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Regulation of glycolysis in head and neck squamous cell carcinoma. 头颈部鳞状细胞癌中糖酵解的调节。
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-01-01 DOI: 10.14304/SURYA.JPR.V5N1.4
Dhruv Kumar
{"title":"Regulation of glycolysis in head and neck squamous cell carcinoma.","authors":"Dhruv Kumar","doi":"10.14304/SURYA.JPR.V5N1.4","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N1.4","url":null,"abstract":"Glycolysis is highly upregulated in head and neck squamous cell carcinoma (HNSCC). HNSCC glycolysis is an important contributor to disease progression and decreases sensitivity to radiation or chemotherapy. Despite therapeutic advances, the survival rates for HNSCC patients remain low. Understanding glycolysis regulation in HNSCC will facilitate the development of effective therapeutic strategies for this disease. In this review, we will evaluate the regulation of altered HNSCC glycolysis and possible therapeutic approaches by targeting glycolytic pathways.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"20 1","pages":"14-28"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73449194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Targeting extracellular protein disulphide isomerase to control Burkholderia cenocepacia lung infections 靶向细胞外蛋白二硫异构酶控制新绿伯克氏菌肺部感染
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016Proceedings.09
F. Pacello
{"title":"Targeting extracellular protein disulphide isomerase to control Burkholderia cenocepacia lung infections","authors":"F. Pacello","doi":"10.14304/FFC2016Proceedings.09","DOIUrl":"https://doi.org/10.14304/FFC2016Proceedings.09","url":null,"abstract":"Background. We have shown that the interaction between Burkholderia cenocepacia and lung epithelial cells is mediated by redox sensitive enzymes of the protein disulphide isomerase (PDI) family, in particular by ERp57. In fact, either thiol reactive agents (DTT, GSH, and DTNB) or ERp57 inhibitors are able to drastically reduce the adhesion and the invasion of B. cenocepacia into epithelial cells and to attenuate the proinflammatory response elicited by bacteria. These observations suggest that defects in GSH export in the airway surface liquid, observed in cystic fibrosis (CF) patients, may favour B. cenocepacia infection.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67005907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OPINION : Cancer Cell Psychology: When People Behave Like Cancer Cells 观点:癌细胞心理学:当人们表现得像癌细胞时
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/SURYA.JPR.V4N11.4
Nzola De Magalhães
{"title":"OPINION : Cancer Cell Psychology: When People Behave Like Cancer Cells","authors":"Nzola De Magalhães","doi":"10.14304/SURYA.JPR.V4N11.4","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V4N11.4","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67013850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cystic fibrosis modifier genes related to Pseudomonas aeruginosa lung disease 与铜绿假单胞菌肺病相关的囊性纤维化修饰基因
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016Proceedings.24
Il et al Lorè
{"title":"Cystic fibrosis modifier genes related to Pseudomonas aeruginosa lung disease","authors":"Il et al Lorè","doi":"10.14304/FFC2016Proceedings.24","DOIUrl":"https://doi.org/10.14304/FFC2016Proceedings.24","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67006504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting pathogenic pathways leading to inflammatory Th17 responses in cystic fibrosis: from drug discovery to preclinical validation 靶向致病性途径导致囊性纤维化的炎性Th17反应:从药物发现到临床前验证
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016PROCEEDINGS.23
M. Pariano
{"title":"Targeting pathogenic pathways leading to inflammatory Th17 responses in cystic fibrosis: from drug discovery to preclinical validation","authors":"M. Pariano","doi":"10.14304/FFC2016PROCEEDINGS.23","DOIUrl":"https://doi.org/10.14304/FFC2016PROCEEDINGS.23","url":null,"abstract":"Background. In patients with Cystic Fibrosis (CF), the progressive decline of pulmonary function is due to a vicious cycle of airways infection and inflammation. Inflammation can be more damaging than the insult itself if uncontrolled, excessive, or prolonged. Although there is debate over whether inflammation in the CF lung is primary (i.e., caused by CFTR mutations) or secondary to chronic infection, inflammation remains the single most significant contributor to disease progression, and its control is crucial for improving patient outcomes. Building upon the results from our past projects–indicating how the application of a systems biology approach and new findings from the laboratory may translate into the development of new therapeutics and rationales for their use–we have proposed a preclinical evaluation study of anakinra, a recombinant, non-glycosylated version of human IL-1 receptor I antagonist (IL-1Ra) in CF. Since 2001, anakinra has proved to be efficacious in a broad spectrum of autoinflammatory diseases with a remarkable record of safety.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67006429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis: computer assisted drug design, synthesis and biological evaluation 新型氨基芳基噻唑衍生物作为囊性纤维化氯离子转运缺陷校正剂:计算机辅助药物设计、合成和生物学评价
