MOJ immunology最新文献

{"title":"Case of chromosome 22q11.2 deletion syndrome in Russian family","authors":"Svetlana Deriabina, M. Bolkov, I. Tuzankina, E. Vlasova","doi":"10.15406/MOJI.2018.06.00208","DOIUrl":"https://doi.org/10.15406/MOJI.2018.06.00208","url":null,"abstract":"Our Center for Clinical Immunology has been working in the sphere of primary immunodeficiencies (PID) for 30 years. Early diagnostics and management of PID patients is our priority.1,2 Followup of adults and children in our Center can be done as it has two main clinical bases Region Children Clinical Hospital No 1 and Region Clinical Hospital No 1 (Yekaterinburg, Ural region, Russia). Center also closely collaborates with the Institute of Immunology and Physiology of Russian Academy of Sciences and international organizations on PID jproject (collaboration with Professor L. Marodi, University of Debrecen) and Jeffrey Modell Foundation. There are 15 patients with chromosome 22q11.2 deletion (14 children and 1 adult) out of total number of 309 PID patients in our Center for Clinical Immunology. Thereby, the prospects for identifying these patients are wide. According to many reports, chromosome 22q11.2 deletion occurs 1: 3,000 6,000 live births, affecting both sexes equally.3,4 It has been reported that chromosome 22q11.2 deletion is found in 90% of the patients with disgorge phenotype, 70% of the patients with Velo-Cardio-Facial Syndrome (VCFS), and 15% of the patients with isolated conotruncal cardiac defect.5 Most of the patients were diagnosed by slightly and severely decreased immunity, facial defects, and heart anomalies and some patients had kidney abnormalities, hypoparathyroidism, hypothyroidism, and developmental retardation.6 Chromosome 22q11.2 deletion is mostly diagnosed in early childhood by pediatricians as a congenital disease so that the syndrome is difficult to diagnose in the late adulthood7‒9 In literature there are only a few works devoted to adult patients with chromosome 22q11.2 deletion syndrome.3,4,10‒12 This is due to low awareness of physicians and other specialists of chromosome 22q11.2 deletion syndrome as well as high variability of phenotypic manifestations of this syndrome and the presence of mild forms. Under our surveillance there is a family K, wherein two siblings and their mother have the chromosome 22q11.2 deletion syndrome. The purpose of this study is to analyze phenotypic manifestations in family members with chromosome 22q11.2 deletion syndrome. Methods","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44451915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial dysbiosis in allergic lower airway disease (asthma)","authors":"Ö. Özdemir","doi":"10.15406/MOJI.2018.06.00207","DOIUrl":"https://doi.org/10.15406/MOJI.2018.06.00207","url":null,"abstract":"","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44370302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential immune response generation in rats acutely exposed to hypobaric hypoxia and determination of susceptibility and tolerance","authors":"Shweta, K. Mishra, H. Tanwar, Sudipta Ch, S. Singh, L. Ganju","doi":"10.15406/moji.2018.06.00206","DOIUrl":"https://doi.org/10.15406/moji.2018.06.00206","url":null,"abstract":"Abbreviations DAMP: Damage-Associated Molecular Pattern; DCFH2-DA:2′,7′dichloro-dihydro-fluorescein diacetate; ELISA: Enzyme Linked Immunosorbent Assay; FACS: Fluorescenceactivated cell sorting; HIF1α: Hypoxia-inducible factor 1-alpha; iNOS: Inducible Nitric oxide Synthase; MFI: Median Fluorescence Intensity; NO: Nitric Oxide; ROS: Reactive Oxygen Species; TLR: Toll-like receptors; TNF-α: Tumor Necrosis Factor Alpha; CD18: Cluster of Differentiation 18.","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43576488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application of animal based extracellular matrix in hernioplasty","authors":"Raghuvanshi, D. Mohan, D. Gautam, S. Shivaraju, S. K. Maiti, Naveen Kumar","doi":"10.15406/MOJI.2018.06.00205","DOIUrl":"https://doi.org/10.15406/MOJI.2018.06.00205","url":null,"abstract":"Biological scaffolds are composed of natural ECM (extracellular matrix) due to their origin from animal-based proteinous molecules; they have efficient in the potential of therapeutic applications. The ECM has full potential which increases constructive remodeling. The structural and functional molecules of ECM are capable to establish proper attachment or communication with an adjacent environment of healing area of injury. Their biocompatibility is responsible for positive signaling to recipient own matrix formation.1 The ECM degradation with the promotion of native matrix is another property which makes it an ideal biomaterial.2","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46971910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory response induced by resistance exercise","authors":"E. S. Vasconcelos","doi":"10.15406/MOJI.2018.06.00204","DOIUrl":"https://doi.org/10.15406/MOJI.2018.06.00204","url":null,"abstract":"In the body human, there are around 640 skeletal muscles which together account for ~38% of total body mass for men and 30% for women.1 Skeletal muscle is crucial