Boletín médico del Hospital Infantil de México最新文献

{"title":"Diagnostic criteria for growth disorders requiring growth hormone therapy: updated consensus from the Sociedad Mexicana de Endocrinología Pediátrica.","authors":"Patricia G Medina-Bravo, Ana C Hill-de Titto, América L Miranda-Lora, Angélica Martínez-Ramos-Méndez, Giselle Alcalá-Fernández, M de la Luz Domínguez-Carrillo, Elisa L Dávila-Sotelo, Luis A López-Rivera, Reyna A Paredes-Flores, Mercedes B Medina-Aguilar, Julio C Valenzuela-Montoya, Lilia T Avena-Portillo, Raúl Calzada-León, Margarita Barrientos-Pérez, Aleida Rivera-Hernández, Lidia Cuevas-Martínez, Hanna G Marrodan-García, M Esther Gloria-Quintero, Concepción Valverde-Ocaña, María D Hernández-Almaguer, Nayely Garibay-Nieto, Berenice Aguirre-Gómez, Luis M Dorantes-Álvarez, Ma de la Luz Ruíz-Reyes, Héctor R Rivero-Escalante","doi":"10.24875/BMHIM.26000033","DOIUrl":"10.24875/BMHIM.26000033","url":null,"abstract":"<p><p>En los últimos años, tanto el conocimiento de los trastornos del crecimiento como el enfoque de las directrices para el uso de la hormona de crecimiento humana recombinante (HChr) han evolucionado de manera significativa. El abordaje diagnóstico de estos trastornos requiere una evaluación física exhaustiva y sistemática, cuyos hallazgos deben integrarse con los de estudios paraclínicos y genéticos, cuando estén indicados. Esto permitirá lograr un diagnóstico preciso e identificar aquellas condiciones que pueden beneficiarse del uso de HChr. El presente documento es el resultado del trabajo realizado por el Grupo de Interés sobre Crecimiento, así como otros miembros de la Sociedad Mexicana de Endocrinología Pediátrica, con el objetivo principal de señalar los criterios clínicos y paraclínicos de distintas entidades en las que puede estar indicado el uso de HChr.</p><p><p>In recent years, both the understanding of growth disorders and the clinical guidelines concerning recombinant human growth hormone (hrGH) therapy have evolved considerably. The diagnostic evaluation of these disorders requires a comprehensive and systematic physical examination, the findings of which should be integrated with relevant paraclinical and genetic investigations when indicated. Such an integrated diagnostic approach enables greater accuracy in establishing the underlying etiology and in identifying those conditions that are most likely to benefit from hrGH therapy. This document represents the collective work of the Growth Interest Group, together with other members of the Mexican Society of Pediatric Endocrinology. Its primary objective is to delineate and standardize the clinical and paraclinical criteria for a spectrum of growth-related conditions in which hrGH therapy may be considered appropriate.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"83 Supl 2","pages":"1-22"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148223121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of general movements and the potential of video-tracking to predict high risk of cerebral palsy in premature infants: prospective, analytical, and observational study.","authors":"Nestor H Rosendo, Agustina Vericat, Ramiro Freudenthal","doi":"10.24875/BMHIM.25000109","DOIUrl":"10.24875/BMHIM.25000109","url":null,"abstract":"<p><strong>Background: </strong>Cerebral palsy (CP) is the most common motor disability in childhood; however, its prevalence remains insufficiently documented in particularly vulnerable populations, such as premature infants in low- and middle-income regions. To objective is identify abnormal movements associated with an increased risk of CP in a sample of premature infants and to determine the main perinatal criteria associated with CP; and to explore the possibilities of video-tracking as a complementary screening tool.</p><p><strong>Methods: </strong>Prospective, analytical, observational study that included premature newborns admitted to neonatal intensive care units at two hospitals in La Plata, Argentina, between January 1 and June 30, 2022.</p><p><strong>Results: </strong>Assessment of general movements in 39 newborns revealed that 12 (30.7%) had abnormal movements, characterized by absent fidgety movements, associated with an increased risk of CP. In this subgroup, 92% had a mean birth weight of 1,105.8 ± 405.1 g, a mean gestational age of 28.6 ± 2.8 weeks, 50% had an Apgar score < 5 at one minute of life, and 75% developed bronchopulmonary dysplasia. In two selected cases, the videos were processed with video-assisted tracking software to analyze the amplitude and complexity of the movement patterns.