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016PROCEEDINGS.05
N. Liessi
{"title":"Novel aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis: computer assisted drug design, synthesis and biological evaluation","authors":"N. Liessi","doi":"10.14304/FFC2016PROCEEDINGS.05","DOIUrl":"https://doi.org/10.14304/FFC2016PROCEEDINGS.05","url":null,"abstract":"Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy, Department of Pharmacy, Section of Medicinal Chemistry, University of Genoa, Genoa, Italy, Istituto Giannina Gaslini, Genoa, Italy, Institute for Biomedical Technologies e National Research Council (ITB-CNR), Segrate (MI), Italy, Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Genoa, Italy. (FFC#7/2015) [doi.org/bwjx]","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67005703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A CF IL-8 transgenic mouse model for the in vivo long-term monitoring of the anti-inflammatory role of metallo-protease inhibitors and antibiotics with mechanisms of action similar to that of azithromycin 建立CF IL-8转基因小鼠模型，在体内长期监测金属蛋白酶抑制剂和类似阿奇霉素作用机制的抗生素的抗炎作用
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016PROCEEDINGS.06
A. Sandri
{"title":"A CF IL-8 transgenic mouse model for the in vivo long-term monitoring of the anti-inflammatory role of metallo-protease inhibitors and antibiotics with mechanisms of action similar to that of azithromycin","authors":"A. Sandri","doi":"10.14304/FFC2016PROCEEDINGS.06","DOIUrl":"https://doi.org/10.14304/FFC2016PROCEEDINGS.06","url":null,"abstract":"Sandri A, Bergamini G, Ortombina A, Boschi F, Sorio C, Melotti P, Stellari F, Lleò MM Dipartimento di Diagnostica e Salute Pubblica, Sezione di Microbiologia, Dipartimento di Informatica, Dipartimento di Medicina, Sezione Patologia, Università di Verona, Italy; Centro Regionale per la Fibrosi Cistica, AOUI Verona, Italy, Dipartimento di Farmacologia e Tossicologia, Chiesi Farmaceutici, Parma, Italy (FFC#10/2015) [doi.org/bwjz]","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67005749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intra-individual biological variation in sweat chloride concentrations 汗液氯化物浓度的个体内生物学变异
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016Proceedings.31
N. Cirilli
{"title":"Intra-individual biological variation in sweat chloride concentrations","authors":"N. Cirilli","doi":"10.14304/FFC2016Proceedings.31","DOIUrl":"https://doi.org/10.14304/FFC2016Proceedings.31","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"225 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67007610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of L-Proline in Stabilization of Biological Membranes l -脯氨酸在生物膜稳定中的作用
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/SURYA.JPR.V4N11.3
Li-Wen Weng
{"title":"Role of L-Proline in Stabilization of Biological Membranes","authors":"Li-Wen Weng","doi":"10.14304/SURYA.JPR.V4N11.3","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V4N11.3","url":null,"abstract":"L-proline, a natural I±-amino acid, has been found useful as an osmoprotectant and antioxidant. It can prevent the denaturation of...","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"11 1","pages":"18-21"},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67013762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells 通过综合计算和实验方法获得的CF细胞ptc的新分子的鉴定和验证
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2016-11-20 DOI: 10.14304/FFC2016PROCEEDINGS.01
A. Leonardo, A. Pace, R. Melfi, I. Pibiri, L. Lentini, M. Tutone, G. Barone
{"title":"Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells","authors":"A. Leonardo, A. Pace, R. Melfi, I. Pibiri, L. Lentini, M. Tutone, G. Barone","doi":"10.14304/FFC2016PROCEEDINGS.01","DOIUrl":"https://doi.org/10.14304/FFC2016PROCEEDINGS.01","url":null,"abstract":"Background. Cystic Fibrosis patients with nonsense-mutation in the CFTR gene generally make virtually no CFTR protein and thus often have a more severe form of CF. Recently, Ataluren (formerly PTC124) was suggested to induce the read-through of premature termination codons (PTCs) mainly the UGA codon. However, despite promising results there is not a general consensus of Ataluren efficacy and mechanism of action.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67006066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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