New horizons in translational medicine最新文献

{"title":"Methodologies and limitations in the analysis of potential neuroprotective compounds derived from natural products","authors":"John T. Weber","doi":"10.1016/j.nhtm.2015.01.001","DOIUrl":"https://doi.org/10.1016/j.nhtm.2015.01.001","url":null,"abstract":"<div><p><span>Plant-derived polyphenols have attracted the attention of scientists, the public, and the media due to their potential use as nutraceutical products. The high quantities of polyphenols found in some berry species, </span><span><em>e.g. </em><em>Vaccinium</em></span><span> species such as blueberries and lingonberries, and their reported antioxidant and anti-inflammatory properties, could be beneficial for brain aging and neurodegenerative disorders<span>. The neuroprotective<span> potential of various polyphenolic compounds have been validated using a variety of </span></span></span><em>in vivo</em> and <em>in vitro</em> techniques. Both <em>in vivo</em> and <em>in vitro</em> methodologies have their respective advantages and disadvantages, including, but not limited to, cost, time, use of resources and technical limitations. For example, <em>in vivo</em> studies can better evaluate the effects of protective compounds and/or their metabolites on various tissues, including the brain, whereas <em>in vitro</em><span> studies can better discern the cellular and/or mechanistic effects of compounds. This short review is meant to provide a synopsis of some of the inherent benefits and drawbacks of methods used for assessing neuroprotection and how findings may translate to the human population, particularly related to my specific area of research analyzing the potential neuroprotective effects of berries and their associated polyphenolic compounds.</span></p></div><div><h3>Focal points</h3><p></p><ul><li><span>•</span><span><p>Benchside</p><p>Both <em>in vivo</em> and <em>in vitro</em> experimental approaches are necessary to determine the full potential that berries and their constituents hold for treating and preventing neurological diseases and syndromes.</p></span></li><li><span>•</span><span><p>Bedside</p><p>Ingestion<span> of compounds from berries may reduce the amount and severity of neurodegenerative diseases, thereby providing a form of translational preventative medicine.</span></p></span></li><li><span>•</span><span><p>Industry</p><p>Neuroprotective compounds from berries, including both the fruits and leaves, hold potential as nutraceutical products.</p></span></li><li><span>•</span><span><p>Community</p><p>The development of nutraceutical products with neuroprotective potential by industry could provide local economic benefits.</p></span></li><li><span>•</span><span><p>Regulatory agencies</p><p>As nutraceutical products are produced from the fruits and leaves of berries, care will need to be taken on labeling as well as claims made by the manufacturers.</p></span></li></ul></div>","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"2 3","pages":"Pages 81-85"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2015.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91753847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of chemical elements in melanoma","authors":"Angelo M. Facchiano ,&nbsp;Francesco Facchiano ,&nbsp;Antonio Facchiano","doi":"10.1016/j.nhtm.2014.11.056","DOIUrl":"10.1016/j.nhtm.2014.11.056","url":null,"abstract":"<div><p>Publication of several studies attest the growing interest to investigate the real impact chemical elements and industrial pollution may have on the human health.</p><p>In the current study we present novel data referring to the occurrence of the name of all chemical elements taken from the Mendeleev table, in the title of PubMed indexed melanoma articles. Nine hundred fifty four manuscripts were found to have in the title field the “melanoma” word and at least one of the 117 chemical elements.</p><p><span>The occurrence of each chemical element in melanoma articles was then compared to the occurrence in epithelioma articles and squamous cell carcinoma articles, unrevealing substantial quantitative differences. Manuscripts having “skin” in the title were used as control manuscripts. The 10 elements most studied in melanoma manuscripts were found to be iodine, oxygen, ruthenium, boron, calcium, carbon, sodium, zinc, iron and </span>technetium, accounting for more than 50% of the 954 identified manuscripts. In all such cases, the occurrence in melanoma manuscripts was found to be largely different as compared to epithelioma articles, as well as squamous cell carcinoma articles.</p><p>The role of each of these elements in melanoma is discussed.</p></div><div><h3>Focal points</h3><p></p><ul><li><span>•</span><span><p>Bedside</p><p>The ten most common elements identified to play key roles in melanoma are shown here to be different from the ten most common found in other control conditions, such as epithelioma or other skin cancers.</p></span></li><li><span>•</span><span><p>Benchside</p><p>New ways are necessary to organize the immense literature data currently available and to collect it in an ordered, systematic manner, easy to read and to interpret.</p></span></li><li><span>•</span><span><p>Industry</p><p>Systematic searches in PubMed -indexed literature leading to ordered outputs may facilitate the interpretation of published data. In the present study the role each chemical element plays in melanoma has been investigated by exhaustive searches in PubMed -indexed literature.</p></span></li><li><span>•</span><span><p>Governments</p><p>There is an increasing interest to investigate the impact chemical elements and industrial pollution have on the human health.