</p><p><strong>Conclusions: </strong>Given the scarcity of records in low- and middle-income countries, this study provides evidence on the frequency of general movement patterns associated with the risk of developing CP. It also explores the possibilities of video-assisted screening and highlights the importance of early detection of one of the most prevalent motor disorders in the premature population.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"83 3","pages":"161-169"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hirschsprung's disease and Mowat-Wilson syndrome: should a pull-through be performed?","authors":"Itzamara Martain-Pérez, Roberto Dávila-Pérez, Emilio Fernández-Portilla, Itzel Lizárraga-Rodríguez, Rodrigo Moreno-Salgado, Jaime Nieto-Zermeño, Adria Costa-Roig, Alfredo Domínguez-Muñoz","doi":"10.24875/BMHIM.24000139","DOIUrl":"10.24875/BMHIM.24000139","url":null,"abstract":"<p><strong>Background: </strong>Hirschsprung's disease (HSCR) is characterized by the absence of ganglion cells. Five percent of cases are associated with syndromic conditions, one of which is Mowat-Wilson syndrome (MWS), with an incidence rate of 50%. HSCR may be the first feature of this syndrome to be diagnosed. MWS is an autosomal dominant genetic disorder caused by a variant in the ZEB2 gene (ZFHX1B). OMIM #235730. It involves severe clinical manifestations such as ocular hypertelorism, intellectual disability, congenital heart defects, epilepsy, and HSCR. The association between MWS and HSCR is regarded as a serious condition with unpredictable post-operative outcomes, and many reported complications related to motility disorders are noted.</p><p><strong>Methods: </strong>We conducted a retrospective study and reviewed the medical records of patients with MWS treated at our center. We examined the relationship among HSCR, clinical features, molecular characteristics, surgical complications, and pre-operative and post-operative enterocolitis events.</p><p><strong>Results: </strong>The study included four patients with MWS. Three (75%) were found to be associated with HSCR. Rectal biopsy confirmed HSCR in all patients. Two patients underwent a transanal pull-through Swenson procedure, and both experienced surgical complications. Both cases encountered multiple episodes of enterocolitis, and one of them required a permanent stoma. The third patient has not undergone surgical correction but has responded well to medical treatment (laxatives).</p><p><strong>Conclusions: </strong>The association between MWS and HSCR presents a severe condition with high morbidity. The outcome after the pull-through procedure is unpredictable. Further studies are necessary to gain a deeper understanding of this condition. We recommend evaluating these patients in a multidisciplinary consensus based on the existing literature and our findings. Those without recurrent enterocolitis or chronic motility disorders are suitable candidates for conservative management.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"83 2","pages":"87-93"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconceptualizing the newborn: from \"feed-sleep-clean\" to behavioral state, stress, and self-regulation surveillance as the foundation of neurodevelopment.","authors":"Vania Aldrete-Cortez, Mario E Rendón-Macías","doi":"10.24875/BMHIM.25000153","DOIUrl":"https://doi.org/10.24875/BMHIM.25000153","url":null,"abstract":"","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"83 3","pages":"214-215"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial impact assessment of the current PAIDOS clinical care model for school-age children living with obesity in Mexico.","authors":"Salvador Villalpando-Carrión, M José Adame-Vivanco, Daniela Felgueres-Nacach, Montserrat Remís-Colín, Fuentes-Balderrama Jaime","doi":"10.24875/BMHIM.25000154","DOIUrl":"https://doi.org/10.24875/BMHIM.25000154","url":null,"abstract":"<p><strong>Background: </strong>Given the increasing prevalence and public health burden of childhood obesity in Mexico, the development of multidisciplinary evidence-based clinical care models is urgent. The PAIDOS clinical care model was active from 2011 to 2013 in the Mexican Children's Hospital. This model was redesigned and launched in 2015 as a more comprehensive and holistic protocol.</p><p><strong>Methods: </strong>This updated model consists of six in-hospital sessions aimed at engaging the nutritional, physical, psychological, and family elements associated with childhood obesity.