Biomedicine Hub最新文献_第10页

Ultrasound-Guided Cervical Lymph Node Sampling Performed by Respiratory Physicians. 呼吸内科医生超声引导下的颈部淋巴结取样。

Biomedicine Hub Pub Date : 2019-07-26 eCollection Date: 2019-05-01 DOI: 10.1159/000501119

Mohammed Ahmed, Cyrus Daneshvar, David Breen

{"title":"Ultrasound-Guided Cervical Lymph Node Sampling Performed by Respiratory Physicians.","authors":"Mohammed Ahmed, Cyrus Daneshvar, David Breen","doi":"10.1159/000501119","DOIUrl":"https://doi.org/10.1159/000501119","url":null,"abstract":"Background: A variety of disease processes investigated by respiratory physicians can lead to cervical lymphadenopathy. Ultrasound (US) has revolutionised respiratory investigations, and neck ultrasound (NUS) is increasingly recognised as an additional important skill for respiratory physicians.Objectives: We aimed to assess the feasibility of NUS performed by respiratory physicians in the workup of patients with mediastinal lymphadenopathy.Methods: This is a single-centre retrospective cohort study. All patients that underwent US-guided cervical lymph node sampling were included. The diagnostic yield is reported, and specimen adequacy is compared for respiratory physicians and radiologists.Results: Over 5 years, 106 patients underwent NUS-guided lymph node sampling by respiratory physicians compared to 35 cases performed by radiologists. There was no significant difference in the adequacy of sampling between the two groups (respiratory physicians 91.5% [95% CI 84.5-96%] compared to 82.9% [95% CI 66.4-93.4%] for radiologists [p = 0.2]). In the respiratory physician group, a diagnosis was achieved based on lymph node sampling in 89 cases (84%). Neck lymph node sampling was the only procedure performed to obtain tissue in 48 cases (45.3%).Conclusion: NUS and sampling performed by respiratory physicians are feasible and associated with an adequacy rate comparable to that of radiologists. It can reduce the number of invasive procedures performed in a selected group of patients. Guidelines for training and competency assessment are required.","PeriodicalId":9075,"journal":{"name":"Biomedicine Hub","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000501119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37587441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Rapid Progression of Tracheoesophageal Fistula Caused by Immunotherapy Administered after Tracheal Stent Placement. 气管支架置入术后免疫治疗引起的气管食管瘘快速进展。

Biomedicine Hub Pub Date : 2019-07-25 eCollection Date: 2019-05-01 DOI: 10.1159/000501157

Shinjiro Mizuguchi, Makoto Takahama, Ryu Nakajima, Hidetoshi Inoue, Ryuichi Ito, Ryoji Yamamoto

{"title":"Rapid Progression of Tracheoesophageal Fistula Caused by Immunotherapy Administered after Tracheal Stent Placement.","authors":"Shinjiro Mizuguchi, Makoto Takahama, Ryu Nakajima, Hidetoshi Inoue, Ryuichi Ito, Ryoji Yamamoto","doi":"10.1159/000501157","DOIUrl":"https://doi.org/10.1159/000501157","url":null,"abstract":"Development of a tracheoesophageal fistula (TEF) is a serious complication of treatment for esophageal or lung cancer, especially following radiation therapy. However, development of a TEF as a complication of chemotherapy or tracheal stenting after surgical debulking is quite uncommon. We herein report a rare case involving a patient with advanced adenocarcinoma invading the mediastinum who rapidly developed a TEF after placement of a tracheal stent and administration of nivolumab immunotherapy. A 55-year-old heavy ex-smoker was diagnosed with lung adenocarcinoma with mediastinal invasion. Nine months after first-line therapy (chemotherapy and radiation therapy), he underwent treatment with nivolumab (3 mg/kg) as fourth-line therapy. Two weeks after the first dose, he underwent mechanical debulking of the tumor with tracheal stenting because of the rapid development of paraesophageal lymph node swelling and severe tracheal stenosis. He received a second dose of nivolumab 2 weeks later; however, imaging studies 12 days after this second dose revealed a huge fistula between the upper trachea and esophagus through a metastatic lymph node. Neither an additional stent nor replacement of the stent was considered because of the fistula site expansion and suffocation risk. Despite further treatment, the patient died of his primary disease 2 months later. Our findings will be of great interest to the readers, especially those involved in the clinical treatment of patients with advanced lung cancer treated by immunotherapy. The knowledge of potentially devastating TEF formation in the presence of transmural tracheal metastasis/invasion will allow clinicians to provide the best possible care for their patients.","PeriodicalId":9075,"journal":{"name":"Biomedicine Hub","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000501157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37587439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Asymptomatic Dialysate Turbidity and Repeated Intraductal Clots in a Peritoneal Dialysis Patient. 一例腹膜透析患者无症状透析液混浊和导管内重复凝块。

