Journal of blood & lymph最新文献

{"title":"Primary Central Nervous System Hodgkin Lymphoma versus Lymphoproliferative Disorder in an Asymptomatic Immunocompromised Patient - A Case Report and Review of the Current Literature","authors":"Godbe Kn, Guilliams El, Benko Mj, Grider Dj, Stump Ms","doi":"10.37421/JBL.2019.9.250","DOIUrl":"https://doi.org/10.37421/JBL.2019.9.250","url":null,"abstract":"Primary central nervous system (CNS) Hodgkin’s lymphoma is extremely rare. An 82 year old female presented to the Emergency Department after she tripped and hit her head, resulting in a head laceration with no other apparent injuries. Head CT revealed a hyperdense area consistent with either a parieto-occipital hemorrhage or mass. She was transferred to a tertiary care institution, where head MRI revealed a parieto-occipital mass concerning for metastatic disease. No primary source or evidence of metastatic disease were found. The tumor was resected and identified to be a classical Hodgkin’s lymphoma, mixed cellularity type. The patient had no complications and was discharged home. Recommendations for patient’s future treatment included a PET scan and radiotherapy. After a consultation with a lymphoma expert at the NIH, the patient’s diagnosis was changed to an atypical lymphoproliferative disorder with Reed-Sternberg/Hodgkin like cells based on the patient’s history of rheumatoid arthritis treated with an immunosuppressant. A review of the literature revealed several primary CNS Hodgkin’s lymphoma cases that were extremely similar to the patient in this study. This case’s diagnosis as an atypical lymphoproliferative disorder casts doubt on if previously reported cases of CNS primary Hodgkin’s disease were misclassified as the pathological staining of this patient and the immunosuppressant history are extremely similar.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48758064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Asymptomatic Plasmodium falciparum Driven Anemia in a Treatment Re-infection Pediatric Cohort in a Rural Health District of Cameroon","authors":"Ouambo Hf, Ngu Ln, Lissom A, Ngoh Aa, Okoli As, Atabonkeng Pe, Takoua D, Garcia R, Gutiérrez A, Chukwuma Go, Ngouadjeu E, Okeke Mi, Esimone Co, Achidi Ea, Mbacham Wn, Kaptue L, Park Cg, Waffo Ab, Assob Anc, Nchinda Gw","doi":"10.37421/jbl.2019.9.248","DOIUrl":"https://doi.org/10.37421/jbl.2019.9.248","url":null,"abstract":"Background: Asymptomatic Plasmodium falciparum infection (APFI) resulting from partial immunity is beneficial to individuals living in malaria hyper endemic regions like Cameroon. However APFI sustains not only persistent malaria transmission in the general population but equally accounts for complications related to untreated malaria such as anemia. The aim of this study therefore was to determine the rate of anemia within a population of children with persistent APFI, living in a rural area of Cameroon. Materials and methods: A cohort of children from nursery and primary school was monitored for four months in the Bikop Health District of Cameroon. Using pretested questionnaire data was collected from 80 children less than 13 years old during the months of November 2016 and February 2017. Blood samples were collected twice by venipuncture during this period. Children with acute symptoms of malaria, fever or chills and children recently sick or under malaria treatment were excluded. Using malaria rapid diagnostic kits (RDTs) and fluorescent microscopy we screened for malaria positive people and also for the hemoglobin level using a hemoglobinometer. Results: The median age of participants was 6.5 (4-10). The rate of APFI increased from 41.25% in November 2016 to 65% in February 2017 irrespective of the use of Long Lasting Insecticidal Nets (LLIN). Similarly, the rate of anemia also increased (100% for the 2-5, 100% for the 6-9 years and 92.31% for the 10-13 years old children respectively). The changes in asymptomatic malaria associated anemia correlated positively (r=0.93, p=0.002) with increasing Plasmodium falciparum parasitemia especially with respect to moderate anemia (38.75% in the month of November and 50.00% in the month of February). Conclusion: Thus asymptomatic Plasmodium falciparum parasitemia could be a driving force behind persistent anemia in school age children in rural areas of Cameroon.