in precise movement and your functional unit cell (muscle fibre) has a vigorous regenerative capacity, with rapid reestablishment (by 3 weeks) of full power occurring even after severe damage that causes widespread myofibre necrosis.2 Exercise-induced muscle damage (EIMD) in humans frequently occurs after unaccustomed exercise, particularly if the exercise involves a large amount of eccentric contractions. There are three types of muscle actions: concentric, eccentric and isometric. The eccentric actions occur during the lowering phase of any weightlifting exercise and are defined as muscle actions at the places where the muscle lengthens because the contraction force is less than the resistive force.3 Initial resistance exercise stress affects muscle homeostasis promoting changes in muscle morphology, loss of sarcomeric structural proteins (e.g. desmin and dystrophin), muscle fibre segmental necrosis, alterations in connective tissue, in T-tubules and sarcoplasmic reticulum.4,5 Muscle damage is commonly defined by disruption of the extracellular matrix, basal lamina, and sarcolemma as well as damage within the muscle fiber to the contractile and cytoskeletal proteins. Sarcolemma disruption is confirmed by an increase in blood-borne levels of intramuscular proteins such as creatine kinase (CK), which in turn has been linked to production of an inflammatory response.6 The severity of the inflammation depends on the type, duration and intensity of exercise. Moreover, exercise with eccentric contractions will cause more damage and inflammation than concentric exercise of equal intensity and duration.7 In addition, regular exercise is beneficial to up regulating defense mechanisms against oxidative stress and to increased resistance against infection and a lower risk of appearance of disease. The aim in this review was to focus attention in inflammatory process caused by muscle damage after resistance exercises and, in addition, show the benefits of regular intensity exercise against oxidative stress, infections and some diseases.","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46690384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the immune system of plant and animal kingdoms share any pathways or mechanisms of action in phytotherapy","authors":"D. Beghelli","doi":"10.15406/moji.2018.06.00203","DOIUrl":"https://doi.org/10.15406/moji.2018.06.00203","url":null,"abstract":"The question arises from the need to understand why the use of phytotherapy may modulate the immune responses even in the animal kingdom as reported by some authors.1 In fact, even if the traditional use of herbal medicine products may guarantee efficacy, for very few medical plants scientific data on mechanisms of action are available.2 The term Phytotherapy, derived from the Greek words ‘Phyto’ and ‘therapy’, was introduced into science by the French physician Henri Leclerc (1870-1955) and indicates the therapy practiced with medicaments of vegetable origin. A study conducted by the World Health Organization had reported that about 80% of world’s population relies on traditional medicine. The history of phytotherapy is very old and was presumably one of the first therapeutic methods undertaken by man. Already in ancient times (since the Egyptian and Mesopotamian era), mankind was so fascinated by the therapeutic action of plants that for centuries magical and divine properties were attributed to them. Later on, humans have learnt by experience and observations how to use plants correctly and since the nineteenth century the empirical use of plants has been brought back within the boundaries of rationality and scientific rigor. But in what way has man been using these plants for millenia? These ‘preparations’ of vegetable origin have always been used through essentially three administration routes: at a lesser extent, by local applications or fumigation, otherwise mainly by ingestion. The administration of herbal medicine products through the oral route may represent a crucial point, as we will discuss below, to explain the efficacy of the traditional medicine. Therefore, the text found in the work On Aliment: “In food excellent medication, in food bad medication, bad and good relatively”,3 nowadays attributed to the Hellenistic period, but in Antiquity (by Galenus in particular) erroneously associated with Hippocrates, brings us back to why mankind at some point has started to ingest plants or their fruits, roots and leaves in order to find in them not only nourishment and gratification, but also a therapeutic remedy for its illnesses. Indeed, the idea of using plants as medicine treatment was probably born from fortuitous observations or from the experiences that many plants used in nutrition could also prove to be toxic or poisonous or, better, able to improve disorders. However, also Hippocrates from Cos (around 460 BC-around 375 BC), the father of Western modern medicine, knowing that food was closely linked to health and disease, applied dietetic measures for the benefit of the sick.4 According to the World Health Organization (WHO), every vegetable that contains, in one or more of its organs, pharmacologically active