Phage therapy against Pseudomonas aeruginosa infections in cystic fibrosis patients

Abstract

Essential methods. Advantages on antibiotic therapy are that bacteriophages: 1) multiply at the infection site, increasing their number, whereas antibiotics are metabolized and eliminated from the body; 2) target only specific bacteria, with no effect on commensal flora; 3) contrary to antibiotics that are defined chemical molecules, phages can mutate and overcome bacterial resistance; 4) have the capacity to reach bacteria trapped inside biofilms, the matrix that acts as a shield for pathogenic bacteria in the CF patients lungs.