BMC Neuroscience最新文献

{"title":"APOE4 rat model of Alzheimer's disease: sex differences, genetic risk and diet.","authors":"Bradley Colarusso, Richard Ortiz, Julian Yeboah, Arnold Chang, Megha Gupta, Praveen Kulkarni, Craig F Ferris","doi":"10.1186/s12868-024-00901-z","DOIUrl":"10.1186/s12868-024-00901-z","url":null,"abstract":"<p><p>The strongest genetic risk factor for Alzheimer's disease (AD) is the ε4 allele of apolipoprotein E (ApoE ε4). A high fat diet also adds to the risk of dementia and AD. In addition, there are sex differences as women carriers have a higher risk of an earlier onset and rapid decline in memory than men. The present study looked at the effect of the genetic risk of ApoE ε4 together with a high fat/high sucrose diet (HFD/HSD) on brain function in male and female rats using magnetic resonance imaging. We hypothesized female carriers would present with deficits in cognitive behavior together with changes in functional connectivity as compared to male carriers. Four-month-old wildtype and human ApoE ε4 knock-in (TGRA8960), male and female Sprague Dawley rats were put on a HFD/HSD for four months. Afterwards they were imaged for changes in function using resting state BOLD functional connectivity. Images were registered to, and analyzed, using a 3D MRI rat atlas providing site-specific data on 173 different brain areas. Resting state functional connectivity showed male wildtype had greater connectivity between areas involved in feeding and metabolism while there were no differences between female and male carriers and wildtype females. The data were unexpected. The genetic risk was overshadowed by the diet. Male wildtype rats were most sensitive to the HFD/HSD presenting with a deficit in cognitive performance with enhanced functional connectivity in neural circuitry associated with food consumption and metabolism.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"25 1","pages":"57"},"PeriodicalIF":2.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tapping into the vocal learning and rhythmic synchronization hypothesis.","authors":"Constantina Theofanopoulou","doi":"10.1186/s12868-024-00863-2","DOIUrl":"10.1186/s12868-024-00863-2","url":null,"abstract":"<p><p>In this article, I present three main points that could benefit the \"vocal learning and rhythmic synchronization hypothesis\", encompassing neurogenetic mechanisms of gene expression transmission and single motor neuron function, classification of different behavioral motor phenotypes (e.g., spontaneous vs. voluntary), and other evolutionary considerations (i.e., the involvement of reward mechanisms).</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"25 1","pages":"63"},"PeriodicalIF":2.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De-sync: disruption of synchronization as a key factor in individual and collective creative processes.","authors":"Julien Laroche, Asaf Bachrach, Lior Noy","doi":"10.1186/s12868-024-00874-z","DOIUrl":"10.1186/s12868-024-00874-z","url":null,"abstract":"<p><p>Creativity is a key skill for the twenty-first century, where the individual and collective imperative to adapt is omnipresent. Yet, it is still unclear how to put creativity theories into practice, which signals a lacuna in our understanding of the pragmatic means by which we get creative. This paper starts from the identification of a number of gaps in the literature. In particular, individual and group creativity are usually treated separately, and the emphasis on the search for novelty seems to overshadow the importance experts give to the disruption of their habitual patterns of behavior. To overcome these gaps, we propose foundations for a unifying framework that takes the perspective of dynamical systems. Specifically, we suggest that de-synchronization, a hallmark of disruption, is an integral part of the creative processes that operate across individual and collective levels of analysis. We show that by conjuring uncertainty, de-synchronized states provide opportunities for creative reorganization. In order to ground this framework, we survey and discuss existing literature, and focus on group improvisation practices (in particular, music and dance improvisation), where partners use the dynamics of their interaction to bring forth a collective performance in real-time. In these practices, disruption by de-synchronization, termed here as 'problematization of coordination', is a pragmatic approach used to push the creative process forward. We suggest that this approach might also be relevant in other types of individual and collective creative processes.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"25 1","pages":"67"},"PeriodicalIF":2.