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Association of daily physical activity and bone microarchitecture in young adults with type 1 diabetes — A pilot exploratory study 1 型糖尿病年轻成人的日常体育锻炼与骨骼微结构的关系--一项探索性试点研究
IF 2.1
Bone Reports Pub Date : 2024-11-09 DOI: 10.1016/j.bonr.2024.101813
Sarah L. West , Michelle Furman , Rahim Moineddin , Etienne Sochett
{"title":"Association of daily physical activity and bone microarchitecture in young adults with type 1 diabetes — A pilot exploratory study","authors":"Sarah L. West ,&nbsp;Michelle Furman ,&nbsp;Rahim Moineddin ,&nbsp;Etienne Sochett","doi":"10.1016/j.bonr.2024.101813","DOIUrl":"10.1016/j.bonr.2024.101813","url":null,"abstract":"<div><h3>Purpose</h3><div>Physical activity (PA) is an important determinant of skeletal health. In young adults with type 1 diabetes (T1D) fracture risk is increased, yet few studies have examined the PA and bone health relationship. Therefore, this pilot cross-sectional study characterized PA levels and their association with bone parameters measured by high resolution peripheral quantitative computed tomography (HR-pQCT) in young adults with T1D.</div></div><div><h3>Methods</h3><div>HR-pQCT (Xtreme CTII) was used to measure bone outcomes at the distal tibia and radius, and accelerometery (ActiGraph GT3X) recorded daily minutes of light and moderate-vigorous physical activity (MVPA). Quadratic regression analyses were conducted with a <em>p</em>-value ≤ 0.05 considered significant.</div></div><div><h3>Results</h3><div>PA data from 19 young adults (23.1 ± 1.9 years) with T1D was analyzed. Over half (63 %) of participants completed ≥150 min of MVPA per week, however, most measured activity time per day (57 %) was spent in sedentary pursuits. Significant non-linear associations were found between the duration of MVPA and several trabecular bone parameters at the tibia.</div></div><div><h3>Conclusions</h3><div>In young adults with T1D, MVPA may have site specific (tibia) and compartment specific (trabecular) non-linear associations with bone. Further studies should confirm these findings, which may help inform evidence-based exercise recommendations to optimize bone health in young adults with T1D.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"23 ","pages":"Article 101813"},"PeriodicalIF":2.1,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zoledronate interrupts pre-osteoclast-induced angiogenesis via SDF-1/CXCR4 pathway 唑来膦酸钠通过 SDF-1/CXCR4 通路阻断破骨细胞前期诱导的血管生成
IF 2.1
Bone Reports Pub Date : 2024-11-04 DOI: 10.1016/j.bonr.2024.101812
Mohamed Awad , Elizabeth Taylor-Diaz , Amany Tawfik , Khaled Hussein , Ahmed Elmansi , Mahmoud Elashiry , Ranya Elsayed , Linah Shahoumi , James Borke , William Hill , Fanglong Dong , Mohammed E. Elsalanty
{"title":"Zoledronate interrupts pre-osteoclast-induced angiogenesis via SDF-1/CXCR4 pathway","authors":"Mohamed Awad ,&nbsp;Elizabeth Taylor-Diaz ,&nbsp;Amany Tawfik ,&nbsp;Khaled Hussein ,&nbsp;Ahmed Elmansi ,&nbsp;Mahmoud Elashiry ,&nbsp;Ranya Elsayed ,&nbsp;Linah Shahoumi ,&nbsp;James Borke ,&nbsp;William Hill ,&nbsp;Fanglong Dong ,&nbsp;Mohammed E. Elsalanty","doi":"10.1016/j.bonr.2024.101812","DOIUrl":"10.1016/j.bonr.2024.101812","url":null,"abstract":"<div><h3>Introduction</h3><div>In this study, we tested the hypothesis that pre-osteoclast signaling is key in triggering post-traumatic angiogenesis in alveolar bone via the SDF-1/CXCR4 pathway. Interruption of osteoclast differentiation through zoledronate (Zol) disrupts the crosstalk between pre-osteoclasts and endothelial cells, hindering the initial angiogenic reaction following dental trauma. This disruption could therefore play a role in the pathogenesis of medication-related osteonecrosis of the jaw (MRONJ).