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Diabetic retinopathy for the non-ophthalmologist. 非眼科医生的糖尿病视网膜病变。
IF 4.4
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2022-03-01 DOI: 10.7861/clinmed.2021-0792
Timothy Hm Fung, Bakula Patel, Emma G Wilmot, Winfried Mk Amoaku
{"title":"Diabetic retinopathy for the non-ophthalmologist.","authors":"Timothy Hm Fung, Bakula Patel, Emma G Wilmot, Winfried Mk Amoaku","doi":"10.7861/clinmed.2021-0792","DOIUrl":"10.7861/clinmed.2021-0792","url":null,"abstract":"<p><p>Diabetic retinopathy is a microangiopathy resulting from the chronic effects of diabetes mellitus. Healthcare professionals often work in isolation to deliver highly specialised care efficiently and effectively for people living with diabetes. It is not uncommon for people with diabetes to be making frequent visits to community and hospital clinics to see a variety of specialists and healthcare professionals, with seemingly little opportunity for coordination of this complex health management programme between the wider team. In a field that is so diverse and rapidly changing, healthcare professionals of all specialties need to be aware of developments across all aspects of diabetes management. In this article, we discuss the epidemiology and natural history of diabetic retinopathy and describe an approach to its assessment and diagnosis. We provide an overview of the principles of diabetic retinopathy management and outline possible future treatments for diabetic retinopathy.</p>","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"4 1","pages":"112-116"},"PeriodicalIF":4.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89127562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Changing science, the next time around 社论:改变科学，下一次
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-09-20 DOI: 10.14304/SURYA.JPR.V6N9.2
T. Broek
{"title":"Editorial: Changing science, the next time around","authors":"T. Broek","doi":"10.14304/SURYA.JPR.V6N9.2","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V6N9.2","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48950934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of TET Proteins During Development TET蛋白在发育过程中的作用
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-05-20 DOI: 10.14304/SURYA.JPR.V6N5.2
Rita Khoueiry, Kian Peng Koh
{"title":"The Role of TET Proteins During Development","authors":"Rita Khoueiry, Kian Peng Koh","doi":"10.14304/SURYA.JPR.V6N5.2","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V6N5.2","url":null,"abstract":"In 2009, a new family of DNA modifying enzymes, the Tet-eleven translocation family was identified as 2-oxoglutarate (2-OG) and Fe(II)dependent dioxygenases. This family of enzymes comprises three proteins TET1, TET2 and TET3 that share a carboxyl-terminal core catalytic domain consisting of a conserved cysteine-rich domain, a double stranded β-helix domain and binding sites for the cofactors Fe(II) and 2oxoglutarate. At their amino-terminal region, TET1 and TET3 have a CXXC DNA-binding domain. Interestingly, during evolution, the segment encoding the CXXC domain of TET2 was separated from the region encoding the catalytic domain and is now encoded separately by a neighboring gene, IDAX (also called CXXC4).","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42947221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of Contractile Protein S-Nitrosation in Preterm Myometrium Underlies the Dysfunctional Relaxation to Nitric Oxide 早产子宫内膜收缩蛋白S-亚硝化的调节是一氧化氮功能性舒张障碍的基础
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-05-20 DOI: 10.14304/SURYA.JPR.V6N5.3
I. Buxton, S. Barnett
{"title":"Regulation of Contractile Protein S-Nitrosation in Preterm Myometrium Underlies the Dysfunctional Relaxation to Nitric Oxide","authors":"I. Buxton, S. Barnett","doi":"10.14304/SURYA.JPR.V6N5.3","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V6N5.3","url":null,"abstract":"Preterm labor leads to preterm delivery in over 50% of cases. Current treatment for preterm labor is inadequate and relies on findings in other smooth muscles. No treatment can prevent labor to allow a fetus to remain in the womb until term. Regulation of contraction/relaxation of the uterine smooth muscle is poorly understood. Recent work in our laboratory has revealed major disparity between term and preterm human uterine smooth muscle that suggests new approach to drug discovery.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46758164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publication Delays in Peer-Reviewed Journals of Otolaryngology, Audiology And Speech Language Pathoogy 耳鼻喉科、听力学和言语病理学同行评审期刊的出版延误
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-05-20 DOI: 10.14304/surya.jpr.v6n5.1
Yike Li, D. Zealer
