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Phyllanthus niruri niosomes ameliorate obesity-induced hepatic steatosis in rats via modulating MALAT1/miR-206/GLP-1R signaling and hepatic lipid metabolism. 余甘子小体通过调节MALAT1/miR-206/GLP-1R信号和肝脏脂质代谢改善肥胖诱导的大鼠肝脂肪变性。
IF 4.6 2区 生物学
Biological Research Pub Date : 2026-04-27 DOI: 10.1186/s40659-026-00682-1
Safaa I Khater, Mohamed M A Hussein, Saydat S Abdel-Magied, Marwa M Lotfy, Tarek Khamis, Sahar Abdelaziz, Mahmoud Mostafa, Noha Osama El-Shaer, Mahran Mohamed Abd El-Emam
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引用次数: 0
Effects of MICT and HIIT on mitochondrial dynamics-related proteins in visceral adipose tissue of type 2 diabetic rats. MICT和HIIT对2型糖尿病大鼠内脏脂肪组织线粒体动力学相关蛋白的影响。
IF 4.6 2区 生物学
Biological Research Pub Date : 2026-04-24 DOI: 10.1186/s40659-026-00694-x
Mohammad Rahman Rahimi, Ian G Davies, Hadi Golpasandi, Narges Fatahi
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引用次数: 0
Characterization of GH18 chitinase in Leishmania braziliensis: expression, structural insights, and implications for vaccine and therapeutic development. 巴西利什曼原虫GH18几丁质酶的表征：表达、结构见解以及对疫苗和治疗开发的影响
IF 4.6 2区 生物学
Biological Research Pub Date : 2026-04-16 DOI: 10.1186/s40659-026-00685-y
Maura Rojas-Pirela, Marirene Chacón-Arnaude, Cristóbal Lárez-Velásquez, María Verónica Rojas, Constanza Cardenas, Ana J Cáceres, Luis-Antonio Corchete, Diego Andrade-Alviárez, Luis A Prieto-Rojas, Daniel Salete-Granado, María Á Pérez-Nieto, Wilfredo Quiñones, Paul A M Michels, Miguel Marcos
{"title":"Characterization of GH18 chitinase in Leishmania braziliensis: expression, structural insights, and implications for vaccine and therapeutic development.","authors":"Maura Rojas-Pirela, Marirene Chacón-Arnaude, Cristóbal Lárez-Velásquez, María Verónica Rojas, Constanza Cardenas, Ana J Cáceres, Luis-Antonio Corchete, Diego Andrade-Alviárez, Luis A Prieto-Rojas, Daniel Salete-Granado, María Á Pérez-Nieto, Wilfredo Quiñones, Paul A M Michels, Miguel Marcos","doi":"10.1186/s40659-026-00685-y","DOIUrl":"https://doi.org/10.1186/s40659-026-00685-y","url":null,"abstract":"","PeriodicalId":9084,"journal":{"name":"Biological Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OGDH mediates α-ketoglutarate-induced follicular development and antioxidative response by interacting with CAT/SOD2. OGDH通过与CAT/SOD2相互作用介导α-酮戊二酸诱导的卵泡发育和抗氧化反应。
IF 4.6 2区 生物学
Biological Research Pub Date : 2026-04-10 DOI: 10.1186/s40659-026-00688-9
Enyuan Huang, Jingyu Zhou, Mengting Hu, Liuhong Zhang, Jiahao Shao, Meng Lv, Fen Miao, Yao Jiang, Nian Li, Jiaqi Li, Xiaolong Yuan
{"title":"OGDH mediates α-ketoglutarate-induced follicular development and antioxidative response by interacting with CAT/SOD2.","authors":"Enyuan Huang, Jingyu Zhou, Mengting Hu, Liuhong Zhang, Jiahao Shao, Meng Lv, Fen Miao, Yao Jiang, Nian Li, Jiaqi Li, Xiaolong Yuan","doi":"10.1186/s40659-026-00688-9","DOIUrl":"https://doi.org/10.1186/s40659-026-00688-9","url":null,"abstract":"","PeriodicalId":9084,"journal":{"name":"Biological Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-21 silencing inhibits the proliferation, growth, and migration of colorectal cancer cells via suppressing phosphorylation of ERK1/2 and STAT3. IL-21沉默通过抑制ERK1/2和STAT3的磷酸化抑制结直肠癌细胞的增殖、生长和迁移。
IF 4.6 2区 生物学
Biological Research Pub Date : 2026-04-09 DOI: 10.1186/s40659-026-00692-z
Ching Yi Ong, Wen Tao Xiong, Nor Suhada Anuar, Eshtiyag Abdalla Abdalkareem, Ming Thong Ong, Boon Yin Khoo
{"title":"IL-21 silencing inhibits the proliferation, growth, and migration of colorectal cancer cells via suppressing phosphorylation of ERK1/2 and STAT3.","authors":"Ching Yi Ong, Wen Tao Xiong, Nor Suhada Anuar, Eshtiyag Abdalla Abdalkareem, Ming Thong Ong, Boon Yin Khoo","doi":"10.1186/s40659-026-00692-z","DOIUrl":"https://doi.org/10.1186/s40659-026-00692-z","url":null,"abstract":"","PeriodicalId":9084,"journal":{"name":"Biological Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alternatives for fetal bovine serum (FBS) and sustainability of milk derivatives in cell culture. 胎牛血清（FBS）的替代品和乳衍生物在细胞培养中的可持续性。
IF 4.6 2区 生物学
Biological Research Pub Date : 2026-03-28 DOI: 10.1186/s40659-026-00691-0