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The social and neural bases of creative movement: workshop overview.","authors":"Shihab Shamma, Jose Contreras-Vidal, Jonathan Fritz, Soo-Siang Lim, Betty Tuller, Emmeline Edwards, Sunil Iyengar","doi":"10.1186/s12868-024-00893-w","DOIUrl":"10.1186/s12868-024-00893-w","url":null,"abstract":"<p><p>This editorial provides a background and overview of the interdisciplinary workshop on \"The Social and Neural Bases of Creative Movement,\" bringing together dancers, choreographers, musicians, artists, kinesiologists and neuroscientists to share perspectives and develop a common language to define and explore the relationship between dance and the brain.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"25 1","pages":"68"},"PeriodicalIF":2.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dance as mindful movement: a perspective from motor learning and predictive coding.","authors":"W Tecumseh Fitch, Rebecca Barnstaple","doi":"10.1186/s12868-024-00894-9","DOIUrl":"10.1186/s12868-024-00894-9","url":null,"abstract":"<p><p>Defining \"dance\" is challenging, because many distinct classes of human movement may be considered dance in a broad sense. Although the most obvious category is rhythmic dancing to a musical beat, other categories of expressive movement such as dance improvisation, pantomime, tai chi, or Japanese butoh suggest that a more inclusive conception of human dance is needed. Here we propose that a specific type of conscious awareness plays an overarching role in most forms of expressive movement and can be used to define dance (in the broad sense). We can briefly summarize this broader notion of dance as \"mindful movement.\" However, to make this conception explicit and testable, we need an empirically verifiable characterization of \"mindful movement.\" We propose such a characterization in terms of predictive coding and procedural learning theory: mindful movement involves a \"suspension\" of automatization. When first learning a new motor skill, we are highly conscious of our movements, and this is reflected in neural activation patterns. As skill increases, automatization and overlearning occurs, involving a progressive suppression of conscious awareness. Overlearned, habitual movement patterns become mostly unconscious, entering consciousness only when mistakes or surprising outcomes occur. In mindful movement, this automatization process is essentially inverted or suspended, reactivating previously unconscious details of movement in the conscious workspace, and crucially enabling a renewed aesthetic attention to such details. This wider perspective on dance has important implications for potential animal analogs of human dance and leads to multiple lines of experimental exploration.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"25 1","pages":"69"},"PeriodicalIF":2.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beat-based dancing to music has evolutionary foundations in advanced vocal learning.","authors":"Aniruddh D Patel","doi":"10.1186/s12868-024-00843-6","DOIUrl":"10.1186/s12868-024-00843-6","url":null,"abstract":"<p><p>Dancing to music is ancient and widespread in human cultures. While dance shows great cultural diversity, it often involves nonvocal rhythmic movements synchronized to musical beats in a predictive and tempo-flexible manner. To date, the only nonhuman animals known to spontaneously move to music in this way are parrots. This paper proposes that human-parrot similarities in movement to music and in the neurobiology of advanced vocal learning hold clues to the evolutionary foundations of human dance. The proposal draws on recent research on the neurobiology of parrot vocal learning by Jarvis and colleagues and on a recent cortical model for speech motor control by Hickock and colleagues. These two lines of work are synthesized to suggest that gene regulation changes associated with the evolution of a dorsal laryngeal pitch control pathway in ancestral humans fortuitously strengthened auditory-parietal cortical connections that support beat-based rhythmic processing. More generally, the proposal aims to explain how and why the evolution of strong forebrain auditory-motor integration in the service of learned vocal control led to a capacity and proclivity to synchronize nonvocal movements to the beat. The proposal specifies cortical brain pathways implicated in the origins of human beat-based dancing and leads to testable predictions and suggestions for future research.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"25 1","pages":"65"},"PeriodicalIF":2.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mobile brain imaging in butoh dancers: from rehearsals to public performance.","authors":"Constantina Theofanopoulou, Sadye Paez, Derek Huber, Eric Todd, Mauricio A Ramírez-Moreno, Badie Khaleghian, Alberto Muñoz Sánchez, Leah Barceló, Vangeline Gand, José L Contreras-Vidal","doi":"10.1186/s12868-024-00864-1","DOIUrl":"10.1186/s12868-024-00864-1","url":null,"abstract":"<p><strong>Background: </strong>Dissecting the neurobiology of dance would shed light on a complex, yet ubiquitous, form of human communication. In this experiment, we sought to study, via mobile electroencephalography (EEG), the brain activity of five experienced dancers while dancing butoh, a postmodern dance that originated in Japan.