</p><p><strong>Results: </strong>Participants in this model were 119 children and adolescents from 7 to 16 years of age (X̅ = 11.91, standard deviation = 2.32, 66% male, with a body mass index [BMI] ≥ 95^th percentile). Repeated measure analysis of covariances exhibits significant reductions in BMI at post-test, as well as maintenance at the 6-month follow-up. Negative self-esteem presented a significant decrease at post-test, while other dimensions of depression displayed significant changes only for girls.</p><p><strong>Conclusions: </strong>The current PAIDOS clinical care program shows promise as it is effective in reducing and maintaining BMI. Future directions are discussed.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"83 4","pages":"287-295"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148812035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and dyslipidemia in patients with craniopharyngioma before and one year after surgical resection.","authors":"Aleida Rivera-Hernández, Adriana de J Gaspar-Rodríguez, Jessie N Zurita-Cruz","doi":"10.24875/BMHIM.25000042","DOIUrl":"10.24875/BMHIM.25000042","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introducción: &lt;/strong&gt;El craneofaringioma se caracteriza por manifestaciones clínicas derivadas de la compresión de estructuras del sistema nervioso central, deficiencias hormonales hipofisarias, así como obesidad. El objetivo fue identificar la frecuencia de obesidad y dislipidemia y sus factores de riesgo en pacientes pediátricos con craneofaringioma antes y después de la resección quirúrgica.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Métodos: &lt;/strong&gt;Estudio de cohorte retrospectivo del año 2014 al 2023 en pacientes pediátricos craneofaringiomas evaluados antes de la cirugía y a los 12 meses posteriores. Se recopilaron datos antropométricos, perfil de lípidos y estudios. Las variables cualitativas se expresaron como frecuencias y porcentajes, y las cuantitativas como mediana. Se usaron pruebas estadísticas según el tipo de variable y regresiones logística y lineal para identificar factores asociados y cambios en el incremento (Δ) del índice de masa corporal estandarizado (zIMC, Z score del IMC).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Resultados: &lt;/strong&gt;Se incluyeron 47 pacientes, mediana de edad 6 años, el 61.7% de sexo masculino. Al diagnóstico, el 27.7% tenía obesidad y el 10.6% sobrepeso. El diámetro tumoral fue de 3 cm. El zIMC aumentó significativamente (0.46 vs. 1.70; p &lt; 0.001), con incremento de obesidad al 68.1%. La dislipidemia aumentó del 12.7 al 32.6%, principalmente la hipertrigliceridemia (25.5%). Inicialmente, el 66% no tenía deficiencias hormonales, pero a los 12 meses posquirúrgico el 95.7% ya tenían alguna deficiencia. El sexo masculino y presentar obesidad al inicio del seguimiento fueron los factores relacionados a presentar obesidad a los 12 meses posquirúrgico.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusiones: &lt;/strong&gt;La obesidad y dislipidemia aumentaron significativamente tras la cirugía, acompañadas de un incremento en las disfunciones hormonales.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Craniopharyngioma is characterized by clinical manifestations resulting from the compression of central nervous system structures, pituitary hormonal deficiencies, and obesity. The aim was to identify the frequency of obesity and dyslipidemia and their risk factors in pediatric patients with craniopharyngioma before and after surgical resection.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This was a retrospective cohort study conducted from 2014 to 2024 in pediatric patients with craniopharyngioma, evaluated before surgery and 12 months postoperatively. Anthropometric data, lipid profiles, and laboratory studies were collected. The Wilcoxon test was used for quantitative variables and the McNemar test for qualitative variables.