BMJ Open Respiratory Research最新文献

{"title":"Peripheral blood innate lymphoid cell profiles of patients with COPD reflect their clinical phenotype as identified by cluster analysis.","authors":"Cathelijne Marianne van Zelst, Johannes In 't Veen, Marjolein de Bruijn, Menno van Nimwegen, Esmee van der Ploeg, Lisette Krabbendam, Denise van Uden, Ralph Stadhouders, Rudi Hendriks, Gert-Jan Braunstahl","doi":"10.1136/bmjresp-2024-003030","DOIUrl":"10.1136/bmjresp-2024-003030","url":null,"abstract":"","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"13 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive airway pressure initiation and pulmonary outcomes in persons with cystic fibrosis.","authors":"Nicholas T Vozoris, Isobel Sharpe, Jenna Sykes, Clodagh M Ryan, Elizabeth Tullis, Anne Stephenson","doi":"10.1136/bmjresp-2026-004456","DOIUrl":"10.1136/bmjresp-2026-004456","url":null,"abstract":"","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"13 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary and pleural schwannomas: a 20-year multicampus retrospective cohort study.","authors":"Aryan Shiari, Mamta S Chhabria","doi":"10.1136/bmjresp-2026-004390","DOIUrl":"10.1136/bmjresp-2026-004390","url":null,"abstract":"","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"13 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol and rationale for a randomised, double-blind, placebo-controlled phase 3 trial of admilparant (BMS-986278), an oral lysophosphatidic acid receptor 1 antagonist, in patients with idiopathic pulmonary fibrosis: ALOFT-IPF.","authors":"Toby M Maher, Fernando Martinez, Michael Kreuter, Tamera J Corte, Marlies Wijsenbeek, Takashi Ogura, Takafumi Suda, Zuojun Xu, Aryeh Fischer, Yue Wang, Elizabeth Cerullo, Walid Elsharkawi, Aditya Patel, Vincent Cottin","doi":"10.1136/bmjresp-2026-004324","DOIUrl":"10.1136/bmjresp-2026-004324","url":null,"abstract":"","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"13 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of anti-inflammatory reliever (AIR) or maintenance and reliever therapy (MART) for mild to moderate asthma: a systematic review.","authors":"Nqobile Ndimande, Kevin Mortimer, Marie Stolbrink, Josue Mbonigaba, Nicola Marozva, Refiloe Masekela","doi":"10.1136/bmjresp-2026-004148","DOIUrl":"10.1136/bmjresp-2026-004148","url":null,"abstract":"","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"13 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of lung ultrasound surface wave elastography in patients with interstitial lung disease.","authors":"Nuria Albacar, Olatz Saenz de Argandoña, Blanca Domenech-Ximenos, Judit Mestres, Fernanda Hernandez-Gonzalez, Xavier Alsina-Restoy, Estrella Caballeria, Mariasol Martínez-Carranza, Mariana Benegas, Marcelo Sánchez, Ivan Vollmer, Jacobo Sellarés Torres","doi":"10.1136/bmjresp-2025-003667","DOIUrl":"10.1136/bmjresp-2025-003667","url":null,"abstract":"<p><strong>Objectives: </strong>To assess whether lung ultrasound surface wave elastography (LUSWE), a non-invasive measure of lung stiffness, correlates with pulmonary function and high-resolution CT (HRCT) patterns in suspected interstitial lung disease (ILD). We hypothesised that LUSWE-derived lung stiffness would be associated with functional impairment and radiological ILD patterns.</p><p><strong>Setting: </strong>Prospective, single-centre pilot study conducted in a tertiary referral ILD unit in Barcelona, Spain.</p><p><strong>Participants: </strong>68 consecutive patients (41 men and 27 women) with suspected ILD were enrolled between June 2020 and February 2024 and completed LUSWE assessment at diagnosis under clinically stable conditions. Final diagnoses comprised sarcoidosis, idiopathic pulmonary fibrosis, combined pulmonary fibrosis and emphysema, fibrosing ILD, connective tissue disease-related ILD, other ILD and absence of pulmonary disease.