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42179629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of ABO and RH Blood Group and Sub-Group A1 and A2 in Blood Donors of Odisha - Experience of One Tertiary Centre","authors":"Pradhan Pk, Mishra Sc, Patnaik Bk, D. Mohanty","doi":"10.37421/JBL.2019.9.249","DOIUrl":"https://doi.org/10.37421/JBL.2019.9.249","url":null,"abstract":"The paucity of report from Odisha regarding prevalence of ABO and Rh blood group promoted us to undertake the present retrospective study. Total number of subjects studied are 45,564. Prevalence rate of A, B and O are 9679 (21.24%), 13881 (30.46%) and 16662 (36.56%) respectively. The subgroup analysis showed of A1 and A2 has also been carried out in the present study. One case of A2 has been described which had antibody to A1 where there was difficulty in arranging the blood transfusion insisting there by the importance of subgroup analysis in the blood bank.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44658877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologus Hematopoeitic Stem Cell Transplant: Horizon 202","authors":"Raut Ss, Shah Sa","doi":"10.37421/JBL.2019.9.245","DOIUrl":"https://doi.org/10.37421/JBL.2019.9.245","url":null,"abstract":"Autologus stem cell transplant (ASCT) has evolved over last 5 decades a lot. There are enormous advances in the technique right from mobilization, collection, counting of stem cells to preservation, conditioning and peritransplant care. By the end of this decade we feel necessity to explore the scope and update the details and minutes of ASCT particularly in oncology grossly as well as disease-wise. We delineate the basics of the procedure and advances till date. Also we aimed to summarise the implementation of these advances in India by analyzing the data and information in published articles. This may further help physicians to understand the complex procedure with simplicity and may guide the research workers and authors as reference tool.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70054207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Romiplostim as a Viable and Long-term Remedy for Refractory Immune Thrombocytopenia and Concomitant Small B-Cell Lymphoma","authors":"Germame Ajebo, P. Dainer, J. Pantin, N. Ryan, C. Bruker","doi":"10.37421/jbl.2019.9.236","DOIUrl":"https://doi.org/10.37421/jbl.2019.9.236","url":null,"abstract":"Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by immune-mediated destruction of otherwise normal platelets and can be either primary, without obvious initiating or underlying cause, or secondary ITP due to an underlying disease or drug exposure. The goals of therapy for ITP include achieving an adequate platelet level for hemostasis and minimizing toxicities with current options including: corticosteroids, rituximab, splenectomy, intravenous gamma globulin (IVIG), Anti-D, and thrombopoietin receptor agonists (TPO) like romiplostim and eltrombopag. TPO mimetics like romiplostim have emerged as viable and practical option in relapsed and refractory ITP. We present a 70-year-old Caucasian male patient with chronic lymphocytic leukemia/small cell lymphoma (CLL/SLL) related secondary ITP who had been maintained for nearly a decade on romiplostim after failing all other options of therapy. We report this case to demonstrate the efficacy and sustainability of romiplostim use in the relapse/ refractory ITP in such a patient who failed to respond to other therapeutic options. Figure 1: Highlights bone marrow involvement of approximately five percent by mature neoplastic cells (H&E, 100x magnification). Citation: Ajebo G, Dainer P, Pantin J, Ryan N, Bruker C (2019) Romiplostim as a Viable and Long-term Remedy for Refractory Immune Thrombocytopenia and Concomitant Small B-Cell Lymphoma. J Blood Lymph 9: 236.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70053739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Iron Deficiency and Anemia among Adolescents in a Multi-Cultural Country","authors":"M. Haimi, Galit Goldzak-Kunik, E. Katz, T. Matthias, A. Lerner","doi":"10.37421/JBL.2019.9.242","DOIUrl":"https://doi.org/10.37421/JBL.2019.9.242","url":null,"abstract":"Background: Adolescence is a vulnerable period for the development of nutritional anemia. Aim: To evaluate the determinants of iron deficiency, anemia, and associated factors among adolescents who performed routine blood tests in a large district in Israel during 2014. Methods: A community-based cross-sectional observational study was conducted among adolescents aged 11-18 years, belonging to Haifa and west Galilee district of ‘Clalit’ Health Services, who routinely performed blood tests during 2014. The blood tests were investigated for iron deficiency (ferritin<20 ng/mL) or anemia (hemoglobin (HGB)<12 g/dl). Results: Among 22310 adolescents who performed blood tests during 2014, 4116 (18.45%) were found to fulfill the inclusion criteria. 