发布求助
文献互助 智能选刊 最新文献

BMJ Case Reports最新文献

筛选
英文 中文
In vitro correction of venom-induced coagulopathy in Daboia russelii envenomation demonstrated using tranexamic acid-modified rotational thromboelastometry. 体外校正毒液诱导的凝血功能在大鼠中毒证明使用氨甲环酸修饰的旋转血栓弹性测量。
IF 0.4
BMJ Case Reports Pub Date : 2026-10-07 DOI: 10.1136/bcr-2026-272120
Aboobacker Mohamed Rafi, Siju V Abraham, Susheela J Innah, Punchalil Chathappan Rajeev
{"title":"In vitro correction of venom-induced coagulopathy in <i>Daboia russelii</i> envenomation demonstrated using tranexamic acid-modified rotational thromboelastometry.","authors":"Aboobacker Mohamed Rafi, Siju V Abraham, Susheela J Innah, Punchalil Chathappan Rajeev","doi":"10.1136/bcr-2026-272120","DOIUrl":"https://doi.org/10.1136/bcr-2026-272120","url":null,"abstract":"<p><p>Snakebite-associated coagulopathy is usually attributed to venom-induced consumption of clotting factors, but underlying mechanisms may be heterogeneous and not reliably detected by conventional coagulation tests. A man in his late 40s presented early after Russell's viper envenomation with local signs and a prolonged bedside modified Lee and White clotting time despite normal prothrombin time and activated partial thromboplastin time. Given this discordance, rotational thromboelastometry (ROTEM) was performed at admission. Extrinsically activated thromboelastometry (EXTEM) demonstrated rapid and complete clot lysis, while tranexamic acid-modified antifibrinolytic thromboelastometry (t-APTEM) showed restoration of clot stability with inhibition of fibrinolysis, supporting a hyperfibrinolytic component.The patient was managed with antivenom and supportive care, including plasma transfusion, with subsequent resolution of coagulopathy and an uncomplicated recovery. This report establishes a diagnostic and mechanistic framework for systematic evaluation of fibrinolysis in snakebite-associated coagulopathy and highlights that the role of antifibrinolytic therapy requires further exploration in patients demonstrating evidence of hyperfibrinolysis.</p>","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"19 10","pages":""},"PeriodicalIF":0.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical presentations of Lhermitte's sign after treatment for human papillomavirus-associated oropharyngeal squamous cell carcinoma. 人乳头瘤病毒相关口咽鳞状细胞癌治疗后Lhermitte症状的不典型表现
IF 0.4
BMJ Case Reports Pub Date : 2026-10-07 DOI: 10.1136/bcr-2026-273768
Alifya Altaf Lokhandwala, Jonathan Paly, Thomas Roberts, Jong Chul Park, Manisha Patel, Lori Wirth, Gilbert Youssef, Jennifer L Powers, Ross D Merkin
{"title":"Atypical presentations of Lhermitte's sign after treatment for human papillomavirus-associated oropharyngeal squamous cell carcinoma.","authors":"Alifya Altaf Lokhandwala, Jonathan Paly, Thomas Roberts, Jong Chul Park, Manisha Patel, Lori Wirth, Gilbert Youssef, Jennifer L Powers, Ross D Merkin","doi":"10.1136/bcr-2026-273768","DOIUrl":"https://doi.org/10.1136/bcr-2026-273768","url":null,"abstract":"<p><p>Lhermitte's sign (LS) is characterised by a brief electric shock-like sensation elicited by neck flexion that radiates down the spine and may extend into the posterior aspects of the legs. It is a clinical indicator of cervical or upper thoracic dorsal column dysfunction, most commonly due to demyelination or intrinsic spinal cord pathology. It may occur after head and neck (chemo)radiotherapy. We describe two patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma who developed LS following chemoradiotherapy. One patient developed protracted LS lasting 20 months beyond completion of definitive concurrent chemoradiotherapy with volumetric modulated arc radiotherapy and weekly cisplatin and another patient developed protracted LS after adjuvant de-escalated volumetric modulated arc radiotherapy lasting 12 months beyond treatment completion. These cases show the variable course of LS in the modern conformal era and highlight its benign prognosis but potential for persistent symptoms that affect patient quality of life.</p>","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"19 10","pages":""},"PeriodicalIF":0.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meckel's diverticulum leading to axial torsion and volvulus of the small bowel. 梅克尔憩室导致小肠轴向扭转和扭转。
