Breast最新文献

{"title":"8th International consensus guidelines for the management of advanced breast cancer (ABC8 guidelines).","authors":"Fatima Cardoso, Joana Mourato Ribeiro, Eva Schumacher-Wulf, Sandra M Swain, Shani Paluch-Shimon, Frederique Penault-Llorca, Nancy U Lin, Prudence A Francis, Marion Kuper-Hommel, Anne May, Florentine Hilbers, Angel Guerrero, Matti S Aapro, Rania Azmi, Jyoti Bajpai, Carlos Barrios, Laura Biganzoli, Fran Boyle, Valeria Caceres, Lisa A Carey, Mariana Chavez-MacGregor, Javier Cortés, Rebecca Dent, Amanda Drury, Nagi S El Saghir, Hesham Elghazaly, Alexandru Eniu, Lesley Fallowfield, Sandra Ximena Franco Millan, Karen Gelmon, Jenny Gilchrist, Joseph Gligorov, William J Gradishar, Nadia Harbeck, Xichun Hu, Orit Kaidar-Person, Ranjit Kaur, Belinda Kiely, Sung-Bae Kim, Sarah Kutika Nyagabona, Maryam Lustberg, Volkmar Mueller, Miriam Mutebi, Silvia Neciosup, Shinji Ohno, Barbara Pistilli, Hope S Rugo, Tanja Spanic, Janice Tsang, Peter Vuylsteke, Binghe Xu, Larry Norton, Eric P Winer","doi":"10.1016/j.breast.2026.104921","DOIUrl":"https://doi.org/10.1016/j.breast.2026.104921","url":null,"abstract":"<p><p>The Advanced Breast Cancer (ABC) 8th international consensus conference took place on 6-8 November 2025, in Lisbon, and updated the previous ABC international consensus guidelines that are described in this manuscript. These guidelines reflect the work of a large and global consensus panel, comprising healthcare professionals and patients, and provide recommendations on how to best manage patients with advanced breast cancer (inoperable locally advanced or metastatic), of all breast cancer subtypes. The guidelines are based on the best available evidence or on expert opinion when a higher level of evidence is lacking and aim to cover the needs of the person living with ABC, including but also beyond the main therapeutic recommendations. Each guideline is accompanied by the level of evidence (LoE), the grade of recommendation (GoR), and the percentage of consensus reached at the consensus session. Updated diagnostic and treatment algorithms are also provided. These guidelines are endorsed by several international oncology organizations (AGO, AORTIC, ECO, EONS, ESO, ESTRO, EUSOMA, GECO Perú, SUMA, MASCC, French Breast Cancer Guidelines and AMAAC) and have official representation from ASCO, NCCN and ABC-NZ. Inequalities in access to high-quality care have increased in the last decade, both between and within countries, and are a major concern. The ABC guidelines provide guidance on the best available management options for patients living with ABC globally, assuming availability of the recommended therapies. Their adaptation is often needed in resource-constrained settings, and the grading of each recommendation may help in prioritizing access to available options.</p>","PeriodicalId":9093,"journal":{"name":"Breast","volume":"90 ","pages":"104921"},"PeriodicalIF":5.2,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Less is more? Questioning the walking dose in the WISE trial","authors":"Gai Liang,&nbsp;Feng Yuan","doi":"10.1016/j.breast.2026.104829","DOIUrl":"10.1016/j.breast.2026.104829","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"88 ","pages":"Article 104829"},"PeriodicalIF":5.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148194278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on: A. G. Nerlich, J. C. Dewaal, A. Perciaccante, S. Di Cosimo, L. Cortesi, J. Wimmer, S. T. Donnell, R, Bianucci: Did Michelangelo paint a young adult woman with breast cancer in “The Flood” (Sistine Chapel, Rome)? Breast 2024, 78, 103823","authors":"Paul Gelinsky","doi":"10.1016/j.breast.2026.104755","DOIUrl":"10.1016/j.breast.2026.104755","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"88 ","pages":"Article 104755"},"PeriodicalIF":5.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on comparator design in regional versus general anesthesia for ambulatory breast-conserving surgery","authors":"Ming-Hui Hung,&nbsp;Shu-Yueh Cheng","doi":"10.1016/j.breast.2026.104854","DOIUrl":"10.1016/j.breast.2026.104854","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"88 ","pages":"Article 104854"},"PeriodicalIF":5.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Enhanced prognostic score for breast cancer brain metastases incorporating contemporary clinical features and leptomeningeal disease: development and validation” [The Breast 88 (2026) 104826]","authors":"Yun Hwa Roh,&nbsp;Dongyeong Kim,&nbsp;Ho Sung Kim,&nbsp;Seo Young Park,&nbsp;Shinkyo Yoon,&nbsp;Jae Ho Jeong,&nbsp;Sang Woo Song,&nbsp;Young-Hoon Kim,&nbsp;Young Hyun Cho,&nbsp;Beomseok Sohn,&nbsp;Ji Eun Park","doi":"10.1016/j.breast.2026.104858","DOIUrl":"10.1016/j.breast.2026.104858","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"88 ","pages":"Article 104858"},"PeriodicalIF":5.