Bio-medical materials and engineering最新文献

{"title":"Biomechanical effect of fibular osteotomy on the knee joint in high tibial osteotomy: A cadaveric study.","authors":"Osamu Tanifuji,&nbsp;Tomoharu Mochizuki,&nbsp;Yoshio Koga,&nbsp;Yuji Tanabe,&nbsp;Hiroyuki Kawashima","doi":"10.3233/BME-221395","DOIUrl":"https://doi.org/10.3233/BME-221395","url":null,"abstract":"<p><strong>Background: </strong>Closed-wedge high tibial osteotomy (CWHTO) with a fibular osteotomy (FO) causes medial joint space widening in the knee. However, the effect of FO on the joint space width remains unclear.</p><p><strong>Objective: </strong>This study aimed to examine the effect of FO on the knee in HTO.</p><p><strong>Methods: </strong>A compression load test was performed on two amputated human limbs under four conditions: (1) normal (without any osteotomy), (2) open-wedge HTO (OWHTO), (3) OWHTO with FO, and (4) CWHTO. The contact area of the femoral and tibial cartilages and the medial and lateral joint space widths in each condition were evaluated using a motion capture system with computed tomography (CT) and magnetic resonance imaging (MRI) data.</p><p><strong>Results: </strong>The contact area increased on the lateral side after OWHTO, which increased more on the lateral side with a concomitant decrease on the medial side in both subjects when FO was added to OWHTO. An increase in the medial joint space width and a decrease on the lateral side were seen in both OWHTO with FO and CWHTO.</p><p><strong>Conclusions: </strong>The contact area and joint space widths are affected by the FO, and the effect is more pronounced than the way of HTO (OWHTO or CWHTO).</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"34 2","pages":"123-131"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9148056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced fibrous capsule elastic fibers from biologic ECM-enveloped CIEDs in minipigs, supported with a novel compression mechanics model.","authors":"Roche C de Guzman,&nbsp;Allison S Meer,&nbsp;Aidan A Mathews,&nbsp;Atara R Israel,&nbsp;Michael T Moses,&nbsp;Clarence M Sams,&nbsp;Daniel B Deegan","doi":"10.3233/BME-221488","DOIUrl":"https://doi.org/10.3233/BME-221488","url":null,"abstract":"<p><strong>Background: </strong>Fibrous capsules (Fb) in response to cardiovascular implantable electronic devices (CIEDs), including a pacemaker (P) system, can produce patient discomfort and difficulties in revision surgery due partially to their increased compressive strength, previously linked to elevated tissue fibers.</p><p><strong>Objective: </strong>A preliminary study to quantify structural proteins, determine if biologic extracellular matrix-enveloped CIEDs (PECM) caused differential Fb properties, and to implement a realistic mechanical model.</p><p><strong>Methods: </strong>Retrieved Fb (-P and -PECM) from minipigs were subjected to biomechanical (shear oscillation and uniaxial compression) and histological (collagen I and elastin) analyses.</p><p><strong>Results: </strong>Fb-PECM showed significant decreases compared to Fb-P in: low strain-loss modulus (390 vs. 541 Pa) across angular frequencies, high strain-compressive elastic modulus (1043 vs. 2042 kPa), and elastic fiber content (1.92 vs. 3.15 μg/mg tissue). Decreases in elastin were particularly noted closer to the implant's surface (Fb-PECM = 71% vs. Fb-P = 143% relative to dermal elastin at mid-tangential sections) and verified with a solid mechanics hyperelasticity with direction-dependent fiber viscoelasticity compression simulation (r2 ≥ 98.9%).</p><p><strong>Conclusions: </strong>The biologic envelope composed of decellularized porcine small intestine submucosa ECM for CIEDs promoted fibrous tissues with less elastic fibers. Novel compression modeling analyses directly correlated this singular reduction to more desirable subcutaneous tissue mechanics.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"34 4","pages":"289-304"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10224308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of robot-assisted and traditional surgeries in the treatment of thoracolumbar fractures based on 1-year follow-up observation.","authors":"Xu-Qi Hu,&nbsp;Hui-Gen Lu,&nbsp;Xiao Zhou,&nbsp;Min-Jie Hu,&nbsp;Xue-Kang Pan,&nbsp;Bao Chen,&nbsp;Ye-Feng Yu","doi":"10.3233/BME-222521","DOIUrl":"https://doi.org/10.3233/BME-222521","url":null,"abstract":"<p><strong>Background: </strong>There are conflicting results for robot-assisted (RA) pedicle screw fixation compared with freehand (FH) pedicle screw fixation.</p><p><strong>Objective: </strong>This study was designed to retrospectively compare the accuracy and efficacy of RA percutaneous pedicle screw fixation and traditional freehand FH pedicle screw fixation in the treatment of thoracolumbar fractures.</p><p><strong>Methods: </strong>A total of 26 cases were assigned to the RA group, and 24 cases were assigned to the FH group. The operation time, bleeding volume, and visual analog scale (VAS) score 1 day after the operation, and the anterior/posterior (A/P) vertebral height ratio of the injured vertebrae at 3 days and at internal fixation removal 1 year after the operation were compared between the two groups. Pedicle screw position accuracy was assessed according to Gertzbein criteria.