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 47 patients were included, with a median age of 6 years; 61.7% were male. At diagnosis, 27.7% had obesity and 10.6% were overweight. The median tumor diameter was 3 cm. The body mass index Z score increased significantly (0.46 vs. 1.70; p &lt; 0.001), with obesity rising to 68.1%. Dyslipidemia increased from 12.7 to 32.6%, mainly due to hypertrigly","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"83 2","pages":"102-112"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid congenital lung malformation: case report.","authors":"Zeidy P Ramírez-López, Karla Ma Oliva-Adrover, Rocío A Godínez-Cabrera, Eify D Roca-Girón, Juan P Zaldaña-Figueroa, Natalia I Ybarra-García, Javier Bolaños-Bendfeldt","doi":"10.24875/BMHIM.25000006","DOIUrl":"10.24875/BMHIM.25000006","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introducción: &lt;/strong&gt;Una causa poco frecuente de morbilidad en el recién nacido son las malformaciones congénitas del tracto respiratorio. Muchas de ellas pueden tener un origen común, es por ello que existe la posibilidad de que se presenten en conjunto, lo que se conoce como malformación pulmonar híbrida. La aparición conjunta de secuestro pulmonar y malformación adenomatoidea quística se ha descrito en muy pocos casos, aproximadamente 40-60 pacientes desde el primer caso reportado en 1949. Secuestro pulmonar se define como tejido quístico pulmonar ectópico no funcionante, con vascularización arterial propia de origen sistémico. Es una enfermedad congénita infrecuente, de presentación clínica variable, que puede ser intralobar o extralobar, y se puede acompañar de otras malformaciones, como en el caso de la enfermedad adenomatosa congénita. En la mayoría de los casos el tratamiento es quirúrgico y consiste en resecciones lobares por medio de videotoracoscopia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Caso clínico: &lt;/strong&gt;Paciente de 7 días de vida que al nacer inicia con dificultad respiratoria grave, requiriendo ventilación mecánica invasiva. Identifican derrame pleural y neumotórax izquierdo, por lo que colocan tubo de toracostomía, sin embargo, no resuelve completamente. Parte la sospecha clínica de malformación congénita pulmonar, la cual se confirma por medio de tomografía computarizada pulmonar y angiotomografía pulmonar, la cual evidencia vaso accesorio de origen aórtico, por lo que se realiza tratamiento quirúrgico.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusiones: &lt;/strong&gt;La resección temprana puede ser beneficiosa para el crecimiento pulmonar.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;A rare cause of morbidity in the newborn is congenital malformations of the respiratory tract. Many of them can have a common origin, which is why there is the possibility of presenting them together, known as hybrid pulmonary malformation. The joint appearance of pulmonary sequestration and cystic adenomatoid malformation has been described in very few cases, approximately 40-60 patients since the first case reported in 1949. Pulmonary sequestration is defined as ectopic nonfunctioning pulmonary cystic tissue, with its own arterial vascularization of systemic origin. It is a rare congenital disease, with variable clinical presentation, which can be intralobar or extralobar, and may be accompanied by other malformations as in the case of congenital adenomatous disease. In most cases the treatment is surgical, consisting of lobar resections through video thoracoscopy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical case: &lt;/strong&gt;Seven-day-old patient who at birth begins with severe respiratory difficulty requiring invasive mechanical ventilation. Left pleural effusion and pneumothorax are identified, so a thoracostomy tube is placed, however, it does not completely resolve, the clinical suspicion of congenital pulmonary malformation arises, which is confirmed by means of pulmonary computed tomography and pulmonary ang","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"83 1","pages":"57-61"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in U.S. vaccination policies (2026) and their potential implications for Mexican pediatrics: a review by the Mexican Academy of Pediatrics.","authors":"Fortino Solórzano-Santos, Mónica Reyes-Berlanga, Miguel Á Villasís-Keever, Luis Xochihua-Díaz, Mariana Merlo-Palomera, María Del C Espinosa-Sotero, Raúl Romero-Feregrino, Patricia Saltigeral-Simental, Marte Hernández-Porras, Antonio Luévanos-Velázquez, Gloria Huerta-García, Denisse N Vaquera-Aparicio, Claudia López-Enríquez, Rosa M Wong-Chew, Azarell Anzures-Gutiérrez, Sarbelio Moreno-Espinosa, Mercedes Macías-Parra, María G Miranda-Novales","doi":"10.24875/BMHIM.26000017","DOIUrl":"10.24875/BMHIM.26000017","url":null,"abstract":"<p><p>En los últimos meses de 2025, EE. UU. ha experimentado cambios profundos y controversiales en sus políticas de vacunación. El Departamento de Salud y Servicios Humanos (HHS), bajo