A population-based estimation of breast cancer recurrence in northeast Italy with administrative healthcare databases

IF 7.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Pub Date : 2025-05-01 DOI:10.1016/j.breast.2025.104487

Fabiola Giudici , Federica Toffolutti , Stefano Guzzinati , Francesco Schettini , Marina Bortul , Silvia Francisci , Manuel Zorzi , Sara De Vidi , Daniela Pierannunzio , Luigino Dal Maso

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引用次数: 0

Abstract

Background/Aim

Information on the long-term frequency of recurrence is of paramount importance for the increasing number of women living several years after breast cancer (BC) diagnosis and for their caregivers.

The study aims to estimate the cumulative incidence of recurrence until 10 years after diagnosis in Italian women diagnosed with BC using population-based cancer registries.

Methods

Women diagnosed with stage I to III BC during 2004–2010 from Friuli Venezia Giulia and Veneto (Italy) cancer registries were included (n = 5825). Recurrence status after a disease-free period was ascertained through individual-level linked databases using treatment or procedure codes from claims. Cumulative incidence of recurrence was calculated in the presence of competing risks (second cancer or death).

Results

During a median follow-up of 13.5 years, 1522 out of 5825 women experienced a recurrence with an estimated 10-years cumulative incidence of 20.8 % (95 %CI:19.7–21.8 %), decreasing from 23.7 % in 2004–2006 to 18.5 % in 2007–2010. Women younger than 40 years (40.5 %), with stage III (41.8 %) and triple-negative BC (32.5 %) showed a higher 10-year incidence of recurrence.

At 10 years after a BC diagnosis, 83.9 % of women were alive: 67.5 % without any cancer-related events, 12.4 % after recurrence and 4.0 % after second primary cancer. 10-years survival was higher than 90 % for women with stage I BC and 58.1 % for those with stage III (3.2 % and 27.3 % deaths after recurrence, respectively).

Discussion

This Italian study provide detailed population-based information on the incidence of recurrence and other outcomes after BC and may be replicated in other Italian and European areas.

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基于人口的估计乳腺癌复发在意大利东北部的行政保健数据库

背景/目的对于越来越多的乳腺癌（BC）诊断后存活数年的妇女及其护理人员来说，长期复发频率的信息至关重要。该研究的目的是利用基于人群的癌症登记来估计诊断为BC的意大利妇女在诊断后10年的累积复发率。方法纳入2004-2010年期间在意大利弗留利、威尼斯、朱利亚和威尼托癌症登记处诊断为I至III期BC的妇女（n = 5825）。无病期后的复发状态通过使用索赔中的治疗或程序代码的个人层面关联数据库确定。在存在竞争风险（第二次癌症或死亡）的情况下计算累积复发率。结果在中位13.5年的随访期间，5825名女性中有1522名复发，估计10年累积发病率为20.8% (95% CI:19.7 - 21.8%)，从2004-2006年的23.7%下降到2007-2010年的18.5%。年龄小于40岁的女性（40.5%），III期（41.8%）和三阴性BC（32.5%）的10年复发率较高。在BC诊断后10年，83.9%的女性存活：67.5%没有任何癌症相关事件，12.4%复发，4.0%第二原发癌症。I期乳腺癌患者的10年生存率高于90%，III期乳腺癌患者的10年生存率高于58.1%（复发后分别有3.2%和27.3%死亡）。意大利的这项研究提供了详细的基于人群的BC后复发率和其他结果的信息，可能在意大利和欧洲其他地区复制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast 医学-妇产科学

CiteScore

8.70

自引率

2.60%

发文量

165

审稿时长

59 days

期刊介绍： The Breast is an international, multidisciplinary journal for researchers and clinicians, which focuses on translational and clinical research for the advancement of breast cancer prevention, diagnosis and treatment of all stages.