</p><p><strong>Primary and secondary outcome measures: </strong>The primary outcome was the association between LUSWE velocity and pulmonary function parameters, specifically forced vital capacity (FVC) and diffusing capacity of the lung for carbon monoxide (DLCO). Secondary outcomes included associations with HRCT radiological patterns, fibrosing vs non-fibrosing ILD, usual interstitial pneumonia (UIP)/probable UIP vs other HRCT patterns and quantitative HRCT-derived fibrosis extent.</p><p><strong>Results: </strong>LUSWE velocity did not significantly correlate with FVC (r=0.23, 95% CI -0.01 to 0.45; p=0.07) or DLCO (r=0.13, 95% CI -0.12 to 0.36; p=0.31). No significant differences in LUSWE velocity were observed across HRCT patterns (Kruskal-Wallis χ²=1.2018; p=0.8778). Exploratory point-by-point analyses showed one significant association between the R2 point and FVC (r=0.33; p=0.0068), but this did not remain significant after correction for multiple comparisons (adjusted p=0.137). LUSWE distributions were similar between fibrosing and non-fibrosing ILD groups (3.35 (IQR 2.87-4.16) vs 3.55 (IQR 2.98-4.17) m/s; p=0.526) and between UIP/probable UIP and other HRCT patterns (3.36 (IQR 2.89-4.21) vs 3.59 (IQR 2.86-4.15) m/s; p=0.876). Quantitative HRCT analyses also showed weak, non-significant correlations between hemithorax-level fibrosis extent and corresponding LUSWE values.</p><p><strong>Conclusions: </strong>In this heterogeneous cohort of patients evaluated at diagnosis for suspected ILD, LUSWE was not meaningfully associated with pulmonary function impairment, HRCT patterns or quantitative fibrosis extent. Larger multicentre studies using standardised acquisition protocols and focused on well-defined fibrosing ILD populations with predominant subpleural involvement are needed.</p>","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"13 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high-dose supplemental oxygen therapy on pulmonary haemodynamics at 3250 m in high-altitude residents at risk for pulmonary hypertension.","authors":"Alessandro Vella, Julian Müller, Adilet Omuralieva, Anna Titz, Laura Mayer, Maamed Mademilov, Mona Lichtblau, Michael Furian, Talant Sooronbaev, Silvia Ulrich","doi":"10.1136/bmjresp-2026-004376","DOIUrl":"10.1136/bmjresp-2026-004376","url":null,"abstract":"<p><strong>Question addressed by the study: </strong>Hypoxic pulmonary vasoconstriction increases systolic pulmonary artery pressure (sPAP) and may contribute to high-altitude pulmonary hypertension (HAPH). While supplemental oxygen therapy (SOT) lowers sPAP during acute hypoxic exposure, its haemodynamic effects in permanent high-altitude residents remain unclear. In particular, the relative contribution of fixed vascular remodelling to chronically elevated sPAP is uncertain.</p><p><strong>Participants and methods: </strong>In this open-label, non-randomised, sequential interventional trial, Kyrgyz highlanders living >2500 m with tricuspid regurgitation velocity >2.8 m/s underwent echocardiography under ambient air and after >15 min of high-dose SOT (FiO₂≈0.95, 10 L/min) at 3250 m.</p><p><strong>Results: </strong>48 participants (56% females, mean±SD age 53±12 years) completed the study per-protocol. SOT reduced sPAP from 45±11 to 31±5 mm Hg, cardiac output (CO) from 5.1±1.2 to 4.3±1.4 L/min and total pulmonary resistance (TPR) from 9.2±2.7 to 7.5±1.5 WU (all p<0.001). In an exploratory subanalysis, a larger sPAP decrease was associated with higher baseline sPAP and younger age.</p><p><strong>Answer to the question: </strong>High-dose SOT acutely lowers sPAP in high-altitude residents at risk for HAPH. The decrease in sPAP is driven by reductions in both CO and TPR. The decline in TPR indicates a largely reversible hypoxic-vasoconstrictor component, whereas the contribution of fixed vascular remodelling to elevated PAP appears minimal. These findings underscore the physiological potential of short-term high-dose oxygen to reduce right ventricular afterload and improve pulmonary haemodynamics in this high-altitude population at risk for HAPH.