</p><p><strong>Results: </strong>We report the experimental design, methods, and practical execution of a highly interdisciplinary project that required the collaboration of dancers, engineers, neuroscientists, musicians, and multimedia artists, among others. We explain in detail how we technically validated all our EEG procedures (e.g., via impedance value monitoring) and minimized potential artifacts in our recordings (e.g., via electrooculography and inertial measurement units). We also describe the engineering details and hardware that enabled us to achieve synchronization between signals recorded at different sampling frequencies, along with a signal preprocessing and denoising pipeline that we used for data re-sampling and power line noise removal. As our experiment culminated in a live performance, where we generated a real-time visualization of the dancers' interbrain synchrony on a screen via an artistic brain-computer interface, we outline all the methodology (e.g., filtering, time-windows, equation) we used for online bispectrum estimations. Additionally, we provide access to all the raw EEG data and codes we used in our recordings. We, lastly, discuss how we envision that the data could be used to address several hypotheses, such as that of interbrain synchrony or the motor theory of vocal learning.</p><p><strong>Conclusions: </strong>Being, to our knowledge, the first study to report synchronous and simultaneous recording from five dancers, we expect that our findings will inform future art-science collaborations, as well as dance-movement therapies.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"25 1","pages":"62"},"PeriodicalIF":2.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZA-II-05, a novel NMDA-receptor antagonist reverses vanadium-induced neurotoxicity in Caenorhabditis elegans (C. elegans).","authors":"Amany Ladagu, Funmilayo Olopade, Paul Chazot, Taiwo Elufioye, Toan Luong, Madison Fuller, Ethan Halprin, Jessica Mckay, Zeynep Ates-Alagoz, Taidinda Gilbert, Adeboye Adejare, James Olopade","doi":"10.1186/s12868-024-00902-y","DOIUrl":"10.1186/s12868-024-00902-y","url":null,"abstract":"<p><strong>Introduction: </strong>Vanadium is a widely used transition metal in industrial applications, but it also poses significant neurotoxic and environmental risks. Previous studies have shown that exposure to vanadium may lead to neurodegenerative diseases and neuropathic pain, raising concerns about its impact on human health and the ecosystem. To address vanadium neurotoxicity, through targeting NMDA glutamate and dopamine signaling, both involved in neurodegenerative disorders, shows promise. Using Caenorhabditis elegans as a model, we evaluated a novel compound with a mixed NMDA glutamate receptor-dopamine transporter pharmacology, ZA-II-05 and found it effectively ameliorated vanadium-induced neurotoxicity, suggesting a potential neuroprotective role.</p><p><strong>Methods: </strong>Synchronized young adult worms were assigned to four different experimental groups; Controls; 100 mM of Vanadium; Vanadium and 1 mg/ml ZA-II-05; and ZA-II-05 alone. These were examined with different markers, including DAPI, MitoTracker Green and MitoSox stains for assessment of nuclei and mitochondrial density and oxidative stress, respectively.</p><p><strong>Results: </strong>Exposure to vanadium in C. elegans resulted in decreased nuclear presence and reduction in mitochondrial content were also analyzed based on fluorescence in the pharyngeal region, signifying an increase in the production of reactive oxygen species, while vanadium co-treatment with ZA-II-05 caused a significant increase in nuclear presence and mitochondrial content.</p><p><strong>Discussion: </strong>Treatment with ZA-II-05 significantly preserved cellular integrity, exhibiting a reversal of the detrimental effects induced by vanadium by modulating and preserving the normal function of chemosensory neurons and downstream signaling pathways. This study provides valuable insights into the mechanisms of vanadium-induced neurotoxicity and offers perspectives for developing therapeutic interventions for neurodegenerative diseases related to environmental toxins.