{"title":"Publication Delays in Peer-Reviewed Journals of Otolaryngology, Audiology And Speech Language Pathoogy","authors":"Yike Li, D. Zealer","doi":"10.14304/surya.jpr.v6n5.1","DOIUrl":"https://doi.org/10.14304/surya.jpr.v6n5.1","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46066028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stock Risk Assessment via Multi-Objective Genetic Programming 基于多目标遗传规划的股票风险评估
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-03-20 DOI: 10.14304/SURYA.JPR.V6N3.6
A. Tahmassebi, A. Gandomi, A. Meyer-Baese
{"title":"Stock Risk Assessment via Multi-Objective Genetic Programming","authors":"A. Tahmassebi, A. Gandomi, A. Meyer-Baese","doi":"10.14304/SURYA.JPR.V6N3.6","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V6N3.6","url":null,"abstract":"Funding information None Recent exponential growth of investors in stock markets brings the idea to develop a predictive model to forecast the total risk of investment in stock markets. In this paper, an evolutionary approachwas proposed to predict the total risk in stock investment based on an S&P 500 database in a time period of 1991-2010 employing a multi-objective genetic programming alongwith an adaptive regression bymixing algorithm. The reasonable results suggest that the proposed model can be applied to various stock databases to assess the total risk of investment. The proposedmodel along with stock selection decision support systems can overcome the disadvantages of weighted scoring stock selection.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47756718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in Mammalian Cell Transfection Techniques 哺乳动物细胞转染技术的最新进展
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-03-20 DOI: 10.14304/surya.jpr.v6n3.5
A. Tay, N. Melosh
{"title":"Recent Advances in Mammalian Cell Transfection Techniques","authors":"A. Tay, N. Melosh","doi":"10.14304/surya.jpr.v6n3.5","DOIUrl":"https://doi.org/10.14304/surya.jpr.v6n3.5","url":null,"abstract":"Cell transfection is an essential step for gene editing and intracellular delivery of cargoes such as mRNA and proteins. Significant improvements have been made to reduce the cytotoxicity and to improve efficiency associated with transfection over the few decades. Nevertheless, with new, exciting biological questions, the demand for the ideal transfection technique with high throughput, single cell transfection ability and control of cargo dosage has increased. This review focuses on recent innovations in cell transfection techniques, and discusses the pros and cons of each method.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67014845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Editorial: Injecting new life into intracellular delivery methods 社论:给细胞内递送方法注入新的生命
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-03-20 DOI: 10.14304/SURYA.JPR.V6N3.4
K. M. Gschweng
{"title":"Editorial: Injecting new life into intracellular delivery methods","authors":"K. M. Gschweng","doi":"10.14304/SURYA.JPR.V6N3.4","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V6N3.4","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41892278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Leptin - The Central Regulator of Starvation 社论:瘦素-饥饿的中央调节器
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-03-20 DOI: 10.14304/surya.jpr.v6n3.1
V. Raje
{"title":"Editorial: Leptin - The Central Regulator of Starvation","authors":"V. Raje","doi":"10.14304/surya.jpr.v6n3.1","DOIUrl":"https://doi.org/10.14304/surya.jpr.v6n3.1","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43924946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Potential of Biologically Active Resin Glycoside Natural Products 生物活性树脂糖苷天然产物的治疗潜力
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-03-20 DOI: 10.14304/surya.jpr.v6n3.7
Ehesan U. Sharif
{"title":"Therapeutic Potential of Biologically Active Resin Glycoside Natural Products","authors":"Ehesan U. Sharif","doi":"10.14304/surya.jpr.v6n3.7","DOIUrl":"https://doi.org/10.14304/surya.jpr.v6n3.7","url":null,"abstract":"Resin glycosides are naturally occurring oligosaccharides, primarily found in the morning glory plants (convolvulaceous family). The unique structural feature of this class of natural products is the presence of a macrolactone ring. The hydrophobic side-chain of the macrolactone maintains a fine balance on the highly polar polysaccharide backbone, making them amphiphilic. Various parts of the morning glory plant have been used as folk medicines for centuries throughout the world. The commentary bellow emphasizes on the potential application of resin glycosides in the development of new therapies.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42599942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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