IF 0.4
BMJ Case Reports Pub Date : 2026-10-07 DOI: 10.1136/bcr-2026-274665
Fabian Wehrmann, Niamh Keating, Munir Saeed
{"title":"Meckel's diverticulum leading to axial torsion and volvulus of the small bowel.","authors":"Fabian Wehrmann, Niamh Keating, Munir Saeed","doi":"10.1136/bcr-2026-274665","DOIUrl":"https://doi.org/10.1136/bcr-2026-274665","url":null,"abstract":"<p><p>A Meckel's diverticulum is a blind-ending pouch that arises on the antimesenteric border of the terminal ileum. It is the most common gastrointestinal anomaly and the result of an incomplete obliteration of the vitelline duct during the first 8 weeks of gestation. The 'rule of two' is a mnemonic which refers to key characteristics of Meckel diverticula: it is found in 2% of the population, it is 2 inches long, 2 feet from the ileocaecal valve and twice as common in males. Only 2%-4% of those with a Meckel's develop complications in their lifetime. The majority present in early childhood with complications such as intussusception, bleeding and diverticulitis. Here we present a rare case of a giant Meckel's diverticulum measuring 22 cm×11 cm×9.8 cm, causing mass effect, small bowel volvulus and obstruction. The patient required an emergent laparotomy, resection and primary anastomosis.</p>","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"19 10","pages":""},"PeriodicalIF":0.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Idiopathic multicentric Castleman disease in an HIV-positive child. 1例hiv阳性儿童的特发性多中心Castleman病
IF 0.4
BMJ Case Reports Pub Date : 2026-10-07 DOI: 10.1136/bcr-2025-270749
Noelle Pretorius, Anne-Cecilia van Marle, Christie Esterhuysen, Leriska Haupt
{"title":"Idiopathic multicentric Castleman disease in an HIV-positive child.","authors":"Noelle Pretorius, Anne-Cecilia van Marle, Christie Esterhuysen, Leriska Haupt","doi":"10.1136/bcr-2025-270749","DOIUrl":"https://doi.org/10.1136/bcr-2025-270749","url":null,"abstract":"<p><p>A preadolescent HIV-positive girl from Southern Africa presented to a public healthcare facility with fever and unilateral facial and neck swelling. Clinical examination revealed generalised lymphadenopathy, hepatosplenomegaly, hypertension and haematuria. A provisional diagnosis of poststreptococcal glomerulonephritis was made; however, when the patient displayed no clinical improvement on supportive treatment, she was referred to a tertiary hospital for further evaluation. The peripheral blood smear showed marked agglutination, which improved on warming. Serum protein electrophoresis demonstrated a monoclonal protein, yet the bone marrow plasmacytosis of 30% was polyclonal and human herpesvirus 8 negative. Subsequently, a lymph node biopsy confirmed a diagnosis of plasmacytic idiopathic multicentric Castleman disease. The atypical presentation contributed to delayed diagnosis and prompted unnecessary invasive investigations in a paediatric patient.</p>","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"19 10","pages":""},"PeriodicalIF":0.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fregoli syndrome in an adolescent with Moyamoya disease. 烟雾病青少年的弗雷戈利综合征。
IF 0.4
BMJ Case Reports Pub Date : 2026-10-07 DOI: 10.1136/bcr-2025-269907
Nisha Rajan, Kiruthika Asokan, Venkatesh Karthik, Pediredla Karunakar
{"title":"Fregoli syndrome in an adolescent with Moyamoya disease.","authors":"Nisha Rajan, Kiruthika Asokan, Venkatesh Karthik, Pediredla Karunakar","doi":"10.1136/bcr-2025-269907","DOIUrl":"https://doi.org/10.1136/bcr-2025-269907","url":null,"abstract":"<p><p>Moyamoya disease (MMD) is a progressive cerebrovascular disorder characterised by distal internal carotid artery (ICA) stenosis and compensatory collateral vessel formation. Psychiatric manifestations are rare, particularly in children. We report the case of an early adolescent with previously diagnosed MMD who developed acute-onset psychosis following a febrile illness associated with headache and vomiting. Symptoms included auditory hallucinations, persecutory delusions, emotional lability and Fregoli syndrome, a rare condition in which different strangers are believed to be a familiar person in disguise. Neuroimaging revealed bilateral ICA narrowing with extensive collateral networks. Infectious, autoimmune and metabolic evaluations were unremarkable. The patient underwent superior temporal artery-middle cerebral artery bypass with encephalo-duro-arterio-myo-synangiosis. Psychotic symptoms resolved after surgery, and he returned to baseline functioning within 1 month. This case highlights the importance of considering cerebrovascular aetiologies in abrupt-onset childhood psychosis, even in the absence of major neurological deficits.