</p><p><strong>Trial registration number: </strong>NCT06489756.</p>","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"13 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality and risk factors associated with death in patients with obesity hypoventilation syndrome and of predominantly Afro-Caribbean origin in Martinique.","authors":"Moustapha Agossou, Astrid Monfort-Brafine, Cédric Fagour, Berenice Awanou, Salvatore Metanmo, Marie-Elodie Jean-Charles-Catan, Océane L'heveder, Jocelyn Inamo, Marion Duféal, Mathilde Provost, Nelly Ahouansou, Mathilde Andreu, Jean-Michel Arnal, Chantal Raherison-Semjen, Moustapha Dramé","doi":"10.1136/bmjresp-2025-003819","DOIUrl":"10.1136/bmjresp-2025-003819","url":null,"abstract":"<p><strong>Background: </strong>Obesity hypoventilation syndrome (OHS) is a respiratory complication of obesity. Mortality from OHS is non-negligible. Risk factors for OHS-related mortality are not well established and vary in the literature. This study aimed to assess mortality from OHS in patients in Martinique and to identify risk factors for death.</p><p><strong>Methods: </strong>We performed a single-centre, observational study from 1 January 2019 to 31 December 2024, including patients with OHS.</p><p><strong>Results: </strong>Among 167 included patients, 44 (26.4%) died as of 31 December 2024. 5-year mortality was 12.6%.In multivariable Cox regression, independent predictors of mortality were: OHS diagnosed during acute respiratory failure (HR 6.60, 95% CI 1.50 to 29.10), irregular follow-up (HR 5, 95% CI 1.82 to 14.29), left heart disease (HR 3.63, 95% CI 1.51 to 8.70), lower haematocrit (HR 1.12 per percentage point, 95% CI 1.03 to 1.22) and older age at diagnosis (HR 1.04 per year, 95% CI 1.01 to 1.08).</p><p><strong>Conclusion: </strong>Mortality among patients with OHS in Martinique remains high. Strategies to improve early diagnosis, cardiovascular risk management and long-term follow-up are essential to improving outcomes in this high-risk population.</p>","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"13 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-centred understanding of quality of life, symptoms, health equity in cystic fibrosis (PULSE-CF): study protocol for an observational study.","authors":"Alexander Evan Soltoff, Jane Lowers, Cade Hovater, Kasey Seymour, Elisabeth P Dellon, Brandi Middour-Oxler, Chris Driggers, Reva Crandall, Joshua D Chandler, Nicholas A Giordano, Min Huang, Anne Fitzpatrick, Arlene Stecenko, Ryan A Harris, Rishikesan Kamaleswaran, Scott Gillespie, Dio Kavalieratos","doi":"10.1136/bmjresp-2026-004440","DOIUrl":"10.1136/bmjresp-2026-004440","url":null,"abstract":"<p><strong>Introduction: </strong>Cystic fibrosis (CF) is a progressive, life-limiting condition affecting more than 160 000 people worldwide. Despite major therapeutic advances that have extended life expectancy, people living with CF continue to experience substantial physical, emotional and social symptom burdens that impair quality of life (QOL). Symptoms in CF often co-occur, indicating the presence of specific symptom clustering. Different clusters of co-occurring symptoms may reflect distinct underlying biological mechanisms influenced by social determinants of health. This study aims to identify clusters of co-occurring symptoms among adults with CF, characterise the biological pathways that may underlie these clusters and examine how social and structural factors influence symptom experiences and QOL.