Physicians’ knowledge, practice, and attitudes on fertility and pregnancy-related issues in young women with advanced breast cancer: results of the ABC6 and ABC7 survey

IF 5.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Pub Date : 2025-04-24 DOI:10.1016/j.breast.2025.104479

Simone Nardin , Luca Arecco , Virginia Delucchi , Eva Blondeaux , Mihaela Stana , Luciana de Moura Leite , Luiza Nardin Weis , Giang Pham Hoang , Arianna Daneri , Francesca Bruzzone , Arianna Meacci , Chiara Molinelli , Maria Grazia Razeti , Martina Perrone , Shani Paluch-Shimon , Ann H. Partridge , Fatima Cardoso , Tanja Spanic , Joanna Kufel-Grabowska , Matteo Lambertini

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引用次数: 0

Abstract

Background

Fertility and pregnancy-related issues are critical for young patients with breast cancer. No proper evidence exists on physicians' knowledge, practice, and attitudes on dealing with these concerns in the specific group of patients with advanced disease.

Methods

A 26-item questionnaire was administered via e-mail in December 2023 to physicians who attended the ABC6 consensus conference (virtually, November 2021) and those who were registered for the ABC7 consensus conference (Lisbon, November 2023). The questionnaire was divided into 3 main sections: 1) demographic, medical training, and background information; 2) knowledge, practice, and attitudes of physicians towards fertility preservation and pregnancy-related issues in patients with advanced breast cancer; 3) approach to hypothetical clinical cases.

Results

A total of 133 physicians completed the survey. Most reported discussing always (40.6 %) or usually (36.1 %) the possible treatment-related loss of ovarian function in patients with advanced breast cancer. Regarding fertility preservation and pregnancy-related issues, 23.3 % would always feel comfortable discussing these topics with patients, and 45.9 % would feel comfortable depending on the clinical situation. 20.3 % reported not prescribing any type of contraception, and 10–20 % would prescribe treatments that are contraindicated during pregnancy.

Conclusions

Our survey showed that many concerns exist when discussing and dealing with fertility and pregnancy-related issues in patients with advanced breast cancer. It is essential to increase physicians' awareness on how to address fertility and pregnancy-related issues in patients with advanced breast cancer, especially as oncological treatments continue to improve, resulting in longer survival and, in some cases, potential cure.

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医生对年轻晚期乳腺癌妇女生育和妊娠相关问题的知识、实践和态度：ABC6和ABC7调查结果

生育和妊娠相关问题对年轻乳腺癌患者至关重要。没有适当的证据表明医生在处理特定的晚期疾病患者群体中对这些问题的知识、实践和态度。方法于2023年12月通过电子邮件对参加ABC6共识会议（虚拟会议，2021年11月）的医生和注册参加ABC7共识会议（里斯本会议，2023年11月）的医生进行26项问卷调查。问卷分为3个主要部分：1)人口统计、医学培训和背景信息；2)医生对晚期乳腺癌患者保留生育能力及妊娠相关问题的认识、实践和态度；3)假设性临床病例处理方法。结果共133名医生完成调查。大多数报道总是（40.6%）或通常（36.1%）讨论晚期乳腺癌患者可能与治疗相关的卵巢功能丧失。对于保留生育能力和妊娠相关的问题，23.3%的人认为与患者讨论这些话题是很舒服的，45.9%的人认为根据临床情况而定。20.3%的医生报告没有开任何避孕处方，10 - 20%的医生会开孕期禁忌症的治疗处方。结论我们的调查显示，在讨论和处理晚期乳腺癌患者的生育和妊娠相关问题时存在许多担忧。提高医生对如何处理晚期乳腺癌患者的生育和妊娠相关问题的认识是至关重要的，特别是随着肿瘤治疗的不断改进，患者的生存时间更长，在某些情况下，还可能治愈。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast 医学-妇产科学

CiteScore

8.70

自引率

2.60%

发文量

165

审稿时长

59 days

期刊介绍： The Breast is an international, multidisciplinary journal for researchers and clinicians, which focuses on translational and clinical research for the advancement of breast cancer prevention, diagnosis and treatment of all stages.