Biomedicine Hub Pub Date : 2019-07-08 eCollection Date: 2019-05-01 DOI: 10.1159/000500944

Tian Xu, Jingyuan Xie, Weiming Wang, Hong Ren, Nan Chen

引用次数: 2

Metoprolol Significantly Improves Visual Clarity and Hemodynamic Parameters during Functional Endoscopic Sinus Surgery. 美托洛尔显著改善功能性内窥镜鼻窦手术期间的视觉清晰度和血流动力学参数。

Biomedicine Hub Pub Date : 2019-05-15 eCollection Date: 2019-05-01 DOI: 10.1159/000497045

Ahmed A Sadek, Mokhtar Mostafa, Tarek Abdel-Monem

{"title":"Metoprolol Significantly Improves Visual Clarity and Hemodynamic Parameters during Functional Endoscopic Sinus Surgery.","authors":"Ahmed A Sadek, Mokhtar Mostafa, Tarek Abdel-Monem","doi":"10.1159/000497045","DOIUrl":"https://doi.org/10.1159/000497045","url":null,"abstract":"Background and objectives: The success of functional endoscopic sinus surgery (FESS) depends on the visual clarity of the surgical field, which is understudied. Controlled hypotension has many advantages for FESS including reduction in blood loss and improved quality of the surgical field. This study determined whether the use of β-blockers as a premedication could improve the operative field in FESS. Methods : Sixty patients aged from 18 to 50 years, undergoing septoplasty and FESS were included in this prospective, randomized, double-blind, placebo-controlled study. Patients were randomly assigned to receive either metoprolol (100 mg, group 1) or a placebo (a vitamin tablet, group 2) 60 min before surgery.Results: The average blood loss and surgery duration were not significantly higher in the placebo group. The surgical field was graded using the Fromme-Boezaart scale, and it was significantly clearer (p < 0.001) in metoprolol group. The mean arterial blood pressure was significantly lower in the metoprolol group after 30 min of induction until the end of surgery (p < 0.001). The heart rate was also significantly lower (p < 0.001) in those who received metoprolol from before induction of anesthesia up to the end of surgery. Conclusion : Metoprolol significantly improves visual clarity and hemodynamics during FESS. We would recommend the use of metoprolol in FESS and septoplasty.","PeriodicalId":9075,"journal":{"name":"Biomedicine Hub","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000497045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37587518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Usefulness of Ultrasound-Computer-Craniocorpography in Unilateral Ménière's Disease. 单侧梅尼埃病超声-计算机-颅骨造影的实用性。

Biomedicine Hub Pub Date : 2019-05-13 eCollection Date: 2019-05-01 DOI: 10.1159/000500398

Stephanie Maihoub, László Tamás, András Molnár, Agnes Szirmai

{"title":"Usefulness of Ultrasound-Computer-Craniocorpography in Unilateral Ménière's Disease.","authors":"Stephanie Maihoub, László Tamás, András Molnár, Agnes Szirmai","doi":"10.1159/000500398","DOIUrl":"10.1159/000500398","url":null,"abstract":"Background: Ménière's disease (MD) is composed of a set of fluctuating symptoms, whereby vertigo is the most unpleasant among them and often accompanied by deterioration of the balance system.Objectives: The purpose of this study is to objectively assess the Romberg and Unterberger-Fukuda tests by ultrasound-computer-craniocorpography (US-COMP-CCG) in patients suffering from MD and to characterize the balance disorders in different frames of MD.Methods: This is a case-control study where 51 patients with normal vestibular system and 42 patients suffering from definite MD were examined by US-COMP-CCG. They were divided into three grades according to the attack rates and the complaints of the patient during the attack-free periods.Results: Parameters of significance showing the worsening of the balance system with the aggravation of the disease are seen in both tests. In the standing test, the longitudinal and lateral sway and the forehead covering values are of importance, whereas in the stepping test, the parameter of relevance is the lateral sway.Conclusions: The severity of worsening of the balance system, based on the objective results of the system parameters, are parallel to the worsening of MD based on our findings.","PeriodicalId":9075,"journal":{"name":"Biomedicine Hub","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/a7/bmh-0004-0001.PMC6985893.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37587442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Influence of ACE Inhibition on C1-Inhibitor: A Biomarker for ACE Inhibitor-Induced Angioedema? ACE抑制对c1抑制剂的影响:ACE抑制诱导血管性水肿的生物标志物?