</div></div><div><h3>Methods</h3><div>The effect of zoledronate on the expression of SDF1 was tested in pre-osteoclasts (POC) in vitro. Then, we tested the effect of pre-osteoclast conditioned medium on HUVEC cell differentiation, migration, tube-formation, and CXCR4 expression and activity in-vitro. Lastly, we quantified the effect of zoledronate treatment on post-traumatic vascular perfusion of alveolar bone, using microCT-angiography and immunohistochemistry.</div></div><div><h3>Results</h3><div>SDF-1 mRNA expression decreased in Zol-treated POCs (<em>p</em> = 0.02). Flow-Cytometry analysis showed a decrease in CXCL-12<sup>+</sup> (SDF-1α) expressing POCs with Zol treatment (<em>p</em> = 0.0058). On the other hand, CXCR4 mRNA expression was significantly inhibited in Zol-treated HUVECs (<em>p</em> = 0.0063). CXCR4 protein expression and activity showed a corresponding dose-dependent downregulation HUVEC surface treated with conditioned media from POC treated with Zol (<em>p</em> = 0.008 and 0.03, respectively). Similar inhibition was observed of HUVEC migration (<em>p</em> = 0.0012), and tube formation (<em>p</em> &lt; 0.0001), effects that were reversed with SDF-1. Finally, there was a significant reduction of CD31<sup>+</sup> HUVECs in Alveolar bone of Zol-treated rats (<em>p</em> = 0.0071), confirmed by significantly lower percentage of blood vessel volume (<em>p</em> = 0.026), and marginally lower vessel number (<em>p</em> = 0.062) in the alveolar bone.</div></div><div><h3>Conclusion</h3><div>Pre-osteoclasts play a crucial role in the initial angiogenic response in alveolar bone following dental extraction. Disruption of this process may be a predisposing factor to osteonecrosis.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"23 ","pages":"Article 101812"},"PeriodicalIF":2.1,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment with bariatric surgery in patients with osteogenesis imperfecta and severe obesity 用减肥手术治疗成骨不全症和重度肥胖症患者
IF 2.1
Bone Reports Pub Date : 2024-10-21 DOI: 10.1016/j.bonr.2024.101811
Jannie Dahl Hald , Asta-Marie Welander Hald , Torben Harsløf , Bente Langdahl , Jens Meldgaard Bruun
{"title":"Treatment with bariatric surgery in patients with osteogenesis imperfecta and severe obesity","authors":"Jannie Dahl Hald ,&nbsp;Asta-Marie Welander Hald ,&nbsp;Torben Harsløf ,&nbsp;Bente Langdahl ,&nbsp;Jens Meldgaard Bruun","doi":"10.1016/j.bonr.2024.101811","DOIUrl":"10.1016/j.bonr.2024.101811","url":null,"abstract":"","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"23 ","pages":"Article 101811"},"PeriodicalIF":2.1,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Voluntary exercise in mice triggers an anti-osteogenic and pro-tenogenic response in the ankle joint without affecting long bones 小鼠的自主运动会引发踝关节的抗骨质生成和促韧反应,但不会影响长骨
IF 2.1
Bone Reports Pub Date : 2024-10-15 DOI: 10.1016/j.bonr.2024.101810
Anne Briolay , François Duboeuf , Séverine Delplace , Leyre Brizuela , Olivier Peyruchaud , David Magne , Carole Bougault
{"title":"Voluntary exercise in mice triggers an anti-osteogenic and pro-tenogenic response in the ankle joint without affecting long bones","authors":"Anne Briolay ,&nbsp;François Duboeuf ,&nbsp;Séverine Delplace ,&nbsp;Leyre Brizuela ,&nbsp;Olivier Peyruchaud ,&nbsp;David Magne ,&nbsp;Carole Bougault","doi":"10.1016/j.bonr.2024.101810","DOIUrl":"10.1016/j.bonr.2024.101810","url":null,"abstract":"<div><div>Biomechanical stimulation is proposed to occupy a central place in joint homeostasis, but the precise contribution of exercise remains elusive. We aimed to characterize in vivo the impact of mechanical stimulation on the cell-controlled regulation of ossification