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EUSOMA recommendations without EUSOMA certification: a credibility gap","authors":"Wiebren A. Tjalma","doi":"10.1016/j.breast.2026.104754","DOIUrl":"10.1016/j.breast.2026.104754","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"88 ","pages":"Article 104754"},"PeriodicalIF":5.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary meeting for breast cancer care: EUSOMA recommendations for optimization","authors":"G. Curigliano,&nbsp;L. Marotti,&nbsp;C. Barrios,&nbsp;N.M.L. Battisti,&nbsp;K.L. Cheung,&nbsp;S. Chia,&nbsp;S.L. Graff,&nbsp;O.J. Hartmann,&nbsp;I. Rubio,&nbsp;D. Santini,&nbsp;F. Sardanelli,&nbsp;E. Senkus,&nbsp;P. van Dam,&nbsp;M. Walker,&nbsp;J. Wu,&nbsp;C. Aristei","doi":"10.1016/j.breast.2026.104828","DOIUrl":"10.1016/j.breast.2026.104828","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"88 ","pages":"Article 104828"},"PeriodicalIF":5.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From CDK4/6 to CDK2 and KAT: Evolving therapeutic approaches in HR+/HER2– breast cancer","authors":"Paulina Stachyra,&nbsp;Cristina Hernando Meliá,&nbsp;José Antonio López-Guerrero,&nbsp;Joaquín Gavilá Gregori,&nbsp;Ángel Luis Guerrero-Zotano","doi":"10.1016/j.breast.2026.104806","DOIUrl":"10.1016/j.breast.2026.104806","url":null,"abstract":"<div><div>Despite the initial clinical success of CDK4/6 inhibitors in combination with endocrine therapy, the development of resistance (intrinsic and acquired) remains a significant challenge in the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2–) metastatic breast cancer (mBC). Emerging evidence highlights cell cycle reprogramming as a central mechanism of resistance, driven by alterations such as RB1 loss, cyclin E1 overexpression with CDK2 activation, and CDK4/6 upregulation, enabling bypass of CDK4/6 dependency. While additional pathways, including PI3K/AKT/mTOR and FGFR signaling, also contribute, their relative importance varies across tumor contexts. These findings have highlighted the need for next-generation therapeutic approaches aimed at overcoming resistance. Selective targeting of CDK2 and CDK4 represents a promising approach, particularly by inhibiting CDK2-mediated escape mechanisms and improving therapeutic index. Early-phase clinical trials have shown encouraging activity, although evidence remains limited. Beyond cell cycle kinases, epigenetic regulators such as lysine acetyltransferases (KATs) have emerged as novel therapeutic targets, with the potential to restore endocrine sensitivity and modulate oncogenic transcriptional programs. In parallel, AURKA inhibitors are being explored to target cell cycle reprogramming associated with resistance. This review focuses on cell cycle–centric mechanisms of resistance to CDK4/6 inhibitors, with particular emphasis on CDK2/CDK4-directed strategies and emerging epigenetic approaches such as KAT inhibition.</div></div>","PeriodicalId":9093,"journal":{"name":"Breast","volume":"88 ","pages":"Article 104806"},"PeriodicalIF":5.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148625230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “From CDK4/6 to CDK2 and KAT: Evolving therapeutic approaches in HR+/HER2– breast cancer” [The Breast 88 (2026) 104791]","authors":"Paulina Stachyra,&nbsp;Cristina Hernando Meliá,&nbsp;José Antonio López-Guerrero,&nbsp;Joaquín Gavilá Gregori,&nbsp;Ángel Luis Guerrero-Zotano","doi":"10.1016/j.breast.2026.104805","DOIUrl":"10.1016/j.breast.2026.104805","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"88 ","pages":"Article 104805"},"PeriodicalIF":5.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148625251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withdrawal notice to: “From CDK4/6 to CDK2 and KAT: Evolving therapeutic approaches in HR+/HER2– breast cancer” [The Breast 88 (2026) 104791]","authors":"Paulina Stachyra,&nbsp;Cristina Hernando Meliá,&nbsp;José Antonio López-Guerrero,&nbsp;Joaquín Gavilá Gregori,&nbsp;Ángel Luis Guerrero-Zotano","doi":"10.1016/j.breast.2026.104864","DOIUrl":"10.1016/j.breast.2026.104864","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"88 ","pages":"Article 104864"},"PeriodicalIF":5.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}