Bone Reports最新文献

{"title":"Correlations between 6-minute walk test, chair-rise test, and lower extremity functional scale among patients with hypophosphatasia","authors":"Lothar Seefried,&nbsp;Franca Genest","doi":"10.1016/j.bonr.2025.101853","DOIUrl":"10.1016/j.bonr.2025.101853","url":null,"abstract":"<div><h3>Purpose</h3><div>Hypophosphatasia (HPP) is a rare disease characterized by skeletal and nonskeletal manifestations that can increase patient disability. The 6-Minute Walk Test (6MWT) is frequently used to assess mobility in patients with HPP, although the test is laborious to conduct in clinical practice. The purpose of the current study was to determine correlations between time to complete the 6MWT, time to complete the Chair-Rise Test (CRT), and scores on the Lower Extremity Functional Scale (LEFS) in adults with HPP.</div></div><div><h3>Methods</h3><div>Pearson correlations between time to complete outcomes on the 6MWT and CRT, time to complete the 6MWT and scores on the LEFS, and time to complete the CRT and scores on the LEFS were calculated using de-identified data from adults with HPP who had first onset of symptoms in childhood. All patients were enrolled in the previously conducted, observational EmPATHY study.</div></div><div><h3>Results</h3><div>Pearson correlation analyses showed inverse correlations between 6MWT and CRT outcomes (<em>r</em> = −0.584) and between CRT and LEFS outcomes (<em>r</em> = −0.596) and a direct correlation between 6MWT and LEFS outcomes (<em>r</em> = 0.808).</div></div><div><h3>Conclusions</h3><div>Time to complete the 6MWT was correlated with time to complete the CRT and scores on the LEFS in adults with HPP. CRT and LEFS may be suitable, expeditious options to amend or substitute 6MWT when assessing functional status in patients with HPP.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"25 ","pages":"Article 101853"},"PeriodicalIF":2.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-assisted classification of hip conditions in pediatric cerebral palsy patients using migration percentage measurements","authors":"Sema Ertan Birsel ,&nbsp;Ekrem Demirci ,&nbsp;Ali Seker ,&nbsp;Kadriye Yasemin Usta Ayanoğlu ,&nbsp;Emir Oncu ,&nbsp;Fatih Ciftci","doi":"10.1016/j.bonr.2025.101852","DOIUrl":"10.1016/j.bonr.2025.101852","url":null,"abstract":"<div><div>Hip displacement is a significant concern in children with cerebral palsy (CP), necessitating accurate and timely assessment to prevent long-term complications. This study developed a support vector machine (SVM) model to classify hip conditions using migration percentage (MP) measurements obtained from 176 hips across 88 anteroposterior pelvic radiographs. MP values were categorized into three groups: normal (MP ≤ 30 %), risky (30 % &lt; MP ≤ 60 %), and dislocated (MP &gt; 60 %). The SVM model was evaluated using stratified k-fold cross-validation, with accuracy, precision, recall, and F1-scores as key metrics. Its classifications were compared to manual evaluations performed by an orthopedic resident and a pediatric orthopedic surgeon. The model achieved an overall accuracy of 92.898 %, surpassing the consistency and reliability of manual assessments, particularly in identifying dislocated hips. Statistical analysis showed no significant differences between the model's MP measurements and those of the clinicians, validating its effectiveness. This study highlights the potential of SVM models to enhance diagnostic accuracy, reduce variability in evaluations, and support clinical decision-making. Future research should expand the dataset and incorporate advanced machine learning models to further improve diagnostic precision.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"25 ","pages":"Article 101852"},"PeriodicalIF":2.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevention of osteoporotic vertebral fractures in eastern and in western countries","authors":"Fjorda Koromani ,&nbsp;Jiawei Li ,&nbsp;Hiroshi Hagino ,&nbsp;Richard Eastell ,&nbsp;Annegreet Vlug ,&nbsp;Ling Wang ,&nbsp;Hua Yue ,&nbsp;Yong-Chan Ha ,&nbsp;Steven Cummings ,&nbsp;Salvatore Minisola ,&nbsp;Claus-C. Glüer ,&nbsp;Ling Oei ,&nbsp;the East Meets West Action Group of the European Calcified Tissue Society","doi":"10.1016/j.bonr.2025.101851","DOIUrl":"10.1016/j.bonr.2025.101851","url":null,"abstract":"<div><div>Osteoporotic vertebral fractures (VFs) are among the most common and clinically significant manifestations of skeletal fragility, contributing substantially to morbidity, disability, and future fracture risk worldwide. Yet, their