la dirección de Robert F. Kennedy Jr. y siguiendo un memorando presidencial de Donald Trump, ha modificado el calendario de vacunación de los Centros para el Control y la Prevención de Enfermedades (CDC). La medida principal consiste en reducir de 17 a 11 el número de enfermedades para las cuales se recomienda la vacunación sistemática y universal en niños. Numerosos especialistas en salud pública, junto con organizaciones como la American Academy of Pediatrics (AAP) y la American Public Health Association (APHA), han manifestado su preocupación ante estos cambios. En este documento se revisan los cambios en las políticas de vacunación en EE. UU. y sus posibles repercusiones en salud pública. Se presenta el esquema de vacunación incluido en la Cartilla Nacional de Vacunación en México y las principales características de las vacunas. Un análisis del comportamiento epidemiológico de las enfermedades prevenibles por vacunación de nuestro país permite plantear los riesgos de hacer modificaciones en el esquema y lograr un mayor convencimiento a los pediatras y a la población en general del impacto positivo de la vacunación, y continuar con el esquema de vacunación universal ya establecido.</p><p><p>In the last months of 2025, the United States has experienced profound and controversial changes in its vaccination policies. The Department of Health and Human Services (HHS), under the leadership of Robert F. Kennedy Jr. and following a presidential memorandum issued by Donald Trump, has modified the vaccination schedule of the Centers for Disease Control and Prevention (CDC). The main measure involves reducing from 17 to 11 the number of diseases for which routine and universal vaccination in children is recommended. Numerous public health specialists, together with organizations such as the American Academy of Pediatrics (AAP) and the American Public Health Association (APHA), have expressed concern regarding these changes. This document reviews the changes in vaccination policies in the United States and their potential public health implications. We present the vaccination schedule included in Mexico’s National Vaccination Card and the main characteristics of the vaccines. An analysis of the epidemiological behavior of vaccine-preventable diseases in our country makes it possible to outline the risks of modifying the schedule and to recommend strengthening awareness among pediatricians and the general population about the positive impact of vaccination, as well as maintaining the already established universal vaccination schedule.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"83 2","pages":"69-86"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of delirium in children hospitalized with acute respiratory failure outside the intensive care unit.","authors":"Cecilia Echeverría-Puig, Romina Bustos, Maximiliano Carballedas, Mónica Pujadas, Sebastián González-Dambrauskas","doi":"10.24875/BMHIM.25000046","DOIUrl":"10.24875/BMHIM.25000046","url":null,"abstract":"<p><strong>Introducción: </strong>La incidencia de delirium fuera de unidades de cuidados intensivos pediátricos (UCIP) es desconocida. Esta investigación buscó determinar la incidencia de delirium en niños con insuficiencia respiratoria aguda admitidos en salas de sostén respiratorio no invasivo (SRNI) fuera de UCIP.</p><p><strong>Métodos: </strong>Se realizó un estudio observacional prospectivo en menores de 5 años hospitalizados y que requirieron SRNI fuera de UCIP. Se pesquisó delirium con la Escala de Cornell aplicada periódicamente durante los primeros cinco días de admisión.</p><p><strong>Resultados: </strong>Cincuenta y cinco niños se incluyeron en el análisis final, de los cuales el 34% (n = 19) desarrollaron delirium durante la internación. El fenotipo hipoactivo fue el más prevalente (10/55; 52.63%).</p><p><strong>Conclusiones: </strong>Uno de cada tres niños admitidos por insuficiencia respiratoria aguda y tratados con SRNI fuera de UCIP desarrollaron delirium, siendo el fenotipo hipoactivo el más frecuente.</p><p><strong>Background: </strong>The incidence of delirium outside pediatric intensive care units (PICUs) is unknown. This research aimed to determine the incidence of delirium in children with acute respiratory failure (ARF) admitted to non-invasive respiratory support (NIRS) wards outside of PICUs.</p><p><strong>Methods: </strong>A prospective observational study was conducted on children under the age of five, who were hospitalized and required NIRS outside of PICUs. Delirium was screened using the Cornell Scale, applied periodically during the first five days since admission.