Healthy aging research最新文献

{"title":"Chronic <i>Pseudomonas aeruginosa</i> lung infection in aged mice via agar beads delivery","authors":"Xiaoying Wan, Ying Sun, Chongkui Sun","doi":"10.26599/agr.2025.9340059","DOIUrl":"https://doi.org/10.26599/agr.2025.9340059","url":null,"abstract":"Pulmonary infections pose significantly greater threats to the elderly than to younger populations. At the same time, <i>Pseudomonas aeruginosa</i>, a major opportunistic pathogen, frequently causes a typical bacterial chronic infection in clinically vulnerable elderly individuals. To understand the underlying mechanisms of chronic infection in the elderly, a reliable and stable model using aged mice is essential. However, initial attempts using intratracheal instillation of planktonic <i>P. aeruginosa</i> caused 100% mortality, prompting us to optimize current infection methodology in regular young mice. By embedding bacteria in agar beads for intratracheal delivery, we successfully established persistent <i>P. aeruginosa</i> colonization with significantly improved survival. This model provides a crucial platform for elucidating the molecular mechanisms of host-pathogen interactions during chronic infection in the context of aging. Additionally, it offers vital insights into age-specific immune responses against pulmonary bacterial infections and facilitates the development of novel therapeutic strategies tailored for the elderly population.","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"3 4","pages":"9340059-9340059"},"PeriodicalIF":0.0,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/article_pdf/1986333539000979458.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on the Promotion of Diabetic Wound Healing by Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells under the Influence of Aging","authors":"志勇 颜","doi":"10.12677/ar.2024.115264","DOIUrl":"https://doi.org/10.12677/ar.2024.115264","url":null,"abstract":"","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"11 05","pages":"1823-1830"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147899104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional Regulation of Osteoporosis by the NF-κB Pathway under the Influence of Aging","authors":"苗苗 郑","doi":"10.12677/ar.2024.113110","DOIUrl":"https://doi.org/10.12677/ar.2024.113110","url":null,"abstract":"","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"11 03","pages":"823-828"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147893517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the incidence and influencing factors of sarcopenia in elderly patients with radiation enteritis","authors":"Wenwen Fu, Lina Zhang, Tenghui Ma","doi":"10.26599/agr.2023.9340016","DOIUrl":"https://doi.org/10.26599/agr.2023.9340016","url":null,"abstract":"<sec><strong>Objective</strong> To investigate the incidence of sarcopenia and its influencing factors in elderly patients with chronic radiation proctitis and radiation enteritis. </sec><sec><strong>Results</strong> Patients in the experimental group exhibited significantly lower levels of total cellular fluid volume, total protein content, lean tissue, skeletal muscle mass (SLM), fat-free mass (FFM), appendicular skeletal muscle mass (ASM), relative skeletal muscle mass index (RSMI), visceral fat area (VFA), body mass index (BMI), and phase angle compared to the control group, with statistical significance (<i>P</i> &lt; 0.05). Furthermore, within the experimental group, patients with sarcopenia had lower average body mass, BMI, protein levels, ASM, RSMI, body fat, and phase angle compared to those without sarcopenia, with statistical significance (<i>P</i> &lt; 0.05). There was a statistically significant difference in the incidence of sarcopenia among different BMI groups within the experimental group (<i>P</i> &lt; 0.05). Pearson correlation analysis revealed a significant positive correlation between RSMI and height, body weight, BMI, protein, FFM, SLM, and ASM ( <i>P</i> &lt; 0.001), while it showed a significant negative correlation with age and percentage of body fat (PBF) (<i>P</i> &lt; 0.05). Regression analysis indicated that a higher BMI and ASM were protective factors against the development of sarcopenia in elderly patients with chronic radiation enteritis. </sec><sec><strong>Conclusion</strong> Sarcopenia is highly prevalent in elderly patients with chronic radiation enteritis. Maintaining a suitable high BMI and ASM level is protective against the development of sarcopenia in these patients. </sec><sec><strong>Methods</strong> Elderly patients with chronic radiation enteritis treated at the Sixth Affiliated Hospital, Sun Yat-sen University were selected as the experimental group. Simultaneously, elderly individuals undergoing health check-ups during the same period were chosen as the control group. Relevant parameters of the participants were collected. Diagnoses on whether these patients suffer from sarcopenia were collected. </sec>","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"1 2","pages":"9340016-9340016"},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/AGR.2023.9340016.