</p></span></li></ul></div>","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"2 3","pages":"Pages 73-80"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2014.11.056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80231168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational medicine and varicella zoster virus: Need for disease modeling","authors":"Aamir Shahzad ,&nbsp;Don Gilden ,&nbsp;Randall J. Cohrs","doi":"10.1016/j.nhtm.2015.03.001","DOIUrl":"10.1016/j.nhtm.2015.03.001","url":null,"abstract":"<div><p>VZV<span><span> is a ubiquitous human pathogen typically encountered early in life when primary infection causes chickenpox. During this time the virus infects ganglionic neurons at all levels of the neuraxis where the virus remains latent in host neurons. The fact that &gt;95% of the world’s inhabitants have an immunologic response to VZV highlights the problem encountered when ascribing disease etiology to VZV reactivation. There are multiple challenges and problems to better understand pathobiology of VZV latency. There is currently no suitable disease model that mirrors the human diseases caused when virus reactivates. Without a disease model, Koch’s postulates cannot be met and ascribing a causal relationship is tenuous. Without a suitable model for all facets of </span>VZV infection, latency and reactivation, understanding of VZV pathobiology will be difficult.</span></p></div><div><h3>Focal points</h3><p></p><ul><li><span>•</span><span><p><strong>Benchside</strong></p><p>Suitable models for all facets of VZV infection, latency and reactivation are required to better understand the mechanism of VZV pathobiology.</p></span></li><li><span>•</span><span><p><strong>Governments</strong></p><p>Due to the increasing number of geriatric population at risk for severe disease caused by varicella zoster virus reactivation, there is immediate need to increase funding for research studies to find suitable models for VZV infection, latency and reactivation.</p></span></li></ul></div>","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"2 3","pages":"Pages 89-91"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2015.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33397789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodologies and limitations in the analysis of potential neuroprotective compounds derived from natural products","authors":"J. Weber","doi":"10.1016/J.NHTM.2015.01.001","DOIUrl":"https://doi.org/10.1016/J.NHTM.2015.01.001","url":null,"abstract":"","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"7 1","pages":"81-85"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79058095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium efflux pump, PMCA2, in human breast tissue with lactational change and as a therapeutic target in breast cancer [Conference abstract]","authors":"Amelia A Peters, Wei-Chen Lee, Eloise V. Dray, C. Smart, L. Reid, L. Silva, S. Lakhani, S. Roberts-Thomson, G. Monteith","doi":"10.1016/J.NHTM.2014.11.041","DOIUrl":"https://doi.org/10.1016/J.NHTM.2014.11.041","url":null,"abstract":"","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72898200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Listening to shiny body: In vivo photoacoustic tomography","authors":"Chulhong Kim","doi":"10.1016/j.nhtm.2014.11.048","DOIUrl":"10.1016/j.nhtm.2014.11.048","url":null,"abstract":"<div><p><span>High-resolution volumetric optical imaging modalities, such as </span>confocal microscopy<span><span>, two-photon microscopy, and optical coherence tomography, have become increasing important in </span>biomedical imaging<span> fields. However, due to strong light scattering, the penetration depths of these imaging modalities are limited to the optical transport mean free path (~1 mm) in biological tissues. Photoacoustic imaging, an emerging hybrid modality that can provide strong endogenous and exogenous optical absorption contrasts with high ultrasonic spatial resolution, has overcome the fundamental depth limitation while keeping the spatial resolution. The image resolution, as well as the maximum imaging depth, is scalable with ultrasonic frequency within the reach of diffuse photons. In biological tissues the imaging depth can be up to a few centimeters deep. In this presentation, the following topics of photoacoustic imaging will be discussed; (1) multi-scale photoacoustic imaging systems, (2) morphological, functional, and molecular photoacoustic imaging, (3) potential clinical applications, and (4) contrast agents for photoacoustic imaging.</span></span></p></div>","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"2 2","pages":"Page 69"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2014.11.048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80005328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging pathways in treating human epidermal growth factor receptor-2-negative breast cancer","authors":"Sotirios G. Stergiopoulos","doi":"10.1016/j.nhtm.2014.11.059","DOIUrl":"10.1016/j.nhtm.2014.11.059","url":null,"abstract":"<div><p><span><span>Breast cancer remains the leading cause of new cancer cases in women and is responsible for the most cancer-related deaths in women worldwide. The goals of breast cancer treatment are to maintain or improve </span>quality of life<span><span><span>, prolong survival, and increase disease-free progression. The majority of breast cancer cases are estrogen receptor<span> (ER)-positive and human epidermal growth factor receptor-2 (HER-2)-negative, and current treatment guidelines recommend multiple lines of endocrine therapy followed by chemotherapy </span></span>in patients<span> with locally recurrent or metastatic