</p><p><strong>Results: </strong>Fifty-five children met inclusion criteria, from which 34% (n = 19) developed delirium during hospital admission. The hypoactive phenotype was the most prevalent (10/55; 52.63%).</p><p><strong>Conclusions: </strong>One in three children admitted for ARF and supported with NIRS outside of PICUs developed delirium, the hypoactive phenotype was the most frequent.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"83 2","pages":"113-119"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory indices predictors of presence, severity and mortality of necrotizing enterocolitis: an observational study.","authors":"Gloria P Sosa-Bustamante, Alejandro Covarrubias-Gil, Diana L Colmenero-Carrera, Ulises P Villalpando-Sosa, Arturo M Reyes-Sosa, Carlos Paque-Bautista, Paulina P Reyes-Sosa, Joselin Chavero-Espínola, Alexis D Arroyo-Tovar, Aurelia Del C Ramos-Jiménez, Arturo Reyes-Hernández, Alma P González","doi":"10.24875/BMHIM.25000108","DOIUrl":"10.24875/BMHIM.25000108","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introducción: &lt;/strong&gt;La enterocolitis necrosante (ECN) es una enfermedad grave en recién nacidos pretérmino (RNPT) que requiere de biomarcadores predictores. Los índices neutrófilo/linfocito (INL), plaqueta/linfocito (IPL) e inmunidad/inflamación sistémica (IIS) han mostrado utilidad en entidades neonatales. El objetivo de la investigación fue evaluar los índices inflamatorios como predictores de presencia, gravedad y mortalidad en ECN en RNPT.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Métodos: &lt;/strong&gt;Estudio observacional, retrospectivo. Se incluyeron RNPT de 26-36 semanas de gestación, con biometría hemática completa, distribuidos en dos grupos, con ECN (n = 85) y sin ECN (n = 85). Se registraron datos clínicos y hematológicos de los RNPT, así como la evolución y desenlace para los casos de ECN.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Resultados: &lt;/strong&gt;Se incluyeron 170 RNPT con edad gestacional de 32.5 (RIC: 31-34) semanas y peso de 1,402.5 g (RIC: 1,170-1,691 g), 52% hombres y 48% mujeres. Para ECN, la sensibilidad fue para INL 48%, IPL 8% e IIS 34%; especificidad del 98% de INL, IPL e IIS. Para ECN quirúrgica, sensibilidad del INL del 66%, IPL 20% e IIS 58%; especificidad del 95% de INL, IPL e IIS. Para ECN grave, sensibilidad del INL del 60%, IPL 15% e IIS 45%; especificidad del 90% de INL y 93% de IPL e IIS.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusiones: &lt;/strong&gt;El INL y el IIS demostraron ser predictores de diagnóstico, gravedad y desenlace quirúrgico de ECN, aunque no para mortalidad. Pueden ser marcadores de bajo costo y accesibles desde unidades de primer nivel hasta áreas neonatales especializadas.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Necrotizing enterocolitis (NEC) is a serious disease in preterm newborns (PTNBs) that requires predictive biomarkers. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immunity-inflammation index (SII) have proven useful in neonatal conditions. The study objective was to evaluate inflammatory indexes as predictors of NEC presence, severity and mortality in PTNBs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Retrospective, observational study. PTNBs at 26-36 weeks’ gestation with complete blood count were included and divided into two groups: those with NEC (n = 85) and without NEC (n = 85). Clinical and hematological data were recorded from participants, along with the course and outcome for those with NEC.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;One hundred seventy PTNBs infants with a gestational age of 32.5 (IQR: 31-34) weeks and a weight of 1,402.5 g (IQR: 1,170-1,691 g) were included, 52% male and 48% female. For NEC, sensitivity was 48% for the NLR, 8% for PLR, and 34% for SII; specificity was 98% for NLR, PLR, and SII. For surgical NEC, sensitivity was 66% for NLR, 20% for PLR, and 58% for SII; specificity was 95% for NLR, PLR, and SII. For severe NEC, sensitivity was 60% for NLR, 15% for PLR, and 45% for SII; the specificity was 90% for NLR, and 93% for PLR and SII.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;NLR and SII were shown to be predi","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"83 4","pages":"261-273"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148812005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}