Breast最新文献

{"title":"Response to Verma et al., Letter to the editor","authors":"Natali Shiron , Ayelet Shai","doi":"10.1016/j.breast.2026.104713","DOIUrl":"10.1016/j.breast.2026.104713","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"86 ","pages":"Article 104713"},"PeriodicalIF":7.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between alcohol consumption and breast cancer incidence and prognosis: A systematic review and meta-analysis","authors":"Luca Arecco ,&nbsp;Pedro M. Cacilhas ,&nbsp;Camila Bobato Lara Gismondi ,&nbsp;Marco Bruzzone ,&nbsp;Gabriella Gentile ,&nbsp;Riccardo Gerosa ,&nbsp;Eva Blondeaux ,&nbsp;Elisa Agostinetto ,&nbsp;Chiara Dauccia ,&nbsp;Soraia Lobo-Martins ,&nbsp;Rafael Grochot ,&nbsp;Kamal S. Saini ,&nbsp;Hatem A. Azim Jr. ,&nbsp;Marcio Debiasi ,&nbsp;Alex De Caluwé ,&nbsp;Laurence Buisseret ,&nbsp;Lucia Del Mastro ,&nbsp;Matteo Lambertini ,&nbsp;Evandro de Azambuja","doi":"10.1016/j.breast.2026.104719","DOIUrl":"10.1016/j.breast.2026.104719","url":null,"abstract":"<div><h3>Background</h3><div>While alcohol consumption appears to influence the incidence of breast cancer (BC), its association with prognosis after a BC diagnosis remains less established. This meta-analysis aimed to explore the association between alcohol consumption on both BC incidence and outcomes.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted up to May 1st, 2025 (CRD42025593784). Retrospective and prospective studies reporting BC incidence, recurrences, and survival outcomes in women with history of alcohol consumption were included. Analyses according to alcohol intake levels (light, intermediate, heavy consumption) were performed. Main outcomes were BC incidence, BC recurrences, BC-specific survival (BCSS), and overall survival (OS). Pooled relative risk (RR) and hazard ratio (HR) with 95% confidence interval (CI) were calculated.</div></div><div><h3>Results</h3><div>Out of 5208 screened records, 37 studies including 2,565,920 women were included.</div><div>Among 17 studies reporting on BC incidence, any alcohol consumption was associated with an increased BC incidence (RR 1.17, 95%CI 1.09–1.26; p &lt; 0.001). BC incidence increased proportionally with higher levels of alcohol consumption: light RR 1.13 (95%CI 1.05–1.23; p = 0.002), intermediate RR 1.28 (95%CI 1.18–1.39; p &lt; 0.001)​, and heavy consumption RR 1.52 (95%CI 1.38–1.67; p &lt; 0.001).</div><div>Among 20 studies assessing BC outcomes, no associations were found between alcohol consumption and BC recurrences (RR 1.02, 95%CI 0.93–1.11) nor BCSS (HR 0.93, 95%CI 0.87–1.00), while light and intermediate alcohol consumption were associated with slightly improved OS: HR 0.85 (95%CI 0.78–0.92; p &lt; 0.001) and HR 0.84 (95%CI 0.75–0.94; p = 0.002), respectively.</div></div><div><h3>Conclusions</h3><div>Among over 2.5 million women, alcohol consumption was associated with a dose-dependent increased risk of BC, while alcohol consumption did not appear to worsen prognosis in patients with prior BC diagnosis.</div></div>","PeriodicalId":9093,"journal":{"name":"Breast","volume":"86 ","pages":"Article 104719"},"PeriodicalIF":7.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgeon seniority and performance in breast-conserving surgery for non-palpable lesions: evidence from a multicenter study","authors":"Fabio Corsi MD ,&nbsp;Maria Luisa Gasparri MD, PhD ,&nbsp;Sara Albasini MsC ,&nbsp;Matilde Pelizzola MsC ,&nbsp;Carlo Morasso PhD ,&nbsp;Giulia Armatura MD, PhD ,&nbsp;Alessandro Asaro MD ,&nbsp;Virginia Casati MD ,&nbsp;Corrado Chiappa MD ,&nbsp;Virginia Coli MD ,&nbsp;Francesca Combi MD ,&nbsp;Andrea Cuccaro MD ,&nbsp;Angelica Della Valle MD ,&nbsp;Raimondo Di Giacomo MD ,&nbsp;Secondo Folli MD ,&nbsp;Massimo Maria Grassi MD ,&nbsp;Stefano Mancini MD ,&nbsp;Ilaria Maugeri MD ,&nbsp;Andrea Papadia MD, PhD ,&nbsp;Laura Roveda MD ,&nbsp;Simone Zanotti MD","doi":"10.1016/j.breast.2026.104736","DOIUrl":"10.1016/j.breast.2026.104736","url":null,"abstract":"<div><div>Breast-conserving surgery (BCS) for non-palpable lesions is technically demanding, often performed by surgical trainees under supervision. Despite extensive literature evaluating localization techniques, only few studies have directly examined the role of surgeon seniority in determining surgical performance in this specific setting.