Healthy aging research最新文献_第8页

Vertex-wise shape analysis of subcortical structures in Alzheimerʼs disease 阿尔茨海默病皮质下结构的顶点形状分析

Healthy aging research Pub Date : 2016-01-01 DOI: 10.1097/01.HXR.0000511867.64463.39

B. Bagepally, J. John, P. Sivakumar, S. Bharath, S. Jain, M. Varghese

{"title":"Vertex-wise shape analysis of subcortical structures in Alzheimerʼs disease","authors":"B. Bagepally, J. John, P. Sivakumar, S. Bharath, S. Jain, M. Varghese","doi":"10.1097/01.HXR.0000511867.64463.39","DOIUrl":"https://doi.org/10.1097/01.HXR.0000511867.64463.39","url":null,"abstract":"Background: Most MRI studies in Alzheimer’s disease (AD) have focused on cortical and hippocampal atrophy. This study, however, examines regional volumetric and shape abnormalities of subcortical and limbic structures in AD. Methods: Thirty-six patients with AD and 36 matched controls were included in the study. All subjects were right-handed, evaluated using standard clinical assessment scales and genotyped at ApoE locus. Structural T1- weighted images were acquired using 3 Tesla MRI. Vertex-wise shape analysis was performed, with age, gender and total brain volume used as covariates of no interest. Data on the volumes of the hippocampus, amygdala, caudate, putamen and thalamus were statistically analyzed. Results: The bilateral hippocampus, amygdala, caudate, putamen and thalamus of AD patients were significantly lower in volume than controls. With respect to ApoE4 carrier status, there were no within-group volumetric differences in either AD or controls. Vertex-wise shape analysis of AD patients revealed significant surface reductions at the bilateral hippocampus, amygdala, caudate and putamen. No shape-wise difference was observed between ApoE4 carrier and non-carrier subjects in either group. Correlation analysis revealed a significant negative correlation between the Hindi mental status examination score, and shape analysis of atrophy of the hippocampus, caudate and putamen. Conclusions: Significant volume reductions and shape differences were observed in subcortical and limbic structures in AD patients. The observed atrophy of neocortical and deep grey matter structures in AD patients indicates ongoing degenerative processes in the amygdala, caudate and putamen – similar to the hippocampus – which may contribute to cognitive and/or other clinical features in AD.","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"5 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61603860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A downhill course from vitrectomy for floaters to end-stage glaucoma 从飞蚊症患者的玻璃体切除术到终末期青光眼的下坡路

Healthy aging research Pub Date : 2016-01-01 DOI: 10.1097/01.HXR.0000511869.72087.31

Priyamvada M Pitale, M. Waisbourd, Mila J Heersink, M. Moster, L. Hark, G. Spaeth

引用次数: 0

Prevalence of clinically probable obstructive sleep apnea in American veterans with chronic musculoskeletal pain 慢性肌肉骨骼疼痛的美国退伍军人临床可能的阻塞性睡眠呼吸暂停患病率

Healthy aging research Pub Date : 2016-01-01 DOI: 10.1097/01.HXR.0000511865.62678.78

R. Nadeem, Ahmed Ghadai, S. Iftikhar, Kristin Lee, Bharathi Swaminathan, Tamseela Hussain, Mohamed Khamis, M. Yousaf, Banan Turkman, A. Qureshi, Maham Mansoor

{"title":"Prevalence of clinically probable obstructive sleep apnea in American veterans with chronic musculoskeletal pain","authors":"R. Nadeem, Ahmed Ghadai, S. Iftikhar, Kristin Lee, Bharathi Swaminathan, Tamseela Hussain, Mohamed Khamis, M. Yousaf, Banan Turkman, A. Qureshi, Maham Mansoor","doi":"10.1097/01.HXR.0000511865.62678.78","DOIUrl":"https://doi.org/10.1097/01.HXR.0000511865.62678.78","url":null,"abstract":"Background: Coexistence of obstructive sleep apnea (OSA) and chronic musculoskeletal pain (CMP) is common. Patients experiencing pain have a lower threshold for arousals associated with apnea episodes. Pain treatment with analgesics affects upper airway patency during sleep. Methods: Eighty-one patients with CMP, and 100 without, were evaluated using the Berlin Questionnaire (BQ), which classifies patients as high or low risk for clinically probable OSA. Confounding variables including demographics (age, gender, BMI), medication use (sedatives, hypnotics, antidepressants), and Epworth sleepiness score (ESS) were compared between groups. Results: There was no significant difference in gender, use of sedatives and antidepressants, BMI or ESS between cases and controls. There was, however, a significant difference in use of analgesics, and hypnotics. Patients in the control group were significantly older than cases. There was a significant difference in the proportion of high versus low risk BQ values between cases and controls. Logistic regression was performed while adjusting for covariates, which were significantly different between groups (use of analgesics, hypnotics and age). Cases with high-risk BQ scores were not sleepier than controls with high-risk BQ scores. Conclusions: Patients with CMP have a high prevalence of clinically probable OSA. Sleepiness is not prevalent among patients with probable OSA and CMP. High-risk BQ patients were not sleepier than low risk BQ patients.","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"33 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61603836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Protective personality variables and their effect on well‐being and participation in the elderly: A pilot study 保护性人格变量及其对老年人幸福感和参与的影响:一项初步研究