</p><p><strong>Results: </strong>The operation times of the RA group and FH group were 138.69 ± 32.67 minutes and 103.67 ± 14.53 minutes, respectively, and the difference was statistically significant. The intraoperative blood loss was 49.23 ± 22.56 ml in the RA group and 78.33 ± 23.90 ml in the FH group, and the difference was statistically significant. There was a significant difference in the A/P vertebral height ratio of the injured vertebrae 3 days after the operation compared with before the operation in both groups (P < 0.05). There was a significant difference in the A/P vertebral height ratio of the injured vertebrae 3 days after the operation compared with that at fixation removal in both groups (P < 0.05).</p><p><strong>Conclusion: </strong>The application of RA orthopedic treatment for thoracolumbar fractures can achieve good fracture reduction.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"34 4","pages":"375-383"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9780466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human adipose-derived stem cells can optimize the filling material in rats.","authors":"Siwei Qu,&nbsp;Ning Ma,&nbsp;Weixin Wang,&nbsp;Sen Chen,&nbsp;Qi Wu,&nbsp;Yangqun Li,&nbsp;Zhe Yang","doi":"10.3233/BME-222503","DOIUrl":"https://doi.org/10.3233/BME-222503","url":null,"abstract":"<p><strong>Background: </strong>Human adipose-derived stem cells have been identified as a promising candidate for cell-assisted therapy to improve graft survival.</p><p><strong>Objective: </strong>To objective of the study was to add human adipose-derived stem cells into filling materials.</p><p><strong>Methods: </strong>The filling materials were prepared and divided into 6 groups: fat particles with phosphate buffer saline or human adipose-derived stem cells; acellular dermal matrix particles with phosphate buffer saline or human adipose-derived stem cells; mixture of fat particles and acellular dermal matrix particles with phosphate buffer saline or human adipose-derived stem cells. The survival rate, vascular density and histological at 2, 6 and 12 weeks were investigated.</p><p><strong>Results: </strong>Human adipose-derived stem cells significantly improved survival rate in each group at 6 and 12 weeks, and it significantly increased the vascular density in the fat particles and porcine acellular dermal matrix combined group and porcine acellular dermal matrix group at three time points, but human adipose-derived stem cells did not have a significant effect in the fat particles group.</p><p><strong>Conclusion: </strong>Human adipose-derived stem cells as assisted cells added into filling material can improve survival rate and vascular density in rats.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"34 4","pages":"345-355"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9842621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design modifications and evaluation of the silicone artificial finger joints.","authors":"F A Alnaimat, H A Owida, Jamal I Al-Nabulsi, B Al-Naami, A Al-Ghraibah, M Al-Ayyad, Muneera Altayeb, Ashraf Al Sharah","doi":"10.3233/BME-222527","DOIUrl":"10.3233/BME-222527","url":null,"abstract":"<p><strong>Background: </strong>There are many reasons that could lead to finger joint arthroplasty, and the most familiar reason is osteoarthritis. Silicone finger joint are the most commonly used implants. However, these implants might fracture with time and cause wear which will lead to chronic inflammation and synovitis for the patient and then implant failure.</p><p><strong>Objective: </strong>The aim of this study is to improve the design of the silicone finger joint and simulate the different designs using finite element analysis (FEA) simulation.</p><p><strong>Method: </strong>Three different designs were drawn and FEA has been used in this study using Solidworks software. The first design is the silicone finger joint design without any modification, the second one is modified design with added ribs to the junction of distal stem and hinge and the third design was added filler material inside the body of the artificial joint. An axial force with 625 N that was applied on the upper part of the distal stem which is nearly represents the maximum value of the grip strength for normal males.</p><p><strong>Results: </strong>The results showed improvement on the design in which the concentrated stress at the junction of the distal stem and hinge of the design was distributed. In addition, the Von Mises stress was stable for the modified design with added ribs and the added filler material designs after 15°.</p><p><strong>Conclusion: </strong>The design modification could improve the stress distribution and stability of the artificial finger joint and increase the lifetime expectancy of these implants.