</div><div>We conducted a retrospective multicenter analysis (LOCALIZATION01 study, NCT05942105) including 3,195 patients who underwent BCS for non-palpable breast lesions between 2016 and 2024 across 12 Breast Units. Four localization techniques were used: wire-guided (WGL), radioguided occult lesion localization (ROLL), magnetic seed localization (MSL), carbon localization (CL). Outcomes included margin status, calculated resection ratio (CRR), operative time, and complications, stratified by surgeon seniority (attending vs resident).</div><div>Most procedures were performed by attending surgeons (89.3%, n = 2,855) compared to residents (10.7%, n = 340). Margin positivity rates didn't differ significantly across localization techniques (e.g., ROLL 3.7% vs 2.3%, p = 0.30; MSL 9.4% vs 4.4%, p = 0.11, WGL 2.7% vs 5.9 p = 0.16, CL 0% vs 9.6% p = 0.10). Residents achieved better CRR in ROLL procedures (2.0, IQR 3, [1-47] vs 2.8, IQR 5, [1-78], p = 0.006), but had longer operative times, particularly with SLNB (e.g., MSL 60 min, IQR 31, [37-98] vs 55 min, IQR 20, [18−180], p = 0.02). Complication rates were low and comparable between groups.</div><div>In a supervised setting, surgeon seniority doesn't significantly impact margin status, complication rates, or overall oncologic safety in BCS for non-palpable breast lesions. Localization methods with high reproducibility, such as ROLL and MSL, may mitigate the influence of surgical inexperience. These findings support the safe involvement of trainees in BCS under adequate supervision.</div></div>","PeriodicalId":9093,"journal":{"name":"Breast","volume":"86 ","pages":"Article 104736"},"PeriodicalIF":7.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness comparison of first-line CDK4/6 inhibitors in patients with hormone-positive HER2-negative advanced breast cancer according to tumor histology: a sub-analysis of the real-world, multicenter, Italian study PALMARES-2","authors":"Giacomo Mazzoli ,&nbsp;Leonardo Provenzano ,&nbsp;Maria Vittoria Dieci ,&nbsp;Giuseppe Curigliano ,&nbsp;Mario Giuliano ,&nbsp;Andrea Botticelli ,&nbsp;Matteo Lambertini ,&nbsp;Gianpiero Rizzo ,&nbsp;Rebecca Pedersini ,&nbsp;Marianna Sirico ,&nbsp;Nicla La Verde ,&nbsp;Alessandra Gennari ,&nbsp;Alberto Zambelli ,&nbsp;Angela Toss ,&nbsp;Marta Piras ,&nbsp;Monica Giordano ,&nbsp;Barbara Tagliaferri ,&nbsp;Daniele Generali ,&nbsp;Donata Sartori ,&nbsp;Giuseppe Fotia ,&nbsp;Claudio Vernieri","doi":"10.1016/j.breast.2026.104692","DOIUrl":"10.1016/j.breast.2026.104692","url":null,"abstract":"<div><h3>Introduction</h3><div>Invasive lobular breast cancer (ILC) is the second most common breast cancer subtype, with distinctive biological and epidemiologic features. Although phase III trials of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in hormone receptor-positive, HER2-negative advanced breast cancer (HR+/HER2-aBC) included patients with ILC, their real-world effectiveness in this population remains poorly characterized.</div></div><div><h3>Material and methods</h3><div>In this sub-analysis of the multicenter, real-world PALMARES-2 study (NCT06805812), we assessed the predictive and prognostic value of lobular histology in HR+/HER2-aBC treated with first-line endocrine therapy (ET) plus CDK4/6i. The primary endpoint was real-world progression-free survival (rwPFS). Associations between histology and outcomes were adjusted for 15 covariates using multivariable Cox-regression and inverse probability of treatment weighting.