Journal of blood & lymph最新文献

{"title":"BCR/ABL-1-Positive Myeloproliferative Neoplasm Presenting with Isolated Remarkable Thrombocytosis with Atypical Clinicopathological Features: Discussion from Management Point of View","authors":"D. Soliman, M. A. Abdulla, A. Sabbagh, S. Akiki, F. Ibrahim, Afraa Mustafa, M. Yassin","doi":"10.37421/JBL.2019.9.243","DOIUrl":"https://doi.org/10.37421/JBL.2019.9.243","url":null,"abstract":"Chronic Myeloid Leukaemia can rarely present in essential Thrombocythaemia-like picture. Apart from the genetic defining marker (BCR-ABL fusion), these cases lack almost all typical features of CML. Here, we highlight the response of these patients to different therapeutic approaches and to emphasize that although the proliferation is solely limited to the platelets; this group of patients did not show any response except after initiation of Tyrosine kinase inhibitors which highpoints the essentiality of excluding CML by performing BCR/ABL-1 in all cases with features of myeloproliferative neoplasms in order to avoid delayed management and adverse outcome. Apparently, many hematologists have not been persuaded to always test for BCR/ABL-1 when there are no features suggesting CML. Unlike what was previously reported, upon literature review, we found no significant difference in disease prognosis in this group of patients compared to classic CML, provided TKI was started early in disease course.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70054142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular Treatment of a Symptomatic Mural Thrombus of the Descending Thoracic Aorta: A Case Report","authors":"A. Sigdel, A. Dwivedi, Erik J. Wayne","doi":"10.37421/JBL.2019.9.234","DOIUrl":"https://doi.org/10.37421/JBL.2019.9.234","url":null,"abstract":"Aortic mural thrombus is an uncommon source of peripheral embolization. We present a case of a patient with a symptomatic mobile mural thrombus in the proximal descending thoracic aorta who presented with left hand ischemia. The patient was treated with anticoagulation and radial artery thrombectomy followed by thoracic aortic stent graft placement.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70053763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfusion Therapy in Sickle Cell Disease","authors":"K. Akaba, B. Bassey, I. Akpan, Ofonimeh E Effiong","doi":"10.37421/JBL.2019.9.244","DOIUrl":"https://doi.org/10.37421/JBL.2019.9.244","url":null,"abstract":"Background: Blood transfusion is an important therapy in the management of sickle cell disease (SCD); especially in developing countries. Transfusion aids the restoration of the oxygen carrying capacity in patients with SCD and also prevents vaso-occlusion by dilution of the Hbs in circulation. However, there is paucity of information on transfusion as a therapy in the management of SCD. Aim and objective: This study is aimed at reviewing the available publications on transfusion as a therapy for SCD management. Materials and methods: Relevant literatures were searched on databases including PubMed, Google Scholar, Scopus, Cochrane and standard texts on haematology and transfusion medicine. The keywords used in the search are sickle cell disease, transfusion, simple and chronic transfusion, complications of transfusion, choice of blood for transfusion and guidelines for blood transfusion. The literatures gathered were reviewed, summarized and presented in this review. Results: Blood transfusion is a cornerstone in the management of patients with SCD. The management of SCD patients requires a multidisciplinary approach with a great deal of commitment been required from all the experts. Although, many hazards are associated with blood transfusion, it is pertinent that proper care is taken in the handling and administration of blood and blood products. Conclusion: Transfusion therapy still remains a cornerstone in SCD management and it tends to mitigate the severity and complication associated with SCD disorders. Adequate knowledge and information is needed by experts on the importance of transfusion therapy and its modalities in SCD.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70054199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-8 as a Surrogate Marker in Risk Stratification of Patients with Acute Myeloid Leukemia","authors":"M. Almorish, W. Al-Kahiry, M. Rabie, E. Dammag","doi":"10.4172/2165-7831.1000240","DOIUrl":"https://doi.org/10.4172/2165-7831.1000240","url":null,"abstract":"Introduction: When molecular and cytogenetic studies are not available, the risk stratification of AML patients will be difficult. This study was conducted to evaluate the prognostic value of IL-8 among AML patients with its relation to outcome. Methods: This is a cross sectional study; 42 newly diagnosed AML patients (<65 years) were investigated with determination of serum IL-8 by ELISA and followed up for 36 months. In addition, 20 sex and age matched normal volunteers were included as control. Results: In AML patients, serum IL-8 was ranging from 5 to 200 pg/mL with a mean of 76.5 pg/mL. It was significantly higher among AML patients when compared to the control (76.5 vs 32.3 pg/mL). The mean did not show any significant relationship to patients’ sex or the FAB classification of AML (p>0.05). While significant higher mean was observed among poor cytogenetic risk group (110.4 pg/mL) as well as among died patients (108.8 pg/mL) and refractory patients (84.2 pg/mL). In regard to survival, among those with IL-8>40 pg/mL, the mean survival time was higher in comparison to AML patients with IL-8 ≤ 40 pg/mL (34.6 months vs 26.3 months). Conclusion: This study concluded that serum IL-8 concentration at presentation of AML patients is high and it could be used as a marker for risk stratification for AML patients.