</p>","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"19 10","pages":""},"PeriodicalIF":0.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual radiological presentation of Staphylococcus aureus acute osteomyelitis. 急性金黄色葡萄球菌骨髓炎的异常影像学表现。
IF 0.4
BMJ Case Reports Pub Date : 2026-10-07 DOI: 10.1136/bcr-2025-271758
Madalena Leiria Carvalho, Eduardo Bandeira, Marta Conde, Catarina Gouveia
{"title":"Unusual radiological presentation of <i>Staphylococcus aureus</i> acute osteomyelitis.","authors":"Madalena Leiria Carvalho, Eduardo Bandeira, Marta Conde, Catarina Gouveia","doi":"10.1136/bcr-2025-271758","DOIUrl":"https://doi.org/10.1136/bcr-2025-271758","url":null,"abstract":"","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"19 10","pages":""},"PeriodicalIF":0.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Staged bilateral MR-guided focused ultrasound thalamotomy in a patient with cerebral cavernous malformations. 分阶段双侧磁共振引导聚焦超声丘脑切开术治疗脑海绵状血管瘤1例。
IF 0.4
BMJ Case Reports Pub Date : 2026-10-07 DOI: 10.1136/bcr-2026-275492
Matthew C Henn, Daniel R Cleary
{"title":"Staged bilateral MR-guided focused ultrasound thalamotomy in a patient with cerebral cavernous malformations.","authors":"Matthew C Henn, Daniel R Cleary","doi":"10.1136/bcr-2026-275492","DOIUrl":"https://doi.org/10.1136/bcr-2026-275492","url":null,"abstract":"<p><p>MRI-guided focused ultrasound (MRgFUS) thalamotomy is an effective ablative procedure for medication-refractory essential tremor (ET). However, limited data exist regarding its safety in patients with coexisting intracranial disease such as cerebral cavernous malformations. We present a man in his late 60s with medication-refractory ET who underwent staged bilateral MRgFUS thalamotomy. Preoperative MRI demonstrated heterogeneously T1-hyperintense and T2-hyperintense lesions in the left caudate head and basal ganglia consistent with cavernous malformations, with an associated developmental venous anomaly and no prior haemorrhage. After individualised counselling regarding unknown procedural risks, the patient underwent right-sided thalamotomy, followed 1 year later by left-sided thalamotomy. MRI after each procedure demonstrated expected treatment-related changes without acute intracranial haemorrhage around the cavernous malformations. This case demonstrates successful staged bilateral MRgFUS thalamotomy in a patient with cerebral cavernous malformations, suggesting they may not uniformly preclude MRgFUS in carefully selected patients. Preoperative planning, counselling and MRI surveillance remain essential.</p>","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"19 10","pages":""},"PeriodicalIF":0.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging risks of health optimisation: refractory nausea associated with peptide injections reported to contain retatrutide. 健康优化的新风险：与含有利特鲁肽的肽注射相关的难治性恶心。
IF 0.4
BMJ Case Reports Pub Date : 2026-10-07 DOI: 10.1136/bcr-2026-276106
Raphael M Buzzi, Lars C Huber
{"title":"Emerging risks of health optimisation: refractory nausea associated with peptide injections reported to contain retatrutide.","authors":"Raphael M Buzzi, Lars C Huber","doi":"10.1136/bcr-2026-276106","DOIUrl":"10.1136/bcr-2026-276106","url":null,"abstract":"<p><p>A woman in her mid-20s presented with 5 days of persistent nausea, repeated vomiting, loose stools and markedly reduced oral intake. Blood tests, urinalysis, abdominal ultrasonography and cerebral MRI identified no alternative cause. Symptoms persisted despite intravenous fluids, metoclopramide, ondansetron and domperidone. Repeated, non-judgemental exposure history revealed 4 once-weekly, dose-escalated subcutaneous injections of an unverified product reported