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A kinase-directed approach to rescue functionality of F508del CFTR 一种激酶导向的F508del CFTR修复功能的方法
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016Proceedings.04
Venerando
{"title":"A kinase-directed approach to rescue functionality of F508del CFTR","authors":"Venerando","doi":"10.14304/FFC2016Proceedings.04","DOIUrl":"https://doi.org/10.14304/FFC2016Proceedings.04","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67005669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment and pharmacological correction of abnormalities in bicarbonate (HCO3-) and mucus transport in intestinal biopsies and organoids of CF patients CF患者肠道活检和类器官中碳酸氢盐(HCO3-)和粘液运输异常的评估和药理学纠正
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016Proceedings.02
H. D. Honge, S. Calderer
{"title":"Assessment and pharmacological correction of abnormalities in bicarbonate (HCO3-) and mucus transport in intestinal biopsies and organoids of CF patients","authors":"H. D. Honge, S. Calderer","doi":"10.14304/FFC2016Proceedings.02","DOIUrl":"https://doi.org/10.14304/FFC2016Proceedings.02","url":null,"abstract":"Hypothesis and objectives. Our major aims were (i) development of new protocols to measure bicarbonate transport in rectal biopsies and intestinal organoids from healthy controls and CF patients; (ii) ex vivo testing of CFTR correctors and potentiators for their ability to restore bicarbonate secretion in these models; (iii) validating the concept that CFTR functional variants associated with pancreatitis and sinusitis but not CF have a specific bicarbonate permeation defect.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67006110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The molecular structure and the folding of the whole Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): corrector sites 整个囊性纤维化跨膜传导调节因子(CFTR)的分子结构和折叠:校正位点
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016PROCEEDINGS.17
L. Satriano
{"title":"The molecular structure and the folding of the whole Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): corrector sites","authors":"L. Satriano","doi":"10.14304/FFC2016PROCEEDINGS.17","DOIUrl":"https://doi.org/10.14304/FFC2016PROCEEDINGS.17","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67006171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TRPA1 channels as novel molecular targets for anti-inflammatory therapies in CF lung TRPA1通道作为CF肺抗炎治疗的新分子靶点
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016PROCEEDINGS.19
P. Prandini
{"title":"TRPA1 channels as novel molecular targets for anti-inflammatory therapies in CF lung","authors":"P. Prandini","doi":"10.14304/FFC2016PROCEEDINGS.19","DOIUrl":"https://doi.org/10.14304/FFC2016PROCEEDINGS.19","url":null,"abstract":"Prandini P, De Logu F, Fusi C, Provezza L, Nassini R, Montagner G, Materazzi S, Munari S, Gilioli E, Bezzerri V, Finotti A, Lampronti I, Tamanini A, Dechecchi MC, Lippi G, Ribeiro CM, Rimessi A, Pinton P, Gambari R, Geppetti P, Cabrini G University Hospital of Verona, Italy, University of Florence, Italy; University of Ferrara, Italy; Marsico Lung Institute and University of North Carolina, Chapel Hill, NC, U.S.A. LTTA of the University of Ferrara, Italy. (Grant No. FFC#17/2014) [doi.org/bwkg]","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67006305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GSH inhalation therapies in CF: how useful, how safe? Set-up of a CF murine model for monitoring of inflammation in vivo and assessment of convenient alternatives 谷胱甘肽吸入治疗CF:有用吗，安全吗?建立CF小鼠模型，用于体内炎症监测和评估方便的替代方案
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016Proceedings.12
A. Corti
{"title":"GSH inhalation therapies in CF: how useful, how safe? Set-up of a CF murine model for monitoring of inflammation in vivo and assessment of convenient alternatives","authors":"A. Corti","doi":"10.14304/FFC2016Proceedings.12","DOIUrl":"https://doi.org/10.14304/FFC2016Proceedings.12","url":null,"abstract":"Corti A, Melotti P, Sorio C, Bergamini G, Hector A, Griese M, Pompella A Department of Translational Research NTMC, University of Pisa, Italy, Cystic Fibrosis Center – Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy, Department of Pathology & Diagnostics, University of Verona, Italy, University of Tübingen Children's Hospital, Tübingen, Germany, Children’s Hospital, Ludwig-Maximilians-University Munich, Germany (Grant No. FFC#18/2014) [doi.org/bwj7]","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67005708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Resolvin D1 for Targeting Chronic Lung Inflammation and Infection in cystic fibrosis Resolvin D1在囊性纤维化中靶向慢性肺部炎症和感染
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016Proceedings.22
A. Recchiuti