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70692126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid Artery Disease in Diabetic Patients: Contemporary Perspectives","authors":"N. Siddiqui, Asad Moosa, F. Shaikh, Waryam Saleh, Avgerinose Efthymios","doi":"10.37421/JBL.2019.9.238","DOIUrl":"https://doi.org/10.37421/JBL.2019.9.238","url":null,"abstract":"Carotid artery disease is a significant contributor of diabetic patients’ morbidity and mortality driven by its strong association with ischemic stroke. The link between carotid atherosclerosis and cerebrovascular or coronary artery disease is otherwise well established pointing to a high risk patient. This link gets particularly important in diabetic patients who demonstrate high rates of silent cardiovascular events, as a means of early detection of underlying atherosclerotic disease. Carotid ultrasonography now allows clinicians to visualize the characteristics of the carotid wall and lumen surfaces, to quantify the severity of local and systemic atherosclerosis and better guide the intensity of primary and secondary prevention strategies. Carotid revascularization remains the standard of care for high grade stenosis and while higher perioperative events and restenosis rates may be anticipated the benefits derived from the procedure still outweigh the risks. Current guidelines recommend carotid endarterectomy as a gold standard procedure; however carotid artery stenting can be a valid alternative in high medical risk symptomatic diabetic patients. Optimal glycemic control and confounding risk factor management can ameliorate short and longer term adverse events. Citation: Siddiqui NA, Moosa A, Shaikh F, Saleh W, Efthymios A (2019) Carotid Artery Disease in Diabetic Patients: Contemporary Perspectives. J Blood Lymph 9: 238. doi: 10.4172/2165-7831.1000238","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70053793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing Reference Ranges of Hematological Parameters from Malian Healthy Adults.","authors":"B Kone, M Maiga, B Baya, Yds Sarro, N Coulibaly, A Kone, B Diarra, M Sanogo, Acg Togo, D Goita, M Dembele, M A Polis, J Warfield, M Belson, S Dao, S Orsega, R L Murphy, S Diallo, S Siddiqui","doi":"10.4172/2165-7831.1000154","DOIUrl":"10.4172/2165-7831.1000154","url":null,"abstract":"<p><strong>Introduction: </strong>Measurement of immuno-hematological parameters has been historically helpful in the diagnosis and treatment monitoring of many infectious diseases and cancers. However, these parameters have not yet been established in many developing countries where patient care strongly relies on such low-cost tests. This study describes the immuno-hematological parameter ranges for Malian healthy adults.</p><p><strong>Methods: </strong>A cross sectional study was conducted from August 2004 to May 2013. We included 213 healthy volunteers (173 male and 40 female), aged between 18-59 years. Median, 2.5 and 97.5 percentile ranges for each immuno-hematological parameter are presented.</p><p><strong>Results: </strong>In our study population, the hematological parameters' ranges were mostly different to the universal established ranges. We found in our population a Median white blood cell (WBC) count of 5200 cells/μL [3237.5-11900], Red Blood Cell (RBC) count of 4.94 10^6 [3.56-6.17], hemoglobin (Hb) of 14.2 g/dL [12.2-17.38], platelet count (Plt) of 275 10^3/μL [145.4-614.4], lymphocytes 2050/μL [1200-3800], neutrophils 2200/μL [1040-6220]; monocytes 200/μL [100-660]; eosinophils 131/μL [0-1026]; CD4 902 cells/μL [444-1669] and CD8 485 cells/μL [0-1272]. We found significant gender differences in RBC, Hb level and MPV. However, RBC and Hb were higher in males median values compared to females (median values) (p<0.001), whereas the Mean platelet volume lower values (MPV) in males than females (P<0.047). The hemoglobin level for some West African countries (Mali, Burkina Faso, Togo, and Nigeria) ranged from 13.5 to 15.1 g/dL for males and 12 to 13 g/dL for females. However in East and Southern Africa, the values were anywhere from 14.1 to 16.1 for males and 11.2 to 14.4 for females.</p><p><strong>Conclusion: </strong>Our data may help physicians to better define hematological abnormalities in patients. They may also be used to define new \"normal hematological values\" in Malian population or in the whole West African population.</p>","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35813606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidants in Acute and Chronic Lung Disease.","authors":"Praveen Mannam,&nbsp;Anup Srivastava,&nbsp;Jaya Prakash Sugunaraj,&nbsp;Patty J Lee,&nbsp;Maor Sauler","doi":"10.4172/2165-7831.1000128","DOIUrl":"https://doi.org/10.4172/2165-7831.1000128","url":null,"abstract":"<p><p>Oxidants play an important role in homeostatic function, but excessive oxidant generation has an adverse effect on health. The manipulation of Reactive Oxygen Species (ROS) can have a beneficial effect on various lung pathologies. However indiscriminate uses of anti-oxidant strategies have not demonstrated any consistent benefit and may be harmful. Here we propose that nuanced strategies are needed to modulate the oxidant system to obtain a beneficial result in the lung diseases such as Acute Lung Injury (ALI) and Chronic Obstructive Pulmonary Disease (COPD). We identify novel areas of lung oxidant responses that may yield fruitful therapies in the future.</p>","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"4 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2165-7831.1000128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33074511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}