recognition and management remain inconsistent across regions. To explore differences and similarities in the prevalence, diagnosis, management, and prevention of vertebral fractures, the East Meets West (EmW) Action Group of the European Calcified Tissue Society convened a multi-country exchange among clinical and research experts from Europe, the USA, and East Asia. This report summarizes the discussions and synthesizes current knowledge on the topic. Evidence from China, South Korea, Japan, and Germany shows a wide range in reported VF prevalence and incidence, largely influenced by differences in population aging, imaging access, and diagnostic adjudication methods. While lateral spine radiographs remain the standard for detection in both research and clinical care, variable use of quantitative morphometry (QM), semi-quantitative (SQ), and algorithm-based qualitative (ABQ) methods limits comparability. MRI remains the gold standard for assessing fracture acuity, but is not feasible for widespread screening. VFA via DXA is gaining popularity, although underutilized in several settings. Despite the availability of effective pharmacologic treatments, including bisphosphonates, denosumab, and anabolic agents, treatment rates following VF remain suboptimal across all countries studied. None of the countries currently has a nationwide vertebral fracture screening program, although fracture liaison services (FLS) and AI-assisted imaging offer promising pathways forward. The lack of a universally accepted definition and gold standard for VF adjudication continues to hamper clinical decision-making and data harmonization. This report highlights the need for greater international consensus on diagnostic criteria, improved integration of vertebral fracture screening into clinical workflows, and the development of targeted strategies to close treatment gaps and reduce the global burden of vertebral fractures.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"25 ","pages":"Article 101851"},"PeriodicalIF":2.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144105356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of endurance exercise and dietary protein intake on osteokine, bone turnover, and inflammatory markers in endurance runners: A narrative review","authors":"Sofia Valente Ferreira ,&nbsp;Silar Gardy ,&nbsp;Tyler A. Churchward-Venne ,&nbsp;Andrea R. Josse ,&nbsp;Jenna C. Gibbs","doi":"10.1016/j.bonr.2025.101850","DOIUrl":"10.1016/j.bonr.2025.101850","url":null,"abstract":"<div><div>Bone stress injuries are pervasive among endurance runners due to repetitive sport-specific mechanical loading and a higher prevalence of low energy availability (i.e., inadequate dietary energy intake relative to exercise energy expenditure). Chronic endurance exercise promotes bone formation, thus, runners typically have higher bone mineral density (BMD) than non-weightbearing athletes and sedentary individuals. However, runners may experience increased bone resorption for hours to days following an endurance exercise bout. If recovery is insufficient, uncoupled bone turnover can pose a significant risk to their bone health. While skeletal-immune system crosstalk has been studied, the interaction during and after exercise in athletes is an emerging area of research. Nutritional interventions have been investigated for their effects on bone metabolism surrounding exercise. However, limited research has examined dietary protein intake in endurance athletes, particularly concerning its effects on bone metabolism and osteoimmunology. This narrative review provides an overview of the evidence on the effects of endurance exercise and dietary protein intake on osteokines, bone turnover, and inflammatory markers in endurance athletes. Acute bouts of high-intensity running increase osteokines and bone turnover markers that promote bone resoprtion which parallels increases in pro-inflammatory markers in endurance athletes, suggesting crosstalk between these systems during and after exercise. Chronic endurance exercise promotes increased resting levels of bone formation, while reducing resting pro-inflammatory markers. Adequate dietary protein ingestion habitually and pre-, during, and post-exercise may attenuate bone resportion and pro-inflammatory markers in endurance athletes.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"25 ","pages":"Article 101850"},"PeriodicalIF":2.