Biomedicine Hub Pub Date : 2019-05-07 eCollection Date: 2019-05-01 DOI: 10.1159/000499075

Janina Hahn, Melanie Nordmann-Kleiner, Christoph Bönner, Georg Kojda, Thomas K Hoffmann, Jens Greve

{"title":"The Influence of ACE Inhibition on C1-Inhibitor: A Biomarker for ACE Inhibitor-Induced Angioedema?","authors":"Janina Hahn, Melanie Nordmann-Kleiner, Christoph Bönner, Georg Kojda, Thomas K Hoffmann, Jens Greve","doi":"10.1159/000499075","DOIUrl":"https://doi.org/10.1159/000499075","url":null,"abstract":"Aims: Angioedema is a rare side effect of angiotensin-converting enzyme (ACE) inhibitors. It remains unclear why it is only induced in a few patients taking ACE inhibitors, often after a long period of uneventful treatment. The aim of this study was to analyze the influence of ACE inhibitor treatment on C1-inhibitor (C1-INH) levels.Methods: Captopril (5 mg/25 mg) was added to blood samples of 5 healthy subjects. C1-INH levels were measured before and after incubation for 180 min. The second section of the study was done with 17 patients who received therapy with an ACE inhibitor for the first time. C1-INH levels were measured before ACE inhibitor treatment, 24 h after first drug administration, and 4 weeks later.Results: After incubation of blood samples with 5 mg captopril, there was no detectable change in C1-INH levels. After incubation with 25 mg, C1-INH activity was decreased by an average of 29% and the C1-INH concentration was decreased by an average of 0.06 g/L. In the second study section, inconsistent effects on C1-INH levels were detected. In the majority of patients, 24 h after the first ACE inhibitor administration C1-INH activity was tending to be increased.Conclusions: A dose-dependent effect on C1-INH levels in captopril-incubated blood samples of healthy test persons was shown. In patients with new ACE inhibitor treatment, heterogeneous reactions of C1-INH values were detected. Larger studies are needed over a longer period of time to find correlations between the effect of ACE inhibitor therapy on C1-INH levels and the clinical course/development of side effects.","PeriodicalId":9075,"journal":{"name":"Biomedicine Hub","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000499075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37587440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Erroneously High Lactate: A Guide to Diagnosing Ethylene Glycol Poisoning. 错误的高乳酸:诊断乙二醇中毒指南。

Biomedicine Hub Pub Date : 2019-05-06 eCollection Date: 2019-05-01 DOI: 10.1159/000499967

Mayanka Kamboj, Harini Bejjanki, Saraswathi Gopal, Rupam Ruchi

引用次数: 2

The Diameter of Retinal Arterioles Is Unaffected by Intravascular Administration of the Adenosine A_2A Receptor Agonist Regadenoson in Normal Persons. 正常人血管内注射腺苷A2A受体激动剂Regadenoson对视网膜小动脉直径无影响。

Biomedicine Hub Pub Date : 2019-05-01 DOI: 10.1159/000500563

Anna Dons-Jensen, Line Petersen, Hans-Erik Bøtker, Toke Bek

{"title":"The Diameter of Retinal Arterioles Is Unaffected by Intravascular Administration of the Adenosine A2A Receptor Agonist Regadenoson in Normal Persons.","authors":"Anna Dons-Jensen, Line Petersen, Hans-Erik Bøtker, Toke Bek","doi":"10.1159/000500563","DOIUrl":"https://doi.org/10.1159/000500563","url":null,"abstract":"Background: The neurotransmitter adenosine has been proposed to be involved in the pathogenesis of diabetic retinopathy, which may be due to the vasoactive properties of the compound. Previous studies have shown that adenosine can affect the tone of retinal arterioles in vitro to induce dilatation mediated by A2A and A2Breceptors and constriction mediated by A1 and A3 receptors.Purpose: To investigate effects of intravenous administration of the adenosine A2A receptor agonist regadenoson on the diameter of retinal vessels in vivo.Method: The diameter responses of larger retinal arterioles and venules were evaluated using the dynamic vessel analyser in 20 normal persons (age 22-31 years) after intravenous administration of the adenosine A2A receptor agonist regadenoson during exposure to systemic normoxia and hypoxia.Results: The diameter of retinal arterioles and venules increased significantly during stimulation with flickering light (p < 0.0001). Regadenoson reduced the flicker-induced dilatation of venules during normoxia (p = 0.0006), but otherwise had no effect on vessel diameters (p > 0.08 for all comparisons).Conclusions: Intravenous administration of the adenosine A2A receptor agonist regadenoson had no significant effect on the diameter of retinal arterioles. Future studies should investigate differential effects of intra- and extravascular administration of adenosine receptor agonists on retinal vessels.","PeriodicalId":9075,"journal":{"name":"Biomedicine Hub","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000500563","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10772971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Balance and Sound Conditions in Adults with Bilateral Cochlear Implants 成人双侧人工耳蜗植入后的平衡和声音状况