within the ankles of healthy mice undergoing mild physical activity. DBA/1 male mice were subjected to voluntary running exercise for two weeks, and compared to mice housed in standard conditions (<em>n</em> = 20 per group). Free access to activity wheels resulted in a running exercise of 5.5 ± 0.8 km/day at 14.5 ± 0.5 m/min. Serum levels of alkaline phosphatase, IL-6, IL-8/Kc, IL-17a, and TNF-α were measured. No change in systemic inflammation was detected. The bone architecture of the femur and the calcaneus was unchanged, as revealed by μCT and histology of the enthesis of the Achilles tendon. mRNAs were extracted from femurs, tibias, and ankle joints before RT-qPCR analysis. The expression of the mechanosensitive genes <em>Sclerostin</em> (<em>Sost</em>) and <em>Periostin</em> (<em>Postn</em>) was not impacted by the exercise in long bones. Oppositely, <em>Sost</em> and <em>Postn</em> levels were modulated by exercise in joints, and osteogenic markers (<em>Col10a1</em>, <em>Runx2</em>, <em>Osx</em>, and <em>Dmp1</em>) were downregulated in the exercise group. In addition, the tenogenic markers <em>Scx</em>, <em>Mkx</em>, and <em>Tnmd</em> were upregulated by exercise. Thus, voluntary exercise affected the phenotype of joint cells without impacting long bones. As gene expression of <em>Bmp2</em>, <em>Bmp4</em>, and <em>Id1</em> was also reduced in these cells, an off-regulation of BMP signaling could be partly responsible for their mechanosensitive response. Running exercise seemed to preserve the tendon from its progressive ossification, as seen in numerous enthesopathies. This study paves the way to future experiments for investigating the effects of mechanical stimulation in various mouse models.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"23 ","pages":"Article 101810"},"PeriodicalIF":2.1,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delineating the nexus between gut-intratumoral microbiome and osteo-immune system in bone metastases 阐明骨转移瘤中肠道-瘤内微生物群与骨免疫系统之间的联系
IF 2.1
Bone Reports Pub Date : 2024-10-10 DOI: 10.1016/j.bonr.2024.101809
Shreya Kapoor, Muskan Gupta , Leena Sapra , Taranjeet Kaur, Rupesh K. Srivastava
{"title":"Delineating the nexus between gut-intratumoral microbiome and osteo-immune system in bone metastases","authors":"Shreya Kapoor,&nbsp;Muskan Gupta ,&nbsp;Leena Sapra ,&nbsp;Taranjeet Kaur,&nbsp;Rupesh K. Srivastava","doi":"10.1016/j.bonr.2024.101809","DOIUrl":"10.1016/j.bonr.2024.101809","url":null,"abstract":"<div><div>Emerging insights in osteoimmunology have enabled researchers to explore in depth the role of immune modulation in regulating bone health. Bone is one of the common sites of metastasis notably in case of breast cancer, prostate cancer and several other cancer types. High calcium ion concentration and presence of several factors within the mineralized bone matrix including TGF-β, BMP etc., aid in tumor growth and proliferation. Accumulating evidence has substantiated the role of the gut-microbiota (GM) in tumorigenesis, further providing a strong impetus for the growing “immune-cancer-gut microbiota” relationship. Recent advancements in research further highlight the importance of the intra-tumor microbiota in conjunction with GM in cancer metastasis. Intratumoral microbiota owing to their ability to cause genetic instability, mutations, and epigenetic modifications within the tumor microenvironment, has been recognized to affect cancer cell physiology. The host microbiota and immune system crosstalk shapes the innate and adaptive arms of the immune system, which is the key player in cancer progression. In this review, we aim to decipher the role of microorganisms mediating bone metastasis by shedding light on the immuno-onco-microbiome (IOM) axis. We discussed the feasible cancer therapeutic interventions based on the modulation of the microbiome-immune cell axis which includes prebiotics, probiotics, and postbiotics. Here, we leverage the conceptual framework based on the published articles on microbiota-based therapies to target bone metastases. Understanding this complicated nexus will provide insights into fundamental factors governing bone metastases which will subsequently help in managing this malignancy with better efficacy.