Olga Maria Pittino, Maria Sofia Semprini, Francesca Ruzzi, Stefania Angelicola, Chiara Cappello, Laura Scalambra, Mariateresa Frascino, Patrick L S Michel, Patrizia Nanni, Pier-Luigi Lollini, Arianna Palladini
{"title":"Alternatives for fetal bovine serum (FBS) and sustainability of milk derivatives in cell culture.","authors":"Olga Maria Pittino, Maria Sofia Semprini, Francesca Ruzzi, Stefania Angelicola, Chiara Cappello, Laura Scalambra, Mariateresa Frascino, Patrick L S Michel, Patrizia Nanni, Pier-Luigi Lollini, Arianna Palladini","doi":"10.1186/s40659-026-00691-0","DOIUrl":"10.1186/s40659-026-00691-0","url":null,"abstract":"","PeriodicalId":9084,"journal":{"name":"Biological Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reelin regulates the migration and differentiation of extravillous trophoblastic cells. Reelin调节细胞外滋养层细胞的迁移和分化。
IF 4.6 2区 生物学
Biological Research Pub Date : 2026-03-26 DOI: 10.1186/s40659-026-00690-1
Nicole Sommer, Carlos Alarcon-Godoy, Héctor Pizarro, Aníbal Pacheco, Jorge A Carvajal, Hugo Olguín, Jaime Gutiérrez, Andrea Leiva, María-Paz Marzolo
{"title":"Reelin regulates the migration and differentiation of extravillous trophoblastic cells.","authors":"Nicole Sommer, Carlos Alarcon-Godoy, Héctor Pizarro, Aníbal Pacheco, Jorge A Carvajal, Hugo Olguín, Jaime Gutiérrez, Andrea Leiva, María-Paz Marzolo","doi":"10.1186/s40659-026-00690-1","DOIUrl":"10.1186/s40659-026-00690-1","url":null,"abstract":"","PeriodicalId":9084,"journal":{"name":"Biological Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147520077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in the microRNA cargo of granulosa cell-derived extracellular vesicles under oxidative stress in a bovine model. 牛模型氧化应激下颗粒细胞来源的细胞外囊泡的microRNA载货的变化。
IF 4.6 2区 生物学
Biological Research Pub Date : 2026-03-25 DOI: 10.1186/s40659-026-00689-8
Judith Diaz-Muñoz, Yulia N Cajas, Karina Cañón-Beltrán, Lena Arévalo, Sonia Gago, María Iniesta-Cuerda, Ana Josefa Soler, Dimitrios Rizos, Teresa Mogas
{"title":"Changes in the microRNA cargo of granulosa cell-derived extracellular vesicles under oxidative stress in a bovine model.","authors":"Judith Diaz-Muñoz, Yulia N Cajas, Karina Cañón-Beltrán, Lena Arévalo, Sonia Gago, María Iniesta-Cuerda, Ana Josefa Soler, Dimitrios Rizos, Teresa Mogas","doi":"10.1186/s40659-026-00689-8","DOIUrl":"10.1186/s40659-026-00689-8","url":null,"abstract":"","PeriodicalId":9084,"journal":{"name":"Biological Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The progress and challenges of mesenchymal stromal cell-based therapy for diabetes and its complications. 间充质间质细胞治疗糖尿病及其并发症的进展和挑战。
IF 4.6 2区 生物学
Biological Research Pub Date : 2026-03-16 DOI: 10.1186/s40659-026-00687-w
Leyi Tu, Tianyun Gao, Pingping Shen, Bin Wang
{"title":"The progress and challenges of mesenchymal stromal cell-based therapy for diabetes and its complications.","authors":"Leyi Tu, Tianyun Gao, Pingping Shen, Bin Wang","doi":"10.1186/s40659-026-00687-w","DOIUrl":"10.1186/s40659-026-00687-w","url":null,"abstract":"","PeriodicalId":9084,"journal":{"name":"Biological Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13104284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Substitution of the SEMA3A basic domain with the VEGF165 heparin-binding domain enhances anti-angiogenic potency in ovo. 用VEGF165肝素结合结构域取代SEMA3A基本结构域可增强卵中抗血管生成的效力。
IF 4.6 2区 生物学
Biological Research Pub Date : 2026-03-16 DOI: 10.1186/s40659-026-00684-z
Indrė Valiulytė-Simaitė, Lina Šlekienė, Ingrida Balnytė, Viktorija Daukšaitė, Saulius Tacionis, Gabrielė Paškevičiūtė, Kristina Mašalaitė, Arūnas Kazlauskas
{"title":"Substitution of the SEMA3A basic domain with the VEGF<sub>165</sub> heparin-binding domain enhances anti-angiogenic potency in ovo.","authors":"Indrė Valiulytė-Simaitė, Lina Šlekienė, Ingrida Balnytė, Viktorija Daukšaitė, Saulius Tacionis, Gabrielė Paškevičiūtė, Kristina Mašalaitė, Arūnas Kazlauskas","doi":"10.1186/s40659-026-00684-z","DOIUrl":"10.1186/s40659-026-00684-z","url":null,"abstract":"","PeriodicalId":9084,"journal":{"name":"Biological Research","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13104550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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