14.8% were boys, 85.2% were girls. 2964 (13.2%) adolescents were anemic, with HGB 12 g/dl, but ferritin levels<20 ng/mL, with mean ferritin level of 14.31 ng/mL. Jews significantly had higher mean MCV values, and higher iron levels as compared to non-Jews. The average HGB levels were the lowest in the age groups of 12.5- 15.5 years, and 15.5-17 years. The severity of the anemia correlated significantly with the gender of the adolescent, females having lower HGB concentrations. Ferritin levels correlated significantly with the gender (higher in males), and age of the adolescents (lower at higher ages). Conclusions: Iron deficiency and anemia are common in adolescents, having serious implications. Awareness to this problem should be raised, and decision makers are encouraged to find ways to prevent detect and treat it.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70054094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Plateletpheresis Using Different Cell Separators Fenwal Amicus, Fresenius COM.TEC and MCS Plus","authors":"S. Shaikh, Muhammad Usman, M. Wadood, Aisha Shaikh","doi":"10.37421/JBL.2019.9.247","DOIUrl":"https://doi.org/10.37421/JBL.2019.9.247","url":null,"abstract":"Objective: This objective of the study was to compare the three commonly used apheresis instruments available for Plateletpheresis, i.e., MCS Plus, COM.TEC and Amicus in terms of their Pre and Post donor CBC variables, instrument efficacy and product variables. Methodology: Donors undergoing Plateletpheresis are categorized into three groups. Sixty donors were selected according to the selection criteria of donor for Plateletpheresis by AABB. Later the procedure was performed on MCS Plus, Amicus and COM.TEC. Twenty donors were processed with each instrument. Results: The study revealed that there is no significant difference in pre and post count of donors on CBC in all the instruments. It is observed that the blood volume processed in order to have the standard platelet yield of ≥3. 3 × 1011 is higher in the COM.TEC as compared to Amicus and MCS plus (p 3.3 × 1011. But in COM.TEC, 100% of the products have a platelet count of >3.3 × 1011. Products collected from Amicus and COM.TEC is leucodepleted. On the contrary, the products by MCS Plus are not leucodepleted. The collection efficiency is significantly low in MCS Plus (47 ± 13.6) when compares to Amicus (64 ± 7.9) and COM.TEC (59 ± 10.5). However, the collection rate is significantly higher with Amicus (0.07 ± 0.007) followed by COM.TEC (0.06 ± 0.006) and MCS plus (0.04 ± 0.004). Conclusion: The study concludes that all kits for Plateletpheresis are very efficient for platelet collection. However, both Amicus and COM. TEC is better than MCS Plus, as they give leucodepleted platelet concentrates. Amicus supersedes all as the target platelet yield is achieved more rapidly as compared to COM.TEC and MCS plus.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70054218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Myeloma Diagnosed from Tongue Amyloidosis: A Case Report","authors":"Atsushi Uesugi, Fumihiko Tsushima, Y. Ohata, E. Marukawa, T. Kuroshima, Tohru Ikeda, H. Harada","doi":"10.4172/2165-7831.1000237","DOIUrl":"https://doi.org/10.4172/2165-7831.1000237","url":null,"abstract":"Background: Amyloidosis is a metabolic disease of unknown cause and mainly presents with organ damage due to abnormal amyloid deposition. In the oral cavity, it is characterized by macroglossia with a nodule that frequently develops on the tongue. Moreover amyloidosis is often accompanied by multiple myeloma. Herein, we reported a case of multiple myeloma diagnosed from tongue amyloidosis. Case presentation: The patient was a 66-year-old woman who presented to our department with a chief complaint of roughness on the tongue in July 2014. Her tongue was huge and had nodules. Biopsy of the nodule on the right tongue confirmed a definitive diagnosis of amyloidosis. She complained of paresis on the fingers, for which neuropathy due to amyloidosis was suspected. Blood test showed anemia, increased erythrocyte sedimentation rate, decreased serum albumin, and increased serum β2 microglobulin. Immunoelectrophoresis detected the presence of λ-type M protein in the urine and serum. Bone marrow aspiration from the iliac bone led to the definitive diagnosis of multiple myeloma (IgA λ-type, International Staging System stageⅠ) .Lenalidomide, bortezomib, and dexamethasone therapy and autologous peripheral blood stem cell transplantation were administered for multiple myeloma. The treatment effects were “very good partial response” before transplantation and “stringent complete response” after transplantation. As of July 2018, no new nodular formation was seen in the oral cavity, and the general condition was good. Conclusion: When multiple nodules and macroglossia in the tongue are confirmed to be amyloidosis, a systemic search for the possibility of multiple myeloma is important.