disease<span>. Resistance to current therapies adds to the need for new therapeutic options. Translational research<span> and preclinical data have provided insight into the identification of emerging signaling pathways for novel </span></span></span></span>drug<span> targets, and the development of a growing number of biologic targeted agents is currently underway to identify novel treatments. An alternative approach to improve patient benefit is to boost the efficacy and safety of existing agents by modifying their delivery or pharmacokinetics (ie, adding albumin to paclitaxel) as well as identifying new combination therapies. One combination therapy of interest is the addition of the 130</span></span></span> <span>nm albumin-bound formulation of paclitaxel (</span><em>nab</em>-paclitaxel) to currently approved therapies or targeted agents in development. This review focuses on a number of key agents that are being investigated for the treatment of HER-2-negative breast cancer and the utilization of these agents as combination therapy to achieve prolonged disease control.</p></div><div><h3>Focal points</h3><p></p><ul><li><span>•</span><span><p>Bedside</p></span></li><li><span><p>○ New therapeutic options are necessary for breast cancer patients with HER-2-negative and either hormone receptor positive or negative disease who develop resistance to current therapies. Recent insights into molecular pathways may soon expand the treatment options for all patients with HER-2-negative breast cancer.</p></span></li><li><span>•</span><span><p>Bench</p></span></li><li><span><p>○ Several rationally designed combinations of biologic targeted agents and next generation chemotherapeutic agents are currently under investigation to prolong disease control and overcome treatment resistance in patients with HER-2-negative breast cancer.</p></span></li></ul></div>","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"2 2","pages":"Pages 27-38"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2014.11.059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76721062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification & characterization of tumor cells isolated from body fluids","authors":"Gottfried Köhler","doi":"10.1016/j.nhtm.2014.11.014","DOIUrl":"10.1016/j.nhtm.2014.11.014","url":null,"abstract":"<div><p>The appearance of malignant cells in body fluids like urine, blood or body-cavity fluids are a clear indication for the existence of a tumor and urine or body-cavity fluid cytology<span> are routine diagnostics today. Cytologic examination of the cellular features of fluids is a valuable adjunct to patient diagnosis and the staging and management of tumors. The German-language literature contains the earliest references to the cytology of malignant cells in fluid specimens. Preparation of the specimen has evolved from unstained wet smears to protocols that generally include centrifugation and the generation of stained smears and a cell block. The smears may be alcohol-fixed direct smears, cytospins, or a liquid-based preparation, and they are usually stained with the Papanicolaou method<span><span>. Additional techniques, such as immunocytochemistry and flow cytometry, provide significant help in this differential diagnosis. Evaluation of microscopic images after Papanicolaou staining eluded </span>digital pathology<span><span>, an image-based information environment enabled by computer technology that allows for extracting information from a digital slide. With the advent of full-slide scanning digital methods are regarded as promising way to achieve better, faster and cheaper diagnosis, prognosis and prediction of cancer and other important diseases. One important feature are combinations with immunostaining<span><span>, FISH technology etc., to elude additional information from the specimen. Circulating tumor cells<span> (CTCs) can be found in the bloodstream and are always ready to attach to endothelial cells lining blood vessels and extravasate to enter tissues and organs to form a metastatic site. They show plastic phenotype and a small number of these cells undergo the epithelial-to-mesenchymal (EMT) program. De-differentiation and dissemination from the primary tumor is a basic prerequisite for colonization and growth of </span></span>distant metastasis. Phenotypic and functional plasticity of </span></span>cancer cells and the ability to adapt permanently to demanding conditions provide great challenge for identification and characterization of CTC´s from blood. Their clear identification and characterization is, however, also an important prerequisite to obtain valuable information for diagnosis and prognosis by downstream analytical methods. A novel platform for identification and morphological characterization of cancer cells in body fluids by digital methods is presented.</span></span></span></p></div>","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"2 2","pages":"Page 58"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2014.11.