</div></div><div><h3>Results</h3><div>Among 1982 patients, 367 (18.5 %) had ILC and 1481 (74.7 %) non-special type (NST). Median follow-up was 29.8 and 31.2 months, respectively. ILC was associated with shorter rwPFS versus NST (adjusted hazard ratio [aHR]: 1.24, 95 %CI:1.04–1.47, <em>P=</em>0.017). Palbociclib efficacy was not affected by lobular histology (<em>P</em> for interaction = 0.553) while abemaciclib was less effective in ILC (<em>P</em> = 0.009). All three CDK4/6i achieved similar rwPFS in ILC (ribociclib vs palbociclib: aHR: 1.01, 95 %CI: 0.67–1.45, <em>P</em> = 0.949; abemaciclib vs palbociclib: aHR: 1.13, 95 %CI: 0.75–1.71, <em>P</em> = 0.551; abemaciclib vs ribociclib: aHR: 1.15, 95 %CI: 0.73–1.80, <em>P</em> = 0.549).</div></div><div><h3>Conclusions</h3><div>Tumor histology affects the real-world effectiveness of first line ET plus CDK4/6i. In ILC, all three CDK4/6i performed similarly; therefore, treatment selection should prioritize tolerability, manageability, drug-drug interactions, and patient preferences.</div></div>","PeriodicalId":9093,"journal":{"name":"Breast","volume":"86 ","pages":"Article 104692"},"PeriodicalIF":7.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous pertuzumab–trastuzumab: Efficiency, safety, and the biosimilar horizon","authors":"Asim Armagan Aydin ,&nbsp;Erkan Kayikcioglu","doi":"10.1016/j.breast.2025.104651","DOIUrl":"10.1016/j.breast.2025.104651","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"86 ","pages":"Article 104651"},"PeriodicalIF":7.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reevaluating outcomes in prepectoral breast reconstruction: The unaccounted impact of patient selection and radiotherapy timing.","authors":"Mingxing Xu, Da Qian, Bo Wang","doi":"10.1016/j.breast.2026.104762","DOIUrl":"https://doi.org/10.1016/j.breast.2026.104762","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":" ","pages":"104762"},"PeriodicalIF":7.9,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrine time zero, endocrine effect? Re-reading OFS+AI after residual disease.","authors":"Anxin Wen","doi":"10.1016/j.breast.2026.104768","DOIUrl":"https://doi.org/10.1016/j.breast.2026.104768","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":" ","pages":"104768"},"PeriodicalIF":7.9,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Wein et al.: Endocrine time zero, endocrine effect? Re-reading OFS+AI after residual disease.","authors":"Ayelet Shai, Natali Shiron","doi":"10.1016/j.breast.2026.104753","DOIUrl":"https://doi.org/10.1016/j.breast.2026.104753","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":" ","pages":"104753"},"PeriodicalIF":7.9,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147526686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on: A. G. Nerlich, J. C. Dewaal, A. Perciaccante, S. Di Cosimo, L. Cortesi, J. Wimmer, S. T. Donnell, R, Bianucci: Did Michelangelo paint a young adult woman with breast cancer in \"The Flood\" (Sistine Chapel, Rome)? Breast 2024, 78, 103823.","authors":"Paul Gelinsky","doi":"10.1016/j.breast.2026.104755","DOIUrl":"https://doi.org/10.1016/j.breast.2026.104755","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":" ","pages":"104755"},"PeriodicalIF":7.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EUSOMA recommendations without EUSOMA certification: a credibility gap.","authors":"Wiebren A Tjalma","doi":"10.1016/j.breast.2026.104754","DOIUrl":"https://doi.org/10.1016/j.breast.2026.104754","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":" ","pages":"104754"},"PeriodicalIF":7.9,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}