{"title":"血小板减少症患者骨髓抽吸巨核细胞形态学改变","authors":"R. Sharma, Kira Cm, Anita Ramdas","doi":"10.37421/jbl.2019.9.235","DOIUrl":null,"url":null,"abstract":"Background: Thrombocytopenia is seen in various haematological and non haematological conditions and has been defined as platelet count less than 1.5 lakh/mm3. Dysplastic changes are well known in Myelodysplastic syndrome (MDS) but these can be seen in other haematological conditions. Methods: This was a retrospective study done on 100 bone marrow aspirations in a tertiary care center in South India from Jan 2015 to Dec 2016. All bone marrow aspirations in this study period was retrieved and the slides were reviewed by two pathologists. Results: Total of 100 cases were included in the study. Out of 100 cases of bone marrow aspiration, 78 cases were of thrombocytopenia, 6 cases were of thrombocytosis, and 16 cases were of normal platelet count. The most common cause for which bone marrow aspiration was sought was pancytopenia (30 %), followed by ITP (15%), PUO (12%), Anaemia (10%). Bicytopenia (8%), Hepatosplenomegaly (3%), Lymphoproliferative disorder (5%), GMCSF treatment (1%),MPN (3%), T.B , MM (4% each), MDS (2%), AL (2%), MGUS (1% ). Conclusion: Most common cause of thrombocytopenia in this study was pancytopenia followed by ITP. Dysplastic features were seen in MDS but also present in other conditions like megaloblastic anaemia and acute leukemia.","PeriodicalId":90886,"journal":{"name":"Journal of blood & lymph","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Morphological Alterations in Megakaryocytes in Bone Marrow Aspirate of Thrombocytopenia Cases\",\"authors\":\"R. Sharma, Kira Cm, Anita Ramdas\",\"doi\":\"10.37421/jbl.2019.9.235\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Thrombocytopenia is seen in various haematological and non haematological conditions and has been defined as platelet count less than 1.5 lakh/mm3. Dysplastic changes are well known in Myelodysplastic syndrome (MDS) but these can be seen in other haematological conditions. Methods: This was a retrospective study done on 100 bone marrow aspirations in a tertiary care center in South India from Jan 2015 to Dec 2016. All bone marrow aspirations in this study period was retrieved and the slides were reviewed by two pathologists. Results: Total of 100 cases were included in the study. Out of 100 cases of bone marrow aspiration, 78 cases were of thrombocytopenia, 6 cases were of thrombocytosis, and 16 cases were of normal platelet count. The most common cause for which bone marrow aspiration was sought was pancytopenia (30 %), followed by ITP (15%), PUO (12%), Anaemia (10%). Bicytopenia (8%), Hepatosplenomegaly (3%), Lymphoproliferative disorder (5%), GMCSF treatment (1%),MPN (3%), T.B , MM (4% each), MDS (2%), AL (2%), MGUS (1% ). Conclusion: Most common cause of thrombocytopenia in this study was pancytopenia followed by ITP. Dysplastic features were seen in MDS but also present in other conditions like megaloblastic anaemia and acute leukemia.\",\"PeriodicalId\":90886,\"journal\":{\"name\":\"Journal of blood & lymph\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of blood & lymph\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37421/jbl.2019.9.235\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of blood & lymph","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37421/jbl.2019.9.235","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景:血小板减少症见于各种血液学和非血液学疾病,其定义为血小板计数低于15万/mm3。增生异常变化在骨髓增生异常综合征(MDS)中是众所周知的,但在其他血液学疾病中也可以看到。方法:这是一项回顾性研究,对2015年1月至2016年12月在印度南部一家三级保健中心进行的100例骨髓移植进行了研究。本研究期间所有的骨髓穿刺都被取出,并由两名病理学家检查切片。结果:共纳入100例病例。100例骨髓抽吸患者中,血小板减少78例,血小板增多6例,血小板计数正常16例。最常见的骨髓穿刺原因是全血细胞减少症(30%),其次是ITP (15%), PUO(12%),贫血(10%)。自行车减少症(8%),肝脾肿大(3%),淋巴增生性疾病(5%),GMCSF治疗(1%),MPN (3%), tb, MM(各4%),MDS (2%), AL (2%), MGUS(1%)。结论:本研究中血小板减少最常见的原因是全血细胞减少,然后是ITP。增生异常特征见于MDS,但也存在于其他疾病,如巨幼细胞贫血和急性白血病。
Morphological Alterations in Megakaryocytes in Bone Marrow Aspirate of Thrombocytopenia Cases
Background: Thrombocytopenia is seen in various haematological and non haematological conditions and has been defined as platelet count less than 1.5 lakh/mm3. Dysplastic changes are well known in Myelodysplastic syndrome (MDS) but these can be seen in other haematological conditions. Methods: This was a retrospective study done on 100 bone marrow aspirations in a tertiary care center in South India from Jan 2015 to Dec 2016. All bone marrow aspirations in this study period was retrieved and the slides were reviewed by two pathologists. Results: Total of 100 cases were included in the study. Out of 100 cases of bone marrow aspiration, 78 cases were of thrombocytopenia, 6 cases were of thrombocytosis, and 16 cases were of normal platelet count. The most common cause for which bone marrow aspiration was sought was pancytopenia (30 %), followed by ITP (15%), PUO (12%), Anaemia (10%). Bicytopenia (8%), Hepatosplenomegaly (3%), Lymphoproliferative disorder (5%), GMCSF treatment (1%),MPN (3%), T.B , MM (4% each), MDS (2%), AL (2%), MGUS (1% ). Conclusion: Most common cause of thrombocytopenia in this study was pancytopenia followed by ITP. Dysplastic features were seen in MDS but also present in other conditions like megaloblastic anaemia and acute leukemia.