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of skeletal fragility due to Loeys-Dietz syndrome and treatment with romosozumab followed by denosumab","authors":"Yasutaka Tsujimoto ,&nbsp;Naoki Yamamoto ,&nbsp;Hayato Fukumitsu ,&nbsp;Hironori Bando ,&nbsp;Masaaki Yamamoto ,&nbsp;Keiko Tanaka ,&nbsp;Naoya Morisada ,&nbsp;Miwako Nagasaka ,&nbsp;Keisuke Oe ,&nbsp;Takahiro Niikura ,&nbsp;Mika Yamauchi ,&nbsp;Wataru Ogawa ,&nbsp;Hidenori Fukuoka","doi":"10.1016/j.bonr.2025.101849","DOIUrl":"10.1016/j.bonr.2025.101849","url":null,"abstract":"<div><div>Loeys–Dietz syndrome (LDS) is an autosomal dominant, inherited connective tissue disorder caused by a pathogenic variant in TGF-β signaling-related genes. LDS is associated with a high risk of low bone mineral density (BMD) and fractures.</div><div>We present a case report of a 43-year-old premenopausal woman with skeletal fragility who was diagnosed with LDS type 4 due to a large heterozygous deletion in the <em>TGFB2</em> gene. Upon initial referral, she was evaluated for secondary osteoporosis. Although mild abnormalities in calcium metabolism, menstrual irregularities, and lack of exercise were observed, they were not associated with this condition. However, a thorough family history and physical examination raised the suspicion of Marfan syndrome and related disorders, which were subsequently confirmed using genetic testing. Treatment with romosozumab for 1 year increased the lumbar spine BMD from 0.750 g/cm² (<em>Z</em>-score −2.1) to 0.881 g/cm² (<em>Z</em>-score −1.0) and the femoral neck BMD from 0.407 g/cm² (Z-score − 3.0) to 0.428 g/cm² (Z-score − 2.6), with a slight increase in total hip BMD from 0.525 g/cm² (<em>Z</em>-score −2.6) to 0.527 g/cm² (<em>Z</em>-score −2.4). Subsequent therapy with denosumab for 1 year further improved the lumbar spine BMD to 0.939 g/cm² (Z-score, −0.5), femoral neck BMD to 0.496 g/cm² (Z-score, −2.0), and total hip BMD to 0.552 g/cm² (Z-score, −2.2). To our knowledge, this is the first case report of an improvement in BMD with romosozumab, followed by denosumab, for skeletal fragility due to LDS. Our findings suggest that this treatment regimen may be an effective therapeutic option for the management of skeletal fragility in patients with LDS.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"25 ","pages":"Article 101849"},"PeriodicalIF":2.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteosarcopenia as a risk factor for depression: Longitudinal findings from the SHARE study","authors":"Nicola Veronese ,&nbsp;Francesco Saverio Ragusa ,&nbsp;Shaun Sabico ,&nbsp;Ligia Juliana Dominguez ,&nbsp;Mario Barbagallo ,&nbsp;Gustavo Duque ,&nbsp;Lee Smith ,&nbsp;Nasser Al-Daghri","doi":"10.1016/j.bonr.2025.101848","DOIUrl":"10.1016/j.bonr.2025.101848","url":null,"abstract":"<div><h3>Background</h3><div>Osteosarcopenia (i.e., the co-existence of osteoporosis and sarcopenia) and depression are highly prevalent among older people. However, the association between osteosarcopenia and depression in older people is largely unknown. Therefore, the present study aims to investigate this possible association in a representative sample of the older adult population in Europe and Israel.</div></div><div><h3>Methods</h3><div>Osteosarcopenia was defined as the concomitant presence of osteoporosis and sarcopenia; depressive symptoms in the SHARE study were self-reported using the EURO-D scale. The association between the presence of osteosarcopenia at baseline in people free from depression and incident depression during 12 years of follow-up was analyzed using a Cox's regression analysis, adjusting for several baseline covariates.</div></div><div><h3>Results</h3><div>16,452 participants were included (mean age 63.7, SD 9.6; females 50.6 %). During the follow-up period, 5056 participants (31.1 % of the initial population) became depressed. People affected by osteosarcopenia became depressed in more than half of the cases compared to a quarter of controls. After adjusting for several potential baseline confounding variables, only sarcopenia (HR, hazard ratio = 1.17; 95 % CI, confidence intervals 1.04–1.32; <em>p</em> = 0.009) and osteosarcopenia (HR = 1.27; CI 95 % 1.12–1.58; <em>p</em> = 0.003) were significantly associated with a higher risk of depression.</div></div><div><h3>Limitations</h3><div>Definition of sarcopenia using an anthropometric equation; definition of depression using the EURO-D scale.</div></div><div><h3>Conclusions</h3><div>The present study identified a significant association between osteosarcopenia and depression over 12 years of follow-up, mainly driven by sarcopenia. If future research confirms the present findings, it may then be prudent to target those with osteosarcopenia to aid in the prevention of onset depression.