New insight into potential role of inflammatory factors in the pathogenesis of vitiligo

Abstract

Vitiligo is an autoimmune disorder which causes skin depigmentation along with disorder in pro-inflammatory cytokines like INF-γ & TNF and so leads to dysfunction of melanocytes.1 Depigmentation in these areas occurs with progressive disappearance of melanocytes from basal layer of skin.2 The most common form of vitiligo disease is uniform amelanocytic macules or patches surrounded by normal skin. The color of lesions is usually milky or white. The macules are seen round, oval or linear and usually have convex and hyperpigmented margins.1‒3