{"title":"Resolvin D1 for Targeting Chronic Lung Inflammation and Infection in cystic fibrosis","authors":"A. Recchiuti","doi":"10.14304/FFC2016Proceedings.22","DOIUrl":"https://doi.org/10.14304/FFC2016Proceedings.22","url":null,"abstract":"Recchiuti A, Mari VC, Codagnone M, Cianci E, Lamolinara A, Iezzi M, Bragonzi A, Moretti P, Nespoli A, Arita M, Romano M Department of Medical, Oral, and Biotechnology Science, Department of Medicine and Aging Science, and Center on Aging Sciences and Translational Medicine (CeSI-MeT) “G. d’Annunzio” University of ChietiPescara, Chieti, Italy; Infection and Cystic Fibrosis Unit, Division of Immunology, transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy; Centro Regionale Fibrosi Cistica, Ospedale San Salvatore, Atri (TE), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (Grant No.FFC#21/2014) [doi.org/bwkk]","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67006405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-inflammatory and anti-bacterial activity of bovine lactoferrin administered by aerosol in airway infections of pre-clinical wt and CF mouse models 雾化给药牛乳铁蛋白对临床前wt和CF小鼠气道感染的抗炎和抗菌活性
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016PROCEEDINGS.08
F. Berlutti
{"title":"Anti-inflammatory and anti-bacterial activity of bovine lactoferrin administered by aerosol in airway infections of pre-clinical wt and CF mouse models","authors":"F. Berlutti","doi":"10.14304/FFC2016PROCEEDINGS.08","DOIUrl":"https://doi.org/10.14304/FFC2016PROCEEDINGS.08","url":null,"abstract":"Background. In the airways, the CFTR genetic defect leads to dysregulation of inflammatory and iron homeostasis that precedes bacterial infection that, in turn, worsens host damage. Lactoferrin (Lf), an iron-chelating glycoprotein of the innate immunity present in airway secretions and secreted by neutrophils in infection/inflammation sites, in addition to the well-known antibacterial activity exerts a key role in inflammatory and iron homeostasis.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67005891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phage therapy against Pseudomonas aeruginosa infections in cystic fibrosis patients 噬菌体治疗囊性纤维化患者铜绿假单胞菌感染
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016PROCEEDINGS.20
D. Ghisotti, F. Forti, F. Briani
{"title":"Phage therapy against Pseudomonas aeruginosa infections in cystic fibrosis patients","authors":"D. Ghisotti, F. Forti, F. Briani","doi":"10.14304/FFC2016PROCEEDINGS.20","DOIUrl":"https://doi.org/10.14304/FFC2016PROCEEDINGS.20","url":null,"abstract":"Essential methods. Advantages on antibiotic therapy are that bacteriophages: 1) multiply at the infection site, increasing their number, whereas antibiotics are metabolized and eliminated from the body; 2) target only specific bacteria, with no effect on commensal flora; 3) contrary to antibiotics that are defined chemical molecules, phages can mutate and overcome bacterial resistance; 4) have the capacity to reach bacteria trapped inside biofilms, the matrix that acts as a shield for pathogenic bacteria in the CF patients lungs.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67006323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting PI3Kγ scaffold function to activate airway CFTR, limit lung inflammation and promote bronchorelaxation in cystic fibrosis 靶向PI3Kγ支架功能激活气道CFTR，限制肺炎症，促进囊性纤维化支气管舒张
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016PROCEEDINGS.26
A. Ghigo
{"title":"Targeting PI3Kγ scaffold function to activate airway CFTR, limit lung inflammation and promote bronchorelaxation in cystic fibrosis","authors":"A. Ghigo","doi":"10.14304/FFC2016PROCEEDINGS.26","DOIUrl":"https://doi.org/10.14304/FFC2016PROCEEDINGS.26","url":null,"abstract":"Ghigo A, Murabito A, Ren K, Pirozzi F, Ciraolo E, Montresor A, Richter W, Wenzel D, Matthey M, Quinneu NL, Fleischmann B, Gentzsch M, Laudanna C, Hirsch E Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy, Division of Internal Medicine, Department of Translational Medical Sciences, Federico II University, Naples, Italy, Department of Pathology and Diagnostics, Division of General Pathology, School of Medicine, Verona, Italy, University of South Alabama College of Medicine, Department of Biochemistry & Molecular Biology, Mobile, USA, Institute of Physiology I, Life & Brain Center, University of Bonn, Germany, Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA, Kither Biotech Srl, Torino, Italy (Grant No. FFC#23/2015) [doi.org/bwkq]","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67007018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the biological and therapeutic properties of mesoangioblasts-vessel associated progenitor cells- in the cell based therapy of the cystic fibrosis disease 血管相关祖细胞-成血管细胞在囊性纤维化细胞治疗中的生物学和治疗特性评价
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016PROCEEDINGS.03
Vezzali
{"title":"Evaluation of the biological and therapeutic properties of mesoangioblasts-vessel associated progenitor cells- in the cell based therapy of the cystic fibrosis disease","authors":"Vezzali","doi":"10.14304/FFC2016PROCEEDINGS.03","DOIUrl":"https://doi.org/10.14304/FFC2016PROCEEDINGS.03","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67006121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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