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"25 1","pages":"56"},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and functional sex differences in medial temporal lobe subregions at midlife.","authors":"Marie Caillaud, Isabelle Gallagher, Janelle Foret, Andreana P Haley","doi":"10.1186/s12868-024-00905-9","DOIUrl":"10.1186/s12868-024-00905-9","url":null,"abstract":"<p><strong>Background: </strong>Research has increasingly recognized sex differences in aging and Alzheimer's Disease (AD) susceptibility. However, sex effects on the medial temporal lobe (MTL), a crucial region affected by aging and AD, remain poorly understood when it comes to the intricacies of morphology and functional connectivity. This study aimed to systematically analyze structural and functional connectivity among MTL subregions, which are known to exhibit documented morphological sex differences, during midlife, occurring before the putative pivotal age of cerebral decline. The study sought to explore the hypothesis that these differences in MTL subregion volumes would manifest in sex-related functional distinctions within the broader brain network.</p><p><strong>Methods: </strong>201 cognitively unimpaired adults were included and stratified into four groups according to age and sex (i.e., Women and Men aged 40-50 and 50-60). These participants underwent comprehensive high-resolution structural MRI as well as resting-state functional MRI (rsfMRI). Utilizing established automated segmentation, we delineated MTL subregions and assessed morphological differences through an ANOVA. Subsequently, the CONN toolbox was employed for conducting ROI-to-ROI and Fractional Amplitude of Low-Frequency Fluctuations (fALFF) analyses to investigate functional connectivity within the specific MTL subregions among these distinct groups.</p><p><strong>Results: </strong>Significant differences in volumetric measurements were found primarily between women aged 40-50 and men of all ages, in the posterior hippocampus (pHPC) and the parahippocampal (PHC) cortex (p < 0.001), and, to a lesser extent, between women aged 50-60 and men of all ages (p < 0.05). Other distinctions were observed, but no significant differences in connectivity patterns or fALFF scores were detected between these groups.</p><p><strong>Discussion: </strong>Despite notable sex-related morphological differences in the posterior HPC and PHC regions, women and men appear to share a common pattern of brain connectivity at midlife. Longitudinal analyses are necessary to assess if midlife morphological sex differences in the MTL produce functional changes over time and thus, their potential role in cerebral decline.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"25 1","pages":"55"},"PeriodicalIF":2.4,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring sex differences in auditory saliency: the role of acoustic characteristics in bottom-up attention.","authors":"Naoya Obama, Yoshiki Sato, Narihiro Kodama, Yuhei Kodani, Katsuya Nakamura, Ayaka Yokozeki, Shinsuke Nagami","doi":"10.1186/s12868-024-00909-5","DOIUrl":"10.1186/s12868-024-00909-5","url":null,"abstract":"<p><strong>Background: </strong>Several cognitive functions are related to sex. However, the relationship between auditory attention and sex remains unclear. The present study aimed to explore sex differences in auditory saliency judgments, with a particular focus on bottom-up type auditory attention.</p><p><strong>Methods: </strong>Forty-five typical adults (mean age: 21.5 ± 0.64 years) with no known hearing deficits, intelligence abnormalities, or attention deficits were enrolled in this study. They were tasked with annotating attention capturing sounds from five audio clips played in a soundproof room. Each stimulus contained ten salient sounds randomly placed within a 1-min natural soundscape. We conducted a generalized linear mixed model (GLMM) analysis using the number of responses to salient sounds as the dependent variable, sex as the between-subjects factor, duration, maximum loudness, and maximum spectrum of each sound as the within-subjects factor, and each sound event and participant as the variable effect.</p><p><strong>Results: </strong>No significant differences were found between male and female groups in age, hearing threshold, intellectual function, and attention function (all p > 0.05). Analysis confirmed 77 distinct sound events, with individual response rates of 4.0-100%. In a GLMM analysis, the main effect of sex was not statistically significant (p = 0.458). Duration and spectrum had a significant effect on response rate (p = 0.006 and p < 0.001). The effect of loudness was not statistically significant (p = 0.13).</p><p><strong>Conclusions: </strong>The results suggest that male and female listeners do not differ significantly in their auditory saliency judgments based on the acoustic characteristics studied. This finding challenges the notion of inherent sex differences in bottom-up auditory attention and highlights the need for further research to explore other potential factors or conditions under which such differences might emerge.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"25 1","pages":"54"},"PeriodicalIF":2.4,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}