Healthy aging research Pub Date : 2016-01-01 DOI: 10.1097/01.HXR.0000508388.87759.42

A. Erez, N. Katz, Amiya Waldman-Levi

{"title":"Protective personality variables and their effect on well‐being and participation in the elderly: A pilot study","authors":"A. Erez, N. Katz, Amiya Waldman-Levi","doi":"10.1097/01.HXR.0000508388.87759.42","DOIUrl":"https://doi.org/10.1097/01.HXR.0000508388.87759.42","url":null,"abstract":"Background: Elderly individuals experience a complex array of physiological, psychological, and social changes in their lives, which challenges their ability to participate in meaningful occupations, and can result in a diminished sense of well‐being. In previous work, we proposed a broader perspective that takes into account the contribution of hope and playfulness ‐protective personality characteristics ‐ to participation and well‐being among the elderly. A pilot study was designed to explore this notion and examined the relationship between playfulness, hope, well‐being, and participation, while accounting for cognitive decline and negative emotions. Methods: Forty six participants with mean age of 78.4 years (SD = 7.3), of which 78.3% were women and 21.7% men, were interviewed using standardized questionnaires measuring participation, well‐being, sense of hope, cognitive status, playfulness and emotional status. Results: Moderate to high correlations were found between playfulness and hope and both well‐being and participation. The correlation coefficient range was r = 0.47–0.70 (p < 0.05). In addition, participation correlated with cognitive and emotional status, while well‐being correlated only with emotional status (r = 0.72; p < 0.01). Statistical analysis demonstrated that while playfulness and hope differed among individuals with and without depressive symptoms, they did not affect participants’ cognitive status. Conclusions: The results presented here support the importance of traits such as having a sense of hope and playfulness and their role as resilient factors that may contribute to elderly well‐being and participation.","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"5 1","pages":"1–9"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/01.HXR.0000508388.87759.42","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61603794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Promoting heart health and behavior change in a vulnerable older adult population 促进易受伤害的老年人的心脏健康和行为改变

Healthy aging research Pub Date : 2016-01-01 DOI: 10.1097/01.HXR.0000508389.95382.e2

H. Menne, L. Borato, Evan G Shelton, Justin D. Johnson

{"title":"Promoting heart health and behavior change in a vulnerable older adult population","authors":"H. Menne, L. Borato, Evan G Shelton, Justin D. Johnson","doi":"10.1097/01.HXR.0000508389.95382.e2","DOIUrl":"https://doi.org/10.1097/01.HXR.0000508389.95382.e2","url":null,"abstract":"Background: Older minority populations in low socioeconomic classes are at high risk for cardiovascular disease, stroke, type 2 diabetes, and a host of other heart‐related health conditions. Engaging in unhealthy behaviors such as poor diet, sedentary lifestyle, and poor use of health services is a major contributor to these health disparities. The Heart Health Program was developed to improve health outcomes by encouraging behavior change in a group of low‐income older African Americans attending two urban senior centers. Using the Health Belief Model as a guiding framework, group sessions were conducted bi‐weekly over the course of a three month period. Session leaders engaged participants in educational activities and helped to develop individual ‘action steps’, or actionable goals for each participant to strive toward as a means of improving heart health. Methods: Twenty‐five low‐income, African American seniors participated in the Heart Health Program. A prepost design was used to evaluate the acceptability and feasibility of the program. Results: Participants reported high levels of satisfaction with the program as a whole and successful accomplishment of action steps. Results indicate limited long‐term behavior change at the program's conclusion. Conclusions: Lessons were learned about implementing this type of behavior change program in a senior center focused on: preparation, logistics, and relationships between the project team, senior center staff, and participants. Based on the initial experience of the Heart Health Program, plans are underway to refine the program and broaden its delivery to more older adults.","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"5 1","pages":"1–12"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/01.HXR.0000508389.95382.e2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61603806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Healthy aging research Pub Date : 2015-02-03 DOI: 10.12715/har.2015.4.4