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"481-490"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10302835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study on co-culture of DiI-labeled rat bone marrow mesenchymal stem cells and neonatal rat cardiomyocytes to induce differentiation into cardiomyocyte-like cells.","authors":"Junsheng Mu,&nbsp;Zichang Zhang,&nbsp;Fan Zhou,&nbsp;Jianwei Zheng,&nbsp;Ping Bo,&nbsp;Bin You","doi":"10.3233/BME-221429","DOIUrl":"https://doi.org/10.3233/BME-221429","url":null,"abstract":"<p><strong>Background: </strong>Myocardial infarction is a serious clinical disease with high mortality and poor prognosis. Cardiomyocytes (CMs) have limited regeneration abilities after ischemic injury. Their growth and differentiation can be enhanced by contact co-culture with stem cells.</p><p><strong>Objective: </strong>The aim was to study the contact co-culture of Dil-labeled bone marrow mesenchymal stem cells (BMSCs) and CMs for inducing differentiation of CMs from stem cells for treating myocardial infarction.</p><p><strong>Methods: </strong>After contact co-culture, the differentiation of BMSCs into CMs was analyzed qualitatively by detecting myocardial markers (cardiac troponin T and α-smooth muscle actin) using immunofluorescence and quantitatively using flow cytometry. To examine the mechanism, possible gap junctions between BMSCs and CMs were analyzed by detecting gap junction protein connexin 43 (C×43) expression in BMSCs using immunofluorescence. The functionality of gap junctions was analyzed using dye transfer experiments.</p><p><strong>Results: </strong>The results revealed that BMSCs in contact with CMs exhibited myocardial markers and a significant increase in differentiation rate (P < 0.05); they also proved the existence and function of gap junctions between BMSCs and CMs.</p><p><strong>Conclusions: </strong>It was shown that contact co-culture can induce Dil-labeled BMSCs to differentiate into CM-like cells and examined the principle of gap junction-mediated signaling pathways involved in inducing stem cells to differentiate into cardiomyocytes.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"34 4","pages":"319-330"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9841594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of RGD-fused silk fibroin in a solution format on fibroblast proliferation and collagen production.","authors":"Derya G Aytemiz,&nbsp;Yusuke Kambe,&nbsp;Mitsunobu Hirata,&nbsp;Hirohito Nishi,&nbsp;Tsunenori Kameda","doi":"10.3233/BME-221430","DOIUrl":"https://doi.org/10.3233/BME-221430","url":null,"abstract":"<p><strong>Background: </strong>Collagen production in fibroblasts is important for skin tissue repair. Cell-adhesive Arg-Gly-Asp (RGD) peptides immobilized on scaffolds stimulate fibroblast collagen production, but RGD peptides in solution exhibit opposite effects. Transgenic silkworm technology enables the design of fusion positions for RGD peptides in silk fibroin molecules. The effect of RGD-fused silk fibroin in solution on fibroblast cell activity remains unclear.</p><p><strong>Objective: </strong>To clarify the effects of RGD peptides fused to silk fibroin heavy (H)-chain or light (L)-chain on fibroblast proliferation and collagen production when RGD-fused silk fibroin proteins were added to the culture medium.</p><p><strong>Methods: </strong>Silk fibers with RGD-fused H-chains (H-RGD) or L-chains (L-RGD) were degummed, dissolved, and dialyzed to prepare H-RGD or L-RGD aqueous solutions, respectively. These solutions were added to the fibroblast medium, and their proliferation and collagen production were quantified.</p><p><strong>Results: </strong>Both L- and H-RGD stimulated fibroblast proliferation at a similar level, even in a solution format, but L-RGD promoted fibroblast collagen production significantly, indicating the synergistic effect of the native H-chain and RGD-fused L-chain.</p><p><strong>Conclusion: </strong>RGD-fused silk fibroin in solution stimulated fibroblast proliferation and collagen production, depending on the fusion position of the peptides.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"34 2","pages":"183-193"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9095711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiphase Flow Hemodynamic Evaluation of Vertebral Artery Stenosis Lesions and Plaque Stability.","authors":"Wei Ma, Zhiguo Cheng, Xiaoqin Chen, Chengdu Huang, Guanghao Yu, Guangxin Chen","doi":"10.3233/BME-221436","DOIUrl":"10.3233/BME-221436","url":null,"abstract":"<p><strong>Background: </strong>Atherosclerosis is one of the main causes of vertebral artery stenosis, which reduces blood supply to the posterior circulation, resulting in cerebral infarction or death.</p><p><strong>Objective: </strong>To investigate stenosis rates and locations on the development of vertebral artery plaques.</p><p><strong>Methods: </strong>Stenosis models with varying degrees and positions of stenosis were established. The stenosis area was comprehensively analyzed using multiphase flow numerical simulation. Wall shear stress (WSS), blood flow velocity, and red blood cell (RBC) volume fraction were calculated.</p><p><strong>Results: </strong>Blood flow velocity in 30-70% stenosis of each segment tended to increase significantly higher than normal. Downstream of 50% stenosis exhibited turbulent flow; downstream of 70% displayed reflux. Severe stenosis increases the WSS and distribution area. The mixed area of high and low WSS appeared downstream of the stenosis. The RBC volume fraction at the stenosis increased (maximum value: 0.487 at 70% stenosis in the V4), which was 1.08 times the normal volume fraction. Turbulent and backflow regions exhibited complex RBC volume fraction distributions.