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88329164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive handling of drug nephrotoxicity with antioxidant cotherapies: Preclinical studies and clinical perspectives","authors":"Ana Isabel Morales Martín","doi":"10.1016/j.nhtm.2014.11.029","DOIUrl":"10.1016/j.nhtm.2014.11.029","url":null,"abstract":"<div><p><span>Worldwide, nephrotoxicity poses a considerable health and economic burden. Nearly 25% of the top 100, most used </span>drugs<span><span> in intensive care units are potentially nephrotoxic. Moreover, nephrotoxicity causes 10-20% of the </span>acute renal failure<span><span> cases (ARF). ARF is a very serious condition with high incidence and mortality rate, which is estimated at approximately 50% of the cases despite dialysis application, especially within critically ill patients. Mortality increases to 80% when ARF courses with multi-organ damage. The clinical handling of renal injury and ARF is difficult and expensive because, other than dialysis, there are no available treatments. For this reason the search for strategies to prevent nephrotoxicity constitute an active area of investigation. In addition to </span>drug targeting and medical chemistry for new and safer molecules, a line of interest is the identification of renoprotective adjuvants for co-administration along with potentially nephrotoxic drugs.</span></span></p><p><span>At the preclinical level, many chemically unrelated antioxidants have been shown to protect the kidneys from cisplatin<span> nephrotoxicity, especially in experimental animal models. They include curcumin<span>, N-acetylcysteine, naringenin, selenium, </span></span></span>vitamin C<span><span>, vitamin E<span> and other dietary components that scavenge free radicals formed by exposure to cisplatin. Although promising, antioxidants have not yet demonstrated a clear benefit in the </span></span>clinical research conducted so far, which requires further investigation. In this line, a pre-clinical selection of candidates to be assayed at the clinical level must be pursued in order to (i) improve the efficacy of the preclinical-to-clinical transition; and (ii) to reduce early failure rate in clinical assays through the drug discovery process.</span></p><p><span><span>One of the main problems identified in the translation of antioxidants to the clinical practice is their very low bioavailability derived from a very low absorption upon oral administration. Our research line has been focused on the effect of the </span>natural antioxidants<span><span> resveratrol and </span>quercetin, and the </span></span>antidiabetic<span> metformin, at preventing drug nephroxicity. Our studies clearly show their renoprotective effect at the preclinical level. We are testing these molecules in the clinical setting and developing new nanoformulations which will enhance their solubility and, hence, their bioavailability to prospectively achieve clinical utility.</span></p></div>","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"2 2","pages":"Page 63"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2014.11.029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83290397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium efflux pump, PMCA2, in human breast tissue with lactational change and as a therapeutic target in breast cancer","authors":"Amelia A. Peters,&nbsp;Wei C. Lee,&nbsp;Eloise Dray,&nbsp;Chanel E. Smart,&nbsp;Lynne Reid,&nbsp;Leonard da Silva,&nbsp;Sunil R. Lakhani,&nbsp;Sarah J. Roberts-Thomson,&nbsp;Gregory R. Monteith","doi":"10.1016/j.nhtm.2014.11.041","DOIUrl":"https://doi.org/10.1016/j.nhtm.2014.11.041","url":null,"abstract":"<div><p><span>Calcium pumps<span><span><span><span> and channels modulate cell proliferation and </span>apoptosis by regulating </span>intracellular calcium<span><span> (Ca2+). The plasma membrane Ca2+ ATPase isoform, PMCA2, is a calcium efflux<span><span> mechanism that extrudes Ca2+ from the cytosol into the extracellular space<span>. PMCA2 has a restricted expression, including expression in cochlear hair cells and cerebellar </span></span>Purkinje cells. PMCA2 expression is increased in mouse mammary glands during </span></span>lactation<span> where it plays a major role in the excretion of Ca2+ into milk; however, PMCA2 expression has not been assessed in human breast tissue exhibiting lactational changes. Our previous studies have shown that PMCA2 mRNA levels are elevated in some breast cancer cell lines and that pan-PMCA antisense attenuates the proliferation of MCF-7 breast </span></span></span>cancer cells<span>. However, the consequences of silencing PMCA2 in breast cancer cells are still not well understood. Our study assessed PMCA2 expression in breast tissue exhibiting lactational change and in human malignant breast tissue samples. The role of PMCA2 in the proliferation of breast cancer cells was also evaluated. Immunohistochemistry using a rabbit anti-PMCA2 antibody showed membranous PMCA2 expression in the luminal epithelium of breast tissue exhibiting lactational change. PMCA2 expression was assessed in human breast tumor samples assembled into </span></span></span>tissue microarrays<span><span>. Nine of 96 breast tumours (9.4%) showed membranous PMCA2 staining. PMCA2 expression did not significantly correlate with the breast cancer pathological markers, estrogen, progesterone or HER2 receptor status. High-content imaging demonstrated that PMCA2 silencing in MDA-MB-231 breast cancer cells is associated with a reduction in cell number and an inhibition of the percentage of S-phase positive cells. The effect of PMCA2 silencing combined with various cytotoxics (cisplatin, </span>doxorubicin<span> or mitomycin C) on cell proliferation was assessed in MDA-MB-231 cells using a kinetic imaging system (IncuCyte). The results showed that PMCA2 silencing promotes the effects of some cytotoxics. These findings indicate that PMCA2 protein expression is elevated during human lactation and in some breast cancers. Inhibitors of PMCA2 may represent a novel therapeutic strategy for some breast cancers.</span></span></p></div>","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"2 2","pages":"Page 67"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2014.11.041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92265245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}