension crisis is one of the most common disease problems; it will cause complications and death. Therapeutic management guidelines that the calcium channel blocker group, one of which is nicardipine, can increase the achievement of goals in mean arterial pressure (MAP) in preventing the progression of organ damage. This study aimed to evaluate the use of nicardipine therapy on the MAP and blood pressure (BP) in patients with hypertension crisis. The research design was cross-sectional with statistical analysis—retrospective data collection at Hajj General Hospital Surabaya for August to December 2021. The number of samples in this study matched the inclusion criteria; 20 patients were obtained, 16 with a diagnosis of hypertension emergency, and four with hypertension urgency who received single or combined intravenous nicardipine therapy <0.005 with an average BP decrease of pre 20.375±31.492/103.50±10.400 mmHg and post 121.34±14.364/81.80±11.186 so that intravenous nicardipine therapy was significant in reducing systolic and diastolic BP. In the profile of the MAP value statistically using the paired T-test, it was found that the P-value was 0.000 < 0.005 with a decrease in the MAP pre-value of 135.028±13.8857 mmHg and post 93.650±8.9499 mmHg, showing a reduction in MAP as expected. In conclusion, using nicardipine intravenously at a 5 mg/hour dose has shown an optimal decrease in BP and MAP in hypertensive emergency and urgency patients.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87582131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antisense Oligonucleotides: Concepts and Pharmaceutical Applications 反义寡核苷酸:概念和药物应用

Borneo Journal of Pharmacy Pub Date : 2023-02-28 DOI: 10.33084/bjop.v6i1.2092

Ariana Araya, David Arias, Karla Coto, María Rebeca López, Joselyn Rivera, Juan José Mora

引用次数: 0

Association between Drug-Related Problems and Blood Pressure of Hypertensive Patients Admitted to Universitas Sumatera Utara Hospital 苏门答腊北方大学医院高血压患者药物相关问题与血压的关系

Borneo Journal of Pharmacy Pub Date : 2023-02-28 DOI: 10.33084/bjop.v6i1.3664

Mutiara Siahaan, A. Nasution, W. Wiryanto, I. Iksen

{"title":"Association between Drug-Related Problems and Blood Pressure of Hypertensive Patients Admitted to Universitas Sumatera Utara Hospital","authors":"Mutiara Siahaan, A. Nasution, W. Wiryanto, I. Iksen","doi":"10.33084/bjop.v6i1.3664","DOIUrl":"https://doi.org/10.33084/bjop.v6i1.3664","url":null,"abstract":"Patients with hypertension usually experience chronic comorbidities and complications that require complex treatment (polypharmacy), which can further cause drug-related problems (DRPs) and interfere with the required clinical outcomes. This study, by using a case-control prospective cross-sectional, aimed to analyze the association between DRPs and blood pressures (BPs) of hypertensive patients admitted to Universitas Sumatera Utara (USU) hospital from July to September 2021. The incidence of DRPs was analyzed and classified according to the Cipolle classification system and reliable literature. Blood pressures of the patients were classified into controlled and uncontrolled BPs. The association between DRPs and BP was analyzed using the Chi-Square test. Most of the patients (57.5%) were female. Their mean age was 59±9.94 (years). The mean incidence of DRPs experienced by the patients was 1.78±0.79. The most frequently occurred DRPs were drug interactions. There was a significant association between the number of DRPs experienced by the patients and their BPs (p=0.02). DRPs are the contributing factor to the uncontrolled BPs of hypertensive patients.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77876759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical Trials: The Role of Regulatory Agencies, Pharmacovigilance Laws, Guidelines, Risk Management, Patenting, and Publicizing Results 临床试验:监管机构的作用、药物警戒法律、指南、风险管理、专利申请和公布结果

