Borneo Journal of Pharmacy最新文献_第4页

Development Of Raw Collagen From Waste Mılkfısh (Chanos chanos) Scales As A Preservatıve And Emulsıfyıng Agents 利用废弃Mılkfısh (Chanos Chanos)鳞片制备原胶原蛋白Preservatıve和Emulsıfyıng制剂的研究

Borneo Journal of Pharmacy Pub Date : 2023-03-20 DOI: 10.57174/jborn.v3i1.75

Sudrajat Sugiharta, Euis Prihatini, Iin Lidia Putama Mursal

{"title":"Development Of Raw Collagen From Waste Mılkfısh (Chanos chanos) Scales As A Preservatıve And Emulsıfyıng Agents","authors":"Sudrajat Sugiharta, Euis Prihatini, Iin Lidia Putama Mursal","doi":"10.57174/jborn.v3i1.75","DOIUrl":"https://doi.org/10.57174/jborn.v3i1.75","url":null,"abstract":"Collagen is an essential protein in connective tissue, widely used as a bioactive. Raw collagen is obtained from cattle, buffalo, and pigs with problems spreading infectious animal diseases. Collagen can be obtained from waste milkfish (Chanos chanos) scales as an alternative source of mammal raw materials. This study aims to determine the acetic acid's most effective concentration and maceration time in isolating collagen from milkfish scales based on the preservative and emulsifying determination. This research is quasi-experimental design by testing the isolated collagen against collagen yield, proximate analysis of collagen, pH test, preservative test, and analysis of emulsifier substances. The results of the isolation of collagen in all treatment groups had emulsifying and preservative abilities, where a concentration of 0.5 M acetic acid with a maceration time of 72 hours produced the most effective collagen as an emulsifier based on the results of the emulsion stability test and emulsion layer boundary test, as well as at the concentration of 0, acetic acid 5 M with variations in maceration time of 48 hours and 72 hours produced the most effective collagen as a preservative.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85896033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview of the Use of Antihypertensive Drugs at the Outpatient Pharmacy of Tarakan "X" Hospital in 2022 2022年塔拉干“X”医院门诊药房降压药使用概况

Borneo Journal of Pharmacy Pub Date : 2023-03-20 DOI: 10.57174/j.born.v3i1.81

Benyamin, S. Syuhada, Benazir Evita Rukaya

{"title":"An Overview of the Use of Antihypertensive Drugs at the Outpatient Pharmacy of Tarakan \"X\" Hospital in 2022","authors":"Benyamin, S. Syuhada, Benazir Evita Rukaya","doi":"10.57174/j.born.v3i1.81","DOIUrl":"https://doi.org/10.57174/j.born.v3i1.81","url":null,"abstract":"Hypertension is a global health problem often encountered, and the appropriate use of antihypertensive drugs is very important for optimal blood pressure control. Therefore, it is necessary to research the description of the use of antihypertensive drugs in various health facilities. The purpose of this study was to describe the prescription of antihypertensive drugs in patients at \"X\" hospital in the outpatient department. The research data obtained were digital data from prescription services from January-December 2022. This study used retrospective data by accessing computer service data at the \"X\" hospital outpatient pharmacy to track the history of past hypertensive patients’ treatment. The sampling technique used is total sampling. The results showed that the most prescribed antihypertensive drugs were amlodipine, with 13,203 prescription items. Bisoprolol with 10,704 prescription items, and candesartan with 9,885 prescription items. The frequency of prescribing the antihypertensive drug class the most was calcium channel blockers, as much as 13,784 (23.41%), while for the drug class which was the least prescribed, namely alpha-2 agonists, there were 68 drugs (0.12%). Based on the study results, it can be concluded that the most widely prescribed antihypertensive drugs at the outpatient pharmacy at \"X\" hospital are amlodipine, bisoprolol, and candesartan.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81378590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gambaran Pengetahuan Ibu Hamil tentang Perawatan Payudara Selama Kehamilan di Puskesmas Karang Rejo Tarakan 准孕妇在怀孕期间对乳房护理的了解