substances deserves the name of a medicinal plant. The pharmacognosy studies have evidenced that the set of these pharmacologically active molecules, called phytocomplexes, have the ability to work in synergy with all compone","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":"6 1","pages":"105-109"},"PeriodicalIF":0.0,"publicationDate":"2018-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47149632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insight into potential role of inflammatory factors in the pathogenesis of vitiligo","authors":"R. Ghaderi","doi":"10.15406/moji.2018.06.00202","DOIUrl":"https://doi.org/10.15406/moji.2018.06.00202","url":null,"abstract":"Vitiligo is an autoimmune disorder which causes skin depigmentation along with disorder in pro-inflammatory cytokines like INF-γ & TNF and so leads to dysfunction of melanocytes.1 Depigmentation in these areas occurs with progressive disappearance of melanocytes from basal layer of skin.2 The most common form of vitiligo disease is uniform amelanocytic macules or patches surrounded by normal skin. The color of lesions is usually milky or white. The macules are seen round, oval or linear and usually have convex and hyperpigmented margins.1‒3","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42620296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional medicine–new concept or really what primary care physicians do","authors":"N. Bradshaw","doi":"10.15406/moji.2018.06.00221","DOIUrl":"https://doi.org/10.15406/moji.2018.06.00221","url":null,"abstract":"","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47549839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness about hypertension in biotechnology students","authors":"M. Batool, M. Qadir","doi":"10.15406/moji.2018.06.00220","DOIUrl":"https://doi.org/10.15406/moji.2018.06.00220","url":null,"abstract":"Hypertension can be regarded as one of the most important causes of morbidity worldwide. It is actually due to elevation in the blood pressure levels which is the result of rise in diastolic and systolic pressures. A survey was carried out in the form of questionnaires among biotechnology students. The resultant percentage of both males and females was enough to conclude that the students were truly aware about the causes of the disease.","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43893910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay of vitamin D with T regulatory cells (FOXP3+Treg) and thymic stromal lymphopoietin (TSLP) in children with atopic diseases","authors":"Anil Chauhan, Meenu Singh, A. Agarwal, N. Sachdeva, S. Attri","doi":"10.15406/MOJI.2018.06.00201","DOIUrl":"https://doi.org/10.15406/MOJI.2018.06.00201","url":null,"abstract":"In recent years, vitamin D has been postulated as a risk factor for asthma and evidence suggests a connection between vitamin D deficiency with allergy and asthma. There is also an association between the dysregulated immune response marked by an increase in FOXP3+ and IL-10 T-regulatory (Treg) cells with the inflammatory processes of asthma.1 Severe asthma was associated with lower vitamin D levels in one of the observational study.2 An in vitro study noted an increase in the synthesis of IL-10 from Treg and dendritic cells was seen in the presence of exogenous vitamin D.3 In cultured steroid resistance T cells, vitamin D restored the immunosuppressive ability of dexamethasone.4 Low vitamin D levels, i.e. serum 25-OHD3 less than 30ng/ml as insufficient and less than 20ng/ml as deficient, have been positively correlated with atopic diseases.5 there is negative correlation between asthma exacerbation and vitamin D levels.6 The inverse association between serum vitamin D levels and need for corticosteroid use in patients with asthma has also been observed.7 Decreased expression of FOXP3 (Forkhead boxP3) is associated with increased exacerbation of asthma and steroid sensitivity, and decreased formation, production and differentiation of FOXP3+Treg cells.8‒10 Upregulated expression of FOXP3+Treg cells by vitamin D supplementation reverses steroid resistance.11‒12 In what? Furthermore, increased expression of FOXP3+Treg cells in allergen specific immunotherapy correlated with higher serum vitamin D levels.13 Vitamin D potentiates the efficacy of allergen immunotherapy by increasing the anti-inflammatory cytokines (IL10 and TGF-beta) response in an animal model of OVA challenged and sensitized BALB/C mice.14 The association of TSLP with vitamin D and % FOXP3+Treg cells is yet to be fully explored. It has been observed that when 16 human bronchial epithelial celllines were exposed to 50 and 500nM of vitamin D, inactive 25-OHD3 is converted to active 1,25 D3 and there is increase in TSLP mRNA and protein expression levels.15‒16 In our previous report, we showed that higher concentrations of TSLP and IL-33 correlate negatively with Treg cells in children with asthma.17 Until now, no study has demonstrated an association of vitamin D levels with TSLP and T regulatory cells in children with atopic disease.","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45262054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}