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"25 ","pages":"Article 101848"},"PeriodicalIF":2.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144105355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination or sequential teriparatide for osteoporosis treatment in denosumab-users: real-world bone mineral density outcomes","authors":"Shejil KUMAR ,&nbsp;Courtney STREETER ,&nbsp;Michelle M. MCDONALD ,&nbsp;Roderick J. CLIFTON- BLIGH ,&nbsp;Matti L. GILD ,&nbsp;Christian M. GIRGIS","doi":"10.1016/j.bonr.2025.101847","DOIUrl":"10.1016/j.bonr.2025.101847","url":null,"abstract":"<div><div>The optimal osteoanabolic strategy in denosumab (Dmab)-users remains uncertain. In treatment-naïve patients, Dmab/teriparatide (TPTD) combinations result in dramatic bone mineral density (BMD) gains at the spine and hip. However, BMD outcomes with combination Dmab/TPTD have not been investigated in patients on <em>established</em> Dmab.</div><div>We retrospectively reviewed patients with osteoporosis at two Sydney centers between 2013 and 2023. Eligible patients were managed with Dmab immediately before ≥12-months TPTD. Patients were grouped according to whether TPTD was added to ongoing Dmab (<em>combination</em>) or Dmab was withheld during TPTD (<em>sequence</em>). BMD outcomes were assessed during TPTD.</div><div>The total cohort (<em>N</em> = 23; 11 = combination, 12 = sequence) had mean age 77 ± 7 years and were predominantly female (87 %). Overall, prior vertebral (52 %) and non-vertebral fractures (2.4 ± 1.5) were prevalent and pre-TPTD BMD T-scores (SD) low at lumbar spine (−2.4 ± 1.2) and total hip (−2.2 ± 0.6). Median Dmab exposure was 5-doses (IQR 3–11), median overall antiresorptive exposure was 6-years (IQR 4–11) and majority (&gt;90 %) received 18-months TPTD. Groups were similar in age, sex, Dmab and overall antiresorptive exposure, fracture prevalence, DXA interval and pre-TPTD BMD values. Combination Dmab/TPTD was associated with significant lumbar spine BMD gains (+0.080 g/cm² ± 0.059 g/cm², <em>p</em> = 0.004; +9.8 %). No significant BMD change occurred during sequential Dmab/TPTD (+0.026 g/cm² ± 0.049 g/cm², <em>p</em> = 0.107; +3.5 %). Combination Dmab/TPTD resulted in greater lumbar spine BMD gains (<em>p</em> = 0.039). Hip and femoral neck BMD remained stable in both groups.</div><div>In this retrospective study, significant lumbar spine BMD gains occurred during combined Dmab/TPTD in patients on established Dmab. These results warrant prospective controlled studies to further inform optimal osteoanabolic strategies in Dmab-users.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"25 ","pages":"Article 101847"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A narrative review of recent developments in osseointegration and anti-corrosion of titanium dental implants with nano surface","authors":"Hoda Ghodrati ,&nbsp;Ali Goodarzi ,&nbsp;Mohammad Golrokhian ,&nbsp;Farnaz Fattahi ,&nbsp;Reza Mahmoudi Anzabi ,&nbsp;Meysam Mohammadikhah ,&nbsp;Saiedeh Sadeghi ,&nbsp;Sabah Mirhadi","doi":"10.1016/j.bonr.2025.101846","DOIUrl":"10.1016/j.bonr.2025.101846","url":null,"abstract":"<div><div>Titanium (Ti) is widely acknowledged as the top choice for constructing dental implants because of its remarkable biocompatibility and biomechanical characteristics. Its rapid oxidation in the presence of oxygen forms a protective titanium dioxide (TiO₂) layer on the implants’ surface, ensuring resistance to corrosion. This thin oxide layer plays a crucial role in establishing the favorable biocompatibility of Ti implants. However, under mechanical loading conditions, the integrity of the TiO₂ layer can be compromised through the dynamic interactions between the implant and bone tissue, leading to localized damage and subsequent corrosion. This corrosion weakens the implant and may result in the release of metallic particles or ions into the surrounding living tissues. Consequently, corrosion serves as a potential catalyst for the emergence of malfunctions in dental implants, whether biological or mechanical in nature. To address this issue, extensive research has focused on nanoscale surface modifications aimed at enhancing the durability and resistance to chemical and electrochemical changes exhibited by dental implants made from Ti. Hence, this narrative review specifically examines nano surface modifications of titanium dental implants, focusing on their effects on corrosion resistance, biomechanical performance, and osseointegration, distinguishing it from other reviews that address broader aspects of titanium implants or general corrosion mechanisms.