Borneo Journal of Pharmacy Pub Date : 2023-03-20 DOI: 10.57174/jborn.v3i1.64

Sriargianti amir Argi, Apriorita Apriorita, Rohandi Baharuddin, Satria Hanggara Putra

{"title":"Gambaran Pengetahuan Ibu Hamil tentang Perawatan Payudara Selama Kehamilan di Puskesmas Karang Rejo Tarakan","authors":"Sriargianti amir Argi, Apriorita Apriorita, Rohandi Baharuddin, Satria Hanggara Putra","doi":"10.57174/jborn.v3i1.64","DOIUrl":"https://doi.org/10.57174/jborn.v3i1.64","url":null,"abstract":"Perawatan payudara merupakan suatu intervensi yang penting dilakukan pada masa kehamilan sebagai persiapan dalam proses menyusui setelah melahirkan. Berdasarkan hasil studi pendahuluan bahwa sebagian ibu kurang mengetahui tentang cara perawatan payudara. Tujuan penelitian ini adalah untuk mengetahui gambaran pengetahuan ibu hamil tentang perawatan payudara selama kehamilan. Metode penelitian ini merupakan metode penelitian deskriptif, pengambilan sampel secara non-probability sampling menggunakan teknik accindental sampling dengan jumlah sampel 50 yang sesuai dengan kriteria inklusi dan eksklusi. Teknik pengumpulan data menggunakan kuesioner yang berkaitan dengan pengetahuan perawatan payudara. Hasil penelitian menunjukkan karakteristik responden berdasarkan usia tertinggi yaitu usia 20-35 tahun sebanyak 25 (50,0%) responden, berdasarkan pekerjaan terbanyak didapatkan IRT sebanyak 31 (62,0%) responden, berdasarkan paritas didapatkan jumlah tertinggi dan multipara sebanyak 28 (56,0%) responden, berdasarkan pendidikan didapatkan hasil terbanyak yaitu SMA sebanyak 22 (44,0%), berdasarkan pengetahuan didapatkan hasil pengetahuan baik sebanyak 6 (12,0%), cukup sebanyak 16 (32,0%), dan kurang sebanyak 28 (56,0%) responden. Kesimpulan penelitian ini menunjukkan sebagian besar ibu menyusui di Puskesmas Karang Rejo kota Tarakan adalah berpengetahuan kurang terkait perawatan payudara selama kehamilan.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82961370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Gambaran Penggunaan Obat Anestesi di Instalasi Bedah RSI PKU Muhammadiyah Pekajangan 在我的血管外科手术中使用麻醉剂的描述

Borneo Journal of Pharmacy Pub Date : 2023-03-20 DOI: 10.57174/jborn.v3i1.71

Musa Fitri Fatkhiya, Nitya Rofiana Arrizka

引用次数: 0

Analisis Kandungan Rhodamin B pada Produk Perona Pipi (Blush On) yang Beredar di Pasar Tradisional Kota Tarakan

Borneo Journal of Pharmacy Pub Date : 2023-03-20 DOI: 10.57174/j.born.v3i1.80

P. Annisa, Irma Novrianti, Heriani Heriani

引用次数: 0

Ujı Kualıtatıf Rhodamın B pada Saus Jajanan "Tusuk-Tusuk" dı Taman Berlabuh dan Taman Oval kota Tarakan 塔特Ujı资历特别ııf Rhodamın B在太妃糖酱弄花"椭圆形dı停靠公园和花园城市塔拉坎