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70691956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological Alterations in Megakaryocytes in Bone Marrow Aspirate of Thrombocytopenia Cases","authors":"R. Sharma, Kira Cm, Anita Ramdas","doi":"10.37421/jbl.2019.9.235","DOIUrl":"https://doi.org/10.37421/jbl.2019.9.235","url":null,"abstract":"Background: Thrombocytopenia is seen in various haematological and non haematological conditions and has been defined as platelet count less than 1.5 lakh/mm3. Dysplastic changes are well known in Myelodysplastic syndrome (MDS) but these can be seen in other haematological conditions. Methods: This was a retrospective study done on 100 bone marrow aspirations in a tertiary care center in South India from Jan 2015 to Dec 2016. All bone marrow aspirations in this study period was retrieved and the slides were reviewed by two pathologists. Results: Total of 100 cases were included in the study. Out of 100 cases of bone marrow aspiration, 78 cases were of thrombocytopenia, 6 cases were of thrombocytosis, and 16 cases were of normal platelet count. The most common cause for which bone marrow aspiration was sought was pancytopenia (30 %), followed by ITP (15%), PUO (12%), Anaemia (10%). Bicytopenia (8%), Hepatosplenomegaly (3%), Lymphoproliferative disorder (5%), GMCSF treatment (1%),MPN (3%), T.B , MM (4% each), MDS (2%), AL (2%), MGUS (1% ). Conclusion: Most common cause of thrombocytopenia in this study was pancytopenia followed by ITP. Dysplastic features were seen in MDS but also present in other conditions like megaloblastic anaemia and acute leukemia.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70053997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"â�?�?The TEAM Projectâ�? Results on Management of Placenta-Mediated Pregnancy Complications (PMC): The Impact of Thrombophilia Test and Thromboprophylaxis with Low-Molecular-Weight-Heparin on Recurrences of PMC","authors":"A. Santamaría, E. Marti, C. Medina, A. M. Rodríguez, M. Stevenazzi, Y. Mira, Meritxell López, A. M. Redondo, R. Aguinaco, M. Sabater, A. Oliver","doi":"10.37421/JBL.2019.9.241","DOIUrl":"https://doi.org/10.37421/JBL.2019.9.241","url":null,"abstract":"Aim: In placenta-mediated pregnancy complications, evidence-based guidelines are based on studies with controversial results or expert opinion. In this context, the implementation of those guidelines is quite different among physicians. Our aim was to analyze the management of PMC in a real-world scenario. Methods: From 2010 until 2016, we started the “TEAM Project” as a nested project within a working group of the Spanish Society of Thrombosis and Hemostasis (SETH : Sociedad Espanola de Trombosis y Hemostasia). Results: We included 666 women with PMC, including recurrent pregnancy loss (50%), fetal death (25%), preeclampsia- eclampsia (20%), intrauterine growth restriction (5%) and placental abruption. Although a thrombophilia test was indicated in more than 80% of these patients, antiphospholipid antibodies were tested in less than 70% cases. The presence of PT20210A mutation and positive antiphospholipid antibodies were the most common findings observed. Among the 257 women with previous PMC who were assessed for thrombotic risk, 88.7% received antithrombotic prophylaxis, most frequently (46.8%) low molecular weight heparin (LMWH)+aspirin (AAS) and recurrence was observed in 14% of women. Conclusion: This is the first observational, multicentric and multidisciplinar phase IV study analyzing the real-life clinical management of PMC and other hemostatic/thrombotic events in women from Spain and Uruguay. Our results evidence a lack of homogeneity in the management of these complications as a result of the wide discordance among the existing guidelines, as well as a need for a call to action in fetal-maternal medicine.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70054082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}