Advanced pancreatic neuroendocrine tumour: the success of 'neoadjuvant' chemotherapy.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

BMJ Case Reports Pub Date : 2025-09-18 DOI:10.1136/bcr-2024-263346

Maria Salomé Serranito, Leandro Augusto Silva, Andreia Martins Fernandes, Ana Rita Elvas, Isabel Domingues, Rui Martins, Raquel Martins

引用次数: 0

Abstract

Non-functioning pancreatic neuroendocrine tumours (pNETs) are frequently diagnosed at advanced stages, thus limiting the feasibility of curative surgery. The potential utility of different therapeutic modalities with neoadjuvant proposals aimed at facilitating curative surgery has been discussed in the literature and international guidelines. Nevertheless, clinical trials are warranted to analyse the role and efficacy of various treatment protocols in this context. The heterogeneity inherent in different pNETs should be acknowledged, as it may influence treatment response. We report a case of an unresectable pNET with metastatic disease, which exhibited a partial response to neoadjuvant chemotherapy, enabling an R0 resection.

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晚期胰腺神经内分泌肿瘤：新辅助化疗的成功。

无功能胰腺神经内分泌肿瘤（pNETs）经常在晚期被诊断出来，从而限制了手术治疗的可行性。在文献和国际指南中已经讨论了旨在促进治疗性手术的不同治疗方式和新辅助建议的潜在效用。然而，在这种情况下，临床试验是必要的，以分析各种治疗方案的作用和疗效。应承认不同pNETs固有的异质性，因为它可能影响治疗反应。我们报告一例不可切除的pNET伴转移性疾病，对新辅助化疗有部分反应，可进行R0切除。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMJ Case Reports Medicine-Medicine (all)

CiteScore

1.40

自引率

0.00%

发文量

1588

期刊介绍： BMJ Case Reports is an important educational resource offering a high volume of cases in all disciplines so that healthcare professionals, researchers and others can easily find clinically important information on common and rare conditions. All articles are peer reviewed and copy edited before publication. BMJ Case Reports is not an edition or supplement of the BMJ.