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"23 ","pages":"Article 101809"},"PeriodicalIF":2.1,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Administration of low intensity vibration and a RANKL inhibitor, alone or in combination, reduces bone loss after spinal cord injury-induced immobilization in rats 单独或联合使用低强度振动和 RANKL 抑制剂可减少脊髓损伤引起的大鼠固定后的骨质流失
IF 2.1
Bone Reports Pub Date : 2024-10-02 DOI: 10.1016/j.bonr.2024.101808
Yuanzhen Peng , Helen M. Bramlett , W. Dalton Dietrich , Alex Marcillo , Juliana Sanchez-Molano , Ofelia Furones-Alonso , Jay J. Cao , Jenney Huang , Andrew A. Li , Jian Q. Feng , William A. Bauman , Weiping Qin
{"title":"Administration of low intensity vibration and a RANKL inhibitor, alone or in combination, reduces bone loss after spinal cord injury-induced immobilization in rats","authors":"Yuanzhen Peng ,&nbsp;Helen M. Bramlett ,&nbsp;W. Dalton Dietrich ,&nbsp;Alex Marcillo ,&nbsp;Juliana Sanchez-Molano ,&nbsp;Ofelia Furones-Alonso ,&nbsp;Jay J. Cao ,&nbsp;Jenney Huang ,&nbsp;Andrew A. Li ,&nbsp;Jian Q. Feng ,&nbsp;William A. Bauman ,&nbsp;Weiping Qin","doi":"10.1016/j.bonr.2024.101808","DOIUrl":"10.1016/j.bonr.2024.101808","url":null,"abstract":"<div><div>We previously reported an ability of low-intensity vibration (LIV) to improve selected biomarkers of bone turnover and gene expression and reduce osteoclastogenesis but lacking of evident bone accrual. In this study, we demonstrate that a prolonged course of LIV that initiated at 2 weeks post-injury and continued for 8 weeks can protect against bone loss after SCI in rats. LIV stimulates bone formation and improves osteoblast differentiation potential of bone marrow stromal stem cells while inhibiting osteoclast differentiation potential of marrow hematopoietic progenitors to reduce bone resorption. We further demonstrate that the combination of LIV and RANKL antibody reduces SCI-related bone loss more than each intervention alone. Our findings that LIV is efficacious in maintaining sublesional bone mass suggests that such physical-based intervention approach would be a noninvasive, simple, inexpensive and practical intervention to treat bone loss after SCI. Because the combined administration of LIV and RANKL inhibition better preserved sublesional bone after SCI than either intervention alone, this work provides the impetus for the development of future clinical protocols based on the potential greater therapeutic efficacy of combining non-pharmacological (e.g., LIV) and pharmacological (e.g., RANKL inhibitor or other agents) approaches to treat osteoporosis after SCI or other conditions associated with severe immobilization.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"23 ","pages":"Article 101808"},"PeriodicalIF":2.1,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of ultrasound imaging in monitoring fracture healing in rat femur: Comparison with other imaging modalities 超声成像在监测大鼠股骨骨折愈合中的作用:与其他成像模式的比较
IF 2.1
Bone Reports Pub Date : 2024-09-23 DOI: 10.1016/j.bonr.2024.101807
Satoshi Inoue , Michinori Mori , Masaya Yasui , Miwako Matsuki-Fukushima , Kentaro Yoshimura , Naoko Nonaka