to contain retatrutide, an investigational triple glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and glucagon receptor agonist, administered in a wellness setting by a self-described life coach without medical qualification. She did not consider the injections to be medication. Symptoms improved 2 days after admission and resolved within 1 week. The Naranjo score (7) indicated probable causality. This case illustrates how pharmacologically active substances supplied through the wellness industry may evade routine medication history. Clinicians should ask explicitly about injections, peptides, research chemicals, online products and substances recommended by non-medical wellness practitioners.</p>","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"19 10","pages":""},"PeriodicalIF":0.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eosinophilic angiocentric fibrosis in paediatric IgG4-related disease. 儿童igg4相关疾病中的嗜酸性血管中心性纤维化
IF 0.4
BMJ Case Reports Pub Date : 2026-10-06 DOI: 10.1136/bcr-2026-276113
Rupal Prasad, Parag Vijayvergia, Mahima Khatkar, Puneet Kumar, Bandana Mehrotra
{"title":"Eosinophilic angiocentric fibrosis in paediatric IgG4-related disease.","authors":"Rupal Prasad, Parag Vijayvergia, Mahima Khatkar, Puneet Kumar, Bandana Mehrotra","doi":"10.1136/bcr-2026-276113","DOIUrl":"https://doi.org/10.1136/bcr-2026-276113","url":null,"abstract":"<p><p>A girl in the first decade of life presented with a 1.5 year history of gradually progressive bilateral upper eyelid swelling with bilateral proptosis, more prominent on the right side. She had a partial response to oral prednisolone, but symptoms recurred during tapering. Examination showed firm bilateral upper eyelid masses, preserved vision and mild restriction of upward gaze in the right eye. MRI demonstrated right preseptal/periorbital soft tissue thickening. Further evaluation excluded infection, vasculitis, sarcoidosis and malignancy; serum IgG4 level was normal. Biopsy of the right eyelid lesion showed concentric perivascular fibrosis with eosinophil-rich lymphoplasmacytic infiltrate, consistent with eosinophilic angiocentric fibrosis, supporting a diagnosis of possible organ-limited IgG4-related disease. The patient was treated with oral prednisolone and mycophenolate mofetil, resulting in sustained clinical improvement. This case highlights that paediatric IgG4-related disease may present as isolated orbital swelling with normal serum IgG4, making histopathology crucial for diagnosis.</p>","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"19 10","pages":""},"PeriodicalIF":0.4,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pyelolymphatic backflow demonstrated on computed tomography urography in acute ureteric obstruction. 急性输尿管梗阻的计算机断层尿路造影显示肾盂淋巴回流。
IF 0.4
BMJ Case Reports Pub Date : 2026-10-06 DOI: 10.1136/bcr-2026-273251
Ravi Jineshkumar Jain, Aman Kumar Jasuja, Sanjay Dhangar
{"title":"Pyelolymphatic backflow demonstrated on computed tomography urography in acute ureteric obstruction.","authors":"Ravi Jineshkumar Jain, Aman Kumar Jasuja, Sanjay Dhangar","doi":"10.1136/bcr-2026-273251","DOIUrl":"10.1136/bcr-2026-273251","url":null,"abstract":"<p><p>A man in his early 40s presented with acute right flank pain, vomiting and dysuria. Ultrasonography demonstrated an obstructing right upper ureteric calculus with a contralateral renal calculus. CT urography revealed fine, serpiginous contrast-opacified tubular channels extending from the right renal pelvis into the retroperitoneum without evidence of urinoma. Delayed excretory phase imaging demonstrated convergence towards the para-aortic region, consistent with pyelolymphatic backflow rather than collecting system rupture. The imaging pattern reflected markedly elevated intrarenal pressure and prompted urgent decompression. The patient underwent bilateral ureteric stenting followed by definitive endourological management with complete symptomatic resolution. Early recognition of this radiological entity prevents misdiagnosis and guides appropriate pressure-relieving intervention.</p>","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"19 10","pages":""},"PeriodicalIF":0.4,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书