A. Simpson, K. Simpson, J. Dubno

{"title":"Health-related quality of life in older adults: Effects of hearing loss and common chronic conditions","authors":"A. Simpson, K. Simpson, J. Dubno","doi":"10.12715/har.2015.4.4","DOIUrl":"https://doi.org/10.12715/har.2015.4.4","url":null,"abstract":"Background: Recent findings on hearing loss (HL) and healthy aging have highlighted important clinical and policy implications concerning quality of life in older adults. Our objective was to explore the impact of HL on quality of life in older Americans, independent of survival, using the 2000 Medical Expenditure Panel Survey (MEPS) and 2010 Census data. Methods: A retrospective cohort of 2,567 subjects aged 60‐90 in the MEPS who provided information on selfreported HL, health‐related quality of life and chronic conditions. The EQ‐5D visual analog scale (VAS) transformation was used to estimate marginal utility decrements for 5‐year age categories and conditions, including HL, hypertension, diabetes, angina, joint pain, asthma, emphysema, or blindness. The modeled decrements were applied to the 2010 US census population to estimate annual quality‐adjusted life years (QALYs) lost. Results: Of the respondents, 15.4% had mild HL and 1.1% had moderate/severe hearing loss. Other conditions (utility decrement) included: joint pain 53% (.0643), hypertension 47.2% (.0292), diabetes 15.6% (.0577), angina 9.8% (.0352), asthma 7.9% (.0288), emphysema 4.5% (.1186), blindness 0.8% (.0836), and average age 71.0 with decrements .0033 per year. The decrement from hearing loss ranked 4th at 174,689 in the US population. Conclusions: The substantial impact of hearing loss on healthy aging may not be obvious when quality of life decrements include survival or when diluted with younger populations. Careful consideration of clinical interventions for age‐related HL is warranted and further research is needed on the effect of HL on quality of life in otherwise healthy older adults.","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66242189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Analysis of potential cost reductions related to falls in hospitalized elderly patients by correcting high‐dose prescriptions of sedative hypnotics 通过纠正高剂量镇静催眠药处方，分析住院老年患者跌倒相关的潜在成本降低

Healthy aging research Pub Date : 2015-01-01 DOI: 10.12715/har.2015.4.23

T. Tachi, T. Yokoi, C. Goto, M. Umeda, M. Yasuda, T. Mizui, Y. Noguchi, H. Teramachi

{"title":"Analysis of potential cost reductions related to falls in hospitalized elderly patients by correcting high‐dose prescriptions of sedative hypnotics","authors":"T. Tachi, T. Yokoi, C. Goto, M. Umeda, M. Yasuda, T. Mizui, Y. Noguchi, H. Teramachi","doi":"10.12715/har.2015.4.23","DOIUrl":"https://doi.org/10.12715/har.2015.4.23","url":null,"abstract":"Background: Risk factors for falls include older age, diseases, and certain medications. High‐dose sedative hypnotics have been shown to increase the risk of falls, necessitating caution when these medications are used. High‐dose sedative hypnotics have an increased half‐life in elderly patients with reduced hepatic and renal function, which may increase fall risk. Methods: This retrospective survey evaluated the potential cost reductions associated with fall prevention by changing high‐dose prescriptions. For this purpose, the association between falls and high‐dose usage of sedative hypnotics was analyzed in hospitalized elderly patients. Study participants were 267 ambulatory patients aged ≥65 years who were taking sedative hypnotics and were hospitalized for ≥3 days from May 2012 to April 2013 at the Gifu Municipal Hospital, Japan. Patients' age, sex and usage of sedative hypnotics (high‐dose vs. non‐highdose) were analyzed, as well as the costs incurred by tests, drugs, and wages for medical personnel for patients on high‐dose sedative hypnotics who experienced falls. Results: Analysis revealed a significantly higher rate of falls in the group using high‐dose sedative hypnotics (21.4%; 14/224) compared to the non‐high‐dose group (6.3%; 9/42, p=0.004). Assessment of cost demonstrated potential savings of ¥589 per case if falls could be prevented by correcting high‐dose prescriptions. Conclusions: This study indicates that high‐dose prescriptions of sedative hypnotics may be associated with fall risk in the elderly. Correcting high‐dose prescriptions for these drugs would be beneficial not only for medical safety, but also the medical economy.","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"4 1","pages":"1–8"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66241593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A bidirectional approach to lay definitions vs. theories of successful aging: The Manitoba Follow‐up Study 一个双向的方法奠定定义与理论的成功老龄化:马尼托巴随访研究