{"title":"Utility of ultrasound imaging in monitoring fracture healing in rat femur: Comparison with other imaging modalities","authors":"Satoshi Inoue ,&nbsp;Michinori Mori ,&nbsp;Masaya Yasui ,&nbsp;Miwako Matsuki-Fukushima ,&nbsp;Kentaro Yoshimura ,&nbsp;Naoko Nonaka","doi":"10.1016/j.bonr.2024.101807","DOIUrl":"10.1016/j.bonr.2024.101807","url":null,"abstract":"<div><h3>Objective</h3><div>Fractures are common injuries and various imaging modalities are employed to diagnose and monitor bone union. However, the follow-up of fracture healing using ultrasound imaging (US) remains a topic of debate. In this study, we analyzed of fracture healing process and compared US and radiological analyses with histological analyses to clarify the characteristics and limitations of each modality.</div></div><div><h3>Methods</h3><div>An osteotomy model was created using the femur of Wistar rats, and US, radiological (radiography and micro-computed tomography (micro-CT)), and histological analyses were performed. Radiological assessments were conducted for the evaluation of calcified tissue. The gap between the bony callus and cartilaginous callus was measured.</div></div><div><h3>Results</h3><div>US effectively captured changes on the fracture surface, potentially reflecting the early healing processes. Both US and radiographic findings showed strong correlation in terms of the decrease in the bony callus gap. US was unable to distinguish cartilaginous callus from the surrounding soft tissue. During the remodeling stage, micro-CT offered a detailed assessment of the internal fracture surface, whereas US was limited to evaluating the outer bone surface and lacked accuracy in visualizing the entire fracture site. Radiography provided a general overview of the fractures. The decrease in the bony callus gap measured using US correlated with the reduction in cartilaginous callus observed histologically.</div></div><div><h3>Conclusion</h3><div>This study demonstrated that US could be a valuable tool for evaluating fracture healing. Combining fracture management with US and radiological examinations may provide a more accurate assessment of healing progress.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"23 ","pages":"Article 101807"},"PeriodicalIF":2.1,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352187224000743/pdfft?md5=b4602ad835bfbf30c300979e46abe843&pid=1-s2.0-S2352187224000743-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between trabecular bone score, 10-year probability risk for fracture, and vertebral fractures in rheumatoid arthritis 类风湿性关节炎患者骨小梁评分、10 年骨折概率风险与脊椎骨折之间的关系
IF 2.1
Bone Reports Pub Date : 2024-09-23 DOI: 10.1016/j.bonr.2024.101806
Houssam Boutaibi, Hamida Azzouzi, Fadoua Chennouf, Linda Ichchou
{"title":"Association between trabecular bone score, 10-year probability risk for fracture, and vertebral fractures in rheumatoid arthritis","authors":"Houssam Boutaibi,&nbsp;Hamida Azzouzi,&nbsp;Fadoua Chennouf,&nbsp;Linda Ichchou","doi":"10.1016/j.bonr.2024.101806","DOIUrl":"10.1016/j.bonr.2024.101806","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim was to assess the association and predictive value of trabecular bone score (TBS), fracture risk assessment tool (FRAX), and TBS-adjusted FRAX with prevalent vertebral fractures (VFs) in patients with rheumatoid arthritis (RA).</div></div><div><h3>Methods</h3><div>Patients diagnosed with RA were included in this cross-sectional study. Clinical data and laboratory tests were collected on the same day as the dual-energy x-ray absorptiometry (DXA) scan. TBS, bone mineral density (BMD), and vertebral fracture assessment (VFA) were obtained from the DXA scan. We used the FRAX tool to assess the 10-year probability of major osteoporotic fracture (MOF-FRAX) and hip fracture (HF-FRAX) with and without BMD. These parameters were further adjusted for TBS. Patients with prevalent VFs were defined as those with moderate to severe VFs from T4 to L4. VFs presence was used as the binary variable in the logistic regressions and receiving operator characteristics (ROC) curves analysis.