Borneo Journal of Pharmacy Pub Date : 2023-02-28 DOI: 10.33084/bjop.v6i1.3263

V. Kandi, Sabitha Vadakedath, Purna Singh Addanki, Vikram Godishala, V. Pinnelli

{"title":"Clinical Trials: The Role of Regulatory Agencies, Pharmacovigilance Laws, Guidelines, Risk Management, Patenting, and Publicizing Results","authors":"V. Kandi, Sabitha Vadakedath, Purna Singh Addanki, Vikram Godishala, V. Pinnelli","doi":"10.33084/bjop.v6i1.3263","DOIUrl":"https://doi.org/10.33084/bjop.v6i1.3263","url":null,"abstract":"The research carried out to find a better treatment, improve healthcare, and benefit the current medical practice is termed clinical research. Clinical trial includes the pharmacodynamics (mechanisms of action of a new drug), pharmacokinetics (drug metabolism inside the body), therapeutics (efficacy of the drug), and adverse effects (safety of the drug) of the novel medical products. Clinical research is a process that involves human subjects and their biological specimens. The clinical trial is a meticulously planned protocol-based study of a drug/device to discover a new/better way to prevent, diagnose, and treat a disease/illness. Considering the involvement of both healthy and diseased people in clinical trials, the regulatory authorities have a significant role in the processes involving the conduction of clinical research and carefully evaluate their potential implications on humans. Because clinical trials are usually aimed at assessing the safety and efficacy of novel pharmaceutical compounds and medical devices, pharmacovigilance laws and risk management assume increased significance while conducting clinical research/trials. In this review, we attempt to discuss the regulatory authorities' roles in different geographical regions, including the United States of America, The European Union, and India. We also focus on the importance of pharmacovigilance laws and risk management during clinical trials.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81025740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic Activity of Ethyl Acetate Extract from Voacanga foetida (Bl.) Rolfe Leaves Against T47D Breast Cancer Cells 荆芥叶乙酸乙酯提取物对T47D乳腺癌细胞的细胞毒活性研究

Borneo Journal of Pharmacy Pub Date : 2023-02-28 DOI: 10.33084/bjop.v6i1.3499

Adriani Susanty, Mira Febrina, Dian Sanita Putri, Ihsan Ikhtiarudin, F. Wahyuni, Dachriyanus Dachriyanus

引用次数: 0

Acute Toxicity of Self-Nanoemulsifying Drug Delivery System of Ipomoea reptans Poir Leaves Extract on Female Wistar Rats 地瓜叶提取物自纳米乳化给药系统对雌性Wistar大鼠的急性毒性研究

Borneo Journal of Pharmacy Pub Date : 2023-02-28 DOI: 10.33084/bjop.v6i1.2099

Cynthia Astiti Putri, Farida Hayati, L. Chabib, Muhammad Iqbal Pangestu

引用次数: 0

Pengaruh yoga terhadap peningkatan kualitas tidur pada mahasiswa prodi DIII Keperawatan Politeknik Kaltara 瑜伽对普拉迪·迪尔二学生睡眠质量改善的影响

Borneo Journal of Pharmacy Pub Date : 2022-12-01 DOI: 10.57174/jborn.v2i3.56

Sriargianti Amir, Nining Nining

{"title":"Pengaruh yoga terhadap peningkatan kualitas tidur pada mahasiswa prodi DIII Keperawatan Politeknik Kaltara","authors":"Sriargianti Amir, Nining Nining","doi":"10.57174/jborn.v2i3.56","DOIUrl":"https://doi.org/10.57174/jborn.v2i3.56","url":null,"abstract":"Tidur merupakan suatu kegiatan normal yang akan dialami setiap individu dan menjadi aktivitas manusiawi namun banyak mahasiswa yang tidak memedulikan kualitas tidur yang baik, sehingga mempengaruhi tingkat kebugaran dan akan akan berdampak buruk bagi tubuh. Oleh karena itu, dengan memberikan senam yoga diharapkan menjadi salah satu cara dalam meningkatkan kualitas tidur pada berbagai umur dan penderita ganguan kualitas tidur. Tujuan penelitian ini untuk identifikasi efektifitas yoga terhadap peningkatan kualitas tidur pada mahasiswa. Metode penelitian ini menggunakan desain quasi experimental without control groub yang diberikan pre-test dan post-test. Populasi dalam penelitian adalah semua mahasiswa Prodi keperawatan Politeknik Kaltara dengan jumlah populasi 131 populasi dengan teknik pengambilan sampel menggunakan purposive sampling pada mahasiswa keperawatan tingkat 1 dengan jumlah sampel 33 sampel. Tahapan penelitian terdiri dari 3 tahapan. Analisa data yang digunakan adalah analisis univariat dan bivariat. Hasil uji analisis menggunakan McNemar dan didapatkan ρ-value = 0.000 (< 0,05) yang berarti terdapat perbedaan signifikan terhadap kualitas tidur sebelum dan sesudah intervensi senam yoga. Kesimpulan dari penelitian ini adalah senam yoga dapat meningkatkan kualitas tidur pada mahasiswa Keperawatan di Politeknik Kaltara.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88019756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Ujı aktıvıtas antıbakterı ekstrak etanol daun rambusa (Passiflora foetida L.) terhadap bakterı Pseudomonas aeruginosa

Borneo Journal of Pharmacy Pub Date : 2022-12-01 DOI: 10.57174/jborn.v2i3.61

Sari Wijayanti, Heriani Heriani, Faizal Mustamin, Syuhada Syuhada

引用次数: 0