{"title":"胆碱对短暂性全局失忆（TGA）有影响吗？","authors":"Sasan Rahmanian, Mahsa Shapouri, Mohammad Keshavarz Mohammadian, Zahra Mahmoudi, Zahra Saeedirad, Khadijeh Abbasi Mobarakeh, Abdolrahman Parhiz, Soheila Shekari, Asma Rajabi Harsini, Neda Valisoltani, Sara Khoshdooz, Saeid Doaei, Akram Kooshki, Maryam Gholamalizadeh","doi":"10.1186/s12868-024-00898-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Choline was frequently reported to have some beneficial effects on memory function. However, the association of dietary choline with different types of amnesia is not well understood. The objective of this study was to examine the association between dietary intake of choline and transient global amnesia (TGA).</p><p><strong>Methods: </strong>This case-control study was carried out on 258 patients with TGA and 520 participants without amnesia. Data on dietary choline intake was collected using a validated food frequency questionnaire (FFQ). All participants were examined for amnesia by a neurologist according to the Kaplan and Hodges criteria.</p><p><strong>Results: </strong> There was an inverse association between TGA and dietary choline intake after adjustment for age and gender (OR: 0.98, CI 95% 0.96-0.98, P = 0.03). The association remained significant after additional adjusting for physical activity, body mass index (BMI), occupation, marital status, smoking, and drinking alcohol (OR: 0.98, CI 95% 0.96-0.99, P = 0.04) and after further adjustment for calorie and food groups intake (OR: 0.98, CI 95% 0.96-0.99, P = 0.03).</p><p><strong>Conclusion: </strong>The results of this study indicated that choline may have beneficial effects against TGA. Further longitudinal studies are warranted.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"25 1","pages":"72"},"PeriodicalIF":2.4000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575108/pdf/","citationCount":"0","resultStr":"{\"title\":\"Does choline have an effect on Transient Global Amnesia (TGA)?\",\"authors\":\"Sasan Rahmanian, Mahsa Shapouri, Mohammad Keshavarz Mohammadian, Zahra Mahmoudi, Zahra Saeedirad, Khadijeh Abbasi Mobarakeh, Abdolrahman Parhiz, Soheila Shekari, Asma Rajabi Harsini, Neda Valisoltani, Sara Khoshdooz, Saeid Doaei, Akram Kooshki, Maryam Gholamalizadeh\",\"doi\":\"10.1186/s12868-024-00898-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Choline was frequently reported to have some beneficial effects on memory function. However, the association of dietary choline with different types of amnesia is not well understood. The objective of this study was to examine the association between dietary intake of choline and transient global amnesia (TGA).</p><p><strong>Methods: </strong>This case-control study was carried out on 258 patients with TGA and 520 participants without amnesia. Data on dietary choline intake was collected using a validated food frequency questionnaire (FFQ). All participants were examined for amnesia by a neurologist according to the Kaplan and Hodges criteria.</p><p><strong>Results: </strong> There was an inverse association between TGA and dietary choline intake after adjustment for age and gender (OR: 0.98, CI 95% 0.96-0.98, P = 0.03). The association remained significant after additional adjusting for physical activity, body mass index (BMI), occupation, marital status, smoking, and drinking alcohol (OR: 0.98, CI 95% 0.96-0.99, P = 0.04) and after further adjustment for calorie and food groups intake (OR: 0.98, CI 95% 0.96-0.99, P = 0.03).</p><p><strong>Conclusion: </strong>The results of this study indicated that choline may have beneficial effects against TGA. Further longitudinal studies are warranted.</p>\",\"PeriodicalId\":9031,\"journal\":{\"name\":\"BMC Neuroscience\",\"volume\":\"25 1\",\"pages\":\"72\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-11-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575108/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12868-024-00898-5\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12868-024-00898-5","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Does choline have an effect on Transient Global Amnesia (TGA)?
Background: Choline was frequently reported to have some beneficial effects on memory function. However, the association of dietary choline with different types of amnesia is not well understood. The objective of this study was to examine the association between dietary intake of choline and transient global amnesia (TGA).
Methods: This case-control study was carried out on 258 patients with TGA and 520 participants without amnesia. Data on dietary choline intake was collected using a validated food frequency questionnaire (FFQ). All participants were examined for amnesia by a neurologist according to the Kaplan and Hodges criteria.
Results: There was an inverse association between TGA and dietary choline intake after adjustment for age and gender (OR: 0.98, CI 95% 0.96-0.98, P = 0.03). The association remained significant after additional adjusting for physical activity, body mass index (BMI), occupation, marital status, smoking, and drinking alcohol (OR: 0.98, CI 95% 0.96-0.99, P = 0.04) and after further adjustment for calorie and food groups intake (OR: 0.98, CI 95% 0.96-0.99, P = 0.03).
Conclusion: The results of this study indicated that choline may have beneficial effects against TGA. Further longitudinal studies are warranted.
期刊介绍：
BMC Neuroscience is an open access, peer-reviewed journal that considers articles on all aspects of neuroscience, welcoming studies that provide insight into the molecular, cellular, developmental, genetic and genomic, systems, network, cognitive and behavioral aspects of nervous system function in both health and disease. Both experimental and theoretical studies are within scope, as are studies that describe methodological approaches to monitoring or manipulating nervous system function.
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