</div></div><div><h3>Results</h3><div>Sixty-nine patients were enrolled, with 55.1 % being postmenopausal. The mean TBS was 1.328 ± 0.104. Osteoporosis according to the WHO criteria was present in 39 patients (56.5 %), and six patients (8.7 %) had VFs with thoracic predominance (66.67 %). Univariate and multivariate logistic regression analyses did not show an association between TBS and vertebral fractures, but FRAX scores indicated such an association. The area under the curve (AUC) with 95 % confidence intervals (CI) for the MOF-FRAX score with BMD, MOF-FRAX score without BMD, TBS-adjusted MOF-FRAX score, and TBS were 0.837 [0.686–0.988], 0.795 [0.629–0.961], 0.778 [0.571–0.984], and 0.515 [0.298–0.731], respectively.</div></div><div><h3>Conclusion</h3><div>In our RA patients, FRAX scores were associated with vertebral fractures (VFs), while TBS was not. The MOF-FRAX score combined with BMD, showed the best AUC for VFs in this population.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"23 ","pages":"Article 101806"},"PeriodicalIF":2.1,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142328284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Romosuzumab used to treat a 29-year-old patient with anorexia nervosa related osteoporosis – A case report 罗莫单抗用于治疗一名 29 岁神经性厌食症相关骨质疏松症患者--病例报告
IF 2.1
Bone Reports Pub Date : 2024-09-01 DOI: 10.1016/j.bonr.2024.101803
Pashija Demolli, Diana Frey
{"title":"Romosuzumab used to treat a 29-year-old patient with anorexia nervosa related osteoporosis – A case report","authors":"Pashija Demolli,&nbsp;Diana Frey","doi":"10.1016/j.bonr.2024.101803","DOIUrl":"10.1016/j.bonr.2024.101803","url":null,"abstract":"<div><h3>Summary</h3><p>Osteoporosis and decreased bone density is a frequent complication of anorexia nervosa (AN). As of yet, there have been no studies of accomplished treatment of AN-related osteoporosis with romosuzumab, a monoclonal antibody to sclerostin. We report the first case of a premenopausal, 29-year old patient in Switzerland with decreased bone density and osteoporotic fractures due to anorexia nervosa, who completed the treatment with romosuzumab. There was a significant increase in bone mineral density (BMD) after 12 months of therapy. No serious side effects were reported. To date, only bisphosphonates, denosumab and teriparatide have been evaluated in treatment of AN-related osteoporosis in adolescents and premenopausal individuals respectively. Our report demonstrates that romosuzumab might be an alternative treatment option in patients with anorexia nervosa who are at high risk for osteoporotic fractures. To assess the efficacy and safety of romosuzumab in individuals with AN further studies are needed.</p></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"22 ","pages":"Article 101803"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352187224000706/pdfft?md5=787d170bc85bba3b4eb5a7451b1d87ba&pid=1-s2.0-S2352187224000706-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case report of Tumor-Induced Osteomalacia (TIO) caused by central giant cell granuloma 中心巨细胞肉芽肿引起的肿瘤诱发骨软化症(TIO)病例报告
IF 2.1
Bone Reports Pub Date : 2024-09-01 DOI: 10.1016/j.bonr.2024.101804
Sevil Ghaffarzadeh Rad , Amir Bahrami , Jalil Houshyar , Nazila Farrin , Farzad Najafipour , Halimeh Amirazad
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