</p><p><strong>Methods and analysis: </strong>This is a two-site, prospective mixed-methods cohort study enrolling approximately 140 adults with CF from two academic medical centres in the Southern United States. Participants will be followed for 12 months using validated patient-reported outcome measures to assess symptoms and QOL at baseline and at 3, 6, 9 and 12 months. Clinical data will be collected through chart review, and biospecimens (plasma and exhaled breath condensate) will be obtained at baseline, 6 months and 12 months for metabolomic analysis. Qualitative interviews and healthcare experience surveys will be conducted to explore how social, structural and clinical factors influence symptom burden and care experiences. Statistical analyses will use unsupervised machine learning methods to identify symptom clusters and metabolic endotypes as well as longitudinal regression models to examine associations between symptom patterns and QOL outcomes.</p><p><strong>Ethics and dissemination: </strong>This study involves human participants and was approved by the Emory University Institutional Review Board (2025P011492). All participants will provide informed consent prior to enrolment. We will publish the results of this study in a peer-reviewed journal.</p>","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"13 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma exacerbation requiring ventilatory support in adults: a 10-year retrospective multicentre cohort study - the ESAVA study.","authors":"Nina De Montmollin, Arnaud W Thille, Guillaume Carteaux, Alexis Ferre, Grégoire Jolly, Benoit Painvin, Sébastien Jochmans, Marie Labruyère, Cédric Daubin, Marie Goset, Johann Auchabie, Damien Contou, Gael Piton, Jerôme Devaquet, Stanislas Ledochowski, Thomas Rambaud, Sarah Benhamida, Agathe Delbove, Benjamin Sztrymf, Mickael Landais, Nathanael Lapidus, Nicolas Terzi, Guillaume Voiriot","doi":"10.1136/bmjresp-2026-004261","DOIUrl":"10.1136/bmjresp-2026-004261","url":null,"abstract":"<p><strong>Background: </strong>Little is known about the clinical outcomes of patients admitted to the intensive care unit (ICU) for severe asthma exacerbation requiring ventilatory support.</p><p><strong>Research question: </strong>Our objectives were (i) to describe the initial presentation, therapeutic management and clinical outcomes of adults admitted to the ICU for asthma exacerbation requiring ventilatory support and (ii) to identify risk factors for a prolonged course and/or fatal outcome.</p><p><strong>Study design and methods: </strong>We conducted a 10-year multicentre (n=21) retrospective study in France. All adult patients with asthma admitted to the ICU for an exacerbation requiring invasive (IMV) and/or non-invasive (NIV) mechanical ventilation were included. The primary endpoint was 'complicated course', a composite criterion of death during the ICU stay and/or the need for IMV for ≥7 days.</p><p><strong>Results: </strong>From 2010 to 2019, 349 patients were included (women 57%, age 54 (40-65) years). Acute respiratory failure was the primary reason for ICU admission. However, 12% of patients were admitted following a cardiorespiratory arrest. Respiratory tract infections were documented in 36% of patients, with <i>Haemophilus influenzae</i>, <i>Streptococcus pneumoniae</i> and <i>Rhinovirus</i> as the predominant pathogens. Three-quarters of the patients required IMV, with a median duration of 5 (3-12) days. One-third underwent NIV as initial ventilatory support, but NIV failed in 23% of them. In-hospital mortality was 8%. The composite primary endpoint was observed in 34% of patients. Multivariable analysis identified Sepsis-related Organ Failure Assessment score, pH≤7.3 and a documented respiratory tract infection on ICU admission as independent risk factors for a complicated course.</p><p><strong>Conclusions: </strong>Exacerbation requiring ventilatory support was associated with a substantial burden in adult patients with asthma. Respiratory infection was the predominant suspected triggering factor. Respiratory tract infections were documented in 36% of patients and were independently associated with a prolonged course and/or fatal outcome in the ICU.</p>","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"13 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}