Borneo Journal of Pharmacy Pub Date : 2023-03-20 DOI: 10.57174/jborn.v3i1.79

Agus Amanda Defi Rahayu, Jufri Ubrusun, Irma Novrianti

{"title":"Ujı Kualıtatıf Rhodamın B pada Saus Jajanan \"Tusuk-Tusuk\" dı Taman Berlabuh dan Taman Oval kota Tarakan","authors":"Agus Amanda Defi Rahayu, Jufri Ubrusun, Irma Novrianti","doi":"10.57174/jborn.v3i1.79","DOIUrl":"https://doi.org/10.57174/jborn.v3i1.79","url":null,"abstract":"Jajanan “tusuk-tusuk” merupakan salah satu makanan yang digemari oleh semua kalangan, dengan rasa yang enak dan biasanya disajikan dengan menambahkan saus. Rhodamin B salah satu zat pewarna sintetik yang digunakan ada industri tekstil. Sering kali pedagang nakal menggunakan Rhodamin B pada makanan yang dijual untuk mempercantik warna makanan tersebut. Seperti yang diketahui Rhodamin B dapat menyebabkan iritasi pada mata, saluran pencernaan dan pernapasan. Penelitian ini bermaksud untuk meneliti ada atau tidak adanya identifikasi bahan berbahaya Rhodamin B dalam saus tomat jajanan “tusuk-tusuk” yang beredar di taman Berlabuh dan taman Oval kota Tarakan. Saus masing-masing diperoleh dari jajanan “tusuk-tusuk” yang beredar di taman Berlabuh dan Taman Oval Tarakan. Penelitian yang dilakukan dan diperoleh 10 sampel yang beredar di taman Berlabuh dan Taman Oval, lalu setiap sampel ditimbang sebanyak 25 gram dan dilarutkan sampel tersebut dengan aquadest yang telah dipanaskan. Setelah itu sampel diuji dengan menggunakan metode uji cepat (Rapid test kit). Hasil penelitian ini menunjukkan bahwa dari 10 sampel saus jajanan “tusuk-tusuk” di Taman Berlabuh dan Taman Oval kota Tarakan tidak mengandung Rhodamin B.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78725489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-diabetic Activity of Virgin Coconut Oil (VCO): Review 初榨椰子油(VCO)抗糖尿病活性研究进展

Borneo Journal of Pharmacy Pub Date : 2023-03-20 DOI: 10.57174/j.born.v3i1.73

R. Rahmawati, Bayu Putra, L. Wiyani, Andi Maulana Kamri, S. Azahra

引用次数: 0

Column Chromatography Fractionation and Antioxidant Activity of Passiflora foetida Leaves 西番莲叶的柱层析分离及抗氧化活性研究

Borneo Journal of Pharmacy Pub Date : 2023-02-28 DOI: 10.33084/bjop.v6i1.1830

Nita Triadisti, I. Zamzani

{"title":"Column Chromatography Fractionation and Antioxidant Activity of Passiflora foetida Leaves","authors":"Nita Triadisti, I. Zamzani","doi":"10.33084/bjop.v6i1.1830","DOIUrl":"https://doi.org/10.33084/bjop.v6i1.1830","url":null,"abstract":"Available synthetic antioxidants have been reported to have mutagenic and toxic effects. On the other hand, natural antioxidants show their superiority as they are not or less toxic. Passiflora foetida has the potential as an antioxidant, but the investigation of the antioxidant activity of the P. foetida chromatography column fraction has not been reported. This studied aims to investigate the antioxidant activity of the column chromatographic fractions of P. foetida leaves. An antioxidant assay using the DPPH and FRAP methods. The extraction was carried out by graded maceration, then fractionation using column chromatography. The antioxidant activity test was carried out using the DPPH and FRAP methods. Thin Layer Chromatography analysis was performed to determine the chromatogram pattern. The EC50 using DPPH method from n-hexane extract: 129.035 µg/mL, ethyl acetate extract: 206.398 µg/mL, methanol extract: 97.453 µg/mL, while the EC50 using FRAP method from n-hexane extract: 67.851 µg/mL, ethyl acetate extract : 68.981 µg/mL, and methanol extract: 58.787 µg/mL. Column chromatography fractions have antioxidant activity, with FMetPF6 as the fraction with the best activity, with percent inhibition 41.85±1.96 at concentration 25 µg/mL (DPPH), and with percent antioxidant activity 26.03±0.84 at concentration 9 µg/mL (FRAP). Passiflora foetida leaves have great potential as an antioxidant; both the extract and its fractions have antioxidant activity. The FMetPF6 has the best activity compare to other extracts and fractions. Further analysis to determine the various compounds in FMetPF6 using LC-MS/MS will facilitate the active compound's isolation.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"331 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76577176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Molecular Docking Investigation, Pharmacokinetic Analysis, and Molecular Dynamic Simulation of Some Benzoxaborole-Benzimidazole Hybrids: An Approach to Identifying Superior Onchocerca Inhibitors 苯并恶波罗罗-苯并咪唑复合物的分子对接研究、药代动力学分析及分子动力学模拟——筛选盘尾丝虫抑制剂的方法