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147913401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Principles of Disease and Disability Prevention and Health Promotion with Increasing Age","authors":"N. Sharda, K. Daniel, H. White","doi":"10.1007/978-3-030-06200-2_3","DOIUrl":"https://doi.org/10.1007/978-3-030-06200-2_3","url":null,"abstract":"","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74321243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of SYNTAX score on in-hospital outcomes after Percutaneous Coronary Intervention (PCI)","authors":"A. Salari, F. Mirbolook, H. Moladoust, J. Kheirkhah, A. Salary, Atousa Etezadi","doi":"10.35248/har.2019.8.4","DOIUrl":"https://doi.org/10.35248/har.2019.8.4","url":null,"abstract":"Background: The SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) score has emerged as an anatomical-based tool that quantitatively determines the coronary vasculature due to 9 criteria such as number, location, complexity, and functional impact of angiographically obstructive lesions. Because of the fact that the same study of this scoring system has not been performed in Iran, we aimed to do this study to predict the value of SYNTAX score on in-hospital outcomes after Percutaneous Coronary Intervention (PCI) in patients referred to Heshmat Hospital, Rasht, Iran. Methods: The present cross-sectional study conducted at Heshmat Heart Center, Rasht, Iran. Patients admitted for elective or primary PCI of coronary arteries due to the acute coronary syndrome, ST segment elevation myocardial infarction and chest pain. Each patient’s medical data such as clinical characteristics, procedures and adverse events collected from data bank and medical records. The SYNTAX score was calculated using SYNTAX score version 2.58 (SYNTAX SCORE I, www.syntaxscore.com). All in-hospital outcomes were entered in SPSS software version 23 and analysis was done. Results: In this study 431 patients underwent PCI. The average age of the samples was 57.10 ± 10.67 years (range 23- 85 years). However, the average SYNTAX score in the samples was 15.93 ± 5.53 points. The mean SYNTAX score is significantly higher in positive cases of CVA after PCI (p=0.001), hypotension (p=0.001), arrhythmia (p=0.001), in-hospital death (p=0.002), unsuccessful PCI (p=0.001), CIN (p=0.001) and total adverse event incidence (p=0.001) but not with vascular disorders (p=0.769). ROC curve for predicting outcomes of PCI in the patients based on SYNTAX score, showed the total cutoff point of it was 19.5 and under curve area was calculated 0.79 (CI=0.716-0.865, p<0.0001). Conclusion: It seems that SYNTAX score utilization for samples with anatomic complexity, can predict the in-hospital outcomes in our setting.","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70016600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Prevention and Healthy Aging","authors":"E. Cook, Lonzetta L. Newman","doi":"10.1007/978-3-030-06200-2_17","DOIUrl":"https://doi.org/10.1007/978-3-030-06200-2_17","url":null,"abstract":"","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79042652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Health and Healthy Aging","authors":"P. K. Siddappa, J. Birk","doi":"10.1007/978-3-030-06200-2_7","DOIUrl":"https://doi.org/10.1007/978-3-030-06200-2_7","url":null,"abstract":"","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80960485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resilience, Adapting to Change, and Healthy Aging","authors":"Peter Martin, J. Lee, M. Gilligan","doi":"10.1007/978-3-030-06200-2_29","DOIUrl":"https://doi.org/10.1007/978-3-030-06200-2_29","url":null,"abstract":"","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"25 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82831783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexuality, Intimacy, and Healthy Aging","authors":"Els Messelis, M. Kazer, Jillian A. Gelmetti","doi":"10.1007/978-3-030-06200-2_25","DOIUrl":"https://doi.org/10.1007/978-3-030-06200-2_25","url":null,"abstract":"","PeriodicalId":90841,"journal":{"name":"Healthy aging research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79679857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}