Healthy aging research Pub Date : 2015-01-01 DOI: 10.12715/har.2015.4.38

A. Swift, R. Tate

{"title":"A bidirectional approach to lay definitions vs. theories of successful aging: The Manitoba Follow‐up Study","authors":"A. Swift, R. Tate","doi":"10.12715/har.2015.4.38","DOIUrl":"https://doi.org/10.12715/har.2015.4.38","url":null,"abstract":"Background: In light of evidence from previous work, we identified the overlaps and gaps between six prominent theoretical frameworks of successful aging and lay conceptualizations of the same. It has formerly been suggested that considering complex phenomena from the bottom up and from the top down allows one to get to the root of an issue that warrants inquiry; namely the discrepancy between researcher‐generated theories and lay conceptualizations of successful aging. Methods: In the present study we approached this issue from the bottom up and top down, using the saturated Manitoba Follow‐up Study coding system (the ‘MFUS‐SA‐CM v.1’) as a template. Results: The overlaps we found depicted aspects of successful aging that were well represented by theories in the field. The gaps highlighted aspects of successful aging that were underrepresented by the theories. The gaps were particularly important, since they flagged theoretical areas that could be expanded upon via lay conceptualizations. Conclusions: By broadening the existing theoretical ‘take’ on successful aging to include aspects of lay definitions that have thus far been downplayed, we aim to provide the research community with a much‐needed tool with which to consistently inform their successful aging research.","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"4 1","pages":"1–13"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66242142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Everyday outdoor mobility in old age: Focus group interviews with active senior citizens 老年人日常户外活动:与活跃老年人的焦点小组访谈

Healthy aging research Pub Date : 2015-01-01 DOI: 10.12715/har.2015.4.32

Lina Gyllencreutz, B. Saveman

{"title":"Everyday outdoor mobility in old age: Focus group interviews with active senior citizens","authors":"Lina Gyllencreutz, B. Saveman","doi":"10.12715/har.2015.4.32","DOIUrl":"https://doi.org/10.12715/har.2015.4.32","url":null,"abstract":"Background: Senior citizens are over‐represented in injury statistics, and fall‐related injuries are globally recognized as a major threat to their health and wellbeing. Outdoor falls are likely to occur among those who are active and healthy when walking or cycling. The objective of this study was to explore active senior citizens' experiences and perceptions of how their safety could be increased and their risk reduced in outdoor environments. Methods: Six focus‐group interviews with 31 healthy and active senior citizens were conducted in northern Sweden. Data were analyzed via a qualitative content analysis method. Results: Participants adjusted to age‐related changes in order to stay safe during outdoor mobility. Outdoor activities were facilitated by having confidence of safety within the environment, and by using safety devices. Fear of, for example, falling and dangerous environments, such as uneven surfaces, as well as the shortcomings of safety devices, were constraining elements for outdoor activity. Conclusions: It is of great importance to raise awareness of healthy aging and to illuminate directions for environmental changes. Asking old people about their experiences allows the researcher to identify with their perspective, and may give a more comprehensive understanding of the most appropriate recommendations for health and safety improvements.","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"4 1","pages":"1–10"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66242170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Supporting evidence for using Perispinal Etanercept to inhibit TNF&agr; when treating neuropathologies including dementia, chronic stroke, neuropathic pain or traumatic brain injury: Role of TNF in the regulation of normal brain activity (Part I) 应用依那西普抑制TNF&agr的支持证据在治疗包括痴呆、慢性中风、神经性疼痛或创伤性脑损伤在内的神经病变时:TNF在调节正常脑活动中的作用(第一部分)

Healthy aging research Pub Date : 2015-01-01 DOI: 10.12715/har.2015.4.11

S. Ralph, I. Clark

引用次数: 0