Borneo Journal of Pharmacy Pub Date : 2023-02-28 DOI: 10.33084/bjop.v6i1.3876

F. A. Ugbe, G. Shallangwa, A. Uzairu, I. Abdulkadir

{"title":"Molecular Docking Investigation, Pharmacokinetic Analysis, and Molecular Dynamic Simulation of Some Benzoxaborole-Benzimidazole Hybrids: An Approach to Identifying Superior Onchocerca Inhibitors","authors":"F. A. Ugbe, G. Shallangwa, A. Uzairu, I. Abdulkadir","doi":"10.33084/bjop.v6i1.3876","DOIUrl":"https://doi.org/10.33084/bjop.v6i1.3876","url":null,"abstract":"Onchocerciasis is one of the major neglected tropical diseases caused by the filarial worm (Onchocerca volvulus), affecting an estimated population of about 37 million people living predominantly in tropical Africa. The major treatment approach has been based on the use of Ivermectin, which kills the microfilariae or the less effective Doxycycline targeting Wolbachia, endosymbiont of filarial nematodes. Flubendazole (FBZ) has proved effective in treating adult worms but with threatening adverse effects. Against this backdrop, therefore, a combined molecular docking study and pharmacokinetic screening were conducted on a series of benzimidazole-benzoxaborole hybrids to find more potent analogs with attributes that address the limitations of existing therapies. All the nineteen analogs were found to possess better docking scores than the reference drug (FBZ, Moldock scores = -120.466 and -125.359). The results of pharmacokinetic testing suggest that four molecules (14, 16, 19, and 20) are orally bioavailable and showed better ADMET properties than FBZ. These molecules and FBZ showed good binding interactions with the receptors’ active sites. Also, the molecular dynamic simulation performed on the docked complexes of 20 and FBZ confirmed the rigidity and stability of their interactions. Based on the results of this study, the selected molecules (especially 20) could be considered superior drug candidates for the treatment of Onchocerciasis.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84193991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Morphological and Micromorphological Investigations of Bidens frondosa L. from Flora of Krasnodar Region, Russia 标题俄罗斯克拉斯诺达尔地区植物区系白花Bidens frondosa L.的形态学和显微形态学研究

Borneo Journal of Pharmacy Pub Date : 2023-02-28 DOI: 10.33084/bjop.v6i1.1554

V. Zinchenko, Фатима Казбековна Серебряная

{"title":"Morphological and Micromorphological Investigations of Bidens frondosa L. from Flora of Krasnodar Region, Russia","authors":"V. Zinchenko, Фатима Казбековна Серебряная","doi":"10.33084/bjop.v6i1.1554","DOIUrl":"https://doi.org/10.33084/bjop.v6i1.1554","url":null,"abstract":"Complex morphological and micromorphological studies have been made about bootjack bur (Bidens frondosa) growing on the territory of the Krasnodar region. The lamina is of dorsoventral type. The conduction system has fasciations, three closed collateral bundles, are present near the vein. The leaf is of amphistomatic type, stomatic apparats are present in a small amount. Anticlinical walls of the main cells of the epidermis are strongly flexuose. The lower epidermis if compared to the upper one has a large number of stomatic apparatus of anisocytic type. The trichomes are leggy, represented by multicellular hairs of different shapes and lengths. Micromorphological capabilities of bootjack bur’s transverse section of the caulis and leafstalk have been studied. Received micromorphological data is a fragment of complex pharmacognostic studies of the Bidens kind. For acquiring the anti-allergic medication in the future, it is necessary to make pharma-technological studies and come up with the necessary medical form in the shape of thick extract and also make pharmacological studies in acquiring this medical form.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83100389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0