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Circadian-tumor suppressor crosstalk: Emerging opportunities in cancer chronotherapy 昼夜节律-肿瘤抑制因子串扰:癌症时间治疗的新机遇
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-03-20 DOI: 10.14304/SURYA.JPR.V6N3.3
T. Gotoh, Xianlin Zou, C. Finkielstein
{"title":"Circadian-tumor suppressor crosstalk: Emerging opportunities in cancer chronotherapy","authors":"T. Gotoh, Xianlin Zou, C. Finkielstein","doi":"10.14304/SURYA.JPR.V6N3.3","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V6N3.3","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44145424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Leptin in Maintaining Plasma Glucose During Starvation. 瘦素在饥饿时维持血浆葡萄糖的作用
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-03-01 DOI: 10.14304/surya.jpr.v6n3.2
Rachel J Perry, Gerald I Shulman
{"title":"The Role of Leptin in Maintaining Plasma Glucose During Starvation.","authors":"Rachel J Perry, Gerald I Shulman","doi":"10.14304/surya.jpr.v6n3.2","DOIUrl":"10.14304/surya.jpr.v6n3.2","url":null,"abstract":"<p><p>For 20 years it has been known that concentrations of leptin, a hormone produced by the white adipose tissue (WAT) largely in proportion to body fat, drops precipitously with starvation, particularly in lean humans and animals. The role of leptin to suppress the thyroid and reproductive axes during a prolonged fast has been well defined; however, the impact of leptin on metabolic regulation has been incompletely understood. However emerging evidence suggests that, in starvation, hypoleptinemia increases activity of the hypothalamic-pituitary-adrenal axis, promoting WAT lipolysis, increasing hepatic acetyl-CoA concentrations, and maintaining euglycemia. In addition, leptin may be largely responsible for mediating a shift from a reliance upon glucose metabolism (absorption and glycogenolysis) to fat metabolism (lipolysis increasing gluconeogenesis) which preserves substrates for the brain, heart, and other critical organs. In this way a leptin-mediated glucose-fatty acid cycle appears to maintain glycemia and permit survival in starvation.</p>","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"6 3","pages":"3-19"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909716/pdf/nihms959176.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36032174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent discoveries of Cohesin Establishment and Maintenance in Eukaryotes 真核生物中内聚蛋白建立与维持的新发现
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-01-20 DOI: 10.14304/SURYA.JPR.V6N1.3
Debjani Pal
{"title":"Recent discoveries of Cohesin Establishment and Maintenance in Eukaryotes","authors":"Debjani Pal","doi":"10.14304/SURYA.JPR.V6N1.3","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V6N1.3","url":null,"abstract":"Cohesin is multi-subunit protein that encompasses naked DNA. In eukaryotes, cohesin is essential for accurate segregation of the sister chromatids during mitosis and meiosis. Majority of cohesin complexes are removed from chromosomes during prophase in higher eukaryotes. WAPL mediated opening of the cohesin ring at the junction between the SMC3 ATPase domain and the N-terminal domain of cohesin's α-kleisin subunit has been shown in flies and human. Cohesin complex also plays a role in DNA damage repair, regulation of gene expression and chromosome condensation. In this commentary, recent discoveries of the mode of mechanism of cohesin establishment and maintenance in higher eukaryotes has been highlighted.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46033625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
6-Mercaptopurine Nucleoside Complexes of Gold(I): Synthesis and Cytotoxicity 金的6-巯基嘌呤核苷配合物(I):合成和细胞毒性
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-01-20 DOI: 10.14304/SURYA.JPR.V6N1.2
Ayan Maity, Nihal Deligonul, A. Berdis, Thomas G. Gray
{"title":"6-Mercaptopurine Nucleoside Complexes of Gold(I): Synthesis and Cytotoxicity","authors":"Ayan Maity, Nihal Deligonul, A. Berdis, Thomas G. Gray","doi":"10.14304/SURYA.JPR.V6N1.2","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V6N1.2","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41979815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mining gold to treat the untreatable: Design, Synthesis and Characterization of Gold Based Nucleosidic Compounds 采金处理难处理的物质：金基核苷化合物的设计、合成与表征
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2018-01-20 DOI: 10.14304/surya.jpr.v6n1.1
Sharmistha Mitra
{"title":"Mining gold to treat the untreatable: Design, Synthesis and Characterization of Gold Based Nucleosidic Compounds","authors":"Sharmistha Mitra","doi":"10.14304/surya.jpr.v6n1.1","DOIUrl":"https://doi.org/10.14304/surya.jpr.v6n1.1","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43844997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testing CFTR repair in cystic fibrosis patients carrying nonsense and channel gating mutations 检测携带无义和通道门控突变的囊性纤维化患者的CFTR修复
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-12-10 DOI: 10.14304/SURYA.JPR.FFC2017.3
C. Sorio, M. Averna
{"title":"Testing CFTR repair in cystic fibrosis patients carrying nonsense and channel gating mutations","authors":"C. Sorio, M. Averna","doi":"10.14304/SURYA.JPR.FFC2017.3","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.FFC2017.3","url":null,"abstract":"Background. In order to measure CFTR activity in a minimal invasive manner, we set up a method to assay functional CFTR and focussed on leukocytes from healthy and CF donors. Leukocytes are recognized in the scientific literature as a key component of the pathogenetic events associated to cystic fibrosis and represent an easily accessible source of primary cells that might be exploited to monitor CFTR expression and activity.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44732659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scanning Electron Microscopy Techniques For Preservation and Observation Of Microbe-Mineral Assemblages and Biominerals 微生物矿物组合和生物矿物的扫描电镜保存和观察技术
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-11-20 DOI: 10.14304/SURYA.JPR.V5N11.3
Wendy F. Smythe