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"25 ","pages":"Article 101846"},"PeriodicalIF":2.1,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in pediatric osteopenia diagnosis: evaluating deep network classification and model interpretability using wrist X-rays","authors":"Chelsea E. Harris ,&nbsp;Lingling Liu ,&nbsp;Luiz Almeida ,&nbsp;Carolina Kassick ,&nbsp;Sokratis Makrogiannis","doi":"10.1016/j.bonr.2025.101845","DOIUrl":"10.1016/j.bonr.2025.101845","url":null,"abstract":"<div><div>Osteopenia is a bone disorder that causes low bone density and affects millions of people worldwide. Diagnosis of this condition is commonly achieved through clinical assessment of bone mineral density (BMD). State of the art machine learning (ML) techniques, such as convolutional neural networks (CNNs) and transformer models, have gained increasing popularity in medicine. In this work, we employ six deep networks for osteopenia vs. healthy bone classification using X-ray imaging from the pediatric wrist dataset GRAZPEDWRI-DX. We apply two explainable AI techniques to analyze and interpret visual explanations for network decisions. Experimental results show that deep networks are able to effectively learn osteopenic and healthy bone features, achieving high classification accuracy rates. Among the six evaluated networks, DenseNet201 with transfer learning yielded the top classification accuracy at 95.2 %. Furthermore, visual explanations of CNN decisions provide valuable insight into the blackbox inner workings and present interpretable results. Our evaluation of deep network classification results highlights their capability to accurately differentiate between osteopenic and healthy bones in pediatric wrist X-rays. The combination of high classification accuracy and interpretable visual explanations underscores the promise of incorporating machine learning techniques into clinical workflows for the early and accurate diagnosis of osteopenia.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"25 ","pages":"Article 101845"},"PeriodicalIF":2.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone mechanical loading reduces heart rate and increases heart rate variability in mice","authors":"Julian A. Vallejo ,&nbsp;Mark Gray ,&nbsp;Jackson Klump ,&nbsp;Andrew Wacker ,&nbsp;Mark Dallas ,&nbsp;Mark L. Johnson ,&nbsp;Michael J. Wacker","doi":"10.1016/j.bonr.2025.101844","DOIUrl":"10.1016/j.bonr.2025.101844","url":null,"abstract":"<div><div>Cardiovascular disease and osteoporosis are clinically associated. Bone adapts to mechanical forces by altering its overall structure and mass. In response to mechanical strain bone cells release signaling molecules and activate the nervous system. Bone also exhibits endocrine functions that modulate a number of tissues including the heart. We hypothesized that bone mechanical loading acutely alters cardiac function via neural and/or endocrine mechanisms. To test this hypothesis, we performed in vivo tibia mechanical loading in anesthetized mice while monitoring heart parameters using electrocardiogram (ECG). An immediate, transient reduction in resting heart rate was observed during tibial loading in both adult male and female mice (<em>p</em> &lt; 0.01) with concurrent increases in heart rate variability (HRV) (p &lt; 0.01). ECG intervals, PR, QRS and QTc were unaffected with loading. In further studies, we found that at least 3 N of load was necessary to elicit this heart response in adult mice. With aging to 11–12 months the responsiveness of the heart to loading was blunted, suggesting this bone-heart connection may weaken with age. Administration of lidocaine around the tibia significantly diminished the heart rate response to bone loading (<em>p</em> &lt; 0.05). Moreover, pre-treatment with sympathetic antagonist propranolol inhibited this heart rate response to loading (<em>p</em> &lt; 0.05), while parasympathetic antagonist atropine did not (<em>p</em> &gt; 0.05). This suggests that a neuronal afferent pathway in the hindlimb and reduction in efferent sympathetic tone mediate this bone-neuro-heart reflex. In conclusion, the findings that tibia bone loading age-dependently modulates heart function support the concept of physiological coupling of the skeletal and cardiovascular systems.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"25 ","pages":"Article 101844"},"PeriodicalIF":2.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}