</p><p><strong>Conclusion: </strong>Flow velocity, WSS, and RBC volume fraction at the stenosis increase with stenosis severity, increasing plaque shedding. Narrow downstream spoiler and reflux areas possess low WSS and high erythrocyte volume fractions, accelerating plaque growth.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"34 3","pages":"247-260"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9501882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical analysis of hemodynamics in pulmonary artery stenosis.","authors":"Fan He,&nbsp;Xinyu Wang,&nbsp;Lu Hua,&nbsp;Tingting Guo","doi":"10.3233/BME-221418","DOIUrl":"https://doi.org/10.3233/BME-221418","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary artery stenosis is a serious threat to people's life and health.</p><p><strong>Objective: </strong>The hydrodynamic mechanism of pulmonary artery stenosis is investigated.</p><p><strong>Methods: </strong>Numerical analysis of hemodynamics in pulmonary artery stenosis using computational fluid dynamics techniques is performed. An idealized model of pulmonary artery stenosis is established, and the model is divided into main pulmonary artery, right and left pulmonary arteries, and their branches. The sections at different positions are intercepted to study the distribution trend of maximum velocity, pressure and wall shear stress.</p><p><strong>Results: </strong>The numerical simulation results show that the pressure drop at both ends of the narrow area is large. High velocity and wall shear stress exist in the center of stenosis, and the wall shear stress at the distal end of stenosis gradually decreases, resulting in endothelial dysfunction.</p><p><strong>Conclusions: </strong> To some extent, this study helps clinicians make diagnosis and treatment plans in advance and improve prognosis. This method could be used in the numerical simulation of practical models.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"34 3","pages":"235-246"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9854852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An extracellular matrix hydrogel from porcine urinary bladder for tissue engineering: In vitro and in vivo analyses.","authors":"German Jiménez-Gastélum,&nbsp;Rosalío Ramos-Payán,&nbsp;Jorge López-Gutierrez,&nbsp;Alfredo Ayala-Ham,&nbsp;Erika Silva-Benítez,&nbsp;Mercedes Bermúdez,&nbsp;José Geovanni Romero-Quintana,&nbsp;Guzman Sanchez-Schmitz,&nbsp;Maribel Aguilar-Medina","doi":"10.3233/BME-221450","DOIUrl":"https://doi.org/10.3233/BME-221450","url":null,"abstract":"<p><strong>Background: </strong>The necessity to manufacture scaffolds with superior capabilities of biocompatibility and biodegradability has led to the production of extracellular matrix (ECM) scaffolds. Among their advantages, they allow better cell colonization, which enables its successful integration into the hosted tissue, surrounding the area to be repaired and their formulations facilitate placing it into irregular shapes. The ECM from porcine urinary bladder (pUBM) comprises proteins, proteoglycans and glycosaminoglycans which provide support and enable signals to the cells. These properties make it an excellent option to produce hydrogels that can be used in regenerative medicine.</p><p><strong>Objective: </strong>The goal of this study was to assess the biocompatibility of an ECM hydrogel derived from the porcine urinary bladder (pUBMh) in vitro using fibroblasts, macrophages, and adipose-derived mesenchymal stem cells (AD-MCSs), as well as biocompatibility in vivo using Wistar rats.</p><p><strong>Methods: </strong>Effects upon cells proliferation/viability was measured using MTT assay, cytotoxic effects were analyzed by quantifying lactate dehydrogenase release and the Live/Dead Cell Imaging assay. Macrophage activation was assessed by quantification of IL-6, IL-10, IL-12p70, MCP-1, and TNF-α using a microsphere-based cytometric bead array. For in vivo analysis, Wistar rats were inoculated into the dorsal sub-dermis with pUBMh. The specimens were sacrificed at 24 h after inoculation for histological study.</p><p><strong>Results: </strong>The pUBMh obtained showed good consistency and absence of cell debris. The biocompatibility tests in vitro revealed that the pUBMh promoted cell proliferation and it is not cytotoxic on the three tested cell lines and induces the production of pro-inflammatory cytokines on macrophages, mainly TNF-α and MCP-1. In vivo, pUBMh exhibited fibroblast-like cell recruitment, without tissue damage or inflammation.</p><p><strong>Conclusion: </strong>The results show that pUBMh allows cell proliferation without cytotoxic effects and can be considered an excellent biomaterial for tissue engineering.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"34 4","pages":"331-344"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9847816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}