{"title":"Scanning Electron Microscopy Techniques For Preservation and Observation Of Microbe-Mineral Assemblages and Biominerals","authors":"Wendy F. Smythe","doi":"10.14304/SURYA.JPR.V5N11.3","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N11.3","url":null,"abstract":"Scanning Electron Microscopy (SEM) of microbe-mineral assemblages can be challenging, especially when the objective is to characterize biominerals associated with cellular surfaces and exopolysaccharides (EPS). Biominerals are often loosely associated with the organic substrate on which they form making it difficult to determine the origin of minerals as biogenic or abiotic oxidation products. There are a variety of techniques that can be used for preservation of specimens ensuring that observation of desired relationships can be preserved. Here we examine various fixation, dehydration, and staining techniques using a suite of specimens in an effort to determine which technique works best with a particular type of biofilm. Types of biofilms used for this study included, biofilms attached to glass slides, flocculent non-cohesive biofilms, and cohesive highly mineralized biofilms. Microscopy was done to characterize the integrity of microorganisms, biominerals, microbemineral assemblages, alteration of specimens, and artifacts introduced during fixation and dehydration. Results indicate that vapor fixation of biofilms is the ideal methods of preservation for enumeration and characterization of biofilm architecture. Microbe-mineral assemblages remained intact when collected and immediately preserved in soft agar containing 2% glutaraldehyde.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49588757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noncoding RNA in cancer 癌症中的非编码RNA
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-11-20 DOI: 10.14304/SURYA.JPR.V5N11.5
Isabel A. Calvo
{"title":"Noncoding RNA in cancer","authors":"Isabel A. Calvo","doi":"10.14304/SURYA.JPR.V5N11.5","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N11.5","url":null,"abstract":"Non-coding RNAs (ncRNAs) are diverse classes of RNA molecules not translated into proteins, which possess intricate regulatory and structural functions. NcRNAs belong to a family of regulatory transcripts that affect every stage of gene expression, from transcription and mRNA stability to mRNA translation. Recent evidence has uncovered critical roles for noncoding RNAs in cancer pathogenesis. For example, variation of specific microRNAs has shown to drive tumorigenesis in human cancer cells and mouse models. Long noncoding RNAs (lncRNAs) have also been related to diverse cancer phenotypes and neurological disorders. NcRNAs are deeply involved in the regulation of key genes that are associated with cancer, representing a promising area for new therapies. This review focuses on ncRNAs, their role in cancer, and the translational implications of noncoding RNA research that may contribute to the development of innovative therapeutic solutions to treat cancer, and improve patients’ quality of life and survival.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46960824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Rot1 is degraded by ERAD: new insights into protein homeostasis of an essential gene Rot1被ERAD降解:一个重要基因的蛋白质稳态的新见解
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-11-20 DOI: 10.14304/SURYA.JPR.V5N11.1
Nimrat Chatterjee
{"title":"Rot1 is degraded by ERAD: new insights into protein homeostasis of an essential gene","authors":"Nimrat Chatterjee","doi":"10.14304/SURYA.JPR.V5N11.1","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N11.1","url":null,"abstract":"Rot1, an essential type-I ER (endoplasmic reticulum) membrane protein, is implicated in diverse functions as -1,6 glycan synthesis, actin cytoskeleton polarization dynamics, lysis of autophagic bodies and most importantly as a molecular chaperone [1-4]. For these varied roles, Rot1p adopts an unusual topology whereby the Nterminus, which gets glycosylated, faces the ER lumen and its single hydrophobic Cterminus with its essential serine-250 residue enables cell survivability [5, 6]. In addition, a comprehensive geneticinteraction analysis suggested its interaction with the proteasomal system. Whilst its diverse functions have been extensively studied; the dynamics of Rot1 protein stability in yeast cells is unknown. In this issue, Juanes et.al., [doi.org/cg8p] showed that the Rot1 protein stability is mediated by the ubiquitin proteasome system (UPS), which is dependent on the main degradation pathway located at the ER, the ER-associated degradation system (ERAD). Here the authors employed the GAL4 shut-off assay to ascertain the role of the ERAD system, Ubc6, Ubc7 and Hrd1, along with Pre1 and Pre2 of the UPS on Rot1 protein stability.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47794828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recommendations for improving international study programs in South Korea: a literature review 改善韩国国际学习项目的建议:文献综述
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-11-20 DOI: 10.14304/SURYA.JPR.V5N11.4
Justin Fendos
{"title":"Recommendations for improving international study programs in South Korea: a literature review","authors":"Justin Fendos","doi":"10.14304/SURYA.JPR.V5N11.4","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N11.4","url":null,"abstract":"The recruitment of international students (ISs) has been one of the most effective measures for offsetting declining domestic enrollments in higher education in western countries such as Australia and the UK. These declining enrollments were precipitated by changing demographics that resulted in a decline in the number of high school graduates. In recent years, South Korea has begun a similar decline, even though it is already a significant source of ISs migrating to other countries. The Korean government has sought various ways to increase the number of inbound ISs, but these efforts have been hampered by a number of issues, many of them rooted in cultural and institutional elements. This paper reviews the contemporary literature on these issues and attempt to combine the results into policy recommendations that may allow for the implementation of more sustainable IS programs. These issues and policy recommendations likely apply to the educational contexts of other countries, especially those with similar prospects for demographic change.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67014775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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