Biomedicine Hub Pub Date : 2019-04-25 DOI: 10.1159/000499074

R. Tonini, H. Cohen, A. Mulavara, H. Sangi-Haghpeykar

{"title":"Balance and Sound Conditions in Adults with Bilateral Cochlear Implants","authors":"R. Tonini, H. Cohen, A. Mulavara, H. Sangi-Haghpeykar","doi":"10.1159/000499074","DOIUrl":"https://doi.org/10.1159/000499074","url":null,"abstract":"Purpose: To determine if (1) balance is impaired in patients with bilateral cochlear implants compared to healthy controls and (2) the presence of sound, non-speech, or speech affects standing balance. Materials and Methods: Four patients with bilateral cochlear implants were tested on three balance conditions on Romberg tests on medium-density compliant foam with eyes closed, with head stationary or moving in yaw or pitch, under 5 sound conditions: no sound, ambient background noise, pink noise, foreign language, English language. Results: Dependent measures were duration of standing and kinematics. Three of four subjects performed well with head still and no sound, background noise, or pink noise. All subjects performed poorly during the head movement conditions when hearing either foreign-language or English words. Subjects could not perform enough head movements during yaw and pitch conditions for accurate kinematic measurements. Conclusion: The no-sound condition did not influence standing balance skills. The addition of ambient or pink noise also did not affect their balance. However, when subjects were distracted by paying attention to words, regardless whether or not they understood the words, standing balance skills deteriorated. Thus, distracted attention in these patients leads to impaired balance, which may impair functional motor skills.","PeriodicalId":9075,"journal":{"name":"Biomedicine Hub","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77306576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Abdominal Displacement Ventilation: An Effective Intervention for Sedation-Induced Hypoxia. 腹部置换通气:镇静性缺氧的有效干预。

Biomedicine Hub Pub Date : 2019-04-02 eCollection Date: 2019-01-01 DOI: 10.1159/000497776

Nikhil Meena, Maggie Macchiarella, Jose Diego Caceres, Thaddeus Bartter

{"title":"Abdominal Displacement Ventilation: An Effective Intervention for Sedation-Induced Hypoxia.","authors":"Nikhil Meena, Maggie Macchiarella, Jose Diego Caceres, Thaddeus Bartter","doi":"10.1159/000497776","DOIUrl":"https://doi.org/10.1159/000497776","url":null,"abstract":"Background: Sedation for bronchoscopy at times causes hypoxia. The application of positive pressure ventilation for sedation-induced hypoxia often requires cessation of the bronchoscopy. In contrast, ventilation effected via cyclical abdominal compression, if effective, would allow bronchoscopy to proceed. Initial trials of abdominal displacement ventilation (ADV) proved successful. This report documents extended experience with ADV.Objective: To evaluate and report the efficacy and applicability of ADV in the setting of sedation-induced hypoxia for consecutive patients over an extended interval.Methods: Based upon its initial efficacy, ADV had been incorporated into the standard approach to sedation-induced hypoxia. We retrospectively reviewed all bronchoscopies performed by interventional pulmonary over a 12-month interval. Management and efficacy of every episode of sedation-induced hypoxia were documented.Results: Over the study interval, 893 bronchoscopies had been performed, with sedation-induced hypoxia occurring in 38 (4%). ADV was possible in 37 of the 38 patients. In every case, ADV was effective and allowed completion of the procedure. There were no adverse effects.Conclusion: ADV is a simple, effective, noninvasive approach to sedation-induced hypoxia that effects adequate ventilation and allows safe continuance of procedures.","PeriodicalId":9075,"journal":{"name":"Biomedicine Hub","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000497776","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37585535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0